Testhyperlink123
GSD000101
term (main_entry) : GT1b
glycan_dictionary_accession : GSD000101
glytoucan_accession : G40183QN
term_in_sentence : GT1b ganglioside is axonally transported to the spinal cord dorsal horn and contributes to characteristics of neuropathic pain such as mechanical and thermal hypersensitivity.[PMID: 32030804]
publication : 32030804|26370787|32046393|9712688|7636307|9931455|25520869|19605473|17188834|10233751|22735313|20540782|22746533|1861141|19490186|9521848|11921200|10731661|31431523|15274627|32726962|12573517|18277613|11370834|11234774|11123278|18704164|16291967|11411041|27549393|25253868|22720883|10686582|11511306|29904724|31472390|19156870
definition : A branched amino heptasaccharide comprising a β-D-galactosyl-(1→4)-β-D-glucose disaccharide, the galactosyl residue of which carries an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl trisaccharide unit and an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl disaccharide unit through (2→4) and (2→3) linkages respectively. It corresponds to the carbohydrate portion of ganglioside GT1b.[CHEBI:59225]
term_xref : GlycoMotif:GGM.000112|GTC:G40183QN|GlycoEpitopeEP0067|CID:45266781|CHEBI:59225| GlycoGlycoEpitope:130680|SugarBind_Ligand:26|KEGG:G00116
synonyms :
function :
disease_associations : Toxoplasmosis[SugarBind_Ligand:26]|Lyme disease[SugarBind_Ligand:26]|Cholera[SugarBind_Ligand:26]|Botulism[SugarBind_Ligand:26]|Tetanus[SugarBind_Ligand:26]|Influenza[SugarBind_Ligand:26]
wikipedia :
essentials_of_glycobiology :
GSD000102
term (main_entry) : GT1c
glycan_dictionary_accession : GSD000102
glytoucan_accession : G78818SP
term_in_sentence : We show here that VVH associates with ganglioside GM1a, Fucosyl-GM1, GD1a, GT1c, and GD1b by glycan array.[PMID: 32228455]
publication : 28088450|30085356|32228455|2468656|19841910|23877172|1695858|10564776|1613492|8474578|7798936|11180643|2723647|7066685|9613831|7361620|10699494
definition : A branched amino heptasaccharide consisting of a linear tetrasaccharide of β-D-galactose, N-acetyl-β-D-galactosamine, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→4) and (1→4), to the galactose residue proximal to the reducing end is also linked (2→3) an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl trisaccharide side-chain. The carbohydrate moiety of ganglioside GT1c.[CHEBI:90509]
term_xref : GlycoMotif:GGM.000113|GTC:G78818SP|CID:91846734|CHEBI:90509|GlycoEpitope:EP0033|KEGG:G00120
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000103
term (main_entry) : GT2
glycan_dictionary_accession : GSD000103
glytoucan_accession : G36476BA
term_in_sentence : Biosynthesis of the c-series gangliosides GT3, GT2 and GP1c was studied in Golgi derived from rat liver.[PMID:[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]]
publication : [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]|15498585|16005859|27540730|31533196|31201844
definition : A branched amino hexasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4), to the galactosyl residue of which is also linked (1→4) an N-acetyl-β-D-galactosaminyl residue. The carbohydrate moiety of ganglioside GT2.[CHEBI:72446]
term_xref : GlycoMotif:GGM.000109|GTC:G36476BA|CID:70788971|CHEBI:72446|KEGG:G00119
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 11
GSD000104
term (main_entry) : GT3
glycan_dictionary_accession : GSD000104
glytoucan_accession : G93899SO
term_in_sentence : The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound.[PMID: 28029115]
publication : 28029115|31355968|30987413|27869747|27216753|8631981|29672891|10385047|29642403|10412028|27193023|30068561|23415908|8858920|2303428|27153057|27128741|2654294|26930378|7561885|25860286|30845647|24712339|30070965|8910600|[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]|27356050|8514740|18509108|23000517|29769046|29566611
