Glycan structure dictionary

Glycan structure dictionary host terms commonly used to describe glycan structures in publications. The terms are primarily sourced via automatic and manual literature mining as well as from other bioinformatics databases. The terms are updated regularly to include the new term(s) and are sorted alphabetically. To submit new terms go to section Glycan structure dictionary#Submit new terms. Please note that this is a work in progress. Contact https://www.glygen.org/contact-us/ to report any issues.

Submit new terms

If you feel that a term is missing, you can submit a single term using the online form found at https://data.glygen.org/gsd/ . To submit multiple terms you can use GlyGen file upload https://data.glygen.org/upload. Template for submitting terms can be found here. Contact https://www.glygen.org/contact-us/ for any questions.

Terms

2,6-Branched O-mannose

term (main_entry) : 2,6-Branched O-mannose
term_in_sentence : Collectively, these results strongly suggest that GnT-IX may be a novel beta1,6-N-acetylglucosaminyltransferase that is responsible for the formation of the 2,6-branched structure in the brain O-mannosyl glycan.[PMID:14617637]
publication : 14617637|10469154
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-[[(2R,3S,4S,5S,6S)-5-[(2S,3R,4R,5S,6R)-3-acetamido-5-[(2S,3R,4S,5S,6R)-4-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,6-trihydroxyoxan-2-yl]methoxy]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid.[CHEBI:157265]
term_xref : GTC:G06953DR|CHEBI:157265|GlycoMotif:GGM.000056
best_match :
synonymns : 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2->3)-beta-D-galacto-hexopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-gluco-hexopyranosyl-(1->2)-[5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2->3)-beta-D-galacto-hexopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-gluco-hexopyranosyl-(1->6)]-alpha-D-manno-hexopyranose|NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)]a-Man
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

2,6-sialyl-Sulfo-LN

term (main_entry) : 2,6-sialyl-Sulfo-LN
term_in_sentence : The alpha2-6-sialylated 6-sulfo-LacNAc determinant defined by the antibody was significantly expressed on a majority of normal human peripheral B-lymphocytes as well as follicular B-lymphocytes in peripheral lymph nodes.[PMID:17728258]
publication : 17728258
definition :
term_xref : GTC:G41145LF|GlycoMotif:GGM.000026
best_match :
synonymns : 6-sialyl-6-sulfo LN
function : B-cell interaction with blood vessels and trafficking[PMID: 17728258]
disease_associations :
wikipedia :
essentials_of_glycobiology :

2-Fucosyl-GD1b

term (main_entry) : 2-Fucosyl-GD1b
term_in_sentence : They were fucosyl-Gv., fucoSyl-GDlb, and two uni que fucogangliosides having GMl or GOlb bas ic structure containing a substituent with the blood group B determinant. [PMID:3654655]
publication : 3654655
definition : (2S,4S,5R,6R)-5-Acetamido-6-[(1S,2R)-2-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-1,3-dihydroxypropyl]-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-acetamido-4-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxyoxane-2-carboxylic acid.[CHEBI:156680]
term_xref : GTC:G67383AR|CHEBI:156680|GlycoMotif:GGM.000103
best_match :
synonymns : 6-deoxy-alpha-L-galacto-hexopyranosyl-(1->2)-beta-D-galacto-hexopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-D-galacto-hexopyranosyl-(1->4)-[5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2->3)]-beta-D-galacto-hexopyranosyl-(1->4)-D-gluco-hexopyranose|Fuc(a1-2)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

2-Fucosyl-GM1

term (main_entry) : 2-Fucosyl-GM1
term_in_sentence : These glycolipid products were identified as asialo-Gs.., GM h and fucosyl-Gq, by comparison with authentic glycolipid samples.[PMID:3654655]
publication : 3654655
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-acetamido-4-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid.[CHEBI:151476]
term_xref : GTC:G56526JU|KEGG:G12241|CHEBI:151476|CID:91849786|GlycoMotif:GGM.000101
best_match :
synonymns : Fuc(a1-2)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc|6-deoxy-alpha-L-galacto-hexopyranosyl-(1->2)-beta-D-galacto-hexopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-D-galacto-hexopyranosyl-(1->4)-[5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2->3)]-beta-D-galacto-hexopyranosyl-(1->4)-D-gluco-hexopyranose
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

3-Sialyl-LN (type 2)

term (main_entry) : 3-Sialyl-LN (type 2)
term_in_sentence : Using new crystal structures, we also provide the atomic resolution basis for the differential recognition of 3′ and 6′SiaLacNAc1–4 (with the Galβ1–4 linkage known as Type 2 backbone16; Scheme 1) by TgMIC1-MARR, and make comparisons with the Type 1 chain isomer of 3′SiaLacNAc1–4 (designated 3′SiaLacNAc1–3).[PMID:19593815]
publication : 19593815|15659615|2414279|8586620|2111348|23747419
definition : A linear amino trisaccharide consisting of α-neuraminyl, β-D-galactosyl and N-acetyl-D-glucosamine residues linked in a (2→3) and (1→4) sequence.[CHEBI:52472]
term_xref : GTC:G10203DW|KEGG:G00253|SugarBind_Ligand:109|GlycoEpitope:EP0314|CHEBI:52472|GlycoMotif:GGM.000034
best_match :
synonymns : α-N-acetylneuraminosyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine|α-Neu5Ac-(2→3)-β-D-Gal-(1→4)-D-GlcNAc|N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine
function :
disease_associations : Chronic gastritis[SugarBind_Ligand:109]|Toxoplasmosis[SugarBind_Ligand:109]|Peptic ulcers[SugarBind_Ligand:109]|Gastric cancer[SugarBind_Ligand:109]
wikipedia :
essentials_of_glycobiology :

3'-Sulfo-Lewis a

term (main_entry) : 3'-Sulfo-Lewis a
term_in_sentence : A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes.[PMID:11504739]
publication : 11504739|17499486|17691854|12944557|19394320|7534477|11604107|28025252|9061363|9878545|11918697|24239607|28628803|25339106|21400496|17998215|12626387|11425799|12219077|10955596|9453593
definition : A sulphated version of Lewis a which is a a branched amino trisaccharide consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an α-linkage and a 3-sulfated galactosyl residue attached at the 3-position via a β-linkage.[CHEBI:65149]
term_xref : GTC:G78706CK|GlycoEpitope:EP0009|CID:5289352|GlycoMotif:GGM.000030
best_match : GTC:G78706CK|GlycoEpitope:EP0009|CID:5289352|
synonymns : 3'-Sulfo-Lea|SuLe(a)|3'-sulpho-Le(a)|3-O-sulfo-Le(A)|3'-Sulfo Le^a|3'-Sulfo Lea|3'-Sulfo Lewis a
function : SO3-3-Gal and the SO3-3-Lea blood group antigen bound to H.pylori.[GlycoEpitope:EP0009]
disease_associations :
wikipedia :
essentials_of_glycobiology :

3'-Sulfo-Lewis x

term (main_entry) : 3'-Sulfo-Lewis x
term_in_sentence : A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes.[PMID:11504739]
publication : 11504739|20695481|8688428|10536036|12770775|11352731|9784103|9022803
definition : A sulphated version of lewis X antigen which is a amino trisaccharide with structure Beta-D-Galp3S-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc that consists of N-acetyl-beta-D-glucosamine having an alpha-L-fucosyl residue attached at position 3 and a 3-sulfated beta-D-galactosyl residue attached at position 4; beta-D-Galp3S-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc in which the configuration at the anomeric centre of the reducing-end residue is beta. [CHEBI:65171,RN]
term_xref : GTC:G12295TB|GlycoEpitope:EP0013|CID:5289353|CHEBI:65171|GlycoMotif:GGM.000029
best_match : GTC:G12295TB|GlycoEpitope:EP0013|CID:5289353|CHEBI:65171
synonymns : 3'-sulfo-Le(x)|3'-Sulfo Lewis x|3'-sulfo Le^x|3'-sulfo Lex
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

6,6'-bisSulfo-Lewis x

term (main_entry) : 6,6'-bisSulfo-Lewis x
term_in_sentence : Comparison of the reactivity pattern of HEV with the reactivity of the pure 6-sulfo, 6'-sulfo, or 6,6'-bissulfo sialyl Lewis X determinant with hitherto known anti-sialyl Lewis X antibodies strongly suggested 6-sulfo sialyl Lewis X to be the best candidate for the major sulfated sialyl Lewis X determinant on HEV, followed by 6,6'-bissulfo sialyl Lewis X, whereas 6'-sulfo sialyl Lewis X was unlikely. [PMID:9556613]
publication : 19756298|14593101|15175329|14568956|12163379|11919403|11520459|10728707|10200296|10528213|9712885|9556613|9456330|9556613|9257857|9164959|9015359|8958810|7560094|7485559|7538131|8161542|7684905
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-hydroxy-2-(sulfooxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(sulfooxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid.[CHEBI:146095]
term_xref : GTC:G00659GQ|GlycoEpitope:EP0016|CHEBI:146095｜GlycoMotif:GGM.000028
best_match :
synonymns : 6,6'-DiSulfo Sialyl Lewis x|6,6-bisSulfo-Lewis x (6,60-bissulfo Lewis x )|6,6'- Disulfo Sialyl Lewis x|6,6'-bisSulfo-Lewis x|6,6'-bissulfo Lex|6,6'-Disulfo Sialyl Lewis x|6,6'-bissulfo Le^x
function : lymphocyte homing[GlycoEpitope:EP0016]
disease_associations :
wikipedia :
essentials_of_glycobiology :

6-Sialyl-GalNAc

term (main_entry) : 6-Sialyl-GalNAc
term_in_sentence : mmunohistochemical distributions of carbohydrate antigens based on the type 2 chain in normal as well as fetal and neoplastic tissues of human gastrointestinal tract were investigated with a monoclonal antibody (MAb) H11 (specific for type 2 chain) alone and in combination with the two MAbs MSG15 (for alpha 2----6 sialylated type 2 chain) and IB9 (for the alpha 2----6 sialylated type 2 chain and glycoproteins having NeuAc alpha 2----6Gal-NAc), and 188C1 (for short- and long-chain Lex antigens) and FH2 (for the long-chain Lex antigen). [PMID: 1618643]
publication : 1618643|6194157
definition : An amino disaccharide composed of N-acetylneuraminic acid and 2-(acetylamino)-2-deoxy-D-galactopyranose residues joined by an (α-2→6) glycosidic bond.[CHEBI:146820]
term_xref : GTC:G08371CD|GlycoEpitope:EP0352|KEGG:G00455|KEGG:G10625|CHEBI:146820|CID:11409652|GlycoMotif:GGM.000035
best_match :
synonymns : Sialyl Tn antigen|6-Sialyl-GalNAc|6-Sialyl LN|6-Sialyl LN (type 1)|6-Sialyl LN (type 2)
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

6-Sulfo LacNac

term (main_entry) : 6-Sulfo LacNac
term_in_sentence : In the search for an additional marker to better dissect the two subsets we have explored the marker 6-sulfo LacNAc (slan).[PMID:31572354]
publication : 31572354|31191513|29977237|29900053|30984181|28732748|26510404|28769928|31154896|27541644|25262889|26155414|28499587|27086951|27315572|26162403|26391152|31730025|12354382|27318477|23879812|25340085|24682513|21377044|21098395|18942710|23559493|23890755|22643330|23460612|23402811|22890025|19589615|32939325|20210806|17616642|22907335|16782032|22188261|21283706|29875315|32413173|19546436|19384158|1429720|30519676
definition : An oligosaccharide sulfate that is N-acetyllactosamine in which the hydroxy group at position 6 of the N-acetylglucosamine ring has been converted into its hydrogen sulfate derivative.[CHEBI:148005]
term_xref : GlycoEpitope:EP0141|GTC:G13157WZ|CID:10322152|CHEBI:148005
best_match : GlycoEpitope:EP0141|GTC:G13157WZ|CID:10322152|CHEBI:148005
synonymns : 6-Sulfo LacNAc
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

6'-Sulfo Sialyl Lewis x

term (main_entry) : 6'-Sulfo Sialyl Lewis x
term_in_sentence : Studies using sulfotransferase-deficient mice showed that 6-sulfo sialyl Lewis X (6-sulfo sLe(x)), a major ligand for L-selectin that is expressed on the high endothelial venules (HEVs), plays critical roles in lymphocyte homing to the peripheral lymph nodes.[PMID:2288521]
publication : 2288521|26137907|9400621|32744401|9556613|15972893|9015359|22691873|18652681|9722682|10435581|19458105|19359410|15228275|18250165|10536036|17944600|10460836|27993973|19149511|19150806|17172261|17142960|27956273|7578028|22260995|24519996|21596021|21982762|21775439|17334369|9710564|14593101|16227985|11895802|22750968|15157883|19067429
definition : Alpha-L-Fucp-(1->3)-[alpha-Neup5Ac-(2->3)-beta-D-Galp6S-(1->4)]-beta-D-GlcpNAc is a branched amino tetrasaccharide comprised of a trisaccharide chain of N-acetyl-alpha-neuraminic acid, 6-O-sulfo-beta-D-glactose and N-acetyl-beta-D-glucosamine residues linked sequentially (2->3) and (1->4), to the GlcNAC residue of which is also linked (1->3) an alpha-L-fucose residue. It has a role as an epitope. It is an amino tetrasaccharide and a glucosamine oligosaccharide.[CHEBI:71558]
term_xref : GlycoMotif:GGM.000025|GTC:G00672PE|CID:70698387|GlycoEpitope:EP0014|CHEBI:71558|SugarBind_Ligand:128
best_match : GlycoMotif:GGM.000025|GTC:G00672PE|CID:70698387|GlycoEpitope:EP0014|CHEBI:71558|SugarBind_Ligand:128
synonymns : 6'-sulfated sialyl Lewis x-|6'-sulfo-sLe(x)|Su-SaiLex|Su-SLex
function : lymphocyte homing[GlycoEpitope:EP0014]
disease_associations : Influenza[SugarBind_Ligand:128]
wikipedia :
essentials_of_glycobiology : NBK453042

6'-Sulfo-sialyl Lewis x

term (main_entry) : 6'-Sulfo-sialyl Lewis x
term_in_sentence : Next, we established mAbs (AG97 and AG273) directed against 6-sulfo Lewis X, the asialo form of 6-sulfo sialyl Lewis X.[PMID:9556613]
publication : 9556613|32744401|9400621|9556613|26137907|15972893|11331001|22691873|19458105|18652681|19359410|9722682|10435581|15228275|18250165|22288521|19043084|10536036|19149511|17944600|10460836|17172261|17334369|11895802|27993973|24519996|22260995|7578028|14593101|27357658|21982762|27956273|21596021|22750968|20929857|19067429
definition : A branched amino tetrasaccharide comprised of a trisaccharide chain of N-acetyl-α-neuraminic acid, 6-O-sulfo-β-D-glactose and N-acetyl-β-D-glucosamine residues linked sequentially (2→3) and (1→4), to the GlcNAC residue of which is also linked (1→3) an α-L-fucose residue.[CHEBI:7155]
term_xref : GTC:G00672PE|GlycoEpitope:EP0014|CHEBI:71558|CID:70698387|GlycoMotif:GGM.000025
best_match :
synonymns : 6'-Sulfo Sialyl Lewis x|6-Sulfo-sialyl Lewis x (6-sulfo SLewis x)|6'-sulfo SLex|6'-Sulfo-sialyl Lewis x|6'-sulfo SLe^x
function : lymphocyte homing[GlycoEpitope:EP0014]
disease_associations : bladder urothelial carcinoma[PMID:26137907]
wikipedia :
essentials_of_glycobiology :

9-O-Acetyl GD3

term (main_entry) : 9-O-Acetyl GD3
term_in_sentence : To determine whether 9-O-acetyl GD3 (acGD3) has a general antiapoptotic potential, the apoptosis-sensitive Jurkat cell line and an apoptosis-sensitive variant of the cell line Molt-4 were preincubated with micromolar concentrations of acGD3 and then treated with inducers of apoptosis.[PMID:16432837]
publication : 16432837|21507905|17512674|21930212|18194438|20739294|3216430|14724245|31373393|7558412|11273644|17385751|30694652|22894715|12973826|7859075|9749956|9874495|12486096|1989525|25330147|23478187|21807667|8486686|11465673|9511990|29270199|9268945|25045067|21618115|16434401|12493756|2302705|2198284|2685488|9328574|4055789|10096568|1644805|2582447
definition :
term_xref : GTC:G74121RX |GlycoEpitope:EP0064|CID:91852520|GlycoMotif:GGM.000093
best_match : GTC:G74121RX |GlycoEpitope:EP0064|CID:91852520
synonymns : acGD3|9-O-Acetylated GD3|9-O-Acetyl-GD3|9-O-Ac-GD3|CD60b
function :
disease_associations : pancreas cancer[GlycoEpitope:EP0064]
wikipedia :
essentials_of_glycobiology :

9-O-Acetyl sialic acid

term (main_entry) : 9-O-Acetyl sialic acid
term_in_sentence : Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation.[PMID:31411667]
publication : 31411667|27936566|2509478|10049046|1826463
definition : N-acetyl-9-O-acetyl-alpha-neuraminic acid is a member of the class of N-acetylneuraminic acids that is alpha-neuraminic acid which has acetylated on N-5 and O-9. It has functional parent alpha-neuraminic acid.[CHEBI:84941]
term_xref : GTC:G47325QT |GlycoEpitope:EP0065|CID:13991612|CHEBI:84941
best_match : GTC:G47325QT |GlycoEpitope:EP0065|CID:13991612|CHEBI:84941
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453082-Chapter 77

A Type 2

term (main_entry) : A Type 2
term_in_sentence : Herein we report the synthesis of 3-aminopropyl glycosides of A (type 2) and B (type 2) tetrasaccharides via [3 + 1] block scheme.[PMID:27196314]
publication : 27196314|6583282|8340255|18701592|21901093|2413709|8036794|1615929|3285099
definition : Alpha-D-GalpNAc-(1->3)-[alpha-L-Fucp-(1->2)]-beta-D-Galp-(1->4)-beta-D-GlcpNAc is a branched amino tetrasaccharide comprising N-acetyl-beta-D-glucosamine at the reducing end with a N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl moiety attached at the 4-position. It has a role as an epitope.[CHEBI:62486]
term_xref : GTC:G74353FF|CID:53262376|GlycoEpitope:EP0257|CHEBI:62486|GlycoMotif:GGM.000038
best_match : GTC:G74353FF|CID:53262376|GlycoEpitope:EP0257|CHEBI:62486|GlycoMotif:GGM.000038
synonymns : Blood group A (type 2)
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

A2

term (main_entry) : A2
term_in_sentence : Landsteiner ABO system of blood groups is most important for transfusion medicine and has subtypes of A Antigen, A1 and A2, upon which further groups of A and AB have been classified.[PMID:28658771]
publication : 29000000|28658771
definition :
term_xref : glycomotif:GGM.000041|GTC:G62735WZ|CID:91852328
best_match : glycomotif:GGM.000041|GTC:G62735WZ|CID:91852328
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Alpha-gal antigen

term (main_entry) : Alpha-gal antigen
term_in_sentence : Therefore, alpha-gal antigen might be eliminated after a prolonged culture, when using human cells.[PMID:31267683]
publication : 31267683|29319188|29481481|26140655|30337555|29235434|22909134|28280265|7532618|23390540|22808845|29898796|22262104|31267683|25430953|22993330|23578170|21043478|28294277|27696820|15814276|17991149|25577211|30578545|19895316|28068870|18546155|32907757|26485996|9771839|12042247|27567275|12131678|23114154|19184002|29577591|29806570|15638815|21118731
definition : A glycosylgalactose that consists of β-D-galactose having an α-D-galactosyl residue at the 3-position.[CHEBI:62330]
term_xref : GTC:G24432YB|GlycoMotif:GGM.000015|CID:52939789|CHEBI:62330
best_match : GTC:G24432YB|GlycoMotif:GGM.000015|CID:52939789|CHEBI:62330
synonymns : a-Gal antigen
function : Has role as a carbohydrate allergen, epitope or an antigen.[CHEBI:62330]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

Alpha-galactosylceramide

term (main_entry) : Alpha-galactosylceramide
term_in_sentence : From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (α-GalCer) or vehicle once a week for four weeks.[PMID:29844470]
publication : 29844470|30421497|31575643|30745361|30953000|30556652|29617191|31689579|28872688|30195979|29940370|27004737|27198610|28743554|31649670|31484693|25752588|21383248|25527277|30821985|28947140|31244823|29311431|30803854|29576533|26101952|31213291|22412194|28067024|31199716|27354638|24465013|25445911|28120096|15630427|27803187|21392534|31075434|22683545|26191196|26811064|23935988|28623127|24913977|25434827|23420533|21839133|25314062|27325450|23874157
definition :
term_xref :
best_match :
synonymns : alpha-GalCer|alpha-GalCers|α-GalCer
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Asialo-biantennary

term (main_entry) : Asialo-biantennary
term_in_sentence : Typical crystallizable fragment (Fc) glycans attached to the CH2 domain in therapeutic monoclonal antibodies (mAbs) are core-fucosylated and asialo-biantennary complex-type glycans, e.g., G2F (full galactosylation), G1aF (terminal galactosylation on the Man α1-6 arm), G1bF (terminal galactosylation on the Man α1-3 arm), and G0F (non-galactosylation).[PMID:30990348]
publication : 30990348|17645671|20959391|18615430|16945378|2065054|3084472|2386787|22911097|24692304|17013932|7513972|6626573|10835250|9684342
definition : A binantennary glycan lacking sialic acid as non-reducing terminal residues on either antennae RN,MT
term_xref :
best_match :
synonymns : asialo diantennary
function : Used as an adjuvant for experimental vaccines [1]
disease_associations :
wikipedia :
essentials_of_glycobiology :

Asialo-GM1

term (main_entry) : Asialo-GM1
term_in_sentence : We compared the lateral structure of giant unilamellar vesicles (GUVs) composed of three pseudo binary mixtures of different glycosphingolipid (GSL), i.e. sulfatide, asialo-GM1 or GM1, with POPC.[PMID:29106974]
publication : 29106974|3418980|26975993|8613364|9288228|26710925|24922516|6839313|1828259|2581667|8210226|25062498|9671150|10377092|6171919|3093429|6652964|3124753|8905612|18788941|1467432|8225593|2083955|6171918|7806377|1802483|7927723|9209156|21174147|2584393|12137200|6175621|2936802|8610366|21490162|1548508|3486908|26453755|7910939|3756909|1639356|3259967|2443562|3112077|2572647|25137483|2168971
definition :
term_xref : GlycoMotif:GGM.000099|GTC:G21856LC|CID:10169040|GlycoEpitope:EP0047|CHEBI:59216
best_match : GlycoMotif:GGM.000099|GTC:G21856LC|CID:10169040|GlycoEpitope:EP0047|CHEBI:59216
synonymns : as-GM1|GA-1|Gangliotetraosylceramide|GgO4|Gg4|Asialo-GM1a
function :
disease_associations : Pleuropneumonia[SugarBind_Ligand:2]||Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:2]||Actinomycosis[SugarBind_Ligand:2]||Lazy leukocyte syndrome[SugarBind_Ligand:2]||Pertussis[SugarBind_Ligand:2]||Cutaneous lesions[SugarBind_Ligand:2]||Melioidosis[SugarBind_Ligand:2]||Candidiasis[SugarBind_Ligand:2]||Taiwan acute respiratory agent[SugarBind_Ligand:2]||Trachoma[SugarBind_Ligand:2]||Cystitis[SugarBind_Ligand:2]||Chronic gastritis[SugarBind_Ligand:2]||Peptic ulcers[SugarBind_Ligand:2]||Gastric cancer[SugarBind_Ligand:2]||Klebsiella pneumonia infection[SugarBind_Ligand:2]||Pneumonia[SugarBind_Ligand:2]||Legionnaires' disease[SugarBind_Ligand:2]||Gonorrhea[SugarBind_Ligand:2]||Gastroenteritis[SugarBind_Ligand:2]||Toxoplasmosis[SugarBind_Ligand:2]||Plague[SugarBind_Ligand:2]||Diarrhea[SugarBind_Ligand:2]
wikipedia :
essentials_of_glycobiology :

B-GD1B

term (main_entry) : B-GD1B
term_in_sentence : The Molecular Modelling and 10 ns MD simulation of Botulinum Neuro Toxin/B-GD1A and BoNT/B-GD1B complex revealed that this toxin can interact with GD1A in the single binding mode and with GD1B in two binding modes.[PMID:22929125]
publication : 27956354|22929125
definition :
term_xref : glycomotif:GGM.000104|GTC:G72557NR|CID:91847819|KEGG:G01803|CHEBI:153361
best_match : glycomotif:GGM.000104|GTC:G72557NR|CID:91847819|KEGG:G01803|CHEBI:153361
synonymns : B-GD1b
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

