Glycan structure dictionary
Contains glycan terms detected by automatic literature mining + manual extraction of terms from papers available in GlyGen.
Follows concepts from a regular dictionary such as http://web.hku.hk/mw/exnotes.htm
Term: N-linked glycans
Term in sentence: Structural analysis of N-linked glycans in Caenorhabditis elegans.[PMID:12038976]
Publication: 12038976|17293352|19864504|24279413|29671580|7774715|7774715|8687384|8687384
Definition: The term used to refer to the carbohydrate portion of N-glycoproteins when attached to a nitrogen from asparagine or arginine side-chains.[CHEBI:59520]
Term reference: CHEBI:59520
PMID count: 9
Synonyms:
Function: N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374] Affect transportation of the glycosylated proteins in the Golgi. [PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding. [PMID: 25151374]|extracellular N-glycans act as key modulators of neuronal uptake of αSacetyl [PMID: 31211781]
Disease associations: Rheumatoid arthritis[PMID:17392038]|Type 1 Diabetes[PMID:29146600]|Lung Cancer[PMID: 23766031]
Wikipedia page: N-linked glycans
Essentials of glycobiology: NBK453020-Chapter 9
Term: high-mannose
Term in sentence: Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:11258925]
Publication: 11258925|17956937|2059624|2065054|26791533|4077844|7780197|9136890|30659065
Definition: Any oligosaccharide derivative which typically contains unsubstituted terminal mannose sugars with between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717]
Term reference: CHEBI:5717
PMID count: 9
Synonyms: oligomannose
Function: Involved in promotion of protein folding in ER. [PMID:12417032] High Man glycans are enriched at cell surface during apoptosis [PMID: 17516205]
Relative abundance changes in multiple CDGs [PMID: 30770376][PMID: 28484880][MT]
Disease associations:
Wikipedia page:
Essentials of glycobiology: NBK453020-Chapter 9