definition : A linear amino pentasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4).[CHEBI:72444]
term_xref : GlycoEpitope:EP0070|KEGG:G00118|CID:70788970|GlycoMotif:GGM.000092|GTC:G93899SO|CHEBI:72444
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 11
GSD000105
term (main_entry) : Blood group H (Type 3)
glycan_dictionary_accession : GSD000105
glytoucan_accession : G94435QH
term_in_sentence : One particular lambody, VLRB.aGPA.23, was shown by glycan array analysis to be selective for the blood group H type 3 trisaccharide (BG-H3, Fucα1-2Galβ1-3GalNAcα), aGPA, and TFα (Galβ1-3GalNAcα), with affinity constants of 0.2, 1, and 8 nM, respectively.[PMID:23030719]
publication : 23030719|20466654|1563908|3944092|11218748|11101633|18842005|27550195|2469783|2433836|23118206|8445257|2664192|3063304
definition :
term_xref : GlycoMotif:GGM.000010|GTC:G94435QH
synonyms : H type 3|H antigen (type 3)|Type 3 chain H
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 11
GSD000106
term (main_entry) : Heparan sulfate
glycan_dictionary_accession : GSD000106
glytoucan_accession :
term_in_sentence : In Niemann-Pick C-1 fibroblasts, where deaminative degradation of heparan sulfate is defective, carbonylated proteins were abundant.[PMID: 17540770]
publication : 32266657|29554552|29032302|30003471|25197032|28538085|26236728|16917509|22899865|17080204|23042481|28982096|24146040|25081076|15719168|17453622|25325954|21110089|29797526|21967329|23313092|11212344|28465034|11746174|12512855|8836040|28394734|24182748|28264929|28745308|26555370|14718374|16767693|25246018|19584012|8274190|25034023|8370471|26571620|29920400|31731076|20816205|16880267|31547957|11457867|27241222|28718936|21204109|31016560|11166215|11457866
definition : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815]
term_xref : CHEBI:28815|CID: 53477715|GlycoEpitope: EP0086
synonyms : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate
function : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[GlycoEpitope: EP0086]
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000107
term (main_entry) : Heparin
glycan_dictionary_accession : GSD000107
glytoucan_accession :
term_in_sentence : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:6416324]
publication : 27100512|22566218|27264866|30094590|31077659|26975675|2083874|25088334|3333067|2191809|28118750|28224913|22495506|29385025|10332503|22393937|19947315|27655335|14529394|2419035|22048616|23849978|10204652|28958760|12627673|9042555|15639107|28880550|27238483|1964668|16716101|10796377|25981976|24680753|2191118|21166465|30582884|1322434|15330727|9752370|6416324|14996629|20452241|1340407|29050610|345399|6916469|6565376|26714061
definition : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304]
term_xref : CID:772|CHEBI:28304
synonyms : bemiparin|bemiparin|certoparin|Cy 222|enoxaparin|fluxum|Heparin|Heparinic acid|parnaparin|reviparin|sandoparin
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000108
term (main_entry) : High mannose
glycan_dictionary_accession : GSD000108
glytoucan_accession : G55220VL
term_in_sentence : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:11258925]
publication : 11258925|17956937|2059624|2065054|26791533|4077844|7780197|9136890|30659065|30075362|21421994|31076349|29738673|29508223|[https://pubmed.ncbi.nlm.nih.gov/26747427 26747427 26747427]|30634645|23007868|29051951|24549150|12417032|26724786|26956389|26493153|31102532|29673624|8348230|25586968|24975601|[https://pubmed.ncbi.nlm.nih.gov/29803109 29803109 29803109]|28465212|25776945|30151520|21097542|24326091|27995699|26003537|6722291|2925680|25565276|21460211|25196214|27387600|22373601|3729933|16423983|24174266|30605318
definition : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man .
