Glycan Function Workshop 2023

There will be two glycan function events in Padua, Italy. We encourage everyone who is attending the Sunday pre-workshop to also join us Monday, if they plan to stay for the conference:

All Day Pre-Workshop

Sunday April 23, 2023, 9:00am - 5:00pm

Hotel NH Padova, Padua, Italy

Registration: https://www.eventbrite.com/e/workshop-on-functional-impact-of-glycans-and-their-curation-tickets-489922931677

This event is separate from the 2023 Biocuration Conference.

2-Hour Biocuration Workshop

Monday April 24, 2023, 11:00am - 1:00pm

Cultural Center Altinate San Gaetano, Padua, Italy

Registration: https://biocuration2023.github.io/

This event is hosted by the 2023 Biocuration Conference.

Abstract

Dynamic changes in protein glycosylation impact human health and disease progression. However, current resources that capture disease and phenotype information such as MIM, Monarch Initiative, UniProt, and Genomics England, and others focus primarily on the macromolecules within the central dogma of molecular biology (DNA, RNA, proteins). In order to gain a more complete understanding of human disease, there is a need to capture the functional impact of glycans and glycosylation on biological processes. While the aforementioned resources include glycan-related genes, such as biosynthetic and degradative enzymes, the function and disease annotations are usually associated with the gene product rather than with the relevant glycosylation and glycan structural changes. Expression of glycan-related genes represents only a subset of factors affecting protein glycosylation. The functional impact of a specific glycan structure may depend on the protein to which it is bound, site of attachment, truncation or loss of the entire glycan structure. A catalog of glycosylation combinations, their relationship with other biomolecules, and their functional implications will provide insight into the biological roles of glycans and the impact of genetic and environmental factors on their expression. The purpose of this workshop is to bring together subject matter experts, tool developers and biocurators from resources that annotate content that is related to the functional impact of glycans. Each resource will do a short presentation on their data of interest, including  types of annotations, what impact glycan function might have on these annotations, and standards and ontologies they are using. This will be followed by a jamboree/hackathon where we will discuss selected publications to identify commonalities and gaps in our current curation practices, and provide potential solutions. The attendees will help identify areas where curators, data wranglers, and text mining experts can collaborate to address gaps in glycan and glycosylation annotations, leverage each other’s work to improve their respective resources and encourage data sharing amongst resources.

Organization Committee

Raja Mazumder (GlySpace, GlyGen), Mike Tiemeyer (GlySpace, GlyGen), Rene Ranzinger (GlyGen), Maria Martin (UniProt, GlyGen), Kiyoko Aoki-Kinoshita (GlySpace, GlyCosmos, GlyTouCan), Frederique Lisacek (GlySpace, GlyConnect), Cecilia Arighi (PIR, BioCreative, UniProt), Randi Vita (IEDB), Jeet Vora (GlyGen), Karina Martinez (GlyGen)

All Day Pre-Workshop (Sunday April 23)

GlyGen and the Society for Glycobiology are sponsoring a special pre-workshop prior to the 2023 International Biocuration Conference in Padua, Italy. The purpose of this workshop is to focus on community building and learning what each resource is doing related to the functional impact of glycans.

Venue

Hotel NH Padova, Via Niccolò Tommaseo, 61, 35131 Padova, Italy

https://www.nh-hotels.com/hotel/nh-padova

16 minute walking time to Centro Culturale San Gaetano (Conference venue)

Cost

Free, with lunch and coffee provided. Travel, accommodation and breakfast are not included.

Accommodations

You can book a room at Hotel NH Padova from Saturday, April 22nd onwards. Additional lodging suggestions can be found on the 2023 Biocuration Conference website here.

Schedule

Time	Duration	Topic	Chair	Presenters	Reporters	Group Members
9:00	15 min	Welcome		Raja Mazumder & Rene Ranzinger
9:15	20 min	Glycan Function Overview		Mike Tiemeyer
9:35 9:55	20 min 45 min	Q1. Presentations: How would your resource extract glycan related data from literature or other sources? Q1. Discussions
10:40	15 min	Coffee Break
10:55 11:15	20 min 45 min	Q2. Presentations: What type of glycan related data would be useful to your resource, that you don’t currently have access to? Q2. Discussions
12:00	60 min	Lunch
1:00 1:20	20 min 45 min	Q3. Presentations: What type of data, that you do have, might enhance glycan related data? Q3. Discussions
2:05 2:25	20 min 45 min	Q4. Presentations: What standards does your resource use for the glycan related annotations? Q4. Discussions
3:10	50 min	Presenters, reporters and members meet in groups and prepare summaries for each question (coffee will be provided)
4:00	60 min	15 min presentations by each group

Presentation/Discussion Sessions

Each presentation/discussion session will focus on one of the four questions below. These sessions will be divided into a presentation section (~30mins) followed by a whole-group discussion (~45 mins).

For each question, selected resources will give short presentations (~5 mins) on their ideas and strategic thoughts related to how their data of interest can intersect with glycan-related data, including useful annotations, standards, and ontologies. The goal of the discussions will be to improve coordination amongst resources to harmonize and enhance the impact of data related to glycans and glycoconjugates, including structures, functions, biosynthesis, pathophysiology, etc.

Two chairs will be selected to facilitate each of the presentation/discussion sessions and 2 reporters per question will be responsible for preparing and presenting the results during the final session and the Monday Biocuration workshop.

Registered Attendees (Resource/Project)

	Resource/Project	Attendees
1	GlyGen	Karina, Rene, Vijay, Nathan, Mike, Raja Jeet (remote)
2	GlyConnect	Frederique
3	IEDB	Randi
4	UniProt, BioCreative	Cecilia
5	GlyCosmos	Kiyoko, Yasunori
6	IntAct	Kalpana
7	MGI	Susan
8	UniProt	Maria
9	Microarray curation	Ten, Liu, Yukie
10	GlycoShape-3D	Ives
11	Glycan structure software	Jon A
12	Glyco.me	Hiren
13	GO, PANTHER	Paul
14	Rhea	Kristian
15	Glycowork	Jon L, James, Thomes
16	ELIBIO	Krishna
17	PRIDE	Deepti
18	GlycoEnzOnto	Ted
19	ChEBI	Adnan

2-Hour Biocuration Workshop (Monday April 24)

Biocuration 2023 will be hosting 5 workshops, including Functional impact of glycans and their curation, at the main conference venue. For additional information, visit the Biocuration website here: https://biocuration2023.github.io/workshops#glycans

Contact

For questions about registration or general inquiries, please contact:
Raja Mazumder: mazumder@gwu.edu
Karina Martinez: karinamartinez@gwu.edu
Jeet Vora: jeetvora@gwu.edu