Glycan structure dictionary
Contains glycan structure terms detected by automatic and manual literature mining. It follows the format from a regular dictionary:http://web.hku.hk/mw/exnotes.html
To report any issues or add annotations or new terms to the dictionary contact rsn13@gwu.edu
Term: core fucosylated
Definition: Modification of the N-glycan core structure with fucose moiety attached at the innermost GlcNAc facilitated by FUT8 enzyme. [MT, RN, https://doi.org/10.1016/bs.acr.2014.11.006].
Term reference: N/A
Synonyms: Core Fuc| 6-linked Fuc|Fuca6 to chitobiose core|a6-linked Fuc|a1-6 Fuc|Fuca6 to chitobiose core|Fuc a1-6 to chitobiose core|Fuca6 to internal GlcNAc|Fuc a1-6 to internal GlcNAc
Function: Required for signaling through TCR [PMID: 29434598]. | VGF, PDGFr, and EGFr and TGFbeta receptor dysregulation in Fut8 KO mice [PMID: 17132494]| IgG-Fcg receptor interactions destabilized by core Fuc [PMID: 29062024]
Disease associations: Emphysema[MT]|systemic lupus erythematosus[MT]lung cancer[MT]|autoimmunity[MT]|tumor metastasis[MT]
Publication(s): Exact-Match Non-Exact-Match
Term in sentence: The approach was validated for selective capture and analysis of core fucosylated N-glycans present in complex glycan mixtures derived from mammalian serum IgG.[PMID:27678371]
Wikipedia page: N/A
Essentials of Glycobiology: N/A
Term: sialyl Lewis X
Definition: A sialylated version of Lewis X antigen expressed on cell surfaces with structure Alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc is alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc in which the anomeric configuration of the reducing-end N-acetyl-beta-D-glucosamine residue is beta. It is a ligand for selectins. [MESH:2030970,CHEBI:71622,RN]
Term reference: GTC:G00054MO GlycoEpitope:EP0012 CID:44456859 CHEBI:71622 MESH:2030970GlycoMotif:GM.G00054MO
Synonyms: Slex| SLex| SLe^x
Function: Sialyl Lex was shown to be a specific ligand on human leukocytes for vascular E- and P-selectins,and was shown to mediate leukocyte recruitment.[GlycoEpitope:EP0012]|The determinant is also frequently expressed on human cancer cells,and is involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0012]
Disease associations: colon cancer[GlycoEpitope:EP0012]|colorectal cancer[GlycoEpitope:EP0012]
Publication(s): Exact-Match
Term in sentence: As sialyl Lewis X is a lignad of the selectin family, it has been proposed that sialyl Lewis X-rich colon cancer cells metastasize to the liver by adhesion to selectins on hepatic endothelial cells.[PMID:12828079]
Wikipedia page: Sialyl-Lewis_X
Essentials of Glycobiology: NBK453042-Chapter14
Term: N-linked glycans
Definition: The term used to refer to the carbohydrate portion of N-glycoproteins when attached to a nitrogen from asparagine or arginine side-chains.[CHEBI:59520]
Term reference: CHEBI:59520
Synonyms: N/A
Function: N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374]. Affect transportation of the glycosylated proteins in the Golgi. [PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding. [PMID: 25151374]. extracellular N-glycans act as key modulators of neuronal uptake of αSacetyl [PMID: 31211781]
Disease associations: Rheumatoid arthritis[PMID:17392038]. Type 1 Diabetes[PMID:29146600]. Lung Cancer[PMID: 23766031]
Publication(s): Exact-Match Non-Exact-Match
Term in sentence: Structural analysis of N-linked glycans in Caenorhabditis elegans.[PMID:12038976]
Wikipedia page: N-linked glycans
Essentials of Glycobiology: NBK453020-Chapter 9