term_xref : GTC:G55220VL|CID:70698382|CHEBI:71514
synonyms : oligomannose
function : Involved in promotion of protein folding in ER. [PMID:12417032].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205]
disease_associations : Relative abundance changes in multiple CDGs [PMID: 30770376][PMID: 28484880]
wikipedia :
essentials_of_glycobiology : Chapter 17
GSD000109
term (main_entry) : HNK-1
glycan_dictionary_accession : GSD000109
glytoucan_accession : G54406UD
term_in_sentence : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:28709864]
publication : 28709864|31738061|26738850|30306736|11070366|20855890|18024472|22669261|19729452|19796667|26850637|11769463|18263654|15843379|26659409|9003039|22087768|21771787|15173636|9210489|15258996|17924534|26382082|16171882|18802400|9800516|7504418|[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229 11891229]|15232286|9013478|21621858|11677051|18668221|11414798|19265195|8982638|8798480|28403522|17935701|1691305|10998116|9364602|7528651|12472892|21176892|28416698|19389918|[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937 28427937]|25450311
definition : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322]
term_xref : GTC:G54406UD|GlycoEpitope:EP0001|CID:46906103|CHEBI:60322|GlycoMotif:GGM.000058
synonyms : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen
function : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001]
disease_associations : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001]
wikipedia : https://en.wikipedia.org/wiki/N-linked_glycosylation
essentials_of_glycobiology : Chapter 17
GSD000110
term (main_entry) : Hybrid
glycan_dictionary_accession : GSD000110
glytoucan_accession : G16828VN
term_in_sentence : A hybrid-type N-glycan was accessed by total synthesis, converted to an oxazoline, and used as a donor substrate with both wild type Endo M and an N175Q glycosynthase Endo M mutant allowing the convergent synthesis of a glycosylated amino acid bearing a hybrid N-glycan structure. [PMID:27058295]
publication : 27058295|15044398|28714086|29578688|26999365
definition : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1–Asn-X-Ser/Thr is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the α-linked Man residue.[Essentials of Glycobiology:Chapter 9]
term_xref : GTC:G16828VN|CID:91847108|CHEBI:147471
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
GSD000111
term (main_entry) : i antigen
glycan_dictionary_accession : GSD000111
glytoucan_accession : G00058MO|G46055MA
term_in_sentence : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:2422274]
publication : 2422274|[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458 15679458]|[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254 21912254]|[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428 12468428]|28508465|6203982|30728302|8449405|9122902|10360315|[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787 6159787]|6183759|518539|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951 6715951]|21933024
definition :
term_xref : GlycoMotif:GGM.000004|GlycoMotif:GGM.000002|GTC:G46055MA|GTC:G00058MO
synonyms : Type 2 LN2
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000112
term (main_entry) : I antigen
glycan_dictionary_accession : GSD000112
glytoucan_accession : G56045WU
term_in_sentence : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID:[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458 15679458]]
publication : [https://pubmed.ncbi.nlm.nih.gov/15679458 15679458 15679458]|[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254 21912254]|30705292|33403394|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951 6715951]|[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428 12468428]|6088627|[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787 6159787]
definition : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390]
term_xref : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:91852915|CHEBI:151390
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
GSD000113
term (main_entry) : Isoglobotetraosylceramide
glycan_dictionary_accession : GSD000113
glytoucan_accession : G57710SU
term_in_sentence : Furthermore, isoglobotetraosylceramide seems to play a direct role in the metastatic process since the blocking of exposed antigen with monoclonal antibodies, or their Fab fragments, results in a highly significant decrease in lung colony formation.[PMID:8504431]
publication : 1396705|8504431|2713378|3489485|18997175|7053385|3379797|2465279|3743633|11479210
definition :
term_xref : GlycoMotif:GGM.000071|GTC:G57710SU|CID:91849719|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17
synonyms :
function : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:8504431]
disease_associations : Actinomycosis[SugarBind_Ligand:17]
wikipedia : https://en.wikipedia.org/wiki/Ii_antigen_system
essentials_of_glycobiology :
GSD000114
term (main_entry) : Keratan sulfate
glycan_dictionary_accession : GSD000114
glytoucan_accession : G82109MW
term_in_sentence : Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties.[PMID: 30578672]