B-GM1

term (main_entry) : B-GM1
term_in_sentence : The contribution of GM3 and GD3, which accounted for 95% of the ganglioside sialic acid at birth, decreased during the first 3 weeks of life. GM1, fucosyl-GM1, and B-GM1 were not detected at birth. [PMID: 3680254]
publication : 3680254
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-4-[(2R,3R,4S,5S,6R)-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CHEBI:147588]
term_xref : GlycoMotif:GGM.000102|GTC:G11485ID|CID:91853157|CHEBI:147588|SugarBind_Ligand:181
best_match : GlycoMotif:000102|GTC:G11485ID|CID:91853157|CHEBI:147588|SugarBind_Ligand:181
synonymns :
function :
disease_associations : Cholera[SugarBind_Ligand:181]
wikipedia :
essentials_of_glycobiology : NBK453032

Biantennary

term (main_entry) : Biantennary
term_in_sentence : We found an efficient isopropylidenation reaction that selectively protects the terminal Gal-3,4-OH of a biantennary complex-type nonasaccharide isolated from a natural source.[PMID:29249147]
publication : 29249147|24991291|29409839|30325416|18083109|26926155|16715395|12634321|24211369|23115267|31907993|23360551|20861009|33142198|11442281|18687680|15680603|31888963|14686925|15819890|22530754|22098756|9346821|19341309|18529007|20580347|11784152|7773775|10913832|8547276|10463590|9404657|30525457|15316280|8068637|3881425|6425277|8576139|29956878|1576211|11129583|30421263|8069634|30973186|16704415|21612260|29806066|29443078
definition : Type of N-linked glycan in which two antenna are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). Each antenna can be exteneded or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [NBK453019-Glossary, RN,MT]
term_xref :
best_match :
synonymns : diantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453020-Chapter 9

Biantennary complex

term (main_entry) : Biantennary complex
term_in_sentence : The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F.[PMID:16704415]
publication : 16704415|3731182|26747427|32597008|6626573|29249147|28597152|25045879|30325416|12634321|31888963|26926155|23360551|33142198|9404657|29956878|14686925|18687680|11784152|7773775|22530754|20580347|22098756|21612260|6425277|7691595|26780731|16285669|15819890|3924097|30448401|8547276|17049014|29408873
definition : A complex N-glycan that has two branches attached to the non-reducing terminal Man residues of the trimannosyl core. [MT]. Each branch is initiated with a GlcNAc and can be exteneded or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [CHEBI:156251, RN, MT]
term_xref : CHEBI:156251
best_match : CHEBI:156251
synonymns : diantennary complex type
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Bisecting GlcNac

term (main_entry) : Bisecting GlcNac
term_in_sentence : The presence of a bisecting GlcNAc and the occurrence of alpha 2-6-linked Neu5Ac in the most abundant N-glycans, are new features for hCG-beta.[PMID:1374031]
publication : 1374031|29909448|29274553|32719771|22476631|31375533|26467158|27429195|20816221|26109616|30542567|30144245|25727145|29593568|32612952|9006930|19508951|16000695|32597008|19053837|22530754|30405631|19940114|32719549|9560299|29655002|10589784|29959030|20661133|9061364|31065629|20395209|29549127|30305426|29632412|24108122|24282611|27821068|14686925|10816579|25032906|30025558|9661906|8542600|31585439|29699572|27443163|30315103|23808883|18812317|19776078
definition : The bisecting GlcNAc is a modification of hybrid or complex N-linked glycans in which a single GlcNAc is added to the 3 position of the b-linked Man found in the trimannosyl core structure. The modification is catalyzed by β1,4-N-acetylglucosaminyltransferase III (GlcNAcT-III) or MGAT3 (E.C. 2.4.1.144). The addition of a bisecting GlcNAc on a hybrid or trimmed hybrid glycan prevents the subsequent action of N-glycan branching glycosyltransferases GlcNAcT-IV and GlcNAcT-V, but GlcNAcT3 can add a bisecting GlcNAc to the products of these enzymes. [PMID: 22476631, XD]
term_xref : SID:163312364|KEGG:G13066
best_match : SID:163312364|KEGG:G13066
synonymns :
function : The bisecting GlcNAc of N-glycans regulates cellular signaling and tumor progression through modulating N-glycan/galectin interactions.[PMID: 22476631]Inhibits growth factor signaling and retards mammary tumor progression[PMID: 20395209]Integrin-mediated cell adhesion [PMID: 20816221]Important in fertilization and fetal development, neuritogenesis, immune tolerance, immunoglobulin G (IgG)[PMID: 32719771]
disease_associations : mammary tumor.[PMID: 20395209]
wikipedia :
essentials_of_glycobiology : NBK453020

Bisialo-biantennary

term (main_entry) : Bisialo-biantennary
term_in_sentence : Using anion-exchange liquid chromatography mapping of the oligosaccharide units cleaved from the proteins by glycopeptidase F, compared with elution positions of standard oligosaccharide structures, coupled with monosaccharide compositional analysis, we find that the human plasma protein contained only bisialo-biantennary complex-type carbohydrate and asialo-biantennary complex carbohydrate, confirming earlier work published by this laboratory.
publication : 2386787|2065054
definition : A binantennary glycan with sialic acid residues as non-reducing terminal residues on both antennae .[RN,MT]
term_xref :
best_match :
synonymns : disialo biantennary|disialo diantennary|disialylated biantennary|disialylated diantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Bisialo-biantennary complex-type

term (main_entry) : Bisialo-biantennary complex-type
term_in_sentence : Using anion-exchange liquid chromatography mapping of the oligosaccharide units cleaved from the proteins by glycopeptidase F , compared with elution positions of standard oligosaccharide structures , coupled with monosaccharide compositional analysis, we find that the human plasma protein contained only bisialo-biantennary complex-type carbohydrate and asialo-biantennary complex carbohydrate , confirming earlier work published by this laboratory.[PMID:2386787]
publication : 2386787
definition : A binantennary glycan with sialic acid residues as non-reducing terminal residues on both antennae. [RN,MT]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group A (Type 1)

term (main_entry) : Blood group A (Type 1)
term_in_sentence : The basis of blood group A(1) and A(2) phenotypes has been debated for many decades, and still the chemical basis is unresolved.[PMID: 19121199]
publication : 19121199|10942408
definition : An α-D-GalpNAc-(1→3)-[α-L-Fucp-(1→2)]-β-D-Galp-(1→3)-D-GlcpNAc having β-configuration at the reducing end anomeric centre.[CHEBI:62485]
term_xref : GlycoMotif:000044|GTC:G66163TI|CID:53262359|CHEBI:62485|GlycoEpitope:EP0256
best_match : GlycoMotif:000044|GTC:G66163TI|CID:53262359|CHEBI:62485|GlycoEpitope:EP0256
synonymns : blood group A antigen type 1
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group A (type 2) - Lewis y

term (main_entry) : Blood group A (type 2) - Lewis y
term_in_sentence : Monoclonal antibodies defining blood group A variants with difucosyl type 1 chain (ALeb) and difucosyl type 2 chain (ALey).[PMID:2417620]
publication : 2417620
definition : A branched amino pentasaccharide consisting of the linear trisaccharide N-acetyl-α-D-galactosaminyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine having α-L-fucosyl residues attached at position 2 of the galactose and position 3 of the glucosamine. Corresponds to a partial structure of blood group A type 2 oligosaccharide.[CHEBI:62990]
term_xref : GlycoEpitope:EP0261|GTC:G54826OZ|CHEBI:62990|CID:5289011|GlycoMotif:GGM.000039
best_match :
synonymns : Blood group A (type 2) (A-Ley)|Blood Group A Type 2 (difucosyl)|Blood group A (type 2) (A-Lewis Y)|A-Ley|A-Le^y
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group A (Type 4)

term (main_entry) : Blood group A (Type 4)
term_in_sentence : Moreover, we have found that αGal, but not αGalNAc, is a weak binder itself for DC-SIGN, which could endow an additional binding mode for the blood group B antigen, but not for blood group A.[PMID:31283166]
publication : 7800218|7521740|2458640|31283166
definition :
term_xref : glycomotif:GGM.000088|GTC:G37830TX|CID:91852258|KEGG:G00474|CHEBI:150159|SugarBind_Ligand:48
best_match : glycomotif:GGM.000088|GTC:G37830TX|CID:91852258|KEGG:G00474|CHEBI:150159|SugarBind_Ligand:48
synonymns :
function :
disease_associations : Pyelonephritis[SugarBind_Ligand:48]|Acute cystitis[SugarBind_Ligand:48]
wikipedia :
essentials_of_glycobiology :

Blood group A trisaccharide

term (main_entry) : Blood group A trisaccharide
term_in_sentence : A readily detectable carbohydrate in the urine of two siblings with neuronal ceroid lipofuscinosis was found to be the blood group A trisaccharide.[PMID:7249368]
publication : 19582848|7249368|8774717|2749874|28771597|30619340|2122121|11886841|2991755|12588002|3149698|7048329|7015594|10359132|8724140|1418679|1446307
definition : A branched amino trisaccharide consisting of β-D-galactose having an α-L-fucosyl residue at the 2-position and an N-acetyl-α-D-galactosaminyl residue at the 3-position.[CHEBI:61012]
term_xref : glycoepitope:EP0255|GTC:G00066MO|CID:49852448|KEGG:G10638|CHEBI:61012
best_match : glycoepitope:EP0255|GTC:G00066MO|CID:49852448|KEGG:G10638|CHEBI:61012
synonymns : blood group A trisaccharide|blood group A type 1 trisaccharide
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group A(1)

term (main_entry) : Blood group A(1)
term_in_sentence : he basis of blood group A(1) and A(2) phenotypes has been debated for many decades, and still the chemical basis is unresolved. [PMID:19121199]
publication : 10942408|19121199
definition : An α-D-GalpNAc-(1→3)-[α-L-Fucp-(1→2)]-β-D-Galp-(1→3)-D-GlcpNAc having β-configuration at the reducing end anomeric centre.[CHEBI:62485]
term_xref : GlycoMotif:GGM.000044|GTC:G66163TI|GlycoEpitope:EP0256|CID:53262359|CHEBI:62485
best_match : GlycoMotif:GGM.000044|GTC:G66163TI|GlycoEpitope:EP0256|CID:53262359|CHEBI:62485
synonymns : Blood group A (type 1)|blood group A antigen type 1
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group A1 (type 3)

term (main_entry) : Blood group A1 (type 3)
term_in_sentence : The structure is essentially a repetitive A epitope attached to type 2 chain and is hereby called type 3 chain A. [PMID:2579390]
publication : 2579390|19756298
definition : A branched amino heptasaccharide made up from two repeating (1→3)-linked N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl units that are in turn joined to an N-acetyl-β-D-glucosamine residue via a (1→4)-linkage.[CHEBI:85665]
term_xref : GTC:G44060QH|CHEBI:85665|CID:91825676|GlycoMotif:GGM.000040
best_match :
synonymns : Blood group A1 (type 3)|Blood Group A1
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group A2 (A-associated H type 3)

term (main_entry) : Blood group A2 (A-associated H type 3)
term_in_sentence : The 'H NMR spectrum of the Aassociated H antigen (type 3 chain H) was characterized by the unusual presence of three n-anomeric resonances ('CJ'.~ = 3-4 Hz) in addition to five resonances from @-anomeric protons ("J1:2 = 7-9 Hz).[PMID: 3944091]
publication : 3944091
definition : A branched amino hexasaccharide in which an α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine linear pentasaccharide carries at the galactose residue proximal to the reducing end a second α-L-fucosyl residue via a (1→2) linkage.[CHEBI:152543]
term_xref : GTC:G62735WZ|CHEBI:152543|CID:91852328|GlycoMotif:GGM.000041
best_match :
synonymns : Blood Group A2|Fuca1-2Galb1-3GalNAca1-3(Fuca1-2)Galb1-4GlcNAcb|Fuc(a1-2)Gal(b1-3)GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-4)b-GlcNAc|Fucalpha1-2Galbeta1-3GalNAcalpha1-3(Fucalpha1-2)Galbeta1-4GlcNAcbeta|6-deoxy-alpha-L-galacto-hexopyranosyl-(1->2)-beta-D-galacto-hexopyranosyl-(1->3)-2-acetamido-2-deoxy-alpha-D-galacto-hexopyranosyl-(1->3)-[6-deoxy-alpha-L-galacto-hexopyranosyl-(1->2)]-beta-D-galacto-hexopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-gluco-hexopyranose|6-deoxy-alpha-L-galactopyranosyl-(1->2)-[6-deoxy-alpha-L-galactopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-alpha-D-galactopyranosyl-(1->3)]-beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranose

function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group B (Type 1)

term (main_entry) : Blood group B (Type 1)
term_in_sentence : It has been unknown whether NoV distinguishes between the type 1 and type 2 chains of A and B antigens. In this study, we synthesized A type 1, A type 2, B type 1, and B type 2 pentasaccharides in vitro and examined the function of the core structures in the binding between NoV virus-like particles (VLPs) and HBGAs. [PMID: 18701592]
publication : 18701592|24749871|19387828|19208633|29562255
definition : α-D-Galp-(1→3)-[α-L-Fucp-(1→2)]-β-D-Galp-(1→3)-β-D-GlcpNAc with β configuration at the anomeric carbon of the GlcNAc residue at the reducing end.[CHEBI:63242]
term_xref : GlycoMotif:000043|GTC:G31734OS|CID:56927779|CHEBI:63242|
best_match : GlycoMotif:000043|GTC:G31734OS|CID:56927779|CHEBI:63242|
synonymns : blood group B type 1 tetrasaccharide
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group B (Type 1)

term (main_entry) : Blood group B (Type 1)
term_in_sentence : Forty-seven MoAbs and two polyclonal ABO reagents were tested against red blood cell (RBC) kodecytes prepared with A trisaccharide, A Type 1, A Type 2, A Type 3, A Type 4, B trisaccharide, B Type 1, B Type 2, acquired B trisaccharide, and Le(a) trisaccharide function-spacer-lipid (FSL) constructs. Natural RBCs were tested in parallel.[PMID:25368613]
publication : 25368613|18701592|2413709|19387828
definition : α-D-Galp-(1→3)-[α-L-Fucp-(1→2)]-β-D-Galp-(1→3)-β-D-GlcpNAc with β configuration at the anomeric carbon of the GlcNAc residue at the reducing end.[CHEBI:63242]
term_xref : glycomotif:GGM.000043|GTC:G31734OS|CID:56927779|CHEBI:63242
best_match : glycomotif:GGM.000043|GTC:G31734OS|CID:56927779|CHEBI:63242
synonymns : blood group B type 1|tetrasaccharide
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group B (Type 2)

term (main_entry) : Blood group B (Type 2)
term_in_sentence : The detection of a B type 2 determinant is the first chemical evidence for the presence of an autologous difucosyl blood group B type 2 antigen in human adenocarcinoma cells.[PMID:2432062]
publication : 2432062|27196314|18701592
definition :
term_xref : GlycoMotif:GGM.000037|GTC:G34881WK||GlycoEpitope:EP0262|GlycoMotif:GGM.000037
best_match : GlycoMotif:GGM.000037|GTC:G34881WK||GlycoEpitope:EP0262
synonymns : blood group B type 2
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group B (Type 4)

term (main_entry) : Blood group B (Type 4)
term_in_sentence : The blood group B type-4 heptaglycosylceramide is a minor blood group B structure in human B kidneys in contrast to the corresponding A type-4 compound in A kidneys.[PMID:1390942]
publication : 1390942|1841684
definition :
term_xref : glycomotif:GGM.000087|GTC:G25216QA
best_match : glycomotif:GGM.000087|GTC:G25216QA
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Blood group H (Type 1)

term (main_entry) : Blood group H (Type 1)
term_in_sentence : Blood group H type 1 [Fuc alpha (1,2)Gal beta (1,3)GlcNAc beta-->] is known as the precursor structure of the blood group determinant, Lewis b [Fuc alpha (1,2)Gal beta (1,3)(Fuc alpha (1,4))GlcNAc beta-->].[PMID:7718581]
publication : 7718581|6309836|19208633|27431816|2432062|24219248|6352465|8499478|3348768|3718924
definition :
term_xref : GTC:G00294TN|GlycoMotif:GGM.000042|SugarBind_Ligand:153
best_match : GTC:G00294TN|GlycoMotif:GGM.000042|SugarBind_Ligand:153
synonymns : H type 1
function :
disease_associations : Gastroenteritis[SugarBind_Ligand:153]
wikipedia :
essentials_of_glycobiology : NBK453042

Blood group H (type 2)

term (main_entry) : Blood group H (type 2)
term_in_sentence : We have examined the immunohistochemical distribution of H Type 1 and of H Type 2 substances of the ABO blood group system in human submandibular gland using either of the two anti-H monoclonal antibodies MAb 1E3 and MAb 3A5. MAb 3A5 was specific for H Type 2, and MAb 1E3 reacted with each of H Type 1-H Type 4 artificial antigens.[PMID:9405495]
publication : 9405495|8082855|6177241|3944092|21406562|2410664|8731502|6203846|2238560|
definition : A branched amino tetrasaccharide consisting of N-acetyl-β-D-glucosamine at the reducing end having an α-L-fucosyl residue attached at the 3-position and an α-L-fucosyl-(1→2)-β-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure.[CHEBI:59045]
term_xref : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045|GlycoMotif:GGM.000036
best_match :
synonymns : Lewis y|Blood group H (type 2) (Ley)|Lewis b (Leb)|Lewis a|Blood group H (type 2) (Lewis Y)|Lewis b (Lewis b)|Blood group H (type 2) - Lewis y|H-Ley|H-Le^y|Lewis Y|6-deoxy-alpha-L-galactopyranosyl-(1->3)-[6-deoxy-alpha-L-galactopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->4)]-2-acetamido-2-deoxy-beta-D-glucopyranose|alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc|alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc|Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAcbeta|Fucalpha1-3(Fucalpha1-2Galbeta1-4)GclNAc|Lewis y Tetrasaccharide
function : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018]
disease_associations : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018]|Inappropriate tissue distribution of Ley blood-group antigens was observed in CCs(cholangiocarcinomas) and, much less frequently, in HCCs(hepatocellular carcinomas).[GlycoEpitope:EP0018]|Ley determinant is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC).[GlycoEpitope:EP0018]
wikipedia :
essentials_of_glycobiology :

Blood group H (type 2) - Lewis y

term (main_entry) : Blood group H (type 2) - Lewis y
term_in_sentence : The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes.[PMID: 11479278]
publication : 11479278
definition : A branched amino tetrasaccharide consisting of N-acetyl-β-D-glucosamine at the reducing end having an α-L-fucosyl residue attached at the 3-position and an α-L-fucosyl-(1→2)-β-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure.[CHEBI:59045]
term_xref : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045|GlycoMotif:GGM.000045
best_match :
synonymns : Lewis y|Blood group H (type 2) (Ley)|Lewis b (Leb)|Lewis a||Lewis b (Lewis b)|Blood group H (type 2) - Lewis y|H-Ley|H-Le^y|Lewis Y|H-Ley|H-Le^y|Lewis Y
function : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018]
disease_associations : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018]|Inappropriate tissue distribution of Ley blood-group antigens was observed in CCs(cholangiocarcinomas) and, much less frequently, in HCCs(hepatocellular carcinomas).[GlycoEpitope:EP0018]|Ley determinant is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC).[GlycoEpitope:EP0018]
wikipedia :
essentials_of_glycobiology :

Blood group H (Type 4)

term (main_entry) : Blood group H (Type 4)
term_in_sentence : In addition, the blood group H type 4 chain structure was present together with Le(a) and Le(b) compounds.[PMID:1841684]
publication : 11261842|1841684|11101633|9405495
definition : An amino hexasaccharide consisting of α-L-fucose, β-D-galactose, N-acetyl-α-D-galactosamine, α-D-galactose, β-D-galactose and β-D-glucose residues joined in sequence with (1→2)-, (1→3)-, (1→3)-, (1→4)- and (1→4)-linkages, respectively.[CHEBI:65245]
term_xref : glycomotif:GGM.000086|GTC:G98465JN|CID:10260428|SugarBind_Ligand:61|CHEBI:65245
best_match : glycomotif:GGM.000086|GTC:G98465JN|CID:10260428|SugarBind_Ligand:61|CHEBI:65245
synonymns :
function :
disease_associations : Pyelonephritis[SugarBind_Ligand:61]
wikipedia :
essentials_of_glycobiology :

C2-O-sLex

term (main_entry) : C2-O-sLex
term_in_sentence : PSGL-1 lacks 6-sulfo-sLex but contains sulfated tyrosine residues (Tyr-SO3)at positions 46, 48, and 51 and sLex in a core 2-based O-glycan (C2-O-sLex) on Thr at position 57.[PMID:12736247]
publication : 12736247|19267921|21283832|15596301|17072011
definition : A seven-membered branched galactosamine oligosaccharide that consists of a branched tetrasaccharide unit α-Neu5Ac-(2→3)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc, attached by a glycosidic linkage to position 6 of the GalNAc residue of the trisaccharide α-Neu5Ac-(2→3)-β-D-Gal-(1→3)-D-GalNAc.[CHEBI:65192]
term_xref : glycomotif:GGM.000053|GTC:G97345NY|CID:91860725|KEGG:G10899|CHEBI:155160
best_match : glycomotif:GGM.000053|GTC:G97345NY|CID:91860725|KEGG:G10899|CHEBI:155160
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Ceramide dihexosyl sulfate

term (main_entry) : Ceramide dihexosyl sulfate
term_in_sentence : Although it has been reported that ceramide dihexosyl sulfate is present in human kidney, it is unlikely that it is present in equine kidney.[PMID:818074]
publication : 818074
definition : A sulfatide with two hexose moieties (glucose and galactose) has been isolated from human kidney (Martensson E, Acta Chem Scand 1963, 17, 1174). Equimolar amounts of ceramide, glucose, galactose, and sulfate are found in the molecule. The sulfate group is esterified, as in sulfatides, with carbon 3 of the galactose moiety. The linkage between galactose and glucose is identical to lactose (b-1-4). Its fatty acid composition is similar to that of sulfatides.[2]
term_xref : GTC:G04416BG|GlycoMotif:GGM.000065
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Chitin

term (main_entry) : Chitin
term_in_sentence : In this review, we will focus on the prevalence and structural function of chitin in bacteria, fungi, and protists, with a particular focus on the evolution of chitin synthases and the function of chitin oligosaccharides as a signaling molecule in symbiosis and immunity[PMID: 31102241]
publication : 25738328|31102247|26982439|31685194|29197571|29182521|25725011|27787767|21736263|25300540|30840869|25081074|28250359|29763421|29910219|20161969|32019265|30879650|12587986|29773374|31376451|10906950|26096004|25595947|21673932|29452181|24083454|10856926|22732132|18657571|29175166|28842199|27592817|27302593|27339323|12705640|31635752|31063786|31151236|25940531|26093316|28962761|28093332|30875044|27723949|28119189|30600008|25081085|21673932
definition : An aminoglycan consisting of β-(1→4)-linked N-acetyl-D-glucosamine residues.[CHEBI:17029]
term_xref : CHEBI:17029
best_match : CHEBI:17029
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453054-Chapter 23

Chondroitin sulfate

term (main_entry) : Chondroitin sulfate
term_in_sentence : The industrial production of chondroitin sulfate (CS) uses animal tissue sources as raw material derived from different terrestrial or marine species of animals.[PMID: 31013685]
publication : 31013685|27526113|27194526|26980567|28847361|24413804|29891297|29600622|25129732|31317901|29181550|31250530|22265655|25756648|29402610|17928217|20236040|28091940|30824935|26572336|31207331|21110089|30599999|20399897|27226567|19388612|23186102|31494830|28982096|30241863|30295666|25366475|20521042|29456007|31304829|18661362|28576008|29494632|30016441|26906924|24861964|23774590|31887904|31339761|12512856|26957048|29625000
definition : Any of a class of 10—60 kDa glycosaminoglycan sulfates, widely distributed in cartilage and other mammalian connective tissues.[CHEBI:37397]
term_xref : CHEBI:37397| CID: 24766
best_match : CHEBI:37397| CID: 24766
synonymns : chondroitin polysulfate|chondroitin sulfate|chondroitin sulfates|chondroitin sulfuric acid|chondroitin sulphate|Chondroitinsulfate
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453033-Chapter 17

cisGM1

term (main_entry) : cisGM1
term_in_sentence : Macrophage ganglioside patterns dramatically increase in complexity when murine peritoneal macrophages are stimulated in vivo with the appearance of the sialidase-sensitive monosialoganglioside GM1b (cisGM1) as a major component.[PMID: 9455923]
publication : 9455923
definition : A member of the class of neuraminic acids that is neuraminic acid attached in sequence to β-D-galactopyranosyl, 2-acetamido-2-deoxy-β-D-galactopyranosyl, β-D-galactopyranosyl, and β-D-gucoopyranose units by (2→3), (1→3), (1→4), and (1→4) glycosidic linkages, respectively. It corresponds to the carbohydrate portion of ganglioside GM1b.[CHEBI:145580]
term_xref : GlycoMotif:GGM.000100|GTC:G03277YI|CID:91850212|CHEBI:145580|GlycoEpitope:EP0048|SugarBind_Ligand:92|KEGG:G00125
best_match :
synonymns : GM1b
function :
disease_associations : Influenza[SugarBind_Ligand:92]
wikipedia :
essentials_of_glycobiology :

