API release notes

In addition to the browser-based interface, GlyGen also provides RESTful Glygen webservice-based APIs and SPARQL endpoints, allowing programmatic access to integrated datasets.

Version 2.9

Main article: API release notes/2.9

This version was implemented on September 1st, 2025

• Implemented Disease APIs for new Disease search, list and details pages

• Implemented APIs for Batch Retrieval tool

• Changes to Global and simple search APIs to improve performance

Version 2.8

Main article: API release notes/2.8

Added information from Data Version 2.8

• Implement Clustal container and API
• Filter for tools (prediction and literature mining)
• Glycan list page - separate Pubchem ids
• Column chooser init - separate PubChem compound and substance
• Need to add a type parameter in the evidence object to differentiate
• Need to change simple search api to support all types of glycans.
• Need to add message in protein simple search init api for glycan category/id.
• Text mining algorithm name and url in protein glycosylation text mining tab
• Need to verify if summary message has proper site count in Glycosylation table summary section.
• Link to external resources from GlyGen list pages (API)

Version 1.8

Added information from Data Version 1.8.22

• F protein (P0C045-1) was removed from Hepatitis C virus (genotype 1a, isolate H) proteome
• Hepatitis C Virus (genotype 1a, isolate H) Tax ID changed from 11108 to 63746.
• NCBI GeneID and Refseq datasets for SARS-CoV2 created
• Accession history files created for tracking protein and glycan accessions
• Mouse and rat disease datasets created to add disease data in the disease section
• Data entries for O-GlcNAc data now point to The O-GlcNAc resource instead of the dataset.
• human_proteoform_glycosylation_sites_o_glcnac_mcw updated with new O-GlcNAc data
• n-sequon and n-sequon type fields added to the glycosylation datasets for data validation
• Removed predicted glycosylation data from the UniProtKB data when reported glycosylation data is present for the same data entry.
• Update to the Glycomotif alignment logic, motif keyword, publications
• Update to the GlyConnect data, Automatic Literature Data, Disease data from Genomics England
• Update to the GlyTouCan to ChEBI mapping method.
• Addition of new glycan type and subtypes
• Integration of GlycoTree alignment infrastructure
• addition of semantic names from GlycoMotif
• Addition of ~1800 new GlyTouCan accessions
• Addition of new sections in glycan detail pages:
  • subsumption(related glycans through GNOme)
  • expression(glycans expressed in cell-line/Tissue)
  • History (release no. where the glycan was introduced in GlyGen)
• Addition of glycan keywords (Motif Group), Synonyms, Reducing End information to the Motif detail page.
• Addition of citations from NCFG data for Asparagine-linked glycans
• Addition of GNOme and SandBox references
• Addition of Disease data from Glycosmos
• Addition of evidence to the "Biosynthetic Enzyme" section on the glycan detail page.
• Addition of Rhea and Reactome cross-references to glycan detail pages
• Addition of GlyGen links in ChEBI and GlyTouCan databases.  

Version 1.7.12

Added information from Data Version 1.7.13

• Update to the New Motif list. Replacing GlyTouCan Motif accessions with GlyGen motif list with GlyTouCan Motifs as X-ref's.
• Addition of Motif synonyms.
• Including glycosylation annotation (Protein+PMID+Glycan) on unreported sites from GlyConnect.
• Refined/corrected BioSynthetic enzyme data.
• Addition of new Glycan subtypes (o-fucose, o-mannose).
• Updated glycan images from GlyTouCan.
• New data: Protein+GAGs data from MatrixDB.
• Addition of GlyGen x-ref on GlyConnect protein entry pages.
• Addition of GlyGen x-ref on PubChem compound and PubChem protein pages.
• Addition of new glycans into ChEBI.
• Addition of Mutagenesis data from UniProt
• Addition of PMIDs for SNV data
• GlyGen dataset BCO prefix changed from DSBCO to GLY

Version 1.5.43

Added information from Data Version 1.5.36

• Update to the New Motif list. Replacing GlyTouCan Motif accessions with GlyGen motif list with GlyTouCan Motif's as X-ref's
• Including glycosylation annotation (Protein+PMID+Glycan) on unreported sites from GlyConnect.
• Refined/corrected BioSynthetic enzyme data.

Version 1.5.26

Added information from Data Version 1.5.18

No update for API only.

Version 1.0

Main article: API release notes/1.0

This version was released January 14th, 2020.

• Isoform Alignment.
• Homolog Alignment.
• New Usecase added in the quick search.
• Composition Search.
• Go ID search.
• PMID search.
• Batch search on advanced protein and glycan search page.
• Multi-select option for amino acids on advanced glycoprotein search.
• Multi-select option for organisms on advanced glycan search.
• Integrate subsumption browser.