publication : 29340594|30578672|12512857|29625490|25325967|30025865|29924315|9549787|11030741|28078490|8298243|29096187|30059256|26958998|26773479|22840010|15597951|28110685|28535934|2942429|18234072|8641829|8940154|2027120|30849116|41589|6238957|1907283|7722002|29275050|24274541|2527236|1731862|8991509|24291704|10517185|6451953|7688312|8663590|139406|25770829|25036480|9275006|25179279|32627425|26903438|27941632|12807022|32266652|21624346
definition : A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions.[CHEBI:60924]
term_xref : CHEBI:60924|CID:446715|GlycoEpitope: EP0085|GTC: G82109MW
synonyms : keratan| Kerato sulphate|Kerato sulfate|Keratan sulphate|kerato 6'-sulfate|keratan 6'-sulfate|Kerato 6'-sulphate|Keratan 6'-sulphate
function : Tissue hydration.[PMID: 11030741]
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000115
term (main_entry) : LacdiNac
glycan_dictionary_accession : GSD000115
glytoucan_accession : G31736BK
term_in_sentence : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:25003135]
publication : 25003135|31711843|31145522|27601469|30669833|25210040|24633693|24755437|22653491|30898876|7758724|[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328 22474328]|21305673|31558607|31271862|28549117|26213980|9134425|25561735|31756927|31170332|16282603|15265923|32267274|23015818|32676595|16728562|10814702|9591048|22245701|[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628 29751628]|22997242|15535969|31911241|30622255|29888905|30236114|[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790 30298790]|29373511|22298779|19179461|31606752|15653684|16403022|11162373|32005658|30529570
definition : An amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a β-linkage.[CHEBI:61190]
term_xref : GTC:G31736BK|GlycoEpitope:P0150|CID:25257164|CHEBI:61190|GlycoMotif:GGM.000016
synonyms : LDN
function : Has a role of epitope.[CHEBI:61190]
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000116
term (main_entry) : Lactosylceramide
glycan_dictionary_accession : GSD000116
glytoucan_accession : G84224TW
term_in_sentence : In the 1970s, a neutral glycosphingolipid lactosylceramide (LacCer) was found to bind specifically to several kinds of microorganisms.[PMID:30175814]
publication : 30175814|26900161|30502090|29624959|28444900|25408340|31801289|29099167|25595946|32592089|27729551|24658420|25216636|25638276|9499377|17986153|8143857|23801329|18077097|32708181|15346887|19015977|18393821|25279740|21057870|11915327|25212460|23882130|11915329|8195125|8808768|3396945|22128256|6733104|24968752|32518749|30688114|7666005|8200356|24718572|6193809|25781947|12383912|26086247|30606995|12419803
definition : Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.[MeSH:D007790]
term_xref : GTC:G84224TW|MeSH:D007790|GlycoMotif:GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3
synonyms : LacCer|Lc2|CDH
function : mammalian cell receptors for Neisseria gonorrhoeae recognized by Helicobacter pylori[GlycoEpitope:EP0078]
disease_associations : chronic gastritis[GlycoEpitope:EP0078,SugarBind_Ligand:3]|duodenal ulcers[GlycoEpitope:EP0078]|gastric adenocarcinoma[GlycoEpitope:EP0078,SugarBind_Ligand:3]|gastric ulcers[GlycoEpitope:EP0078]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Actinomycosis[SugarBind_Ligand:3]|Pertussis[SugarBind_Ligand:3]|Candidiasis[SugarBind_Ligand:3]|Cryptococcosis[SugarBind_Ligand:3]|Hemorrhagic colitis[SugarBind_Ligand:3]|Peptic ulcers[SugarBind_Ligand:3]|Histoplasmosis[SugarBind_Ligand:3]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Gonorrhea[SugarBind_Ligand:3]|Sporotrichosis[SugarBind_Ligand:3]|Plague[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3]
wikipedia :
essentials_of_glycobiology : Chapter 17
GSD000117
term (main_entry) : Lactotriaosylceramide
glycan_dictionary_accession : GSD000117
glytoucan_accession : G06239NA
term_in_sentence : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:22411838]
publication : 22411838|20693232|26104834|27435676|26405105|32340400|25241919|23404501|32452379|2960671|272643|27711049|33202844|4060695|27638607|20547865|2277039|6238026|8448388|8489255|9363437|11836161|6892925|[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117 1551117]|6811267|8059935|7861954|11283017|8514762|1291049|[https://pubmed.ncbi.nlm.nih.gov/3805024 3805024 3805024]|10816509|12393713|6417117|11054095|8781973|1692829
definition : A linear amino trisaccharide consisting of β-D-glucose at the reducing end having an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl group attached at the 4-position.[CHEBI:61758]
term_xref : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:10230777|CHEBI:61758|SugarBind_Ligand:20
synonyms : Lc3|Lc(3)Cer|Lc_3
function : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:22411838]
disease_associations : Pharyngitis[SugarBind_Ligand:20]|Tracheobronchitis[SugarBind_Ligand:20]|Gonorrhea[SugarBind_Ligand:20]|Actinomycosis[SugarBind_Ligand:20]|Diarrhea[SugarBind_Ligand:20]
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000118
term (main_entry) : LcGg4