Complex-type N-glycans

term (main_entry) : Complex-type N-glycans
term_in_sentence : In this study, 32 new complex-type glycans are characterized containing the Le(x), Le(Y), and sialyl-Le(x) determinants, the bloodgroup A and H antigens, as well as the ALe(Y) determinant.[PMID:10988252]
publication : 29902282|29212795|29343819|27705835|26745022|18399796|16825488|21964725|15864431|22890903|12417032|28039392|19426135|30253927|16794314|19806620|22975979|25931033|15201278|19129634|19129628|24032650|22530754|31021709|30973186|28091941|23115339|20829342|27304954|29090617|21802690|29725121|30471292|16581187|26098720|31080188|1930135|31888963|30844485|24014058|11129583
definition : Type of N-linked glycan in which at least two antenna are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). Each antenna can be exteneded or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [MT]
term_xref :
best_match :
synonymns :
function : Involved in protein stability.[PMID:12417032]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453020-Chapter 9

Core 2

term (main_entry) : Core 2
term_in_sentence : To investigate the biological roles of core 2 O-glycans, we produced and characterized mice deficient in one or more of the three known glycosyltransferases that generate core 2 O-glycans (C2GnT1, C2GnT2, and C2GnT3).[PMID: 19349303]
publication : 19349303|30315106|23640779|26677400
definition : The trisaccharide β-D-Gal-(1→3)-[β-D-GlcNAc-(1→6)]-D-GalNAc with α configuration at the anomeric centre of the N-acetylglucosamine residue at the reducing end.[CHEBI:62158]
term_xref : GTC:G00033MO|CID:52921656|CHEBI:62158|
best_match : GTC:G00033MO|CID:52921656|CHEBI:62158|
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK20721-Chapter 8

Core 3

term (main_entry) : Core 3
term_in_sentence : Mechanically, we revealed that mucin-type core 3 O-glycan was synthesized at the membrane-tethered MUC1 N terminus because of core 3 synthase expression in colon cancer cells.[PMID: 28745318]
publication : 28745318|27259834|27143302|
definition : An amino disaccharide comprising an N-acetyl-β-D-glucosamine residuelinked (1→3) to an N-acetyl-β-D-galactosamine residue at the reducing end.[CHEBI:71344]
term_xref : GTC:G00035MO|CID:25061208|CHEBI:71344
best_match : GTC:G00035MO|CID:25061208|CHEBI:71344
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK20721-Chapter 8

Core 4

term (main_entry) : Core 4
term_in_sentence : The results confirm the predicted existence of a beta1,6GlcNAc-transferase that functions in both core 2 and core 4 O-glycan branch formation.[PMID: 9988682]
publication : 9988682|10747980|
definition : A branched amino trisaccharide comprising an N -acetyl-α-D-galactosamine residue at the reducing end, to which are (1→3)- and (1→6)-linkedtwo N -acetyl-α-D-glucosamine residues.[CHEBI:71341]
term_xref : GTC:G00037MO| CID:25229562|CHEBI:71341
best_match : GTC:G00037MO| CID:25229562|CHEBI:71341
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK20721-Chapter 8

Core-fucosylated

term (main_entry) : Core-fucosylated
term_in_sentence : The approach was validated for selective capture and analysis of core fucosylated N-glycans present in complex glycan mixtures derived from mammalian serum IgG.[PMID:27678371]
publication : 27678371|26514868|15538974|24914453|17049014|32078267|31268672|28674882|29956878|27798819|32044029|30962950|31548313|30907281|29090617|29571940|28800497|27629418|29733746|31623829|28768188|26897254|31451706|26514868|29427759|28982386|26587313|30940702|15538974|31249452|27282921|31229844|30445455|31325506|24732908|29209018|26965517|28609658|24914453|25573275|17049014|19218400|27012207|27139574|32078267|25861849|32561391|21374780|31669139|25732060|29408166|31268672|30472795|30614075|19003000|25664929
definition : Modification of the N-glycan core structure with fucose moiety attached at the innermost GlcNAc by FUT8 enzyme. Core Fuc is found on paucimannose, hybrid and complex type N-glycans. [MT, RN, https://doi.org/10.1016/bs.acr.2014.11.006].
term_xref :
best_match : GTC:G78059CC|CID:70679232|CHEBI:70967|CHEBI:156499
synonymns : Core Fuc|6-linked Fuc|Fuca6 to chitobiose core|a6-linked Fuc|a1-6 Fuc|Fuca6 to chitobiose core|Fuc a1-6 to chitobiose core|Fuca6 to internal GlcNAc|Fuc a1-6 to internal GlcNAc
function : Required for signaling through TCR [PMID: 29434598]|VGF, PDGFr, and EGFr and TGFbeta receptor dysregulation in Fut8 KO mice [PMID:17132494]|IgG-Fcg receptor interactions destabilized by core Fuc [PMID:29062024]
disease_associations : Emphysema[MT]|systemic lupus erythematosus[MT]lung cancer[MT]|autoimmunity[MT]|tumor metastasis[MT]
wikipedia :
essentials_of_glycobiology :

Core-fucosylated biantennary

term (main_entry) : Core-fucosylated biantennary
term_in_sentence : The IFN-alpha14c N-glycans were shown to exhibit core-fucosylated biantennary glycans , with about 10% carrying an additional alpha1,3-linked fucose unit at the antennae.[PMID:9654101]
publication : 9654101|15819890|28263871|26763099|22256781|23681398|25855029|10529240|26544759|8206921|33149259|8547276
definition : A biantennary glycan with two GlcNAc branches linked to the core and fucosylation on the core GlcNAc.[XD]
term_xref :
best_match : GTC:G78059CC|CID:70679232|CHEBI:70967|CHEBI:156499
synonymns : core-fucosylated diantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Core-fucosylated biantennary complex-type

term (main_entry) : Core-fucosylated biantennary complex-type
term_in_sentence : The oligosaccharide structure at Asn(32 ) is a mixture of the monosialo and asialo forms of a core fucosylated biantennary complex-type oligosaccharide.[PMID:10731668]
publication : 10731668
definition : A biantennary complex glycan with two GlcNAc branches linked to the core and fucosylation on the core GlcNAc.[XD]
term_xref :
best_match : GTC:G78059CC|CID:70679232|CHEBI:70967|CHEBI:156499
synonymns : core fucosylated diantennary complex-type
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Cyclic sialyl 6-sulfo Lewis x

term (main_entry) : Cyclic sialyl 6-sulfo Lewis x
term_in_sentence : Stimulation of the sialyl 6-sulfo Lewis X-positive colon cancer cell line with a calcium ionophore ionomycin markedly reduced sialyl 6-sulfo Lewis X and induced cyclic sialyl 6-sulfo Lewis X expression.[PMID:10728707]
publication : 10728707|31222115|9990070|23088960
definition :
term_xref : glycomotif:GGM.000023|GTC:G80722US|GlycoEpitope:EP0015|CID:70698321|CHEBI:71628
best_match : glycomotif:GGM.000023|GTC:G80722US|GlycoEpitope:EP0015|CID:70698321|CHEBI:71628
synonymns :
function : the accumulated intracellular cyclic sialyl 6-sulfo Lex determinant may function as a dormant pool of selectin ligands.[GlycoEpitope:EP0017]
disease_associations :
wikipedia :
essentials_of_glycobiology :

Cytolipin R

term (main_entry) : Cytolipin R
term_in_sentence : The reaction can be inhibited completely by pure cytolipin R showing that (a) immune hemolysis can be mediated through lipid determinants in the membrane, and (b) that cytolipin R determinants are present in the intact erythrocyte membrane and exposed on the surface.[PMID:4110375]
publication : 893368|4375678|51702|186204|4110375|5068000|24174198|6072378|389925|7054174
definition : A ceramide tetrahexoside isolated from rat lymphosarcoma. The structure of cytolipin R to be N-acetylgalactosaminyl(beta1-->3)galactosyl(alpha1-->3) galactosyl(beta1-->4)glucosyl ceramide.[PMID:5068000]
term_xref : glycomotif:GMM.000083|GTC:G57710SU|CID:91855936|KEGG:G00392|CHEBI:152175|SugarBind_Ligand:17
best_match : glycomotif:GMM.000083|GTC:G57710SU|CID:91855936|KEGG:G00392|CHEBI:152175|SugarBind_Ligand:17
synonymns :
function :
disease_associations : Actinomycosis[SugarBind_Ligand:17]
wikipedia :
essentials_of_glycobiology :

Dermatan sulfate

term (main_entry) : Dermatan sulfate
term_in_sentence : By utilizing sophisticated separation methods followed by compositional analysis, domain mapping, and tandem mass spectrometry coupled with analysis by a modified genetic algorithm approach, the structural motif for the decorin dermatan sulfate chain was determined.[PMID:29111696]
publication : 27526113|29111696|29891297|26164146|30869126|7789716|8597249|12512856|31250530|17928217|12213784|27226567|31455633|28091940|19075609|31071403|15078125|18661328|20581662|17239765|15749837|2777747|20632047|8930750|7762784|31006321|26876822|1522290|131009|26986023|8161353|15315969|12543559|30637950|2525357|18156656|9692613|9200333|19661164|2299256|16075147|1126924|9774430|8537360|15563459|21077227|23275130|17137817|6447930|6209270
definition : Any of a group of glycosaminoglycans with repeating unitsconsisting of variously sulfated β1→4-linked L-iduronyl-(α1→3)-N-acetyl-D-galactosamine units.[CHEBI:18376]
term_xref : CHEBI:18376| CID: 32756
best_match : CHEBI:18376| CID: 32756
synonymns : beta-Heparin|Chondroitin sulfate B|Dermatan L-iduronate
function : Wound healing[NBK453034-Chapter 7]|maintain the structure of the dermis.[NBK453056-Chapter 41]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453033-Chapter 17

Desialylated

term (main_entry) : Desialylated
term_in_sentence : Furthermore, we found no evidence for "desialylated" apoB100 glycans in any of the samples analyzed.[PMID:11588155]
publication : 30015642|26168491|29492899|31774586|32321401|23780974|7600681|18045697|1450583|4137057|28911304|27562992|29950245|31978220|2408573|8612720|10910970|27195066|1434544|22175031|24517196|29794068|30101537|18972200|1478792|4440781|21229239|30844664|31351722|31330845|1872910
definition : A glycan from which sialyl groups have been removed. RN
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Desialylated tetrasaccharide

term (main_entry) : Desialylated tetrasaccharide
term_in_sentence : The structures of a desialylated tetrasaccharide , two monosialylated trisaccharides , and five other minor products were defined.[PMID:8384526]
publication : 8384526
definition : A tetrasachharide (four branches) glycan from which sialyl groups have been removed. [RN]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Difucosylated tetra-antennary N-glycans

term (main_entry) : Difucosylated tetra-antennary N-glycans
term_in_sentence : While fucosylated N-glycans derived from serum haptoglobin of patients with CP slightly increased, di-fucosylated tetra-antennary N-glycans were observed only at this site in PC patients, and were absent in the haptoglobin of normal controls and individuals with CP.[PMID:18214858]
publication : 18214858
definition : The tetra-antennary N-linked glycans that have four GlcNAc branches linked to the core and two fucose added.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations : pancreatic cancer[PMID:18214858]
wikipedia :
essentials_of_glycobiology :

Dimeric Lewis x

term (main_entry) : Dimeric Lewis x
term_in_sentence : The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics.[PMID:32957489]
publication : 32957489|31276881|12062524|15488731|1979361|8737237|17939723|7683631|11384108|11133015|17388629|15483381|12662048|3233598
definition : Beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc is a six-membered glucosamine oligosaccharide consisting of two repeating units of beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc joined by a (1->3)-linkage. It is a glucosamine oligosaccharide and an amino hexasaccharide.[CHEBI:61325]
term_xref : GTC:G79535HZ|GlycoEpitope:EP0093|CID:50909845|CHEBI:61325|GlycoMotif:GGM.00031
best_match : GTC:G79535HZ|GlycoEpitope:EP0093|CID:50909845|CHEBI:61325
synonymns : DimLex^x|Lex–Lex|Lewis X–Lewis X|Lex-Lex|Le^x–Le^x|diLe(x)
function : cancer-associated antigen[GlycoEpitope:EP0093]
disease_associations : colonic cancer[GlycoEpitope:EP0093]|liver cancer[GlycoEpitope:EP0093]
wikipedia :
essentials_of_glycobiology :

Diphosphorylated Man6

term (main_entry) : Diphosphorylated Man6
term_in_sentence : Here we report that the single-chain variable domain (scFv) M6P-1 is a unique antibody fragment with specificity for Man6P monosaccharide that, through an array-screening approach against a number of phosphorylated N-glycans, is shown to bind mono- and diphosphorylated Man6 and Man7 glycans that contain terminal αMan6P(1 → 2)αMan(1 → 3)αMan.[PMID:26503547]
publication : 26503547
definition :
term_xref : GTC:G54792LL|GlycoMotif:GGM.000054
best_match :
synonymns : Diphosphorylated Man_6
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Disialosyl globopentaosylceramide

term (main_entry) : Disialosyl globopentaosylceramide
term_in_sentence : Disialosyl globopentaosylceramide (DSGb5) is often expressed by renal cell carcinomas.[PMID:31339142]
publication : 31339142|24637536|25864532|27344728|12084983|32567311|28205070|20663960|18214042
definition : Disialosyl globopentaosylceramide (DSGb5) is a ganglioside originally isolated from tissue extracts of renal cell carcinoma (RCC) with metastasis.[PMID:28205070]
term_xref : glycomotif:GGM.000082|GTC:G97932OH|GlycoEpitope:EP0098|CID:91860287|KEGG:G00181|SugarBind_Ligand:57
best_match : glycomotif:GGM.000082|GTC:G97932OH|GlycoEpitope:EP0098|CID:91860287|KEGG:G00181|SugarBind_Ligand:57
synonymns : DSGb5|Disialosyl Gb5|V3NeuAcIV6NeuAc-Gb5Cer|Disialosylgalactosylgloboside
function : promotes metastasis[PMID:28205070]
disease_associations : prostate cancer[PMID:24637536]|renal cell carcinoma/RCC[GlycoEpitope:EP0098]|Pyelonephritis[SugarBind_Ligand:57]
wikipedia :
essentials_of_glycobiology :

Disialyl Gb5

term (main_entry) : Disialyl Gb5
term_in_sentence : The major disialoganglioside antigen isolated from ACHN cells, showing specific reactivity with 5F3, was characterized unequivocally as disialosyl Gb5 (V(3)NeuAcIV(6)NeuAcGb5) by identification of the core structure as globopentaosylceramide (Gb5) after enzymatic and acid hydrolysis, and by 2-dimensional (1)H-NMR spectroscopy.[PMID: 12084983]
publication : 12084983
definition :
term_xref : GlycoEpitope:EP0098|GTC:G97932OH|CID:91860287|SugarBind_Ligand:57|KEGG:G00181
best_match : GlycoEpitope:EP0098|GTC:G97932OH|CID:91860287|SugarBind_Ligand:57|KEGG:G00181
synonymns :
function :
disease_associations : renal cell carcinoma/RCC[GlycoEpitope:EP0098]|Pyelonephritis[SugarBind_Ligand:57]
wikipedia :
essentials_of_glycobiology :

Disialyl I

term (main_entry) : Disialyl I
term_in_sentence : Here we present an example of promotion of binding of soluble-form FN from placenta or from hepatoma cells, having a specific carbohydrate epitope termed "disialyl-I," to K562 or VA13 cell surface in the presence of glycosphingolipid Gg3, which interacts specifically with disialyl-I[PMID:10640401]
publication : 10640401
definition :
term_xref : GlycoEpitope:EP0095|GTC:G54937EM|CID:91849523
best_match : GlycoEpitope:EP0095|GTC:G54937EM|CID:91849523
synonymns : disialyl-I
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Disialyl Lewis a

term (main_entry) : Disialyl Lewis a
term_in_sentence : Biosynthesis of disialyl Lewis a (Lea) was analyzed using previously cloned ST6GalNAc V and ST6GalNAc VI, which were responsible for the synthesis of alpha-series gangliosides.[PMID:12668675]
publication : 12668675|17760270|15231659|12668106|30716533|32050430|22467657
definition : Disialyl Lewis is a sialyl Lewis a with an additional sialic acid attached at the C-6 position of penultimate GlcNAc. [PMID:15231659, RN]
term_xref : GTC:G93400AK |GlycoEpitope:EP0040|CID:91854138|CHEBI:155549
best_match : GTC:G93400AK |GlycoEpitope:EP0040|CID:91854138|CHEBI:155549
synonymns : disialyl Lea
function : The 2-3,2-6 disialyl Lea determinant on epithelial cells may play a role in protecting normal epithelial cells.[GlycoEpitope:EP0040]
disease_associations : Mucin antigen carrying 2-3 sialylated Le a antigen or 2-3, 2-6 disialylated Lc4 antigen in cancer patients had the lowest carbohydrate/protein ratio. Thus, the carbohydrate/protein ratio in the type 1 chain mucin antigens in sera of normal subjects is higher than that in sera of cancer patients.[GlycoEpitope:EP0040]
wikipedia :
essentials_of_glycobiology :

Disialyl T antigen

term (main_entry) : Disialyl T antigen
term_in_sentence : The most potent glycoside was disialyl T antigen (NeuAcalpha2-3Galbeta1-3[NeuAcalpha2-6]GalNAc-R), followed by 3-sialyl T antigen (NeuAcalpha2-3Galbeta1-3GalNAc-R), structures expressed on O-linked glycoproteins as well as on gangliosides.[PMID: 15701648]
publication : 29113555|17974963|33242079|12645620|15701648|26598643
definition : Alpha-Neup5Ac-(2->6)-[alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)]-alpha-D-GalpNAc is alpha-Neup5Ac-(2->6)-[alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)]-alpha-D-GalpNAc in which the anomeric configuration of the reducing-end N-acetyl-D-glucosamine residue is alpha. It has a role as an epitope.[CHEBI:71602]
term_xref : GlycoMotif:GGM.000014|GTC:G01614ZM|CID:70698317|CHEBI:71602|GlycoEpitope:EP0023|KEGG:G00027
best_match : GlycoMotif:GGM.000014|GTC:G01614ZM|CID:70698317|CHEBI:71602|GlycoEpitope:EP0023|KEGG:G00027
synonymns : di-sialyl T antigen|disialyl-T antigen|disialylated T-antigen
function : associated with von Willebrand factor(VWF) plasma levels[GlycoEpitope:EP0023]
disease_associations :
wikipedia :
essentials_of_glycobiology :

Disialylated biantennary

term (main_entry) : Disialylated biantennary
term_in_sentence : FAB-MS, electrospray-mass spectrometry, and linkage analysis demonstrated that each monomer of rat CRP contained one oligosaccharide chain , predominantly a disialylated biantennary structure , attached to Asn-128.[PMID:8486673]
publication : 22426998|17171781|25022802|24812685|24780636|26582205|9499382|22978794|22594947|8486673|20356825|1634621|9244386|12966096|1472054|24243045||19579232|27943633
definition : A biantennary glycan with two GlcNAc branches linked to the core and the addition of two sialic acid residues.[XD]
term_xref :
best_match :
synonymns : disialylated diantennary
function : appears in human transferrin[PMID: 24243045]|Appears in human apolipoprotein (apo) B-100.PMID:2344297]
disease_associations : galactosemia.[PMID:9499382]
wikipedia :
essentials_of_glycobiology : NBK453041

Disialylated biantennary complex-type

term (main_entry) : Disialylated biantennary complex-type
term_in_sentence : The glycan was shown to be a disialylated biantennary complex type oligosaccharide N-linked to 318 Asn.[PMID:11738084]
publication : 11738084|9499382|9244386|24243045|12966096|25124522|19371135
definition : A biantennary complex glycan with two GlcNAc branches linked to the core and the addition of two sialic acid residues.[XD]
term_xref :
best_match :
synonymns :
function : appears in human transferrin[PMID:24243045]|Appears in human apolipoprotein (apo) B-100.[PMID:2344297]
disease_associations : galactosemia.[PMID:9499382]
wikipedia :
essentials_of_glycobiology : NBK453041

Disialylated fucosylated

term (main_entry) : Disialylated fucosylated
term_in_sentence : Disialylated fucosylated and monosialylated non-fucosylated oligosaccharides were also identified.[PMID:17591618]
publication : 17591618
definition : A fucosylated glycan with two sialic acid components.[RN]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Forssman antigen

term (main_entry) : Forssman antigen
term_in_sentence : Here we report the crystal structure of the complex between SLL-2 and Forssman antigen tetrasaccharide (GalNAcα1-3GalNAcβ1-3 Galα1-4 Galβ) at 3.4 Ã… resolution.[PMID:28510705]
publication : 28510705|31933576|28134301|7021748|1802714|7512587|7747818|23325748|268649|31816281|22015168|4147161|2857159|6267170|7293775|13367419|20636540|10460829|23255552|2675268|18955372|7020692|31784953|4114942|31273262|6257673|7696847|1916901|11169215|48262|26022515|6175621|31404475|6983878|8381954|10431785|3257757|6792413|25039359
definition : A linear amino pentasaccharide comprising N-acetyl-α-D-galactosamine, N-acetyl-β-D-galactosamine, α-D-galactose, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→3), (1→4) and (1→4).[CHEBI:85789]
term_xref : GTC:G80062GG |GlycoEpitope:EP0037|CID91825690|CHEBI:85789
best_match : GTC:G80062GG |GlycoEpitope:EP0037|CID91825690|CHEBI:85789
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

Forssman glycolipid

term (main_entry) : Forssman glycolipid
term_in_sentence : Analysis of metabolically labeled glycolipids released into the apical and basal culture medium, either as shed membrane vesicles or in budding viruses, also demonstrated the presence of the Forssman glycolipid on both apical and basolateral membranes of polarized cells.[PMID:3040119]
publication : 3040119|268649|23240079|28134301|3495590|1138893|10460829|10506200|8855242|1955453|1933935|3355161|6773959|14573676|29898878|10431785|1747956|11214737|7423202|389939|3871816|6187373|16133832|469271|3753492|2695680|7037611|25703376|23798992|414913|1868069|7960243
definition :
term_xref : GlycoMotif:GGM.000084|GTC:G80062GG|CID:91825690|KEGG:G00095|CHEBI:85789|GlycoEpitope:EP0037|SugarBind_Ligand:86
best_match : glycomotif:GGM.000084|GTC:G80062GG|CID:91825690|KEGG:G00095|CHEBI:85789|GlycoEpitope:EP0037|SugarBind_Ligand:86
synonymns : Forssman antigen|Globopentosylceramide
function : an antigenic marker for a major subpopulation of macrophages from murine spleen and peripheral lymph nodes[PMID:3495590]
disease_associations : Pyelonephritis[SugarBind_Ligand:86]|Acute cystitis[SugarBind_Ligand:86]
wikipedia : https://en.wikipedia.org/wiki/Forssman_antigen
essentials_of_glycobiology :

