Glycan Function Workshop 2023
Workshop on Functional Impact of Glycans and their Curation
April 23, 2023, 9:00am - 5:00pm
Padua, Italy
GlyGen and the Society for Glycobiology are sponsoring a special workshop held in conjunction with the the 2023 International Biocuration Conference (April 24-26th) in Padua, Italy. The purpose of this workshop is to build a community to better annotate glycan function by bringing together subject matter experts, tool developers and biocurators from resources that annotate content related to the functional impact of glycans.
Abstract
Dynamic changes in protein glycosylation impact human health and disease progression. However, current resources that capture disease and phenotype information such as MIM, Monarch Initiative, UniProt, and Genomics England, and others focus primarily on the macromolecules within the central dogma of molecular biology (DNA, RNA, proteins). In order to gain a more complete understanding of human disease, there is a need to capture the functional impact of glycans and glycosylation on biological processes. While the aforementioned resources include glycan-related genes, such as biosynthetic and degradative enzymes, the function and disease annotations are usually associated with the gene product rather than with the relevant glycosylation and glycan structural changes. Expression of glycan-related genes represents only a subset of factors affecting protein glycosylation. The functional impact of a specific glycan structure may depend on the protein to which it is bound, site of attachment, truncation or loss of the entire glycan structure. A catalog of glycosylation combinations, their relationship with other biomolecules, and their functional implications will provide insight into the biological roles of glycans and the impact of genetic and environmental factors on their expression. The purpose of this workshop is to bring together subject matter experts, tool developers and biocurators from resources that annotate content that is related to the functional impact of glycans. Each resource will do a short presentation on their data of interest, including types of annotations, what impact glycan function might have on these annotations, and standards and ontologies they are using. This will be followed by a jamboree/hackathon where we will discuss selected publications to identify commonalities and gaps in our current curation practices, and provide potential solutions. The attendees will help identify areas where curators, data wranglers, and text mining experts can collaborate to address gaps in glycan and glycosylation annotations, leverage each other’s work to improve their respective resources and encourage data sharing amongst resources.
Organization Committee
Raja Mazumder (GlySpace, GlyGen), Mike Tiemeyer (GlySpace, GlyGen), Rene Ranzinger (GlyGen), Maria Martin (UniProt, GlyGen), Kiyoko Aoki-Kinoshita (GlySpace, GlyCosmos, GlyTouCan), Frederique Lisacek (GlySpace, GlyConnect), Cecilia Arighi (PIR, BioCreative, UniProt), Randi Vita (IEDB), Jeet Vora (GlyGen)
Registration
Registration can be completed on Eventbrite here. Tickets are limited, please register as soon as possible to reserve your spot.
Venue
Hotel NH Padova, Via Niccolò Tommaseo, 61, 35131 Padova, Italy
https://www.nh-hotels.com/hotel/nh-padova
16 minute walking time to Centro Culturale San Gaetano (Conference venue)
Cost
Free, with lunch and coffee provided. Travel and accommodation are not included.
Accommodations
You can book a room at Hotel NH Padova from Saturday, April 22nd onwards. Additional lodging suggestions can be found on the 2023 Biocuration Conference website here.
Contact
Raja Mazumder: mazumder@gwu.edu