glycan_dictionary_accession : GSD000118
glytoucan_accession : G62554JH
term_in_sentence : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024 3805024]]
publication : [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024 3805024]|33395290
definition : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521]
term_xref : GlycoMotif:GGM.000075|GTC:G62554JH|CID:91850076|CHEBI:152521|GlycoEpitope:EP0035
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000119
term (main_entry) : Lewis a
glycan_dictionary_accession : GSD000119
glytoucan_accession : G00047MO
term_in_sentence : Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). [PMID:29367698]
publication : 29367698|27187324|30562693|[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625 27646625]|[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286 26911286]|30225822|28600306|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|11064310|23809433|30050155|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|1675497|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|27705835|7593252|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|17630273|9350993|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001]
definition : A lewis blood group antigen with structure beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcpNAc consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an alpha-linkage and a galactosyl residue attached at the 3-position via a beta-linkage. It has a role as an epitope and an antigen. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:62265]
term_xref : GTC:G00047MO|CID:22806751|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155
synonyms : Le(a)|Lea-3|Lea|Le^a
function :
disease_associations : Gastroenteritis[SugarBind_Ligand:155]
wikipedia : https://www.wikidata.org/wiki/Q50687009
essentials_of_glycobiology :
GSD000120
term (main_entry) : Lewis b
glycan_dictionary_accession : GSD000120
glytoucan_accession : G39211DH
term_in_sentence : Human mannose-binding lectin preferentially binds to human colon adenocarcinoma cell lines expressing high amount of Lewis A and Lewis B antigens.[PMID:10328552]
publication : 10328552|23408949|31927399|26601230|28279343|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|30831115|27318698|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|23828675|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|25516619|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|8509439|19832116|15270746|3166398|30909206|7718581|18400963|[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628 29751628]|8982241|30284922|24576035|30974776|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001]|31768613|1651804|25428879|15946883|[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790 30298790]|30544260|29197783|8632739|7679772|18666312|20231766|29922666|95124|2247887|21519121|25153235|28751211
definition :
term_xref : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:45480568|CHEBI:59440
synonyms : Le(b)|Lewis(b)|Le^b
function : possible receptor for Helicobacter pylori[https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/blood-group-lewis-system]
disease_associations : Gastroenteritis[SugarBind_Ligand:146]
wikipedia :
essentials_of_glycobiology :
GSD000121
term (main_entry) : Lewis x
glycan_dictionary_accession : GSD000121
glytoucan_accession : G00051MO
term_in_sentence : In particular, the observation of oxonium ions at m/z 512.2 and 803.2 is useful for probing outer non-reducing terminal fucosylation, which represented carbohydrate structures consisting of Hex Hex , dHex Hex , and HexNAc , and NeuNAc , Hex Hex , dHex Hex , and HexNAc , respectively, from which the Lewis X structure (Galbeta1-4(Fucalpha1-3)GlcNAc) was readily deduced.[PMID:15536627]
publication : 15536627|31666308|29019053|28296340|29593094|17607374|16581086|20858014|19962782|7912739|25121780|24059473|29210428|31276881|9015359|7628844|7499837|16850248|28425129|28869691|19576189|[https://pubmed.ncbi.nlm.nih.gov/10223649 10223649 10223649]|22593503|15632313|27198630|26582608|11500392|31256373|23399157|21984435|26244810|26162743|17335083|15388363|9556613|10760152|11267844|20876654|12131290
definition : A Lewis blood group antigen with structure α-L-Fucp-(1→3)-[β-D-Galp-(1→4)]-D-GlcpNAc where the glucosamine at the reducing end has β-configuration at its anomeric centre. Commonly known as Lewis x trisaccharide or Lex.[CHEBI:59294]
term_xref : GTC:G00051MO |GlycoEpitope:EP0011|CID:44611539|CHEBI:59294|GlycoMotif:GGM.000018
synonyms : Lex|Galbeta1-4(Fucalpha1-3)GlcNAc|Lewis x trisaccharide|Le(X)|Le^x|SSEA-1
function : Involved in carbohydrate-carbohydrate interaction[Glycoepitope:EP0011].|Also implicated in apoptosis.[Glycoepitope:EP0011]|influence antigenic presentation and interfere with pathogen transfer in breastfed infants.[Glycoepitope:EP0011]
disease_associations : acute leukemia[GlycoEpitope:EP0011]|lymphoma[GlycoEpitope:EP0011]
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000122
term (main_entry) : Lewis y
glycan_dictionary_accession : GSD000122
glytoucan_accession : G00052MO