Fucose-containing tetraantennary

term (main_entry) : Fucose-containing tetraantennary
term_in_sentence : The two major N-linked oligosaccharides of Namalwa EPO were fucose-containing tetraantennary and fucose-containing triantennary structures.[PMID:2550193]
publication : 2550193
definition : A tetraantennary glycan with four GlcNAc branches linked to the core and the addition of fucose.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Fucosyl GM1

term (main_entry) : Fucosyl GM1
term_in_sentence : Unique localization of fucosyl GM1 implicates its possible role in cell adhesion and recognition in the nervous system.[PMID:8068725]
publication : 6619101|16880505|9089399|29789847|8068725|19556222|1660040|2420639|9076515|15926079|19555091|2541996|16211870|1336587|21174147|14967068|18923900|30021910|16941490|27070150|8305235|10602885|2645049|7993838|10537341|3002616|8336147|15447995|8905401|11714535|9260862|32228455|3315641|8076384|2317201|3680254|6403518
definition : Alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp is a branched amino hexasaccharide consisting of the linear sequence alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-beta-D-Gal-(1->4)-D-Glc having a Neu5Ac residue attached to the inner galactose via an alpha-(2->3) linkage. It has a role as an epitope. It is an amino hexasaccharide and a galactosamine oligosaccharide.[CHEBI:62686]
term_xref : GTC:G91532KA |GlycoEpitope:EP0049|CID:53356699|CHEBI:62686
best_match : GTC:G91532KA |GlycoEpitope:EP0049|CID:53356699|CHEBI:62686
synonymns :
function :
disease_associations : small-cell lung cancer(SCLC)[GlycoEpitope:EP0049]|hepatoma[GlycoEpitope:EP0049]
wikipedia :
essentials_of_glycobiology :

Fucosylated asialo-biantennary

term (main_entry) : Fucosylated asialo-biantennary
term_in_sentence : We found that approximately 63% of the total N-linked oligosaccharides were of the complex type, with bisialo-biantennary (28%), asialo-biantennary (7%), fucosylated bisialo-biantennary (25%), and fucosylated asialo-biantennary (3%) oligosaccharides representing the major complex-type carbohydrate species.[PMID:2065054]
publication : 2065054|17013932
definition : Describing a biantennary oligosaccharide that has no sialic acid component but has fucose.[XD]
term_xref :
best_match :
synonymns : fucosylated asialo-diantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Fucosylated biantennary

term (main_entry) : Fucosylated biantennary
term_in_sentence : The profiles of the PSA N-glycans from the free and complexed molecules were quite similar to each other and consisted of fucosylated biantennary oligosaccharides as the major class.[PMID:17956937]
publication : 17956937|30525457|1933856
definition : a biantennary glycan with two GlcNAc branches linked to the core and the addition of fucose.[XD]
term_xref :
best_match :
synonymns : fucosylated bisialo-diantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Fucosylated bisialo-biantennary

term (main_entry) : Fucosylated bisialo-biantennary
term_in_sentence : We found that approximately 63% of the total N-linked oligosaccharides were of the complex type, with bisialo-biantennary (28%), asialo-biantennary (7%), fucosylated bisialo-biantennary (25%), and fucosylated asialo-biantennary (3%) oligosaccharides representing the major complex-type carbohydrate species.[PMID:2065054]
publication : 2065054
definition : Describing a biantennary oligosaccharide that has two sialic acid component and fucose added.[XD]
term_xref :
best_match :
synonymns : fucosylated disialo-biantennaryb
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Fucosylated LDN

term (main_entry) : Fucosylated LDN
term_in_sentence : To date, oligomeric LDN and oligomeric fucosylated LDN (LDNF) have been found only on N-glycans from mammalian cells engineered to express Caenorhabditis elegansbeta4-GalNAc transferase and human alpha3-fucosyltransferase IX [Z. S. Kawar et al. (2005) J Biol Chem280, 12810-12819]. [PMID:16403022]
publication : 16403022|28151933|19545571|22448293
definition : An amino trisaccharide comprising an acetamido-β-D-galactose and an α-L-fucose attached to an acetamidoglucose by 1→4 and 1→3 linkages, respectively.[CHEBI:61864]
term_xref : GlycoMotif:GGM.000017|GTC::G02240AO|GlycoEpitope:EP0151|CID:52921591|CHEBI:61864|MeSH:C488538|KEGG:G01594
best_match : GlycoMotif:GGM.000017|GTC::G02240AO|GlycoEpitope:EP0151|CID:52921591|CHEBI:61864|MeSH:C488538|KEGG:G01594
synonymns : LDNF|Fucosylated lacdiNAc|LDN-F|(GalNAc)1 (GlcNAc)1 (LFuc)1
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453068

Fucosylated N-glycans

term (main_entry) : Fucosylated N-glycans
term_in_sentence : Haptoglobin , an acute phase protein , has four potential N-glycosylation sites , although it remains unknown which site is responsible for the change in fucosylated N-glycans.[PMID:18214858]
publication : 18214858|31141660|26869352|29790113|31931062
definition : The fucose from GDP-fucose is transferred to N-linked glycans.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations : pancreatic cancer.[PMID: 26869352]
wikipedia :
essentials_of_glycobiology : NBK453089-Chapter 25

Fucosylated triantennary

term (main_entry) : Fucosylated triantennary
term_in_sentence : Asn184 is only partially glycosylated and substituted by fucosylated triantennary and small amounts of diantennary N-acetyllactosaminic glycans.[PMID:2513186]
publication : 2513186|29642865|7679920|31110965|2551687|15051952|12943224
definition : A triantennary glycan with three GlcNAc branches linked to the core and the addition of fucose.[XD]
term_xref :
best_match :
synonymns :
function : appears in human alpha-fetoprotein (AFP).[PMID: 7679920]
disease_associations : neoplastic diseases of the liver[PMID: 7679920 ]|hepatocellular carcinoma[PMID: 7679920].
wikipedia :
essentials_of_glycobiology :

Fully sialylated biantennary N-glycan

term (main_entry) : Fully sialylated biantennary N-glycan
term_in_sentence : The product (12) was purified using protein A chromatography. LC-MS: calculated for the heavy chain of 12 carrying the fully sialylated biantennary N-glycan, M = 51,421 Da; found (m/z), 51,412 (deconvolution data). [PMCID:PMC4861498]
publication : PMC4861498
definition : A binantennary glycan with sialic acid residues as non-reducing terminal residues on both antennae. [RN,MT]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Galabiosylceramide

term (main_entry) : Galabiosylceramide
term_in_sentence : LacCer and its structural isomer, galabiosylceramide (Gb2, Galα(1,4)Galβ-ceramide), are classified as ceramide dihexosides (CDH).[PMID:33360824]
publication : 33360824|29099167|25582508|2824515|4027258|32854306|32868283|31319156|29530250|27367163|2564247|27727434|10216186|10460829|24992926|23590301|15702404|1854798|14761135|3600200|8603914|8601603|1965141|17400502|3840690|15959771|7930586|7721812|17095952|2500499|3815386|8842706|10746023|3928791|3782065|6440894
definition : A disaccharide consisting of β-D-galactopyranose having a D-galactopyranosyl residue attached at the 4-position via an α-linkage.[CHEBI:59314]
term_xref : GlycoEpitope:EP0113|GTC:G67988RO|CID:5288350|KEGG:G00497|KEGG:G10645|CHEBI:59314
best_match : GlycoEpitope:EP0113|GTC:G67988RO|CID:5288350|KEGG:G00497|KEGG:G10645|CHEBI:59314
synonymns :
function :
disease_associations : tumor/lung[glycoepitope:EP0113]|tumor/gallbladder[glycoepitope:EP0113]|tumor/kidney[glycoepitope:EP0113]|tumor/pancreas[glycoepitope:EP0113]
wikipedia :
essentials_of_glycobiology :

Galactosylceramide

term (main_entry) : Galactosylceramide
term_in_sentence : Galactosylceramide improved behavioral, neuropathological, and biochemical parameters in Cln3 Δex7/8 mice, paving the way for effective therapy for CLN3 disease and use of serum ceramide as a potential biomarker to track impact of therapies.[PMID:31393621]
publication : 31393621|19941861|9883654|33006978|26735924|22032265|18035062|25129050|2802541|1761517|28660574|475780|2302222
definition :
term_xref : GGM.000061|GTC:G65889KE|GlycoEpitope:EP0074|SugarBind_Ligand:1|GlycoMotif:GGM.000061
best_match : GGM.000061|GTC:G65889KE|GlycoEpitope:EP0074|SugarBind_Ligand:1
synonymns : GalCer|Galactocerebroside|LC
function :
disease_associations : Pleuropneumonia[SugarBind_Ligand:1]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:1]|Lyme disease[SugarBind_Ligand:1]|Plague[SugarBind_Ligand:1]|Acquired immune deficiency syndrome[SugarBind_Ligand:1]
wikipedia :
essentials_of_glycobiology : NBK453016

Galnac disialyl Lc4 (Hexasaccharide)

term (main_entry) : Galnac disialyl Lc4 (Hexasaccharide)
term_in_sentence : Therefore, a new marker for prostate cancer is urgently required. We examined expression of a novel carbohydrate antigen, beta1,4-GalNAc-disialyl-Lc(4), defined by the monoclonal antibody RM2, in prostate cancer using 75 cases of radical prostatectomy specimens.[PMID: 12084983]
publication : 15704108|11278988|12084983|7509790
definition : (2R,4S,5R,6R)-5-Acetamido-2-[[(2R,3S,4R,5R,6S)-5-acetamido-4-[(2R,3R,4R,5S,6R)-4-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxy-6-[(3R,4S,5S,6R)-2,3,5-trihydroxy-6-(hydroxymethyl)oxan-4-yl]oxyoxan-2-yl]methoxy]-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CID:91857945]
term_xref : GlycoEpitope:EP0097|GTC:G33532XU|CID:91857945|CHEBI:149360
best_match : GlycoEpitope:EP0097|GTC:G33532XU|CID:91857945|CHEBI:149360
synonymns :
function :
disease_associations : prostate cancer[GlycoEpitope:EP0097]|renal cell carcinoma/RCC[GlycoEpitope:EP0097]
wikipedia :
essentials_of_glycobiology :

Gb5

term (main_entry) : Gb5
term_in_sentence : LnbB, a member of the glycoside hydrolase family 20 isolated from Bifidobacterium bifidum, was shown to release GNB from Gb5 and GA1 oligosaccharides.[PMID:25839135]
publication : 12401210|25839135|31540393|31140679|3028540|3674263|31339142|30026902|10721708|30671362|26176557|25039255|24044869|32567311|27857717|21491978|24910250|29077212|8014006|27107335|32679486|1747956|8679447|28352526|11341836|10837462|7960243|16158941|3297853|2431136|21734356|8625206|30732055|12716912|20128040|2582447|14659673
definition : A linear amino pentasaccharide comprising D-glucose at the reducing end with a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-α-D-galactosyl-(1→4)-β-D-galactosyl moiety at the 4-position.[CHEBI:141842]
term_xref : glycomotif:GGM.000076|GTC:G99053DY|CID:53239691|KEGG:G00097|CHEBI:62311|SugarBind_Ligand:12
best_match : glycomotif:GGM.000076|GTC:G99053DY|CID:53239691|KEGG:G00097|CHEBI:62311|SugarBind_Ligand:12
synonymns : Globopentaosylceramide
function :
disease_associations : Pyelonephritis[SugarBind_Ligand:12]|Actinomycosis[SugarBind_Ligand:12|Influenza[SugarBind_Ligand:12]
wikipedia :
essentials_of_glycobiology :

GD1

term (main_entry) : GD1
term_in_sentence : Hormonal and metabolic disturbances observed in both adult and paediatric patients with Gaucher disease type 1 (GD1) are discussed in this review. The PubMed database was used to identify articles on endocrine and metabolic disorders in GD1.[PMID:31791361]
publication : 5652802|25345088|31791361|29361370|31234327|30264864|25250137|7528216|31669751|20684311|16306603|10420586|7766692|31614613|26384672|31613991|19210136|8926633|29696051|32300455|7513313|26674302|20336376|24259734|31704237|21067946|30516933|27979707|26345314|30516941|31849452|27789132|30218706|29388611|20177787
definition :
term_xref : glycomotif:GGM.000105|GTC:G81983KG|CID:91859783|KEGG:G00126
best_match : glycomotif:GGM.000105|GTC:G81983KG|CID:91859783|KEGG:G00126
synonymns : GD1c
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453023

GD1a

term (main_entry) : GD1a
term_in_sentence : Exclusive exposure of rat oligodendrocytes to GD1a, but not other gangliosides, overcomes aggregated fibronectin-induced inhibition of myelin membrane formation, in vitro, and OPC differentiation in fibronectin aggregate containing cuprizone-induced demyelinated lesions in male mice. [PMID: 28899916]
publication : 28899916|26860251|21930390|32906699|26054879|29951721|11745410|17653976|26119566|21554929|18435913|15342262|26865725|21151139|15716397|21492147|16942752|26973195|24449473|14999485|22735313|20589721|10521808|22929125|7827024|16897174|25062498|17227759
definition : A branched amino hexasaccharide consisting of the linear sequence α-Neu5Ac-(2→3)-β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to a galactose via an α-(2→3) linkage. The oligosaccharide of ganglioside GD1a.[CHEBI:59209]
term_xref : GlycoMotif:GGM.000107|GTC:G46677TE|CID:45266861|CHEBI:59209|GlycoEpitope:EP0056|SugarBind_Ligand:22|KEGG:G00111
best_match : GlycoMotif:GGM.000107|GTC:G46677TE|CID:45266861|CHEBI:59209|GlycoEpitope:EP0056|SugarBind_Ligand:22|KEGG:G00111
synonymns : GD1alpha
function :
disease_associations : Gastroenteritis[SugarBind_Ligand:22]|Actinomycosis[SugarBind_Ligand:22]|Lazy leukocyte syndrome[SugarBind_Ligand:22]|Toxoplasmosis[SugarBind_Ligand:22]|Lyme disease[SugarBind_Ligand:22]|Botulism[SugarBind_Ligand:22]|Keratoconjunctivitis[SugarBind_Ligand:22]|Influenza[SugarBind_Ligand:22]
wikipedia :
essentials_of_glycobiology : NBK453016|NBK453073

GD1b

term (main_entry) : GD1b
term_in_sentence : Gangliosides have been known to play a role in the regulation of apoptosis in cancer cells. This study has employed disialyl-ganglioside GD1b to apoptosis in human breast cancer MCF-7 cells using exogenous treatment of the cells with GD1b and endogenous expression of GD1b in MCF-7 cells.[PMID: 27144558]
publication : 27144558|24859332|18625966|7945223|32518172|26710925|31837178|20594196|30985655|11511306|1742806|11123278|7685064|2709011|33279873|22929125|9179156|17964572|8821498|32726962|26560950|2611779|10072058|20030259|16415013|10797556|11342695|8619520|21519903|16199892|23777091|30246056|10481046
definition : A branched amino hexasaccharide comprising a β-D-galactosyl-(1→4)-β-D-glucose disaccharide, the galactosyl residue of which carries β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl and N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl disaccharide units through (2→4) and (2→3) linkages respectively. It is the carbohydrate portion of ganglioside GD1b.[CHEBI:59222]
term_xref : GlycoMotif:GGM.000108|GTC:G37184KW|CID:45266846|CHEBI:59222|GlycoEpitope:EP0059|SugarBind_Ligand:14
best_match : GlycoMotif:000108|GTC:G37184KW|CID:45266846|CHEBI:59222|GlycoEpitope:EP0059|SugarBind_Ligand:14
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453016

GD2

term (main_entry) : GD2
term_in_sentence : Ganglioside GD2 is a tumor-associated surface antigen found in a broad spectrum of human cancers and stem cells. [PMID: 25440605]
publication : 28154831|32002293|32733795|28145567|31500597|31903906|29180536|28415563|25440605|30617136|25604432|30198960|31075227|31721713|30955398|32195035|27304202|31015228|31653037|31016728|30670592|30613134|29221154|30027525|29442009|31762628|30485077|25642322|29436609|29151270|24773917|30612272|27654028|26298772
definition : A branched amino pentasaccharide consisting of a linear sequence of two α-sialyl residues, a β-D-galactosyl residue and an N-acetyl-β-D-glucosamine residue linked respectively (2→8), (2→8) and (1→4), to the galactosyl residue of which is also linked (1→4) an N-acetyl-β-D-glucosaminyl residue. It is the carbohydrate portion of ganglioside GD2.[CHEBI:59218]
term_xref : GlycoMotif:GGM.000094|GTC:G02657AK|CID:45266844|CHEBI:59218|GlycoEpitope:EP0061|SSugarBind_Ligand:88
best_match : GlycoMotif:000094|GTC:G02657AK|CID:45266844|CHEBI:59218|GlycoEpitope:EP0061|SSugarBind_Ligand:88
synonymns :
function :
disease_associations : breast cancer[PMID:28415563]
wikipedia :
essentials_of_glycobiology : NBK453023

GD3

term (main_entry) : GD3
term_in_sentence : In mammalian cells, the intracellular accumulation of ganglioside GD3, an acidic glycosphingolipid, contributes to mitochondrial damage, a crucial event during the apoptopic program. [PMID: 12531552]
publication : 30245960|27591028|12531552|29069780|12470841|29436609|28295752|27304202|31138648|27288875|30446565|8721669|3903474|16081368|32743804|24372645|26792897|20890432|25330147|20581115|11174200|16040804|23783008|17368571|11023989|12901230|21807667|7061953|2231782|19423750|22632091|18202973|6392333|15896784|8261439|20052288|12847141|12486096|12118012|19912988|22795094|18655184|17043769|21395555|2472199|19776077
definition : A linear amino tetrasaccharide consisting of two sialyl, one galactose and one glucose residue (at the reducing end) connected by sequential α-(2→8)-, α-(2→3)- and β-(1→4)-linkages. The oligosaccharide of ganglioside GD3.[CHEBI:59210]
term_xref : GlycoMotif:GGM.000091|GTC:G98544DH|CID:45266862|CHEBI:59210|GlycoEpitope:EP0062|SugarBind_Ligand:89|MeSH:C509062
best_match : GlycoMotif:GGM.000091|GTC:G98544DH|CID:45266862|CHEBI:59210|GlycoEpitope:EP0062|SugarBind_Ligand:89|MeSH:C509062
synonymns :
function :
disease_associations : Cholera[SugarBind_Ligand:89]|Influenza[SugarBind_Ligand:89]
wikipedia :
essentials_of_glycobiology : NBK453016

Globoside

term (main_entry) : Globoside
term_in_sentence : Results of TLC immunostaining of neutral glycolipids from the cDNA-transfected cells also supported the identity of the newly synthesized component as globoside. [PMID:10993897]
publication : 10993897
definition : GlycoMotif:GGM.000070
term_xref :
best_match :
synonymns : Cytolipin K|Gb4|Globoside I|Globotetraosylceramide|P antigen
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Globotetraosylceramide

term (main_entry) : Globotetraosylceramide
term_in_sentence : Here we report that PUGNAc treatment provokes globotetraosylceramide (Gb4Cer) accumulation in human umbilical vein endothelial cells (HUVEC).[PMID:28392398]
publication : 28392398|25787850|23471986|2559078|32455599|2663859|32796033|3517161|20082214|30853699|15279935|26104834|20732996|30224239|31142708|30338271|25033755|30413389|7104376|29866658|24983355|6794884|31361021|21740983|33168837|31752441|28123520|29068380|24841197|27932383|28535204|31691795|27916888|27558838|10227680|26464281|22348006|22279060|25156739|32314902|22718629|23701631|23906628|8613382|23555772|20059899|7868240
definition : An amino tetrasaccharide consisting of 2-acetamido-2-deoxy-β-D-galactopyranosyl, α-D-galactopyranosyl, β-D-galactopyranosyl, and β-D-glucopyranose units joined together in sequence by (1→3), (1→4), and (1→4) glycosidic linkages, respectively.[CHEBI:145578]
term_xref : GTC:G00061MO|GlycoMotif:GGM.000070|GlycoEpitope:EP0073|CID:5288889|CHEBI:145578|SugarBind_Ligand:18|MeSH:C024032
best_match : GTC:G00061MO|GlycoMotif:GGM.000070|GlycoEpitope:EP0073|CID:5288889|CHEBI:145578|SugarBind_Ligand:18|MeSH:C024032
synonymns : Gb4Cer|Gb4|Globoside|P antigen|Cytolipin K
function :
disease_associations : Actinomycosis[SugarBind_Ligand:18]|Pyelonephritis[SugarBind_Ligand:18]|Acute cystitis[SugarBind_Ligand:18]|Shigellosis[SugarBind_Ligand:18]|Lazy leukocyte syndrome[SugarBind_Ligand:18]|Influenza[SugarBind_Ligand:18]
wikipedia :
essentials_of_glycobiology : NBK453065

Globotriaosylceramide

term (main_entry) : Globotriaosylceramide
term_in_sentence : Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) in various cell types.[PMID:32127409]
publication : 32127409|28674962|30875019|30413389|31778662|31101366|24335674|31241709|24158513|28947349|31566927|28672034|31939530|29530250|27851774|26426881|25031264|29982630|24496231|29983334|28756410|27190352|29274327|29099167|28402705|23680766|28625968|26960552|26797827|22742555|27756537|31630715|3827883|28384397|29523338|31010832|27195818|26661087|23093409|30879639|27081853|17409683|29921669|25575293|26291612|23146289|25857295|26070511
definition : Globotriaosylceramide is a type of globoside(glycosphingolipid) which is formed by alpha linkage of galactose to lactosylceramide. The reaction is catalyzed by enzyme A4GALT.[Wiki:Globotriaosylceramide,RN]
term_xref : GlycoMotif:GGM.000068|GTC:G00059MO|GlycoEpitope:EP0071|CID:5279515|CHEBI:68485|MeSH:C018549|SugarBind_Ligand:27
best_match : GlycoMotif:GGM.000068|GTC:G00059MO|GlycoEpitope:EP0071|CID:5279515|CHEBI:68485|MeSH:C018549|SugarBind_Ligand:27
synonymns : Gb3|GL3|Pk antigen|P^K antigen|Gb(3)|Gb_3|CD77|globotriaosylceramide|ceramide trihexoside|CTH|Trihexosylceramide
function :
disease_associations : Pyelonephritis[SugarBind_Ligand:27]|Acute cystitis[SugarBind_Ligand:27]|Shigellosis[SugarBind_Ligand:27]|Lyme disease[SugarBind_Ligand:27]|Cutaneous lesions[SugarBind_Ligand:27]|Diarrhea[SugarBind_Ligand:27]
wikipedia :
essentials_of_glycobiology :

Glucosylceramide

term (main_entry) : Glucosylceramide
term_in_sentence : Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), is required for embryonic survival, but its role in the lung is unknown.[PMID:31265321]
publication : 31265321|29290548|29627573|20919653|28427052|30550553|24415933|31914593|31051284|23073611|30146946|31619618|26840726|29750412|8065509|27412675|27840079|30611744|31353719|25661072|28686011|25803043|28865794|28154347|31466334|30242129|12531551|30639288|30864417|27711049|22764777|27905603|29077010|28744000|23555901|24115322|12803919|29204666|23628459|28851512|26136173|23563543|30110701|26572681|2193825|29926415|31727994|27479571
definition : Cerebrosides which contain as their polar head group a glucose moiety bound in glycosidic linkage to the hydroxyl group of ceramides. Their accumulation in tissue, due to a defect in beta-glucosidase, is the cause of Gaucher's disease.[MeSH:D005963]
term_xref : MeSH:D005963|GlycoMotif:GGM.000060|CHEBI:83264|GTC:G71142DF
best_match : MeSH:D005963|GGM.000060|CHEBI:83264|GTC:G71142DF
synonymns : GlcCer|G1cβ1–1′Cer|Glucocerebroside|Ceramide monohexoside|CMH
function : The structural characterization of mixed membranes made of cationic lipids and glucosylceramides may be important for developing novel immunotherapeutic tools such as vaccine adjuvants.[PMID:30611744]|Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), is required for embryonic survival, but its role in the lung is unknown.[PMID:31265321]
disease_associations : Gaucher's Disease[RN]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3]
wikipedia :
essentials_of_glycobiology : NBK453016

GM1

term (main_entry) : GM1
term_in_sentence : GM1-induced fluidization of the phospholipid membranes and probable physical contact between bulky sugar head group of GM1 and spectrin, may explain the modulatory role of GM1 on aminophospholipid interactions with nonerythroid brain spectrin.[PMID: 29920238]
publication : 18524657|31761138|29920238|31937438|25762012|25931034|31776384|32013258|30776097|31048748|31447771|30292198|28796418|27806275|21076871|27552916|17986147|26960162|27815022|25851126|32916822|11462671|28236574|15911874|28577204|28497346|1794005|31934908|30267299|16902585|29439846|32325905|29747823|27576485|26338710|27858734|24501414|26818965|26629687|26958633|1854596|32134593|32198666|6619101
definition : A branched amino pentasaccharide consisting of the linear sequence β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the inner galactose via an α-(2→3) linkage. The oligosaccharide of ganglioside GM1a.[CHEBI:59208]
term_xref : GlycoMotif:GGM.000098|GTC:G48558GR|CID:196569|CHEBI:59208|GlycoEpitope:EP0050|SugarBind_Ligand:13|KEGG:G00110
best_match : GlycoMotif:GGM.000098|GTC:G48558GR|CID:196569|CHEBI:59208|GlycoEpitope:EP0050|SugarBind_Ligand:13|KEGG:G00110
synonymns :
function :
disease_associations : Gastroenteritis[SugarBind_Ligand:13]|Actinomycosis[SugarBind_Ligand:13]|Lazy leukocyte syndrome[SugarBind_Ligand:13]|Toxoplasmosis[SugarBind_Ligand:13]|Cholera[SugarBind_Ligand:13]|Botulism[SugarBind_Ligand:13]
wikipedia : https://en.wikipedia.org/wiki/GM1_gangliosidoses
essentials_of_glycobiology : NBK453032

