Glycan structure dictionary: Difference between revisions
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'''Wikipedia page:''' N/A | '''Wikipedia page:''' N/A | ||
'''Essentials of | '''Essentials of Glycobiology:''' N/A | ||
==Term: sialyl Lewis X== | ==Term: sialyl Lewis X== | ||
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'''Term reference:''' [https://glytoucan.org/Structures/Glycans/G00054MO GTC:G00054MO] [https://www.glycoepitope.jp/epitopes/12 GlycoEpitope:EP0012] [https://pubchem.ncbi.nlm.nih.gov/compound/44456859 CID:44456859] [https://www.ebi.ac.uk/chebi/searchId.do?chebiId=71622 CHEBI:71622] [https://www.ncbi.nlm.nih.gov/mesh/2030970 MESH:2030970][https://edwardslab.bmcb.georgetown.edu/glycomotif/GM.G00054MO GlycoMotif:GM.G00054MO] | '''Term reference:''' [https://glytoucan.org/Structures/Glycans/G00054MO GTC:G00054MO] [https://www.glycoepitope.jp/epitopes/12 GlycoEpitope:EP0012] [https://pubchem.ncbi.nlm.nih.gov/compound/44456859 CID:44456859] [https://www.ebi.ac.uk/chebi/searchId.do?chebiId=71622 CHEBI:71622] [https://www.ncbi.nlm.nih.gov/mesh/2030970 MESH:2030970][https://edwardslab.bmcb.georgetown.edu/glycomotif/GM.G00054MO GlycoMotif:GM.G00054MO] | ||
'''Synonyms:''' | '''Synonyms:''' Slex| SLex| SLe^x | ||
'''Function:''' Sialyl Lex was shown to be a specific ligand on human leukocytes for vascular E- and P-selectins,and was shown to mediate leukocyte recruitment.[GlycoEpitope:EP0012]|The determinant is also frequently expressed on human cancer cells,and is involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0012] | '''Function:''' Sialyl Lex was shown to be a specific ligand on human leukocytes for vascular E- and P-selectins,and was shown to mediate leukocyte recruitment.[GlycoEpitope:EP0012]|The determinant is also frequently expressed on human cancer cells,and is involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0012] | ||
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'''Wikipedia page:''' [[wikipedia:Sialyl-Lewis_X|Sialyl-Lewis_X]] | '''Wikipedia page:''' [[wikipedia:Sialyl-Lewis_X|Sialyl-Lewis_X]] | ||
'''Essentials of | '''Essentials of Glycobiology:''' [https://www.ncbi.nlm.nih.gov/books/NBK453042/ NBK453042-Chapter14] | ||
==Term: N-linked glycans== | ==Term: N-linked glycans== | ||
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'''Wikipedia page:''' [[wikipedia:N-linked_glycosylation|N-linked glycans]] | '''Wikipedia page:''' [[wikipedia:N-linked_glycosylation|N-linked glycans]] | ||
'''Essentials of | '''Essentials of Glycobiology:''' [https://www.ncbi.nlm.nih.gov/books/NBK453020/ NBK453020-Chapter 9] | ||
<br /> | <br /> | ||
Revision as of 17:09, 19 November 2020
Contains glycan structure terms detected by automatic and manual literature mining. It follows the format from a regular dictionary:http://web.hku.hk/mw/exnotes.html
To report any issues or add annotations or new terms to the dictionary contact rsn13@gwu.edu
Term: core fucosylated
Definition: Modification of the N-glycan core structure with fucose moiety attached at the innermost GlcNAc facilitated by FUT8 enzyme. [MT, RN, https://doi.org/10.1016/bs.acr.2014.11.006].
Term reference: N/A
Synonyms: Core Fuc| 6-linked Fuc|Fuca6 to chitobiose core|a6-linked Fuc|a1-6 Fuc|Fuca6 to chitobiose core|Fuc a1-6 to chitobiose core|Fuca6 to internal GlcNAc|Fuc a1-6 to internal GlcNAc
Function: Required for signaling through TCR [PMID: 29434598]. | VGF, PDGFr, and EGFr and TGFbeta receptor dysregulation in Fut8 KO mice [PMID: 17132494]| IgG-Fcg receptor interactions destabilized by core Fuc [PMID: 29062024]
Disease associations: Emphysema[MT]|systemic lupus erythematosus[MT]lung cancer[MT]|autoimmunity[MT]|tumor metastasis[MT]
Publication(s): Exact-Match Non-Exact-Match
Term in sentence: The approach was validated for selective capture and analysis of core fucosylated N-glycans present in complex glycan mixtures derived from mammalian serum IgG.[PMID:27678371]
Wikipedia page: N/A
Essentials of Glycobiology: N/A
Term: sialyl Lewis X
Definition: A sialylated version of Lewis X antigen expressed on cell surfaces with structure Alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc is alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc in which the anomeric configuration of the reducing-end N-acetyl-beta-D-glucosamine residue is beta. It is a ligand for selectins. [MESH:2030970,CHEBI:71622,RN]
Term reference: GTC:G00054MO GlycoEpitope:EP0012 CID:44456859 CHEBI:71622 MESH:2030970GlycoMotif:GM.G00054MO
Synonyms: Slex| SLex| SLe^x
Function: Sialyl Lex was shown to be a specific ligand on human leukocytes for vascular E- and P-selectins,and was shown to mediate leukocyte recruitment.[GlycoEpitope:EP0012]|The determinant is also frequently expressed on human cancer cells,and is involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0012]
Disease associations: colon cancer[GlycoEpitope:EP0012]|colorectal cancer[GlycoEpitope:EP0012]
Publication(s): Exact-Match
Term in sentence: As sialyl Lewis X is a lignad of the selectin family, it has been proposed that sialyl Lewis X-rich colon cancer cells metastasize to the liver by adhesion to selectins on hepatic endothelial cells.[PMID:12828079]
Wikipedia page: Sialyl-Lewis_X
Essentials of Glycobiology: NBK453042-Chapter14
Term: N-linked glycans
Term in sentence: Structural analysis of N-linked glycans in Caenorhabditis elegans.[PMID:12038976]
Publication: Exact-Match Non-Exact-Match
Definition: The term used to refer to the carbohydrate portion of N-glycoproteins when attached to a nitrogen from asparagine or arginine side-chains.[CHEBI:59520]
Term reference: CHEBI:59520
Synonyms: N/A
Function: N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374]. Affect transportation of the glycosylated proteins in the Golgi. [PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding. [PMID: 25151374]. extracellular N-glycans act as key modulators of neuronal uptake of αSacetyl [PMID: 31211781]
Disease associations: Rheumatoid arthritis[PMID:17392038]. Type 1 Diabetes[PMID:29146600]. Lung Cancer[PMID: 23766031]
Wikipedia page: N-linked glycans
Essentials of Glycobiology: NBK453020-Chapter 9