term_in_sentence : In conclusion, Lewis y antigen and CD147 were significantly upregulated in ovarian tumors, and the altered expression of Lewis y may cause changes in CD147.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]]
publication : [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]|[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467 20003467]|[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145 24692145]|[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328 24998328]|[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913 25726913]|29299130|[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]|[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467 20003467]|[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145 24692145]|[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328 24998328]|20127027|22138668|23894390|[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913 25726913]|25416440|[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625 27646625]|23725446|21294926|22312289|25973320|23242548|30328452|21119363|29130097|23443083|23708102|28671040|19715603|23468946|27723168|21747684|19771739
definition : A Lewis blood group antigen which is a branched amino tetrasaccharide with structure alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, consisting of consisting of N-acetyl-beta-D-glucosamine at the reducing end having an alpha-L-fucosyl residue attached at the 3-position and an alpha-L-fucosyl-(1→2)-beta-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure. It has a role as an antigen and an epitope. [CHEBI:59045]]
term_xref : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045|GlycoMotif:GGM.000019
synonyms : LeY|Le(y)|Ley|Le^y
function : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018]
disease_associations : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018]
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000123
term (main_entry) : Monosialylated
glycan_dictionary_accession : GSD000123
glytoucan_accession :
term_in_sentence : The structures of the asparagine-linked sugar chains of U- CD59 were biantennary complex type , only 4.2% of which are monosialylated.[PMID:7514386]
publication : 7514386|8477709|8942648|29752599|31669586|29747818|16425369|12089170|31390883|1632647|29733234|31110965|31566965|30555678|28263871|29652662|25915761|16381065|29247593|28370937|23896595|26633899|32155999|25261856|2737211|26945091|27065039|26784838|26582205
definition : A glycan that have the addition of one sialic acid residues.
term_xref :
synonyms :
function : appears in bovine brain gangliosides.[PMID: 29752599]
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000124
term (main_entry) : Monosialyl-biantennary
glycan_dictionary_accession : GSD000124
glytoucan_accession :
term_in_sentence : In contrast, the sugar chain structure of HCC highly specific AFP isoform was found to comprise a monosialyl-biantennary sugar chain with additional fucosylation of the proximal N-acetylglucosamine.[PMID:7686446]
publication : 7686446|1374031|9648261|10460833|19524219|10207016|15797573|15218190
definition : A biantennary glycan with two GlcNAc branches linked to the core and the addition of one sialic acid residues.
term_xref :
synonyms : monosialyl biantennary|sialylated diantennary|sialylated biantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000125
term (main_entry) : Monosialyl-Gb5
glycan_dictionary_accession : GSD000125
glytoucan_accession : G32254QI
term_in_sentence : Thus, malignancy of MCF-7 is highly dependent on monosialyl-Gb5, and its activation of cSrc and FAK in GEM.[PMID:12401210]
publication : 12401210|16995838|27318475
definition : alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp is a linear amino hexasaccharide comprising β-D-glucose at the reducing end with at the 4-position a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-α-D-galactosyl-(1→4)-β-D-galactosyl moiety, α(2→3)-sialylated at the terminal galactosyl residue.[CHEBI:62313]
term_xref : GTC:G32254QI|GlycoEpitope:EP0099|GlycoMotif:GGM.000080|CID:73427363|CHEBI:62313
synonyms : GL-7 globoseries ganglioside (SSEA-4)|Monosialyl Gb5|Sialosyl galactosyl globoside|GL-7 globoseries ganglioside|SSEA-4
function :
disease_associations : renal cell carcinoma/RCC[GlycoEpitope:EP0099]
wikipedia :
essentials_of_glycobiology :
GSD000126
term (main_entry) : Mono-sulfated globopentaosylceramide
glycan_dictionary_accession : GSD000126
glytoucan_accession : G80193TN
term_in_sentence : Mono-sulfated globopentaosylceramide from human kidney.[PMID:2777788]
publication : 2777788
definition :
term_xref : GlycoMotif:GGM.000072|GTC:G80193TN
synonyms : Monosulfated globopentaosylceramide
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000127
term (main_entry) : Mono-sulfated globotetraosylceramide
glycan_dictionary_accession : GSD000127
glytoucan_accession : G05297EK
term_in_sentence : Mono-sulfated globotetraosylceramide from human kidney.[PMID:2559078]
publication : 2559078
definition :
term_xref : GlycoMotif:GGM.000073|GTC:G05297EK