GM2

term (main_entry) : GM2
term_in_sentence : GM1 gangliosidosis has both central nervous system and systemic findings; while, GM2 gangliosidosis is restricted primarily to the central nervous system.[PMID: 27491214]
publication : 29618308|27491214|32867370|30030044|27499644|31097363|29100724|27402091|31852956|30389374|30988135|8786814|14533808|23370522|28192816|32692591|29106755|28833537|11339652|9728335|27270764|9714704|26175473|27018595|28615102|28974375|32951593|11462672|28955902|17192692|26538065|25421609|9572057|11596983|15264019|23236285|11596984|31261761|30113798|24391178|24309906|22224667|7980537|18272501|9006924|
definition : A branched amino tetrasaccharide consisting of the linear sequence β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the galactose via an α-(2→3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2.[CHEBI:59220]
term_xref : GlycoMotif:GGM.000095|GTC:G79389NT|CID:45266845|CHEBI:59220|GlycoEpitope:EP0051|SugarBind_Ligand:39|KEGG:G00109|KEGG:G10351
best_match : GlycoMotif:GGM.000095|GTC:G79389NT|CID:45266845|CHEBI:59220|GlycoEpitope:EP0051|SugarBind_Ligand:39|KEGG:G00109|KEGG:G10351
synonymns :
function :
disease_associations : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051]|Gastroenteritis[SugarBind_Ligand:39]|Cholera[SugarBind_Ligand:39]|Clostridial myonecrosis[SugarBind_Ligand:39]|Tetanus[SugarBind_Ligand:39]
wikipedia :
essentials_of_glycobiology : NBK453016|NBK453095|NBK453018|NBK453082|

GM3

term (main_entry) : GM3
term_in_sentence : We also demonstrated an essential role of GM3 in murine and human auditory systems; a common pathological feature of GM3S deficiency is deafness. [PMID: 29747813]
publication : 29376491|29747813|25613425|30318083|31526872|31004109|28019668|26434718|27313500|27539856|30111401|28544772|29407985|19364317|30190430|31297734|30091781|26043887|32183071|30665141|27873002|25801320|30209782|32378734|23050851|22768242|14993837|24934090|17638075|21518140|26102277|19759399|24502144|25303960|23564406|16636105|16491123|11259118|15102521|12724312|24985965|8496625|25403557|15690123|15939439|25893133|23591593|20634908|2004380|739008|
definition : Ganglioside GM3 (d18:1/16:0) is a glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GM3 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissuesGangliosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Gangliosides are very similar to globosides except that they also contain N-acetyl neuraminic acid (NANA) in varying amounts. The specific names for the gangliosides provide information about their structure. The letter G refers to ganglioside, and the subscripts M, D, T and Q indicate that the molecule contains mono-, di-, tri and quatra-sialic acid. The numbered subscripts 1, 2 and 3 refer to the carbohydrate sequence that is attached to the ceramide. In particular, 1 stands for GalGalNAcGalGlc-ceramide, 2 stands for GalNAcGalGlc-ceramide and 3 stands for GalGlc-ceramide. Deficiencies in lysosomal enzymes that degrade the carbohydrate portions of various gangliosides are responsible for a number of lysosomal storage diseases such as Tay-Sachs disease, Sandhoff disease, and GM1 gangliosidosis. The carbohydrate portion of the ganglioside GM1 is the site of attachment of cholera toxin, the protein secreted by Vibrio cholerae.[HMDB0004844]
term_xref : GlycoMotif:GGM.000090|GTC:G91237TK|CID:5288424|CHEBI:59226|GlycoEpitope:EP0053|SugarBind_Ligand:35
best_match : GlycoMotif:GGM.000090|GTC:G91237TK|CID:5288424|CHEBI:59226|GlycoEpitope:EP0053|SugarBind_Ligand:35
synonymns :
function : Membrane stabilizer|Energy source|Energy storage|Molecular messenger:|Signaling molecule[HMDB0004844]
disease_associations : Gastroenteritis[SugarBind_Ligand:35]|Chronic gastritis[SugarBind_Ligand:35]|Toxoplasmosis[SugarBind_Ligand:35]|Peptic ulcersSugarBind_Ligand:35]|Gastric cancer[SugarBind_Ligand:35]|Influenza[SugarBind_Ligand:35]|Diarrhea[SugarBind_Ligand:35]|Botulism[SugarBind_Ligand:35]
wikipedia :
essentials_of_glycobiology : NBK453016|NBK453023|NBK453042|NBK453088|/NBK453073|NBK453076|NBK453041

GM4

term (main_entry) : GM4
term_in_sentence : GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).[PMID:23999868]
publication : 23999868|2332419|12091485|19542236|8407875|23320941|28808804|3621237|23203271|7057115|26362868|6170387|18034482|7076644|2391348|25464080|3701369|11217952|6201236|30744426|9388026|27177620|30246056|15979459|7586078|6779816|29402905|7335153|3306476|17499534|7074082|9668345|3701884|26862430|6831238|27311552|26831445|24417799|7097284|4169231|16854400|26483798
definition : An amino disaccharide consisting of β-D-galactose having an α-N-acetylneuraminyl residue attached at the 3-position[CHEBI:63155]
term_xref : glycomotif:GGM.000089|GTC:G30207PZ|CID:5289366|CHEBI:63155|KEGG:G00317|SugarBind_Ligand:110
best_match : glycomotif:GGM.000089|GTC:G30207PZ|CID:5289366|CHEBI:63155|KEGG:G00317|SugarBind_Ligand:110
synonymns :
function :
disease_associations : Chronic gastritis[SugarBind_Ligand:110]|Peptic ulcers[SugarBind_Ligand:110]|Gastric cancer[SugarBind_Ligand:110]
wikipedia :
essentials_of_glycobiology : NBK453016

GP1c

term (main_entry) : GP1c
term_in_sentence : n this report, we describe an efficient convergent synthesis of the GP1c glycolipid epitope, which is one of the most complex c-series gangliosides. [PMID:19053458]
publication : 1606358|19053458|1695858|4091974|10775425|2468656|2299350|3064875|11432974|9613831|11831845|1879553|10699494|8969459|8474578|12031286|1304332|9153001|10564776
definition :
term_xref : glycomotif:GGM.000118|GTC:G93805MV
best_match : glycomotif:GGM.000118|GTC:G93805MV
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

GQ1b

term (main_entry) : GQ1b
term_in_sentence : Bilateral infusion of GQ1b into the hippocampus ameliorates cognitive deficits in the triple-transgenic AD mouse model (3xTg-AD).[PMID:31186474]
publication : 30798387|31186474|26704905|23677659|26984947|24184316|23804237|9819299|18514410|22189683|24859332
definition : An amino oligosaccharide that is a branched octasaccharide derivative consisting of four sialyl residues, two galactose residues, one N-acetylglucosamine and a glucose residue at the reducing end.[CHEBI:59212]
term_xref : glycomotif:GGM.000115|GTC:G18625KA|GlycoEpitope:EP0069|CID:45266843|KEGG:G00117|CHEBI:59212
best_match : glycomotif:GGM.000115|GTC:G18625KA|GlycoEpitope:EP0069|CID:45266843|KEGG:G00117|CHEBI:59212
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453044

GQ1ba

term (main_entry) : GQ1ba
term_in_sentence : A few studies have reported the association of autoantibodies to GM1 or GQ1bα with Alzheimer's disease (AD) or vascular dementia.[PMID:25024341]
publication : 25024341|23717411|17870542|10702226|21137678|26748510|8662799|21274438|24649890|16580208|28124591|20095613|17507233|23565921|14505645|20930939|9201997
definition :
term_xref : GlycoMotif:GGM.000116
best_match :
synonymns : GQ1balpha
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

GQ1c

term (main_entry) : GQ1c
term_in_sentence : The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with Gq1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1.[PMID: 6640289]
publication : 6640289|1695858|7798936|1729139|2468656|20368669|2723647|1814411|3064875|6085330|1613492|17883393|11831845|10775425|8219015|8804704|1384262|7066685|2299192|9613831|10350354|1304337|9153001|11959025|8474578|2299350|10564776|10699494|3942818|12031286|7361620
definition : Alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-[alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)]-beta-D-Galp-(1->4)-beta-D-Glcp is a member of neuraminic acids and an amino octasaccharide.[CID:91860352]
term_xref : GlycoMotif:GGM.000117|GTC:G99524KA|CID:91860352|CHEBI:145645|KEGG:G00121
best_match : GlycoMotif:000117|GTC:G99524KA|CID:91860352|CHEBI:145645|KEGG:G00121
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

GT1a

term (main_entry) : GT1a
term_in_sentence : GT1a mimicry was found in the lipo-oligosaccharides of strain ICDCCJ07002 and ICDCCJ07004; but a combination of GM3/GD3 mimics was observed in ICDCCJ07001, although this patient had anti-GT1a IgG antibodies.[PMID:26197476]
publication : 12023422|32623212|26197476|9585812|29747820|23804237|11993188|31683059|19631994|9742882|29709941|8971119|8706663|893404|31829433|8910600|30600291|29319803|26176883|29063860|6766128|31602715|29808463|30711390|29847988|30116054|28187751
definition : A branched heptasaccharide derivative consisting of three sialyl residues, two galactose residues, one N-acetylglucosamine and a glucose residue at the reducing end.[CHEBI:59215]
term_xref : CID:45266863|glycomotif:GGM.000110|GTC:G68110IF|GlycoEpitope:EP0066|KEGG:G00112|CHEBI:59215
best_match : CID:45266863|glycomotif:GGM.000110|GTC:G68110IF|GlycoEpitope:EP0066|KEGG:G00112|CHEBI:59215
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

GT1a alpha

term (main_entry) : GT1a alpha
term_in_sentence : A new class of gangliosides, GT1a alpha and GQ1b alpha, were initially identified as cholinergic neuron-specific antigens in bovine brain. [PMID:8082783]
publication : 7710562|8082783|10972137|9468624|9143254|8221098|9679279|11368158|11878808
definition :
term_xref : GlycoMotif:GGM.000111|GTC:G02149VR|GlycoEpitope:EP0111|CID:91851751|CHEBI:156678|KEGG:G00128
best_match : GlycoMotif:GGM.000111|GTC:G02149VR|GlycoEpitope:EP0111|CID:91851751|CHEBI:156678|KEGG:G00128
synonymns : GT1aa
function : GT1a alpha was a cholinerginic-specific antigen.[GlycoEpitope:EP0111]
disease_associations :
wikipedia :
essentials_of_glycobiology :

GT1b

term (main_entry) : GT1b
term_in_sentence : GT1b ganglioside is axonally transported to the spinal cord dorsal horn and contributes to characteristics of neuropathic pain such as mechanical and thermal hypersensitivity.[PMID: 32030804]
publication : 32030804|26370787|32046393|9712688|7636307|9931455|25520869|19605473|17188834|10233751|22735313|20540782|22746533|1861141|19490186|9521848|11921200|10731661|31431523|15274627|32726962|12573517|18277613|11370834|11234774|11123278|18704164|16291967|11411041|27549393|25253868|22720883|10686582|11511306|29904724|31472390|19156870
definition : A branched amino heptasaccharide comprising a β-D-galactosyl-(1→4)-β-D-glucose disaccharide, the galactosyl residue of which carries an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl trisaccharide unit and an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl disaccharide unit through (2→4) and (2→3) linkages respectively. It corresponds to the carbohydrate portion of ganglioside GT1b.[CHEBI:59225]
term_xref : GlycoMotif:GGM.000112|GTC:G40183QN|GlycoEpitopeEP0067|CID:45266781|CHEBI:59225| GlycoEpitope ID:130680|SugarBind_Ligand:26|KEGG:G00116
best_match : GlycoMotif:000112|GTC:G40183QN|GlycoEpitopeEP0067|CID:45266781|CHEBI:59225| GlycoEpitope ID:130680|SugarBind_Ligand:26|KEGG:G00116
synonymns :
function :
disease_associations : Toxoplasmosis[SugarBind_Ligand:26]|Lyme disease[SugarBind_Ligand:26]|Cholera[SugarBind_Ligand:26]|Botulism[SugarBind_Ligand:26]|Tetanus[SugarBind_Ligand:26]|Influenza[SugarBind_Ligand:26]
wikipedia :
essentials_of_glycobiology : NBK453016

GT1c

term (main_entry) : GT1c
term_in_sentence : We show here that VVH associates with ganglioside GM1a, Fucosyl-GM1, GD1a, GT1c, and GD1b by glycan array.[PMID: 32228455]
publication : 28088450|30085356|32228455|2468656|19841910|23877172|1695858|10564776|1613492|8474578|7798936|11180643|2723647|7066685|9613831|7361620|10699494
definition : A branched amino heptasaccharide consisting of a linear tetrasaccharide of β-D-galactose, N-acetyl-β-D-galactosamine, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→4) and (1→4), to the galactose residue proximal to the reducing end is also linked (2→3) an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl trisaccharide side-chain. The carbohydrate moiety of ganglioside GT1c.[CHEBI:90509]
term_xref : GlycoMotif:GGM.000113|GTC:G78818SP|CID:91846734|CHEBI:90509|GlycoEpitope:EP0033|KEGG:G00120
best_match : GlycoMotif:000113|GTC:G78818SP|CID:91846734|CHEBI:90509|GlycoEpitope:EP0033|KEGG:G00120
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453016

GT2

term (main_entry) : GT2
term_in_sentence : Biosynthesis of the c-series gangliosides GT3, GT2 and GP1c was studied in Golgi derived from rat liver.[PMID:1606358]
publication : 1606358|15498585|16005859|27540730|31533196|31201844
definition : A branched amino hexasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4), to the galactosyl residue of which is also linked (1→4) an N-acetyl-β-D-galactosaminyl residue. The carbohydrate moiety of ganglioside GT2.[CHEBI:72446]
term_xref : GlycoMotif:GGM.000109|GTC:G36476BA|CID:70788971|CHEBI:72446|KEGG:G00119
best_match : GlycoMotif:000109|GTC:G36476BA|CID:70788971|CHEBI:72446|KEGG:G00119
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453084

GT3

term (main_entry) : GT3
term_in_sentence : The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound.[PMID: 28029115]
publication : 28029115|31355968|30987413|27869747|27216753|8631981|29672891|10385047|29642403|10412028|27193023|30068561|23415908|8858920|2303428|27153057|27128741|2654294|26930378|7561885|25860286|30845647|24712339|30070965|8910600|1606358|27356050|8514740|18509108|23000517|29769046|29566611
definition : A linear amino pentasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4).[CHEBI:72444]
term_xref : GlycoEpitope:EP0070|KEGG:G00118|CID:70788970|GlycoMotif:GGM.000092|GTC:G93899SO|CHEBI:72444
best_match : GlycoEpitope:EP0070|KEGG:G00118|CID:70788970|GlycoMotif:GGM.000092|GTC:G93899SO|CHEBI:72444
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453016

H type 2

term (main_entry) : H type 2
term_in_sentence : The human H-transferase (α2FucT) was introduced in Gal-negative pigs to produce pig organs not only free from Gal-antigens, but also in which the uncapped N-acetyllactosamine precursor had been transformed into non-xenogenic blood group H type 2 compounds.[PMID:24219248]
publication : 6177241|9405495|8082855|11261842|6185219|10409676|11218748|2238560|2413709|8731502|11101633|10375377|10585597|30232154|18701592|7539926|11090284|8061795|10212193|9098001|12114800|8737251|2923092|12475934|3473361|2416979|24178382|29467317|26104834|8499478|9760191|95124|12928075|3523995|6203846|29304015|24219248|12820383|17381513|28823097|11479278|1355324|2442094|2535475|2458750
definition :
term_xref : GGM.000045|GGM.000036
best_match : GGM.000045|GGM.000036
synonymns : Blood group H (type 2)
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

H type 3

term (main_entry) : H type 3
term_in_sentence : The expression of type 3 chain H and A antigens was always compatible with the ABO blood type of the individual and seems to be regulated by the secretor genes, as secretors [Lewis (a-b+)] expressed more A and H type 3 chains than nonsecretors [Lewis (a+b-)].[PMID:1563908]
publication : 1563908|3944092|11218748|11101633|18842005|27550195|2469783|2433836|23118206|8445257|2664192|3063304
definition :
term_xref :
best_match :
synonymns : H antigen (type 3)|Type 3 chain H
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Heparan sulfate

term (main_entry) : Heparan sulfate
term_in_sentence : In Niemann-Pick C-1 fibroblasts, where deaminative degradation of heparan sulfate is defective, carbonylated proteins were abundant.[PMID: 17540770]
publication : 32266657|29554552|29032302|30003471|25197032|28538085|26236728|22899865|17080204|23042481|28982096|24146040|25081076|15719168|17453622|25325954|21110089|29797526|21967329|23313092|11212344|28465034|11746174|12512855|8836040|28394734|24182748|28264929|28745308|26555370|14718374|16767693|25246018|19584012|8274190|25034023|8370471|26571620|29920400|31731076|20816205|16880267|31547957|11457867|27241222|28718936|21204109|31016560|11166215|11457866
definition : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815]
term_xref : CHEBI:28815|CID: 53477715|Epitope ID: EP0086
best_match : CHEBI:28815|CID: 53477715|Epitope ID: EP0086
synonymns : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate
function : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[Epitope ID: EP0086]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453033-Chapter 17

Heparin

term (main_entry) : Heparin
term_in_sentence : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:6416324]
publication : 27100512|22566218|27264866|30094590|31077659|26975675|2083874|25088334|3333067|2191809|28118750|28224913|22495506|29385025|10332503|22393937|19947315|27655335|14529394|2419035|22048616|23849978|10204652|28958760|12627673|9042555|15639107|28880550|27238483|1964668|16716101|10796377|25981976|24680753|2191118|21166465|30582884|1322434|15330727|9752370|6416324|14996629|20452241|1340407|29050610|345399|6916469|6565376|26714061
definition : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304]
term_xref : CID:772|CHEBI:28304|
best_match : CID:772|CHEBI:28304|
synonymns : bemiparin|bemiparin|certoparin|Cy 222|enoxaparin|fluxum|Heparin|Heparinic acid|parnaparin|reviparin|sandoparin
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453033-Chapter 17

High mannose

term (main_entry) : High mannose
term_in_sentence : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:11258925]
publication : 11258925|17956937|2059624|2065054|26791533|4077844|7780197|9136890|30659065|30075362|21421994|31076349|29738673|29508223|26747427|30634645|23007868|29051951|24549150|12417032|26724786|26956389|26493153|31102532|29673624|8348230|25586968|24975601|29803109|28465212|25776945|30151520|21097542|24326091|27995699|26003537|6722291|2925680|25565276|21460211|25196214|27387600|22373601|3729933|16423983|24174266|30605318
definition : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man [MT].
term_xref : CHEBI:5717
best_match : GTC:G55220VL|CID:70698382|CHEBI:71514
synonymns : oligomannose
function : Involved in promotion of protein folding in ER. [PMID:12417032].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205]
disease_associations : Relative abundance changes in multiple CDGs [PMID: 30770376][PMID: 28484880][MT]
wikipedia : https://en.wikipedia.org/wiki/N-linked_glycosylation
essentials_of_glycobiology : NBK453020

HNK-1

term (main_entry) : HNK-1
term_in_sentence : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:28709864]
publication : 28709864|31738061|26738850|30306736|11070366|20855890|18024472|22669261|19729452|19796667|26850637|11769463|18263654|15843379|26659409|9003039|22087768|21771787|15173636|9210489|15258996|17924534|26382082|16171882|18802400|9800516|7504418|11891229|15232286|9013478|21621858|11677051|18668221|11414798|19265195|8982638|8798480|28403522|17935701|1691305|10998116|9364602|7528651|12472892|21176892|28416698|19389918|28427937|25450311
definition : Human natural killer-1 or HNK-1 is an amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322,RN]
term_xref : GTC:G54406UD|GlycoEpitope:EP0001|CID:46906103|CHEBI:60322|GGM.00058
best_match : GTC:G54406UD |GlycoEpitope:EP0001|CID:46906103|CHEBI:60322
synonymns : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen
function : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001]
disease_associations : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001]
wikipedia :
essentials_of_glycobiology :

Hybrid

term (main_entry) : Hybrid
term_in_sentence : A hybrid-type N-glycan was accessed by total synthesis, converted to an oxazoline, and used as a donor substrate with both wild type Endo M and an N175Q glycosynthase Endo M mutant allowing the convergent synthesis of a glycosylated amino acid bearing a hybrid N-glycan structure. [PMID:27058295]
publication : 27058295|15044398|28714086|29578688|26999365
definition : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core (Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1) is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the β-linked Man residue.[NBK453020-Chapter 9,RN,MT]
term_xref :
best_match : GTC:G16828VN|CID:91847108|CHEBI:147471
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453020-Chapter 9

i antigen

term (main_entry) : i antigen
term_in_sentence : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:2422274]
publication : 2422274|15679458|21912254|12468428|28508465|6203982|30728302|8449405|9122902|10360315|6159787|6183759|518539|6715951|21933024
definition :
term_xref : GlycoMotif:GGM.000002|GlycoMotif:GGM.000004
best_match : GlycoMotif:GGM.000002|GlycoMotif:GGM.000004
synonymns : Type 2 LN2
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

I antigen

term (main_entry) : I antigen
term_in_sentence : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID:15679458]
publication : 15679458|21912254|30705292|33403394|6715951|12468428|6088627|6159787
definition : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390]
term_xref : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:91852915|CHEBI:151390
best_match : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:91852915|CHEBI:151390
synonymns :
function :
disease_associations :
wikipedia : https://en.wikipedia.org/wiki/Ii_antigen_system
essentials_of_glycobiology :

Isoglobotetraosylceramide

term (main_entry) : Isoglobotetraosylceramide
term_in_sentence : Furthermore, isoglobotetraosylceramide seems to play a direct role in the metastatic process since the blocking of exposed antigen with monoclonal antibodies, or their Fab fragments, results in a highly significant decrease in lung colony formation.[PMID:8504431]
publication : 1396705|8504431|2713378|3489485|18997175|7053385|3379797|2465279|3743633|11479210
definition :
term_xref : glycomotif:GGM.000071|GTC:G57710SU|CID:91849719|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17
best_match : glycomotif:GGM.000071|GTC:G57710SU|CID:91849719|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17
synonymns :
function : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:8504431]
disease_associations : Actinomycosis[SugarBind_Ligand:17]
wikipedia :
essentials_of_glycobiology :

Keratan sulfate

term (main_entry) : Keratan sulfate
term_in_sentence : Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties.[PMID: 30578672]
publication : 29340594|30578672|12512857|29625490|25325967|30025865|29924315|9549787|11030741|28078490|8298243|29096187|30059256|26958998|26773479|22840010|15597951|28110685|28535934|2942429|18234072|8641829|8940154|2027120|30849116|41589|6238957|1907283|7722002|29275050|24274541|2527236|1731862|8991509|24291704|10517185|6451953|7688312|8663590|139406|25770829|25036480|9275006|25179279|32627425|26903438|27941632|12807022|32266652|21624346
definition : A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions.[CHEBI:60924]
term_xref : CHEBI:60924|CID:446715|Epitope ID: EP0085|GTC: G82109MW
best_match : CHEBI:60924|CID:446715|Epitope ID: EP0085|GTC: G82109MW
synonymns : keratan| Kerato sulphate|Kerato sulfate|Keratan sulphate|kerato 6'-sulfate|keratan 6'-sulfate|Kerato 6'-sulphate|Keratan 6'-sulphate
function : Tissue hydration.[PMID: 11030741]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453033-Chapter 17

LacdiNac

term (main_entry) : LacdiNac
term_in_sentence : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:25003135]
publication : 25003135|31711843|31145522|27601469|30669833|25210040|24633693|24755437|22653491|30898876|7758724|22474328|21305673|31558607|31271862|28549117|26213980|9134425|25561735|31756927|31170332|16282603|15265923|32267274|23015818|32676595|16728562|10814702|9591048|22245701|29751628|22997242|15535969|31911241|30622255|29888905|30236114|30298790|29373511|22298779|19179461|31606752|15653684|16403022|11162373|32005658|30529570
definition : Beta-D-GalpNAc-(1->4)-D-GlcpNAc is an amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a beta-linkage. It has a role as an epitope.[CHEBI:61190]
term_xref : GTC:G31736BK|GlycoEpitope:P0150|CID:25257164|CHEBI:61190|GlycoMotif:GGM.000016
best_match : GTC:G31736BK|GlycoEpitope:P0150|CID:25257164|CHEBI:61190|GlycoMotif:GGM.000016
synonymns : LDN
function : Has a role of epitope.[CHEBI:61190]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

Lactosylceramide

term (main_entry) : Lactosylceramide
term_in_sentence : In the 1970s, a neutral glycosphingolipid lactosylceramide (LacCer) was found to bind specifically to several kinds of microorganisms.[PMID:30175814]
publication : 30175814|26900161|30502090|29624959|28444900|25408340|31801289|29099167|25595946|32592089|27729551|24658420|25216636|25638276|9499377|17986153|8143857|23801329|18077097|32708181|15346887|19015977|18393821|25279740|21057870|11915327|25212460|23882130|11915329|8195125|8808768|3396945|22128256|6733104|24968752|32518749|30688114|7666005|8200356|24718572|6193809|25781947|12383912|26086247|30606995|12419803
definition : Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.[MeSH:D007790]
term_xref : GTC:G84224TW|MeSH:D007790|GlycoMotif:GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3
best_match : GTC:G84224TW|MeSH:D007790|GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3
synonymns : LacCer|Lc2|CDH
function : mammalian cell receptors for Neisseria gonorrhoeae recognized by Helicobacter pylori[GlycoEpitope:EP0078]
disease_associations : chronic gastritis[GlycoEpitope:EP0078,SugarBind_Ligand:3]|duodenal ulcers[GlycoEpitope:EP0078]|gastric adenocarcinoma[GlycoEpitope:EP0078,SugarBind_Ligand:3]|gastric ulcers[GlycoEpitope:EP0078]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Actinomycosis[SugarBind_Ligand:3]|Pertussis[SugarBind_Ligand:3]|Candidiasis[SugarBind_Ligand:3]|Cryptococcosis[SugarBind_Ligand:3]|Hemorrhagic colitis[SugarBind_Ligand:3]|Peptic ulcers[SugarBind_Ligand:3]|Histoplasmosis[SugarBind_Ligand:3]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Gonorrhea[SugarBind_Ligand:3]|Sporotrichosis[SugarBind_Ligand:3]|Plague[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3]
wikipedia :
essentials_of_glycobiology : NBK453042

Lactotriaosylceramide

term (main_entry) : Lactotriaosylceramide
term_in_sentence : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:22411838]
publication : 22411838|20693232|26104834|27435676|26405105|32340400|25241919|23404501|32452379|2960671|272643|27711049|33202844|4060695|27638607|20547865|2277039|6238026|8448388|8489255|9363437|11836161|6892925|1551117|6811267|8059935|7861954|11283017|8514762|1291049|3805024|10816509|12393713|6417117|11054095|8781973|1692829
definition : Beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-beta-D-Glcp is a linear amino trisaccharide consisting of beta-D-glucose at the reducing end having an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl group attached at the 4-position. It has a role as an epitope. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:61758]
term_xref : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:10230777|CHEBI:61758|SugarBind_Ligand:20
best_match : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:10230777|CHEBI:61758|SugarBind_Ligand:20
synonymns : Lc3|Lc(3)Cer|Lc_3
function : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:22411838]
disease_associations : Pharyngitis[SugarBind_Ligand:20]|Tracheobronchitis[SugarBind_Ligand:20]|Gonorrhea[SugarBind_Ligand:20]|Actinomycosis[SugarBind_Ligand:20]|Diarrhea[SugarBind_Ligand:20]
wikipedia :
essentials_of_glycobiology :

LcGg4

term (main_entry) : LcGg4
term_in_sentence : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: 3805024]
publication : 3805024|33395290
definition : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521]
term_xref : GlycoMotif:GGM.000075|GTC:G62554JH|CID:91850076|CHEBI:152521|GlycoEpitope:EP0035
best_match : GlycoMotif:GGM.000075|GTC:G62554JH|CID:91850076|CHEBI:152521|GlycoEpitope:EP0035
synonymns :
function :
disease_associations :
wikipedia : https://www.wikidata.org/wiki/Q50687009
essentials_of_glycobiology :

Lewis a

term (main_entry) : Lewis a
term_in_sentence : Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). [PMID:29367698]
publication : 29367698|27187324|30562693|27646625|26911286|30225822|28600306|32527016|2385097|11064310|23809433|30050155|1615929|29527514|9207264|1675497|3677023|27705835|7593252|2579997|17630273|9350993|9098001
definition : A lewis blood group antigen with structure Beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcpNAc consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an alpha-linkage and a galactosyl residue attached at the 3-position via a beta-linkage. It has a role as an epitope and an antigen. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:62265,RN]
term_xref : GTC:G00047MO|CID:22806751|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155
best_match : GTC:G00047MO|CID:22806751|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155
synonymns : Le(a)|Lea-3|Lea|Le^a
function :
disease_associations : Gastroenteritis[SugarBind_Ligand:155]
wikipedia :
essentials_of_glycobiology : NBK453042

Lewis b

term (main_entry) : Lewis b
term_in_sentence : Human mannose-binding lectin preferentially binds to human colon adenocarcinoma cell lines expressing high amount of Lewis A and Lewis B antigens.[PMID:10328552]
publication : 10328552|23408949|31927399|26601230|28279343|32527016|30831115|27318698|9207264|23828675|29527514|1615929|2385097|2579997|25516619|3677023|8509439|19832116|15270746|3166398|30909206|7718581|18400963|29751628|8982241|30284922|24576035|30974776|9098001|31768613|1651804|25428879|15946883|30298790|30544260|29197783|8632739|7679772|18666312|20231766|29922666|95124|2247887|21519121|25153235|28751211
definition :
term_xref : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:45480568|CHEBI:59440|GlycoMotif:GGM.000021
best_match : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:45480568|CHEBI:59440
synonymns : Le(b)|Lewis(b)|Le^b
function : possible receptor for Helicobacter pylori[3]
disease_associations : Gastroenteritis[SugarBind_Ligand:146]
wikipedia :
essentials_of_glycobiology : NBK453042

Lewis x

term (main_entry) : Lewis x
term_in_sentence : In particular, the observation of oxonium ions at m/z 512.2 and 803.2 is useful for probing outer non-reducing terminal fucosylation, which represented carbohydrate structures consisting of Hex Hex , dHex Hex , and HexNAc , and NeuNAc , Hex Hex , dHex Hex , and HexNAc , respectively, from which the Lewis X structure (Galbeta1-4(Fucalpha1-3)GlcNAc) was readily deduced.[PMID:15536627]
publication : 15536627|31666308|29019053|28296340|29593094|17607374|16581086|20858014|19962782|7912739|25121780|24059473|29210428|31276881|9015359|7628844|7499837|16850248|28425129|28869691|19576189|10223649|22593503|15632313|27198630|26582608|11500392|31256373|23399157|21984435|26244810|26162743|17335083|15388363|9556613|10760152|11267844|20876654|12131290
definition : A Lewis blood group antigen with structure α-L-Fucp-(1→3)-[β-D-Galp-(1→4)]-D-GlcpNAc where the glucosamine at the reducing end has β-configuration at its anomeric centre. Commonly known as Lewis x trisaccharide or Lex.[CHEBI:59294, RN]
term_xref : GTC:G00051MO |GlycoEpitope:EP0011|CID:44611539|CHEBI:59294｜GlycoMotif:GGM.000018
best_match : GTC:G00051MO |GlycoEpitope:EP0011|CID:44611539|CHEBI:59294
synonymns : Lex|Galbeta1-4(Fucalpha1-3)GlcNAc|Lewis x trisaccharide|Le(X)|Le^x|SSEA-1
function : Involved in carbohydrate-carbohydrate interaction[Glycoepitope:EP0011].|Also implicated in apoptosis.[Glycoepitope:EP0011]|influence antigenic presentation and interfere with pathogen transfer in breastfed infants.[Glycoepitope:EP0011]
disease_associations : acute leukemia[GlycoEpitope:EP0011]|lymphoma[GlycoEpitope:EP0011]
wikipedia :
essentials_of_glycobiology : NBK453042-Chapter 14

Lewis y

term (main_entry) : Lewis y
term_in_sentence : In conclusion, Lewis y antigen and CD147 were significantly upregulated in ovarian tumors, and the altered expression of Lewis y may cause changes in CD147.[PMID:30816446]
publication : 30816446|20003467|24692145|24998328|25726913|29299130|30816446|20003467|24692145|24998328|20127027|22138668|23894390|25726913|25416440|27646625|23725446|21294926|22312289|25973320|23242548|30328452|21119363|29130097|23443083|23708102|28671040|19715603|23468946|27723168|21747684|19771739
definition : A Lewis blood group antigen which is a branched amino tetrasaccharide with structure Alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, consisting of consisting of N-acetyl-beta-D-glucosamine at the reducing end having an alpha-L-fucosyl residue attached at the 3-position and an alpha-L-fucosyl-(1->2)-beta-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure. It has a role as an antigen and an epitope. [CHEBI:59045,RN]]
term_xref : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045|GlycoMotif:GGM.000019
best_match : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045
synonymns : LeY|Le(y)|Ley|Le^y
function : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018]
disease_associations : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018]
wikipedia :
essentials_of_glycobiology :

Lewisx-Lewisx

term (main_entry) : Lewisx-Lewisx
term_in_sentence : LewisX glycosphingolipids form microdomains on cell surfaces. Homotypic and calcium-mediated LewisX-LewisX (LeX-LeX) interactions were proposed to be responsible for the initial steps of cell adhesion, and to mediate embryogenesis and metastasis.[PMID: 18618154]
publication : 18618154|21892456
definition : A six-membered glucosamine oligosaccharide consisting of two repeating units of β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc joined by a (1→3)-linkage.[CHEBI:61325]
term_xref : GlycoMotif:GGM.000031|GTC:G79535HZ|CID:50909845|CHEBI:61325|GlycoEpitope:EP0093|MeSH: C069719
best_match : GlycoMotif:GGM.000031|GTC:G79535HZ|CID:50909845|CHEBI:61325|GlycoEpitope:EP0093|MeSH: C069719
synonymns :
function : cancer-associated antigen[GlycoEpitope:EP0093]
disease_associations : colonic cancer[GlycoEpitope:EP0093]|liver cancer[GlycoEpitope:EP0093]
wikipedia :
essentials_of_glycobiology :

Monosialylated

term (main_entry) : Monosialylated
term_in_sentence : The structures of the asparagine-linked sugar chains of U- CD59 were biantennary complex type , only 4.2% of which are monosialylated.[PMID:7514386]
publication : 7514386|8477709|8942648|29752599|31669586|29747818|16425369|12089170|31390883|1632647|29733234|31110965|31566965|30555678|28263871|29652662|25915761|16381065|29247593|28370937|23896595|26633899|32155999|25261856|2737211|26945091|27065039|26784838|26582205
definition : A glycan that have the addition of one sialic acid residues.[XD]
term_xref :
best_match :
synonymns :
function : appears in bovine brain gangliosides.[PMID: 29752599]
disease_associations :
wikipedia :
essentials_of_glycobiology :

Monosialyl-biantennary

term (main_entry) : Monosialyl-biantennary
term_in_sentence : In contrast, the sugar chain structure of HCC highly specific AFP isoform was found to comprise a monosialyl-biantennary sugar chain with additional fucosylation of the proximal N-acetylglucosamine.[PMID:7686446]
publication : 7686446
definition : A biantennary glycan with two GlcNAc branches linked to the core and the addition of one sialic acid residues.[XD]
term_xref :
best_match :
synonymns : monosialyl biantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Monosialyl-Gb5

term (main_entry) : Monosialyl-Gb5
term_in_sentence : Thus, malignancy of MCF-7 is highly dependent on monosialyl-Gb5, and its activation of cSrc and FAK in GEM.[PMID:12401210]
publication : 12401210|16995838|27318475
definition : Alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp is a linear amino hexasaccharide comprising beta-D-glucose at the reducing end with at the 4-position a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl moiety, alpha(2->3)-sialylated at the terminal galactosyl residue. It has a role as an antigen and an epitope. It is an amino hexasaccharide and a galactosamine oligosaccharide.[CHEBI:62313]
term_xref : GTC:G32254QI|GlycoEpitope:EP0099|GlycoMotif:GM.G32254QICID:73427363|CHEBI:62313
best_match : GTC:G32254QI|GlycoEpitope:EP0099|GlycoMotif:GM.G32254QICID:73427363|CHEBI:62313
synonymns : GL-7 globoseries ganglioside (SSEA-4)|Monosialyl Gb5|Sialosyl galactosyl globoside|GL-7 globoseries ganglioside|SSEA-4
function :
disease_associations : renal cell carcinoma/RCC[GlycoEpitope:EP0099]
wikipedia :
essentials_of_glycobiology :

Monosulfated globopentaosylceramide

term (main_entry) : Monosulfated globopentaosylceramide
term_in_sentence : Mono-sulfated globotetraosylceramide from human kidney[PMID:2559078]
publication : 2777788|2559078
definition :
term_xref : glycomotif:GMM.000072|GTC:G80193TN|CID:91850303|KEGG:G10437|CHEBI:153750
best_match : glycomotif:GMM.000072|GTC:G80193TN|CID:91850303|KEGG:G10437|CHEBI:153750
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Mono-sulfated globopentaosylceramide

term (main_entry) : Mono-sulfated globopentaosylceramide
term_in_sentence : Mono-sulfated Globopentaosylceramide from HumanKidney.[PMID:2777788]
publication : 2777788
definition :
term_xref : GlycoMotif:GGM.000072

best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Mono-sulfated globotetraosylceramide

term (main_entry) : Mono-sulfated globotetraosylceramide
term_in_sentence : Mono-sulfated globotetraosylceramide from human kidney.[PMID:2559078]
publication : 2559078
definition :
term_xref : GlycoMotif:GGM.000073
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

N-acetyl GM2

term (main_entry) : N-acetyl GM2
term_in_sentence : The appearance of the N-acetyl GM2 antigen correlated well with the degree of differentiation of the cancer cells in patients with squamous cell carcinoma and adenocarcinoma of the lung.[PMID:3167861]
publication : 3167861|2153431|25673107
definition : Beta-D-GlcpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp is a branched amino tetrasaccharide consisting of the linear sequence beta-D-GalNAc-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc having a Neu5Ac residue attached to the galactose via an alpha-(2->3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2. It has a role as an epitope. It is an amino tetrasaccharide and a glucosamine oligosaccharide.[CHEBI:59220]
term_xref : GTC:G79389NT|GlycoEpitope:EP0051|CID:45266845|CHEBI:59220
best_match : GTC:G79389NT|GlycoEpitope:EP0051|CID:45266845|CHEBI:59220
synonymns :
function : The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.[CHEBI:59220]
disease_associations : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051]
wikipedia :
essentials_of_glycobiology :

N-acetyllactosamine

term (main_entry) : N-acetyllactosamine
term_in_sentence : Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial β1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form N-acetyllactosamine in the presence of UDP.[PMID:31165848]
publication : 31165848|31126011|28796164|6236210|9751793|29740087|9151975|10567443|21472942|26477523|6548353|28167527|20056550|7737204|22052010|10223649|11323440|10420596|7766648|25257940|17977857|15556936|26541999|23650594|9692202|29429899|21062783|25034434|8985145|28503789|8720464/
definition : N-acetyllactosamine is a beta-D-galactopyranosyl-(1->4)-N-acetyl-D-glucosamine having beta-configuration at the reducing end anomeric centre. It is also known as galb1-4glcnacb or lacnac, belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group. N-Acetyllactosamine is an extremely weak basic (essentially neutral) compound (based on its pKa). N-Acetyllactosamine exists in all living organisms, ranging from bacteria to humans.[CHEBI:16153,HMDB0001542]
term_xref : GTC:G00055MO|CID:439271|CHEBI:16153|MeSH:C000458|GlycoMotif:GGM.000001
best_match : GTC:G00055MO|CID:439271|CHEBI:16153|MeSH:C000458|GlycoMotif:GGM.000001
synonymns : LacNAc|Type 2 LN
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

N-Glycolyl-GM2

term (main_entry) : N-Glycolyl-GM2
term_in_sentence : The monoclonal antibodies MK2-34 and MK1-16 (both IgM), which specifically detect N-glycolyl GM2 and N-acetyl GM2, respectively, were generated by immunizing mice with liposomes containing monophosphoryl lipid A, trehalose dimycolate, and the antigenic ganglioside.[PMID:3167861]
publication : 3167861|11861662|17980710|3731079|25673107
definition : (2S,4S,5R,6R)-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of carbohydrates and carbohydrate derivatives.[CHEBI:151464]
term_xref : GTC:G56478LD |GlycoEpitope:EP0052|CID:91845742|CHEBI:151464|GlycoEpitope:GGM.000096

best_match : GTC:G56478LD |GlycoEpitope:EP0052|CID:91845742|CHEBI:151464
synonymns :
function :
disease_associations : choriocarcinoma[GlycoEpitope:EP0052]|teratocarcinoma|[GlycoEpitope:EP0052]yolk sac tumor[GlycoEpitope:EP0052]
wikipedia :
essentials_of_glycobiology :

N-linked glycans

term (main_entry) : N-linked glycans
term_in_sentence : Our study identifies extracellular N-linked glycans-and the glycoprotein neurexin 1β specifically-as key modulators of neuronal uptake of αSacetyl, drawing attention to the potential therapeutic value of αSacetyl-glycan interactions.[PMID:31211781]
publication : 31211781|28384382|30305477|31364612|26899268|29945790|29652253|29723274|30962676|29778448|25325701|31100702|28898525|22944671|19277537|24473128|17957771|27554083|15189166|11269317|19577919|24303005|12042249|22191536|28324664|25965797|25434632|30484244|28110657|29865036|20129637|27346875|30280442|26911286|22491358|26582281|26398792|31548313|31066275|28331984|25482090|28518173|30733536|22326428|30063825|30315103|21558494|31676555|31256374
definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the nitrogen of an asparagine side-chain.[CHEBI:59520, MT]
term_xref : CHEBI:59520
best_match : GTC:G78059CC|CID:70679232|CHEBI:70967
synonymns :
function : N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374]|Affect transportation of the glycosylated proteins in the Golgi.[PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding.[PMID: 25151374]|extracellular N-glycans act as key modulators of neuronal uptake of αSacetyl [PMID: 31211781].
disease_associations : Rheumatoid arthritis[PMID:17392038]|Type 1 Diabetes[PMID:29146600]|Lung Cancer[PMID: 23766031]
wikipedia :
essentials_of_glycobiology : NBK453020

Nonfucosylated

term (main_entry) : Nonfucosylated
term_in_sentence : In the carbohydrate moiety , alpha-subunit from normal pregnancy hCG contained nonfucosylated , mono- and biantennary N-linked structures (49.3 and 36.7%, means); fucosylated biantennary and triantennary oligosaccharides were also identified (7.3 and 6.9%).[PMID:9449027]
publication : 9449027|30258536|23554380|16675584|26747427|22457527|24362443|19657637|8811881|19218011|20022111|17363544|17368483|20564614|27054024|28397880|31490688|31860772|17012310|29633346|9442021|30350565|30296068|31800250|30021910|31133022|29224385|28630087|26444434|31697975|30991260
definition : glycans without a fucose component/monosaccharide residue.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Nonfucosylated biantennary

term (main_entry) : Nonfucosylated biantennary
term_in_sentence : Structural analysis combining methylation-mass spectrometry and 400 MHz 1H-n.m.r. spectrometry of oligosaccharide alditols released from human leucocyte lactotransferrin shows the presence of two disialylated and non-fucosylated biantennary glycans of the N-acetyl-lactosaminic type.[PMID:2390069]
publication : 2390069|9449027|1375510|9101715|2390069|2332109
definition : A biantennary glycan with two GlcNAc branches linked to the core and no fucose appears.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Nonfucosylated biantennary N-Linked structures

term (main_entry) : Nonfucosylated biantennary N-Linked structures
term_in_sentence : The beta-subunit from normal pregnancy hCG contained fucosylated and nonfucosylated biantennary N-linked structures; however, mono- and triantennary oligosaccharides were also identified (4.6 and 13.7%).[PMID:9449027]
publication : 9449027
definition : A biantennary N-linked glycan with two GlcNAc branches linked to the core and no fucose appears.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Nonfucosylated triantennary

term (main_entry) : Nonfucosylated triantennary
term_in_sentence : Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.[PMID:7679920]
publication : 7679920|23274891
definition : A triantennary N-linked glycan with three GlcNAc branches linked to the core and no fucose appears.[XD]
term_xref :
best_match :
synonymns :
function : Appears in human alpha-fetoprotein (AFP).[PMID:7679920]
disease_associations : hepatocellular carcinoma[PMID:7679920].
wikipedia :
essentials_of_glycobiology :

Nonsialylated

term (main_entry) : Nonsialylated
term_in_sentence : The pattern of nonsialylated oligosaccharides was used for interpretation of the fully sialylated species using bioinformatics tools. From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively. Glycan structures carry dominantly between 15 and 16 sialic acids indicating an almost complete termination of all antenae with sialic acid.[PMID:30295034]
publication : 14533820|1377689|9705949|30788437|28090561|12498371|26839900|31490688|2656426|30295034|31545048|12381155|25730103|26787879|25646460|29224385|26063435|26954852|32889432|2825412|27504786|22431161
definition : A glycan which is not sialylated.[RN]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

O-fucose glycans

term (main_entry) : O-fucose glycans
term_in_sentence : Recently, a number of laboratories have shown that O-fucose glycans on the epidermal growth factor (EGF)-like repeats of the Notch extracellular domain modulate Notch signaling.[PMID:12417415]
publication : 19594638|30690220|18952191|22415200|12417415|16400812|18948267|21464368|20816394|30207383|20301232|27129198|17132502|22492969|30030822|30214079|26175457|25378397|18272537|28729422|11524432|31722217|23045360|24803430|28876865|25700513|32518939|30523691|18227520|20816217|24909690|17964136|12036964|27268051|15653671|19948734|31590629|32201074|15189151|17263732|32913123|12909620|28785176|17132500|22949680|25053492|28939751
definition : Form of glycosylation where the protein is modified by a fucose residue and can be extended futher to form a tetrasaccharide in certain cases. alpha-linked o-fucose have a consensus motif of C2X4(s/T)C3 where C2 and C3 are conserved cysteines number 2 and 3 respectively of the EGFR like repeats. [NBK453017-Chapter13, RN]
term_xref : GTC:G39294YF|GlycoEpitope:EP0005
best_match : GTC:G39294YF|GlycoEpitope:EP0005
synonymns :
function : modification of Notch signaling.[GlycoEpitope:EP0005]
disease_associations :
wikipedia :
essentials_of_glycobiology :

O-GlcNAc

term (main_entry) : O-GlcNAc
term_in_sentence : A better understanding of the mechanisms of OGT/OGA action would enable us to derive therapeutic benefits of resetting cellular O-GlcNAc levels within an optimal range.[PMID:30464755]
publication : 30464755|29049853|29594839|31654859|29404877|30105004|30669087|29790000|28408483|26862193|30523150|30037904|28408480|29352075|29456783|29577901|29223644|28638491|30221662|29904918|32155042|30298013|31630803|31847126|29784830|30181664|28768194|30134155|25336654|30356792|30199580|32329777|28408494|29774032|29044951|23836420|20301273|29772801|28922739|30100348|30793403|30657688|31237748|29756380|29954943|30018219|32207184|25566193|30626734|24759912|
definition : Form of glycosylation which exclusively occurs in the mitochondrial, cytoplasmic or nuclear compartments of the cell where the protein is modified by a GlcNAc monosaccharide on the serine or threonine residues and is generally not modified or elongated further to form more complex structures. [NBK453063-Chapter19, RN]
term_xref : GTC:G49108TO|GlycoEpitope:EP0004|CID:24139|HMDB:HMDB0000803
best_match : GTC:G49108TO|GlycoEpitope:EP0004|CID:24139|HMDB:HMDB0000803
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