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000128
term (main_entry) : N-acetyl GM2
glycan_dictionary_accession : GSD000128
glytoucan_accession : G79389NT
term_in_sentence : The appearance of the N-acetyl GM2 antigen correlated well with the degree of differentiation of the cancer cells in patients with squamous cell carcinoma and adenocarcinoma of the lung.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]]
publication : [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]|2153431|[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107 25673107]
definition : beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp is a branched amino tetrasaccharide consisting of the linear sequence β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the galactose via an α-(2→3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2.[CHEBI:59220]
term_xref : GTC:G79389NT|GlycoEpitope:EP0051|CID:45266845|CHEBI:59220
synonyms :
function : The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.[CHEBI:59220]
disease_associations : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051]
wikipedia :
essentials_of_glycobiology :
GSD000129
term (main_entry) : N-acetyllactosamine (Type 2)
glycan_dictionary_accession : GSD000129
glytoucan_accession : G00055MO
term_in_sentence : Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial beta1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form N-acetyllactosamine in the presence of UDP.[PMID:31165848]
publication : 31165848|31126011|28796164|6236210|9751793|29740087|9151975|10567443|21472942|26477523|6548353|28167527|20056550|7737204|22052010|[https://pubmed.ncbi.nlm.nih.gov/10223649 10223649 10223649]|11323440|10420596|7766648|25257940|17977857|15556936|26541999|23650594|9692202|29429899|21062783|25034434|8985145|28503789|8720464/
definition : N-acetyllactosamine is a beta-D-galactopyranosyl-(1→4)-N-acetyl-D-glucosamine having beta-configuration at the reducing end anomeric centre. It is also known as galb1-4glcnacb or lacnac, belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group. N-Acetyllactosamine is an extremely weak basic (essentially neutral) compound (based on its pKa). N-Acetyllactosamine exists in all living organisms, ranging from bacteria to humans.[CHEBI:16153,HMDB0001542]
term_xref : GTC:G00055MO|CID:439271|CHEBI:16153|MeSH:C000458|GlycoMotif:GGM.000001
synonyms : LacNAc|Type 2 LN
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000130
term (main_entry) : N-Glycolyl-GM2
glycan_dictionary_accession : GSD000130
glytoucan_accession : G56478LD
term_in_sentence : The monoclonal antibodies MK2-34 and MK1-16 (both IgM), which specifically detect N-glycolyl GM2 and N-acetyl GM2, respectively, were generated by immunizing mice with liposomes containing monophosphoryl lipid A, trehalose dimycolate, and the antigenic ganglioside.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]]
publication : [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]|11861662|17980710|3731079|[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107 25673107]
definition : (2S,4S,5R,6R)-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of carbohydrates and carbohydrate derivatives.[CHEBI:151464]
term_xref : GTC:G56478LD |GlycoEpitope:EP0052|CID:91845742|CHEBI:151464|GlycoEpitope:GGM.000096
synonyms :
function :
disease_associations : choriocarcinoma[GlycoEpitope:EP0052]|teratocarcinoma|[GlycoEpitope:EP0052]yolk sac tumor[GlycoEpitope:EP0052]
wikipedia :
essentials_of_glycobiology :
GSD000131
term (main_entry) : N-linked glycans
glycan_dictionary_accession : GSD000131
glytoucan_accession : G78059CC
term_in_sentence : Our study identifies extracellular N-linked glycans-and the glycoprotein neurexin 1β specifically-as key modulators of neuronal uptake of αSacetyl, drawing attention to the potential therapeutic value of αSacetyl-glycan interactions.[PMID:31211781]
publication : 31211781|28384382|30305477|31364612|26899268|29945790|29652253|29723274|30962676|29778448|25325701|31100702|28898525|22944671|19277537|24473128|17957771|27554083|15189166|11269317|[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919 19577919]|24303005|12042249|22191536|28324664|25965797|25434632|30484244|28110657|[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]|20129637|27346875|30280442|[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286 26911286]|22491358|26582281|26398792|31548313|31066275|28331984|25482090|[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173 28518173]|30733536|22326428|30063825|30315103|21558494|[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555 31676555]|31256374
definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the nitrogen of an asparagine side-chain.[CHEBI:59520]
term_xref : GTC:G78059CC|CID:70679232|CHEBI:70967
synonyms :
function : N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374]|Affect transportation of the glycosylated proteins in the Golgi.[PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding.[PMID: 25151374]|extracellular N-glycans act as key modulators of neuronal uptake of αacetyl [PMID: 31211781].