O-linked glycans

term (main_entry) : O-linked glycans
term_in_sentence : Among these, six fucosylated N-linked glycansand four O-linked glycans exhibited significantly increased expression levels in GC, while five fucosylated N-linked glycans and ten fucosylated O-linked glycans exhibited significantly decreased expression levels in GC.[PMID:29865036]
publication : 29865036|30952424|31611643|19577919|32019882|19139197|26184710|11159917|21536259|25186198|19277556|22261557|24115046|18725413|15966855|24256304|25477510|10359703|24406064|22259135|29279989|15966855|30619255|9673446|31676555|28745859|28196325|27975143|30591584|28518173|17522109|26328495|32178593|27529638|24663386|22474328|28096352|27496768|18952191|11135308|24917611|11532966|22786570|11891229|18332077|26867212|26925665|16769205|23475718|16005634|28785176
definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the hydroxyl oxygen of serine, threonine, hydroxylysine or hydroxyproline side-chains.[CHEBI:59521, MT]
term_xref : CHEBI:59521
best_match : CHEBI:59521
synonymns :
function : Affects several important activities like protein stability, modulation of signaling molecules and enzyme activity.[PMID:9673446]
disease_associations : Cancers[4]
wikipedia :
essentials_of_glycobiology :

O-linked mannose

term (main_entry) : O-linked mannose
term_in_sentence : Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the first step toward the functional matriglycan structure on alpha-dystroglycan that is responsible for binding extracellular matrix proteins and certain arenaviruses.[PMID: 27932460]
publication : 27932460|24526361|25381909|26644575|23851827|28810660|19054127|23929950|21684258|22608994|28973932|24733390|31851597
definition : O-linked glycans that are initiated by the addtion of a Man residue to Ser or Thr. Subsequent extension of the Man defines the O-Man core type, either M1, M2, or M3. The M1 type is initated by addition of a GlcNAc in β-linkage to the 2 position of the Man residue. M2 is initiated by addition of another GlcNAc in β-linkage to the 6 position of the M1 core. M3 is initiated by the addition of a GlcNAc in β-linkage to the 4 position of the Man residue. M1 and M2 type core glycans can be extended and branched with Gal, Fuc, Sialic Acid, and GlcA. The M3 core is uniquely extended by a multienzyme system to generate the matriglycan polysaccharide, a protein-specific modification found only on alpha-dystroglycan. [CHEBI:87761,MT]
term_xref : GlycoMotif:GGM.000055|GTC:G59126YU|CHEBI:87761|GlycoEpitope:EP0002|CID:91859038
best_match : GlycoMotif:000055|GTC:G59126YU|CHEBI:87761|GlycoEpitope:EP0002|CID:91859038
synonymns :
function :
disease_associations : MEB/muscle-eye-brain disease[GlycoEpitope:EP0002]|WWS/walker-warburg syndrome |muscular dystrophy[GlycoEpitope:EP0002]|neuronal migration disorder[GlycoEpitope:EP0002]|Muscle-Eye-Brain disease (MEB) and Walker-Warburg Syndrome (WWS) have mutations in genes encoding glycosyltransferases needed for O -mannosyl oligosaccharide synthesis[GlycoEpitope:EP0002]|Muscular dystrophy and neuronal migration disorder are caused by mutations in a glycosyltransferase, POMGnT1.[GlycoEpitope:EP0002]
wikipedia : https://en.wikipedia.org/wiki/O-linked_glycosylation
essentials_of_glycobiology : NBK453054

O-mannosyl glycan

term (main_entry) : O-mannosyl glycan
term_in_sentence : Defects in the O-mannosyl glycan of an α-DG with laminin-binding activity can cause α-dystroglycanopathy, a group of congenital muscular dystrophies.[PMID:29884773]
publication : 29884773|28711406|14577328|21089343|14617637|9838223|17072003|26328495|11181560|31949166|31988979|20362685|27733679|27493216|20044576|11181560|30643095|29732660|10580142|14568618|28079948|15467391|27812179|23761899|25737452|32930586|25381372|23434682|16857188|21452199|19429925|25361541|24297939|30322079|23428289|28427937|22746206|27533452|17502374|20816174|27496765
definition : A linear amino tetrasaccharide consisting of N-acetyl-α-neuraminyl, β-D-galactosyl, N-acetyl-β-D-glucosaminyl and β-D-mannose residues linked sequentially (2→3), (1→4) and (1→2).[CHEBI:87761]
term_xref : GTC:G59126YU|GlycoEpitope:EP0002|CID:91859038|CHEBI:87761
best_match : GTC:G59126YU|GlycoEpitope:EP0002|CID:91859038|CHEBI:87761
synonymns :
function :
disease_associations : for O-mannosyl glycan/Mammalian: MEB/muscle-eye-brain disease[GlycoEpitope:EP0002]]|WWS/walker-warburg syndrome[GlycoEpitope:EP0002]] |muscular dystrophy[GlycoEpitope:EP0002] |neuronal migration disorder [GlycoEpitope:EP0002]
wikipedia :
essentials_of_glycobiology :

P1 antigen

term (main_entry) : P1 antigen
term_in_sentence : The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively.[PMID: 24046920]
publication : 29622537|26773500|24046920|6207232|8550516|6609976|6375319|817855|2428855|3312011|15364312|1937801|7729906
definition : An amino pentasaccharide consisting of α-D-galactose, β-D-galactose N-acetyl-α-D-glucosamine, β-D-galactose, and β-D-glucose residues joined in sequence with ((1→4)-, (1→4)-, (1→3)- and (1→4)-linkages, respectively.[CHEBI:68484]
term_xref : GlycoMotif:GGM.000069|GTC:G12460DL|CID:71296137|CHEBI:68484|SugarBind_Ligand:160
best_match : GlycoMotif:000069|GTC:G12460DL|CID:71296137|CHEBI:68484|SugarBind_Ligand:160
synonymns :
function :
disease_associations : Shigellosis[SugarBind_Ligand:160]
wikipedia : https://en.wikipedia.org/wiki/P1PK_blood_group_system
essentials_of_glycobiology : NBK453042

Para-Forssman glycolipid

term (main_entry) : Para-Forssman glycolipid
term_in_sentence : A novel pentaglycosyl ceramide containing di-beta-N-acetylgalactos-aminyl residue (Para-Forssman glycolipid) isolated from human erythrocyte membrane. [PMID:6814203]
publication : 6814203
definition : GalNAcβ1→ 3GalNAcβ1→ 3Galα1 →4Galβ1→ 4Glcβ1→ 1Cer[5]
term_xref : glycomotif:GGM.000085|GTC:G51699SI|CID:56836111|KEGG:G00096|SugarBind_Ligand:19|CHEBI:151565
best_match : glycomotif:GGM.000085|GTC:G51699SI|CID:56836111|KEGG:G00096|SugarBind_Ligand:19|CHEBI:151565
synonymns :
function :
disease_associations : Actinomycosis[SugarBind_Ligand:19]
wikipedia :
essentials_of_glycobiology :

Paragloboside

term (main_entry) : Paragloboside
term_in_sentence : Galactosyltransferase activities in sera of cancer patients were determined by assaying the formation of paragloboside from UDP-galactose and lactotriaosylceramide immobilized on microtiter plates by means of the enzyme-linked immunosorbent assay using a monoclonal antibody, H-11, directed to paragloboside. [PMID: 1551117]
publication : 3345524|850070|10569746|30624951|29438961|6816790|1551117|6865961|25039255
definition : The β anomer of β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-D-Glc.[CHEBI:65257]
term_xref : GlycoMotif:GGM.000077|GTC:G58896AZ|CID:21670519|CHEBI:65257|GlycoEpitope:EP0075|SugarBind_Ligand:15
best_match : GlycoMotif:GGM.000077|GTC:G58896AZ|CID:21670519|CHEBI:65257|GlycoEpitope:EP0075|SugarBind_Ligand:15
synonymns :
function :
disease_associations : Pharyngitis[SugarBind_Ligand:15]|Tracheobronchitis[SugarBind_Ligand:15]|Gonorrhea[SugarBind_Ligand:15]|Actinomycosis[SugarBind_Ligand:15]|Diarrhea[SugarBind_Ligand:15]|Hemorrhagic colitis[SugarBind_Ligand:15]|Chronic gastritis[SugarBind_Ligand:15]|Peptic ulcers[SugarBind_Ligand:15]|Gastric cancer[SugarBind_Ligand:15]|Influenza[SugarBind_Ligand:15]
wikipedia :
essentials_of_glycobiology : NBK453042

Paucimannose

term (main_entry) : Paucimannose
term_in_sentence : The galactosylation of core fucose (GalFuc epitope) in paucimannose and complex-type N-glycans is characteristic of protostome organisms, including flatworms (planarians).[PMID:29475940]
publication : 29475940|29803109|12603202|31817246|31719144|21057214|31932305|17132514|30382146|27731363|31325506|25746926|26513758|16522637|21169367|25190359|27928741|22496646|27384337|16897177|15228383|27379103|27189951|23475714|24907509|20558211|28060516|20441997|27720757|28817611|24550396|19494052|19515361|28630087|31320997|30651366|30253927|25922361|31655162|18056652|24467287|32367383
definition : Any N-linked glycan derivative with composition Man1-4Fuc0-1 GlcNAc2, in which the chitobiose core (GlcNAc2) is intact. Found in relatively large amounts in invertebrates and plants, they are formed by removal of the non-reducing terminal GlcNAc (\added by GlcNAcT1) from GlcNAcMan3-5GlcNAc2 by a Golgi hexosaminidase and subsequent removal of Man residues by Golgi mannosidases. Pauscimannose glycans have also been detected in vertebrates.[CHEBI:144386][MT]
term_xref : CHEBI:144386
best_match : CHEBI:144386
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453020-Chapter 9

Polysialic acid

term (main_entry) : Polysialic acid
term_in_sentence : Polysialic acid (PSA) is a negatively charged linear homopolymer linked by N-acetylneuraminic acid and widely present in vertebrates and some pathogens.[PMID:30244279]
publication : 30244279|24692354|23715636|26476642|22851159|31472857|28215308|27105834|30584926|25373518|29674446|28380648|23354723|29874880|30040924|30605619|30058042|30126591|9818258|29536348|29304405|9778105|30989215|26927318|25478909|28185819|28003336|28542923|28576943|28179099|28678638|27975143|8888519|27324620|29790372|30808675|29203765|30392377|31289315|9706867|27789365|21516684|24592947|27611649|27750011|26017094|8605072|9384537|31906121|26990355
definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-D-GlcpNAc with β configuration at the anomeric position of the reducing-end N-acetyl-D-glucosamine residue.[CHEBI:71612]
term_xref : GTC:G00065MO|CID:44611401|CHEBI:71612|GlycoMotif:GGM.000052
best_match : GTC:G00065MO|CID:44611401|CHEBI:71612|GlycoMotif:GGM.000052
synonymns : PSA|PolySia
function : Has a role of an epitope[CHEBI:71612]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

Sd(A)/Cad

term (main_entry) : Sd(A)/Cad
term_in_sentence : The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2.[PMID:24112972]
publication : 24112972|11577689|30067891|15361072
definition : Beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-GlcpNAc is a branched amino tetrasaccharide comprised of a trisaccharide chain of N-acetyl-alpha-neuraminic acid, beta-D-galactose and N-acetyl-beta-D-glucosamine residues linked sequentially (2->3) and (1->4), to the galactose residue of which is also linked (1->4) an N-acetyl-beta-L-galactosamine residue. It has a role as an epitope. It is an amino tetrasaccharide, a glucosamine oligosaccharide and a galactosamine oligosaccharide.[CHEBI:71561]
term_xref : GlycoMotif:GGM.000051|GTC:G41052GC|CID:70698375|CHEBI:71561
best_match : GlycoMotif:GGM.000051|GTC:G41052GC|CID:70698375|CHEBI:71561
synonymns : Sd^a /Cad
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453042

SDlex

term (main_entry) : SDlex
term_in_sentence : Hepatic expression of sialylated difucosyl Lex antigen (SDLex, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-) was studied with monoclonal antibody FH6, which defines this structure.[PMID: 3341453]
publication : 30226570|3341453|12725333
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-5-acetamido-6-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CHEBI:148203]
term_xref : GlycoMotif:GGM.000032|GTC:G19619KS|CID:91856705|CHEBI:148203
best_match : GlycoMotif:GGM.000032|GTC:G19619KS|CID:91856705|CHEBI:148203
synonymns : Sdlex|SDLe^x|SDLex
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Seminolipid

term (main_entry) : Seminolipid
term_in_sentence : A concise total synthesis of seminolipid, a sulfoglycolipid, has been achieved; key features include regioselective, tin-free sulfation of allyl β-d-galactopyranoside using 2,6-bis(trifluoromethyl)phenylboronic acid as protective reagent, stereoselective epoxidation, and site-selective acylation.
publication : 31353379|31736776|12810822|19582571|19542524|20670037|15659616|20817833|870059|10801776|21965315|8095813|1280685|4690236|34199863|4207869|2373957|845131
definition :
term_xref : GlycoMotif:GGM.000062
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Sialopentaosylceramide

term (main_entry) : Sialopentaosylceramide
term_in_sentence : Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosap[PMID: 2139874]
publication : 2139874
definition : A ganglioside in which the oligosaccharide portion is composed of a pentasaccharide containing one or more sialic acid residues.[CHEBI:36542]
term_xref : GlycoMotif:GGM.000097|GTC:G13224CR|CID:91859576|CHEBI:148045|KEGG:G00883|CHEBI:36542
best_match : GlycoMotif:GGM.000097|GTC:G13224CR|CID:91859576|CHEBI:148045|KEGG:G00883|CHEBI:36542
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Sialosyl paragloboside

term (main_entry) : Sialosyl paragloboside
term_in_sentence : Unlike CNS myelin, human peripheral nerve myelin has the acidic glycosphingolipids sialosyl paragloboside (SPG), sialosyl lactosaminyl paragloboside (SLPG), and sulfated glucuronyl paragloboside (SGPG).[PMID:8862128]
publication : 8862128|7236652|2370108|3133978|2905604|1749114|1573418
definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-D-GlcpNAc with β configuration at the anomeric position of the reducing-end N-acetyl-D-glucosamine residue.[CHEBI:71612]
term_xref : glycomotif:GGM.000081|GTC:G50123ZO|CID:91845504|KEGG:G01429|CHEBI:151914
best_match : glycomotif:GGM.000081|GTC:G50123ZO|CID:91845504|KEGG:G01429|CHEBI:151914
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Sialyl Lewis a

term (main_entry) : Sialyl Lewis a
term_in_sentence : By comparing the serum O-glycan profiles from healthy controls with those of cancer patients, we identified a marker candidate, core 1 sialyl Lewis A (NeuAcα2-3Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal) (abbreviated C1SLA), whose concentration appeared to be weakly correlated with CA19-9 values.[PMID:26641888]
publication : 26641888|31424423|26530370|17760270|18343410|16033091|8829184|11907351|20592391|26641888|24128856|30249386|10773785|16149606|10996727|10436809|10667238|7720892|7630017|10612415|9836451|12511721|22623153
definition : A sialyated version of Lewis A with a branched structure of amino tetrasaccharide consisting of a sialyl residue, linked (2→3) to a galactosyl residue that in turn is linked (1→3) to a glucosaminyl residue at the reducing end, which is also carrying a fucosyl residue at the 4-position.[CHEBI:62681,RN]
term_xref : GTC:G00053MO |GlycoEpitope:EP0008|CID:53356732|CHEBI:62681|GlycoMotif:GGM.000024
best_match : GTC:G00053MO |GlycoEpitope:EP0008|CID:53356732|CHEBI:62681
synonymns : SLea|CA19-9|CA19-9 antigen|SLe^a|Slea
function : The carbohydrate determinants,Sialyl Lea and Sialyl Lex,which are frequently expressed on human cancer cells,serve as ligands for a cell adhesion molecule of the selectin family,E-selectin,which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0008]
disease_associations : pancreatic adenocarcinoma[GlycoEpitope:EP0008]|hepatocellular cancer[GlycoEpitope:EP0008]|cholangiocellular cancer[GlycoEpitope:EP0008]|gastric cancer|[GlycoEpitope:EP0008]colorectal cancer[GlycoEpitope:EP0008]|ovarian cancer[GlycoEpitope:EP0008]|lung cancer[GlycoEpitope:EP0008]|breast cancer[GlycoEpitope:EP0008]|uterine cancer[GlycoEpitope:EP0008]
wikipedia :
essentials_of_glycobiology :

Sialyl Lewis x

term (main_entry) : Sialyl Lewis x
term_in_sentence : As sialyl Lewis X is a lignad of the selectin family, it has been proposed that sialyl Lewis X-rich colon cancer cells metastasize to the liver by adhesion to selectins on hepatic endothelial cells.[PMID:12828079]
publication : 12828079|8940172|10075923|19054801|9642161|31054033|15229399|29061785|16033070|10728707|9556613|8940172|9298692|18607721|22593503|25944902|9642161|15780091|20401888
definition : A sialylated version of Lewis X antigen expressed on cell surfaces with structure Alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc is alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc in which the anomeric configuration of the reducing-end N-acetyl-beta-D-glucosamine residue is beta. It is a ligand for selectins. [MESH:2030970,CHEI:71622,RN]
term_xref : GTC:G00054MO |GlycoEpitope:EP0012|CID:44456859|CHEBI:71622|MESH:2030970|GlycoMotif:GGM.000022
best_match : GTC:G00054MO |GlycoEpitope:EP0012|CID:44456859|CHEBI:71622|MESH:2030970
synonymns : SLe(x)|SLe^x|SLex|Slex
function : Sialyl Lex was shown to be a specific ligand on human leukocytes for vascular E- and P-selectins,and was shown to mediate leukocyte recruitment.[GlycoEpitope:EP0012]|The determinant is also frequently expressed on human cancer cells,and is involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0012]
disease_associations : colon cancer[GlycoEpitope:EP0012]|colorectal cancer[GlycoEpitope:EP0012]
wikipedia :
essentials_of_glycobiology :

Sialyl Lewis x-i

term (main_entry) : Sialyl Lewis x-i
term_in_sentence : Univariate analysis showed that survival of NSCLC patients with high (more than 100 units/ml) sialyl Lewis X-i antigen levels was significantly poorer than that of patients with low antigen levels (P = 0.0001).[PMID:9815711]
publication : 9815711|9730796|11867833|9713476|2819663|9372327|9615762|1352835|2575680|9330526|8753037|2210805|12680155|11974864|10453898|2565704|17144590
definition :
term_xref : GTC:G06597DS|GlycoEpitope:EP0043|CID:91855346|CHEBI:147019
best_match : GTC:G06597DS|GlycoEpitope:EP0043|CID:91855346|CHEBI:147019
synonymns :
function : hematogenous metastasis[GlycoEpitope:EP0043]|the progression of inflammation[GlycoEpitope:EP0043]
disease_associations : lung cancer[GlycoEpitope:EP0043]|ovarian cancer[GlycoEpitope:EP0043]|pancreatic adenocarcinoma[GlycoEpitope:EP0043]
wikipedia :
essentials_of_glycobiology :

Sialyl T antigen

term (main_entry) : Sialyl T antigen
term_in_sentence : The expression and functional analysis of the sialyl-T antigen in prostate cancer.[PMID:32583304]
publication : 32583304|31897478|31719620|10365852|25727149|11523928|20407596|25464017|30864133|26391208|19811634|29796594|23725156|8905873|11192238|18275089|27037304|11949946|15604091|24118321
definition : Alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)-alpha-D-GalpNAc is alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)-D-GalpNAc in which the configuration at the GalNAc anomeric carbon is alpha. It has a role as an epitope.[CHEBI:65257]
term_xref : GlycoMotif:GGM.000013|GTC:G65562ZE|CID:44611726|CHEBI:65257
best_match : GlycoMotif:GGM.000013|GTC:G65562ZE|CID:44611726|CHEBI:65257
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453030

Sialylated biantennary

term (main_entry) : Sialylated biantennary
term_in_sentence : Simbucus nigra agglutinin or an antibody specific to sialylated lactosamine with a preference for Neu5Acalpha2-6Gal rather than Neu5Acalpha2-3Gal reduced sperm binding to oviduct isthmic cells, as did occupying putative receptors on sperm with sialylated biantennary glycans.[PMID:23115267]
publication : 23115267|31510952|29265394|31589880|3979568|26045275|29029079|30252064
definition : A binantennary glycan with one or two sialic acid residues as non-reducing terminal residues on one or both antennae. [RN,MT]
term_xref :
best_match :
synonymns : sialyl biantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Sialylated complex-type

term (main_entry) : Sialylated complex-type
term_in_sentence : By using 1H-NMR spectroscopy we were able to establish that our product contains a single N-linked biantennary , fully sialylated complex-type oligosaccharide , typical of human hepatomas.[PMID:1694115]
publication : 1694115|15201278|30471292|30969765|11058758|28342150
definition : Complex N-linked glycan that have added GlcNAc residues at both the α-3 and α-6 mannose sites and do not contain mannose residues apart from the core structure but with sialic acid residues.[XD]
term_xref :
best_match :
synonymns : sialo-complex type
function : enhance the signaling activity of soluble intercellular adhesion molecule-1 in mouse astrocytes [PMID: 15201278] Appears in IgG-Fc.[PMID:20647032 ]
disease_associations :
wikipedia :
essentials_of_glycobiology :

Sialylated diantennary

term (main_entry) : Sialylated diantennary
term_in_sentence : 1H-NMR spectroscopic analysis of the major fractions demonstrates the occurrence of the following sialylated diantennary and triantennary N-linked oligosaccharides.[PMID:1374031]
publication : 1374031|9648261|10460833|19524219|10207016|15797573|15218190
definition : A biantennary glycan with two GlcNAc branches linked to the core and the addition of one sialic acid residues.[XD]
term_xref :
best_match :
synonymns : sialylated biantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453027

Sialylated tetraantennary

term (main_entry) : Sialylated tetraantennary
term_in_sentence : A small amount of sialylated tetraantennary oligosaccharide was detected.[PMID:16321355]
publication : 16321355|1940447|27501865
definition : A tetraantennary glycan with four GlcNAc branches linked to the core and the addition of one sialic acid residues.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Sialyl-Tn antigen

term (main_entry) : Sialyl-Tn antigen
term_in_sentence : The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.[PMID:23035012]
publication : 23035012|29273237|15770530|31595388|26617889|1720922|15466199|10971172|14652017|8616877|1543361|16965854|21566901|9269833|9834267|24970145|22367369|10778170|30018351|28628803|16149605|32134186|28632300|11308020|10365852|17195456|23567325|11014575|2342728|8575847|1851822|11735169|20960853|7846011
definition : N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-alpha-D-galactosamine is an N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-D-galactosamine in which the carbon bearing the anomeric hydroxy group has alpha configuration. It has a role as an epitope. It derives from a N-acetyl-alpha-D-galactosamine and a N-acetyl-alpha-neuraminic acid.[CHEBI:61818]
term_xref : GTC:G36123IU|GlycoEpitope:EP0022|CID:51351800|CHEBI:61818
best_match : GTC:G36123IU|GlycoEpitope:EP0022|CID:51351800|CHEBI:61818
synonymns :
function : apoptosis of monocyte-derived dendritic cells[GlycoEpitope:EP0022]|decrease of adhesion and increase of migration[GlycoEpitope:EP0022]|increase of tumor growth[GlycoEpitope:EP0022]|associated with morphological changes, decreased growth and increased migration of MDA-MB-231 cells.[GlycoEpitope:EP0022]
disease_associations : anaplastic meningioma[GlycoEpitope:EP0022]|Barrett's esophagus[GlycoEpitope:EP0022]|bladder cancer[GlycoEpitope:EP0022]|breast cancer[GlycoEpitope:EP0022]|colon cancer[GlycoEpitope:EP0022]|colorectal cancer[GlycoEpitope:EP0022]|erythroblastic leukemia[GlycoEpitope:EP0022]|esophageal cancer[GlycoEpitope:EP0022]|gastric cancer[GlycoEpitope:EP0022]|helicobacter pylori chronic gastritis(HpCG)[GlycoEpitope:EP0022]|liver cancer[GlycoEpitope:EP0022]|iterome cancer[GlycoEpitope:EP0022]|ovary tumor[GlycoEpitope:EP0022]|pancreas cancer[GlycoEpitope:EP0022]
wikipedia :
essentials_of_glycobiology : NBK453030

SLex Core 2 O-glycan

term (main_entry) : SLex Core 2 O-glycan
term_in_sentence : In particular, the sLeX-modified core 2 O-glycan structure C2-O-sLeX has been directly demonstrated to confer significantly higher affinity selectin binding than sLeX.[PMID:15596301]
publication : 15596301
definition :
term_xref : GlycoMotif:GGM.000053
best_match :
synonymns : SLe^x Core 2 O-glycan
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

SSEA-1

term (main_entry) : SSEA-1
term_in_sentence : Our findings suggest that expression of SSEA-1 immunoreactivity in thyroid neoplasms was associated with more aggressive thyroid carcinomas.[PMID:27550342]
publication : 27550342|25564944|30987116|10778174|19427293|24923741|28092949|16499901|10470652|18787210|2885312|16149609|17003364|27363517|15505339|27990704|2568298|20491542|23572256|1977666|9553168|20458727|2566639|14577357|20960856|15547746|9096265|30639212|1357195|1359630|20181261|20508065|2907526|22624699|22988836|17183690|27188587|7908065|10400391|6137429|1979260|2898921|14736812|30919971
definition :
term_xref : GTC:G85497PI |GlycoEpitope:EP0042|CID:91851144|CHEBI:154343
best_match : GTC:G85497PI |GlycoEpitope:EP0042|CID:91851144|CHEBI:154343
synonymns :
function : This determinant is specifically recognized by the antibody raised against stage-specific embryonic antigen-1 (SSEA-1)[GlycoEpitope:EP0042]. The SSEA-1 antibody requires Lex hapten carried by i-antigenic structure (e.g.,nor-nLc6Cer).[GlycoEpitope:EP0042]
disease_associations :
wikipedia :
essentials_of_glycobiology : NBK453023-Chapter 47

SSEA-3

term (main_entry) : SSEA-3
term_in_sentence : Glycosphingolipids (GSLs), such as the globo-series GSLs stage-specific embryonic antigen 3 (SSEA-3), SSEA-4, and Globo-H, are specifically expressed on pluripotent stem cells and cancer cells, and are known to be associated with various biological processes such as cell recognition, cell adhesion, and signal transduction.[PMID:31817926]
publication : 31817926|30271856|32684574|26677875|23175153|32525407|29227830|18773292|25561682|10837462|2412924|21149348|17008424|2874662|25171543|31304790|31642560|30484221|30525067|21161592|27325407|28170296|29637816|27318475|31346146|7648586|24236059|21964054|27456773|30558911|21559451|29312455|27549315|30599359|6141938|28883415|30733757|26041528|16643871
definition : An amino trisaccharide consisting of β-D-galactopyranose, 2-acetamido-2-deoxy-β-D-galactopyranose and α-D-galactopyranose residues joined in sequence by (1→3) glycosidic linkages. [CHEBI:149071]
term_xref : GTC:G25129BT|GlycoEpitope:EP0039|CID:91855781|CHEBI:149071|GlycoMotif:GGM.000079
best_match : GTC:G25129BT|GlycoEpitope:EP0039|CID:91855781|CHEBI:149071
synonymns :
function :
disease_associations : embryonal carcinoma[GlycoEpitope:EP0039]|teratocarcinoma[GlycoEpitope:EP0039]|yolk sac carcinoma[GlycoEpitope:EP0039]
wikipedia :
essentials_of_glycobiology : NBK453023-Chapter 47

SSEA-4

term (main_entry) : SSEA-4
term_in_sentence : Glycosphingolipids (GSLs), such as the globo-series GSLs stage-specific embryonic antigen 3 (SSEA-3), SSEA-4, and Globo-H, are specifically expressed on pluripotent stem cells and cancer cells, and are known to be associated with various biological processes such as cell recognition, cell adhesion, and signal transduction.[PMID:31817926]
publication : 27845370|31817926|26295543|25171543|25978997|30296654|25853231|24862940|31243630|28736232|22895512|24578244|29478902|23574147|23768762|27797400|29227830|18773292|25123923|22924692|22665977|23330736|31831622|31916611|2412924|16033656|24866102|20458727|21149348|26940129|17008424|2874662|23301556|27836003|19118716|24550271|32988880|22743677|20683402|17062733|23570331|30310530|31545316|23509763|24364909|18273440|28985528|22266579
definition :
term_xref : GTC:G84263XI|GlycoEpitope:EP0044|CID:91845478|CHEBI:154843
best_match : GTC:G84263XI|GlycoEpitope:EP0044|CID:91845478|CHEBI:154843
synonymns :
function :
disease_associations : teratocarcinoma[GlycoEpitope:EP0044]
wikipedia :
essentials_of_glycobiology : NBK453023-Chapter 47

Sulfatide

term (main_entry) : Sulfatide
term_in_sentence : In a previous study we found that sulfatide was efficient in lowering HIV-1 viral loads in SCID mice engrafted with human fetal liver/thymus tissues (SCID-hu).[PMID:23550344]
publication : 23550344|18465098|26542149|15158666|10434709|22619219|29676479|30196830|16143863|1052451|30400820|29887538|26981544|17986152|31739035|19941861|24578319|30531843|25645724|31197846|22821828|27861899|31037952|23593400|23604989|17855742|25966258|25989600|9657940|29497057|12838515|25170267|9878314|20554435|1410493|26585924|17257892|17044925|21089387|11445552|22977233|21437360|17179664|6273571|8370675

definition :
term_xref : GlycoMotif:GGM.000063
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

T antigen

term (main_entry) : T antigen
term_in_sentence : Tn, sTn, and T antigen neo- or over-expression occurs in many types of cancer including gastric, colon, breast, lung, esophageal, prostate, and endometrial cancer.[PMID:27679419]
publication : 723127|19505650|31527246|28113048|25868857|26731525|22994493|3849428|25589241|12709866|26615524|26136575|19671663|18551603|11160729|22261839|30758913|25681708|29113555|24998850|1654819|28039910|29206210|32404521|10555041|26517398|2446015|2998768|3026642|18812503|6092664|2153691|8709258|3009889|15109748|12709866|31787742|27433780|26017382|24048785|26735515|9224657|26061652|29343574|25681708|23805194|26751495|22023388|15381338|8249277|3023660|25866902
definition : An amino disaccharide composed of D-galactose and N-acetyl-α-D-galactosaminyl residues in β-(1→3) linkage.[CHEBI:61820]
term_xref : GTC:G00031MO|GlycoEpitope:EP0020|CID:5288347|CHEBI:61820|GlycoMotif:GGM.000009
best_match : GTC:G00031MO|GlycoEpitope:EP0020|CID:5288347|CHEBI:61820
synonymns : TF antigen
function : accumulation Lipoprotein(a) or LDL within arterial walls in atherogenesis [GlycoEpitope:EP0020]|cancer progression (increase interaction/communication of the cells)[GlycoEpitope:EP0020]|T antigen expression in RMA lymphoma cells leads to a reduced growth of the tumor[GlycoEpitope:EP0020]|correlation with elevated Golgi pH in cancer cell (breast, colorectal cancer cells)[GlycoEpitope:EP0020]|T antigen on apical surfaces of corneal epithelial cells provide protection against rose bengal penetrance.[GlycoEpitope:EP0020]|reduction of a flexibility of the glycosidic bond and thereby favour certain glycan conformation[GlycoEpitope:EP0020]|T antigen is a target for NK cell-mediated lysis[GlycoEpitope:EP0020]|inverse relationship between T antigen expression and VWF plasma levels[GlycoEpitope:EP0020]
disease_associations : anaplastic meningioma[GlycoEpitope:EP0020]|breast cancer[GlycoEpitope:EP0020]|colorectal cancer[GlycoEpitope:EP0020]|colon cancer[GlycoEpitope:EP0020]|esophageal cancer|gastric cancer[GlycoEpitope:EP0020]|liver cancer[GlycoEpitope:EP0020]|ovarian cancer[GlycoEpitope:EP0020]|prostate cancer[GlycoEpitope:EP0020]|bladder tumor[GlycoEpitope:EP0020]|invasive pneumococcal infection (hemolytic uremic syndrome, hemolytic anemia)[GlycoEpitope:EP0020]
wikipedia : https://www.wikidata.org/wiki/Q27104888
essentials_of_glycobiology : NBK453030

Tetraantennary

term (main_entry) : Tetraantennary
term_in_sentence : In contrast, myeloma IgE showed a higher abundance of triantennary and tetraantennary glycan structures and a low abundance of species with a bisecting N-acetylglucosamine.[PMID:24308486]
publication : 24308486||17951374|28880909|9177699|9760189|12322961|20129637|2492275|3402460|2361735|6525453|27730440|2551687|25365149|9751793|29875690|29479898|9134426|30943309|3546284|29888905|30624066|30537828|31110965|29311294|12852965|3015940|1907570|29137999|29359131|29858715|30295034|31829566|8381405|26929217|20662591|30612270|3089784|28186213|3427034|26763099|27354006|24991291|7496138|1940447|11114588|29031301|9448855|3979385|27722599||31126011|28002670|28991403|24032650|15316281|25154914|22490318|22430811|1463783|18803208|7881173|7697655|7240157|1768292
definition : Type of N-linked glycan in which four antennae are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). The four antennae are initiated by addition of 2 GlcNAcs to the α3 Man (at the 2 and 4 positions) and 2 GlcNAcs to the α6 Man (at the 2 and 6 positions) of the trimannosyl core. Each antenna can be extended or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [NBK453019-Glossary, XD,RN,MT]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Tetraantennary complex-type

term (main_entry) : Tetraantennary complex-type
term_in_sentence : A variety of high-mannose structures , as well as bi-, tri-, and tetraantennary complex-type carbohydrate , has been found, in relative amounts of 1-25% of the total oligosaccharides.[PMID:1899031]
publication : 1899031|8251489|8274017|1899031| 6317691|23668542| 6088518|21495009|1457971|1783599|10988252|11425798|7522229|2574992|3730425|10200178|2939068|21584695| 7524670|7682847|2930192|1726466|9881746|11068879|6704968|2302846|24032650|15316281|11051207|10220588|2813359|2174368|21755550|3571208|1929437|3681300|6581225|3364983|2902877|2297756|1315684|6830758|1998670
definition : Type of N-linked glycan in which four antennae are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). The four antennae are initiated by addition of 2 GlcNAcs to the α3 Man (at the 2 and 4 positions) and 2 GlcNAcs to the α6 Man (at the 2 and 6 positions) of the trimannosyl core. Each antenna can be extended or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [NBK453019-Glossary, XD,RN,MT]
term_xref : https://www.sigmaaldrich.com/technical-documents/articles/biology/glycobiology/n-glycans.html
best_match : https://www.sigmaaldrich.com/technical-documents/articles/biology/glycobiology/n-glycans.html
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Tetrasialylated diantennary

term (main_entry) : Tetrasialylated diantennary
term_in_sentence : A further preparation, obtained from the most anionic DEAE-cellulose fraction (peak V) or rTf contained several tetrasialylated diantennary glycans whose precise structures remain to be established in future studies.[PMID:1997323]
publication : 1997323
definition : A biantennary glycan with two GlcNAc branches linked to the core and the addition of four sialic acid residues.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Tn antigen

term (main_entry) : Tn antigen
term_in_sentence : Furthermore, we confirmed that LS174T cells (Tn-positive) transfected with wild-type Cosmc, thus expressing no Tn antigen, had down-regulation of H-Ras expression and subsequent inhibition of EMT process.[PMID:30637914]
publication : 27679419|31938254|30637914|24643043|31225574|21259410|31742337|28514044|33014816|28708980|27432485|33050853|26045765|27542280|24411673|27760846|30115016|1410473|29802864|29669308|29251002|32541028|31019509|1582597|2981150|10842187|29638123|22367369|10778170|1510031|19372570|20641477|16149605|15770530|27856425|23814067|28068458|32134186|8174100|10571017|27453399|1727666|23740330
definition : Tn anitigen or alpha-galnac or N-Acetylgalactosamine is an N-acetyl-D-galactosamine having alpha-configuration at the anomeric centre. It has a role as an epitope. It derives from an alpha-D-galactosamine.[CHEBI:40356,HMDB0000212]
term_xref : GTC:G57321FI|GlycoEpitope:EP0021|CID:84265|CHEBI:40356|HMDB0000212|GlycoMotif:GGM.000008
best_match : GTC:G57321FI|GlycoEpitope:EP0021|CID:84265|CHEBI:40356|HMDB0000212
synonymns :
function : lymphatic metastasis[GlycoEpitope:EP0021]|tube formation in Drosophila development[GlycoEpitope:EP0021]|modulation of malignant phenotype (gastric carcinoma cell)[GlycoEpitope:EP0021]|correlation with tumor stage, lymphatic invasion and lymph node matastasis[GlycoEpitope:EP0021]
disease_associations : breast cancer[GlycoEpitope:EP0021]|cervical cancer[GlycoEpitope:EP0021]|colon cancer[GlycoEpitope:EP0021]|colorectal cancer[GlycoEpitope:EP0021]|fibrosarcoma[GlycoEpitope:EP0021]|gastric cancer[GlycoEpitope:EP0021]|liver cancer[GlycoEpitope:EP0021]|ovarian cancer[GlycoEpitope:EP0021]|pancreas cancer[GlycoEpitope:EP0021]|prostate cancer[GlycoEpitope:EP0021]|Tn syndorome[GlycoEpitope:EP0021]|Barrett'sesophagus[GlycoEpitope:EP0021]|Schindler/Kanzaki desease (alpha-N acetylgalactosaminidase deficiency)[GlycoEpitope:EP0021].
wikipedia :
essentials_of_glycobiology : NBK453030

Triantennary

term (main_entry) : Triantennary
term_in_sentence : Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.[PMID:24992960]
publication : 24992960|27025342|29642865|29456020|26914862|26926155|26299345|28981809|18395704|2211710|23461434|18327885|15264862|22954207|9061362|16581187|26537865|3979568|28129130|7679920|8068017|7783116|3857231|20540518|1706936|2430615|8078981|2211711|6767476|3814128|2597120|7451505|8204583|20619452|10460831|1924399|6643471|31809011|30042045|2477056|7882496|2430614|2551687|2426141|2065052|28988716|31144994|26966183|29809215
definition : Type of N-linked glycan in which three antennae are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). The three antennae can be be initiated by addition of 2 GlcNAcs to the α3 Man (at the 2 and 4 positions) and 1 GlcNAc to the α6 Man (at the 2 position) of the trimannosyl core or 1 on the α3 and 2 on the α6 Man (at the 2 and 6 positions). Each antenna can be extended or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [NBK453019-Glossary, RN,MT]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Triantennary complex

term (main_entry) : Triantennary complex
term_in_sentence : Fucosylated biantennary complex-type and small amounts (less than 5%) of triantennary complex-type structures were identified on the glycosylated asparagine residues using sequential exoglycosidase and endoglycosidase digestions combined with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).[PMID:9118998]
publication : 9118998|9061362|18395704|3814128|7451505|10460831|26926155|26966183|9061362|16581187|16973123|8204583|29809215|11114588|31322324|15044389
definition : A complex N-glycan that has three branches attached to the non-reducing terminal Man residues of the trimannosyl core.[CHEBI:156252, RN] [MT] Each branch is initiated with a GlcNAc and can be exteneded or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [MT]
term_xref : CHEBI:156252
best_match : CHEBI:156252
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Triantennary complex-type

term (main_entry) : Triantennary complex-type
term_in_sentence : The chemical shifts of ring protons of the beta-Man residue in a triantennary complex type N-linked glycan chain having a GlcNAc beta 1-->6(GlcNAc beta 1-->2)Man alpha 1-->6 Man beta sequence were unambiguously determined by two-dimensional proton nuclear magnetic resonance (1H-NMR) spectroscopic methods.[PMID:9061362]
publication : 9061362|18395704|16973123|29809215|15044389|3814128|26926155|16581187|26966183|8204583|16372382|8251489|8299583|1555586|7509658|1569060|16261636
definition : Type of N-linked glycan in which three antennae are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). The three antennae can be be initiated by addition of 2 GlcNAcs to the α3 Man (at the 2 and 4 positions) and 1 GlcNAc to the α6 Man (at the 2 position) of the trimannosyl core or 1 on the α3 and 2 on the α6 Man (at the 2 and 6 positions). Each antenna can be extended or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [NBK453019-Glossary, RN,MT]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Triantennary N-alycans

term (main_entry) : Triantennary N-alycans
term_in_sentence : Increased expression of the high-mannose M6N2 and NeuAc3H3N3M3N2F tri-antennary N-glycans in cholangiocarcinoma.[PMID:29399163]
publication : 29399163|22325877|18439991|24873509|11454001
definition : Type of N-linked glycan in which three antennae are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). The three antennae can be be initiated by addition of 2 GlcNAcs to the α3 Man (at the 2 and 4 positions) and 1 GlcNAc to the α6 Man (at the 2 position) of the trimannosyl core or 1 on the α3 and 2 on the α6 Man (at the 2 and 6 positions). Each antenna can be extended or capped with HexNAc, deoxyHex, Hex, or sialic acid residues. [NBK453019-Glossary, RN,MT]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Triantennary sialylated

term (main_entry) : Triantennary sialylated
term_in_sentence : LC-ESIMS/MS analysis revealed that both light chain and heavy chain were N-glycosylated mainly by A2S2 but also by triantennary sialylated glycans.[PMID:18642129]
publication : 18642129|31964828|3979568|27936604|23681398|21538882|7579793|7613477|2223825|3539023|3674882
definition : A triantennary glycan with three GlcNAc branches linked to the core and the addition of one sialic acid residues.[XD]
term_xref :
best_match :
synonymns :
function : Appears in human serotransferrin.[PMID: 3979568]
disease_associations :
wikipedia :
essentials_of_glycobiology :

Triantennary trisialylated fucosylated

term (main_entry) : Triantennary trisialylated fucosylated
term_in_sentence : Diantennary monosialylated glycans and triantennary trisialylated fucosylated and non-fucosylated structures have also been identified.[PMID:17591618]
publication : 17591618
definition : A triantennary glycan with three GlcNAc branches linked to the core and the addition of three sialic acid residues and fucose added.[XD]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Trifucosyl Lewis b antigen

term (main_entry) : Trifucosyl Lewis b antigen
term_in_sentence : Extended type-1 chain glycosphingolipid antigens. Isolation and characterization of trifucosyl-Leb antigen (III4V4VI2Fuc3Lc6)[PMID:1735443]
publication : 1735443
definition : N-[(2R,3R,4R,5S,6R)-4-[(2R,3R,4S,5S,6R)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-5-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxy-6-(hydroxymethyl)-5-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]acetamide is an amino sugar.[CHEBI:153783]
term_xref : GlycoEpitope：EP0092|GTC:G74578MX|CID:91845957|CHEBI:153783
best_match : GlycoEpitope：EP0092|GTC:G74578MX|CID:91845957|CHEBI:153783
synonymns : trifucosyl-Leb antigen
function : cancer-associated antigen[GlycoEpitope: EP0092]
disease_associations : colonic cancer[GlycoEpitope: EP0092]|endometrial cancer[GlycoEpitope: EP0092]|liver cancer[GlycoEpitope: EP0092]|pancreatic cancer[GlycoEpitope: EP0092]|rectal cancer[GlycoEpitope: EP0092]
wikipedia :
essentials_of_glycobiology :

Trifucosyl lewis y

term (main_entry) : Trifucosyl lewis y
term_in_sentence : The third, major component, common in all eight cases, has been identified as trifucosyl Ley (lactotrifucononaosylceramide, III3FucV3FucVI2FucnLc6, Structure 2 below) based on 1H NMR spectroscopy, methylation analysis, and direct-probe electron-impact mass spectrometry.[PMID:3733752]
publication : 3733752|2426269
definition : A branched heptasaccharide derivative consisting of two repeating units of β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc (joined by a (1→3)-linkage) with an α-L-fucosyl residue attached at the 2-position of the galactose residue at the non-reducing end.[CHEBI:61332]
term_xref : GlycoEpitope: EP0094|GTC:G74917JX|CID:50909806|CHEBI:61332
best_match : GlycoEpitope: EP0094|GTC:G74917JX|CID:50909806|CHEBI:61332
synonymns : trifucosyl Ley
function :
disease_associations : colonic adenocarcinomia[GlycoEpitope: EP0094]
wikipedia :
essentials_of_glycobiology :

Trimannosyl core

term (main_entry) : Trimannosyl core
term_in_sentence : This glycoengineered H. polymorpha strain produced glycoproteins mainly containing trimannosyl core N-glycan (Man(3)GlcNAc(2)), which is the common core backbone of various human-type N-glycans.[PMID:18320567]
publication : 18320567|27629418|26514868|26821880|2477227|6213618|31747570|29273674|31064325|1291063|28353332|1421754|29666272|11421342|15648688|28179475|28903882|27189951|9455915|22768188|9254048|8721739|2249985|22933239|25629585|24489949|2981047|11067815|1729985|1710649|16672288|2719668|19003000|23025485|22500028|10409642|1325461|23136055|23085445|21656680|22448293|22132163|1425696|20696712|18056652|15084511|18633282|15814299
definition : A glycan that constitutes the core structure common to all high-mannose, complex, or hybrid N-glycans. The trimannosyl core composition is Man3 GlcNAc2 and includes a chitobiose at the reducing terminal which is extended by a single b-linked Man residue. The b-linked Man is branched by two additional a-linked Man residues, one at the 3 position and one at the 6 position.[MT]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Trisialylated

term (main_entry) : Trisialylated
term_in_sentence : Many (82.7%) were found to be tetraantennary N-acetyllactosamine-type (22.8% with one, 3.6% with two and 0.4% with three N-acetyllactosamine repeats) being tetrasialylated (41%), trisialylated (29.6%) and disialylated (12.2%) |HPAE-PAD and FACE analysis suggests that they are triantennary and trisialylated with core fucosylation.[PMID:8477709]
publication : 6469957|18818422|18332077|21138277|9136890|10782293|19841910|20067809|14751029|8797382|16877748|19131698|20578731|24669823|22426998|27501865|2121479|24663386|32209427|32737218|33245334|26927318|30962676|28370937|30194503|26321095|30463578|31455764|31566965|31266306|29782424|31247951|30487799|2049094|1997323|10913832
definition : A glycan with three sialic acid components.[RN]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Trisialylated complex-type oligosaccharide-alditols

term (main_entry) : Trisialylated complex-type oligosaccharide-alditols
term_in_sentence : The structures of the two major oligosaccharide-alditols separated by ion-exchange chromatography on a Mono Q column were investigated by means of methylation analysis, glycosidase digestion, and Smith periodate degradation, and they were assigned as typical di- and trisialylated complex-type oligosaccharide-alditols with two and three peripheral chains consisting of Gal-GlcNAc sequences , respectively.[PMID:3571205]
publication : 3571205
definition :
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Trisialylated diantennary

term (main_entry) : Trisialylated diantennary
term_in_sentence : Determination of glycan primary structures and characterization of a new type of trisialylated diantennary glycan.[PMID:1997323]
publication : 1997323
definition : A diantennary/biantennary glycans with three sialic acid components.[RN]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

Trisialylated triantennary

term (main_entry) : Trisialylated triantennary
term_in_sentence : The N-glycans are of the complex type with the core-fucosylated disialylated biantennary and trisialylated triantennary structures predominating.[PMID:8942648]
publication : 30194503|27501865|10998266|20578731|17591618|14751029|18818422|8942648|8900952
definition : A triantennry glycan with three sialic acid components.[RN]
term_xref :
best_match :
synonymns :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :

VIM-2

term (main_entry) : VIM-2
term_in_sentence : Anti-SSEA-1 which binds to glycoconjugates with a Gal beta 1-4(fuc alpha 1-3)GlcNAc epitope and VIM-2 which binds to gangliosides with a NeuAc alpha 2-3GlcNAc beta-4(FUC alpha 1-3) GlcNAc beta 1-3Gal-epitope were used to determine the expression of their corresponding carbohydrate antigens in human leukocytes and leukemia cells.[PMID:1690317]
publication : 27834790|31523406|29978304|29575185|27326514|29029114|32450200|29432937|31906402|28739428|29298123|30976429|29091730|27770796|31330771|31138570|27154587|31542553|30519059|30590504|25880997|27490501|29981456|28559273|28193652|26638216|25897818|26238337|19553129|29644540|26242685|28487556|32622213|30248413|24762211|11451678|33169865|11897589|31479607
definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-β-D-GlcpNAc-(1→3)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-D-GlcpNAc in which the anomeric configuration of the N-acetyl-D-glucosamine residue at the reducing end is β.[CHEBI:85946]
term_xref : GTC:G22418PV |GlycoEpitope:EP0019|CID:91825708|CHEBI:85946|GlycoMotif:GGM.000033
best_match : GTC:G22418PV |GlycoEpitope:EP0019|CID:91825708|CHEBI:85946
synonymns :
function : CDw65 have been shown to interact with the ELAM-1 molecule on activated endothelium.[GlycoEpitope:EP0019]
disease_associations : chronic myelogenous leukemia.[GlycoEpitope:EP0019]
wikipedia : https://www.wikidata.org/wiki/Q27158807
essentials_of_glycobiology :