disease_associations : Rheumatoid arthritis[PMID:17392038]|Type 1 Diabetes[PMID:29146600]|Lung Cancer[PMID: 23766031]
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000132
term (main_entry) : Nonfucosylated
glycan_dictionary_accession : GSD000132
glytoucan_accession :
term_in_sentence : In the carbohydrate moiety , alpha-subunit from normal pregnancy hCG contained nonfucosylated , mono- and biantennary N-linked structures (49.3 and 36.7%, means); fucosylated biantennary and triantennary oligosaccharides were also identified (7.3 and 6.9%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]|30258536|23554380|16675584|[https://pubmed.ncbi.nlm.nih.gov/26747427 26747427 26747427]|22457527|24362443|19657637|8811881|19218011|20022111|17363544|17368483|20564614|27054024|28397880|[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688 31490688]|31860772|17012310|29633346|9442021|30350565|30296068|31800250|30021910|31133022|[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385 29224385]|[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087 28630087]|26444434|31697975|30991260
definition : glycans without a fucose component/monosaccharide residue.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000133
term (main_entry) : Nonfucosylated biantennary
glycan_dictionary_accession : GSD000133
glytoucan_accession :
term_in_sentence : Structural analysis combining methylation-mass spectrometry and 400 MHz 1H-n.m.r. spectrometry of oligosaccharide alditols released from human leucocyte lactotransferrin shows the presence of two disialylated and non-fucosylated biantennary glycans of the N-acetyl-lactosaminic type.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]]
publication : [https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]|1375510|9101715|[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]|2332109
definition : A biantennary glycan with two GlcNAc branches linked to the core and no fucose appears.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
GSD000134
term (main_entry) : Nonfucosylated biantennary N-Linked structures
glycan_dictionary_accession : GSD000134
glytoucan_accession :
term_in_sentence : The beta-subunit from normal pregnancy hCG contained fucosylated and nonfucosylated biantennary N-linked structures; however, mono- and triantennary oligosaccharides were also identified (4.6 and 13.7%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]
definition : A biantennary N-linked glycan with two GlcNAc branches linked to the core and no fucose appears.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000135
term (main_entry) : Nonfucosylated triantennary
glycan_dictionary_accession : GSD000135
glytoucan_accession :
term_in_sentence : Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.[PMID:7679920]
publication : 7679920|23274891
definition : A triantennary N-linked glycan with three GlcNAc branches linked to the core and no fucose appears.
term_xref :
synonyms :
function : Appears in human alpha-fetoprotein (AFP).[PMID:7679920]
disease_associations : hepatocellular carcinoma[PMID:7679920].
wikipedia :
essentials_of_glycobiology :
GSD000136
term (main_entry) : Nonsialylated
glycan_dictionary_accession : GSD000136
glytoucan_accession :
term_in_sentence : The pattern of nonsialylated oligosaccharides was used for interpretation of the fully sialylated species using bioinformatics tools. From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively. Glycan structures carry dominantly between 15 and 16 sialic acids indicating an almost complete termination of all antenae with sialic acid.[PMID:30295034]
publication : 14533820|1377689|9705949|30788437|28090561|12498371|26839900|[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688 31490688]|2656426|30295034|31545048|12381155|25730103|26787879|25646460|[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385 29224385]|26063435|26954852|32889432|2825412|27504786|22431161
definition : A glycan which is not sialylated.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000137
term (main_entry) : O-fucose glycans
glycan_dictionary_accession : GSD000137
glytoucan_accession : G39294YF
term_in_sentence : Recently, a number of laboratories have shown that O-fucose glycans on the epidermal growth factor (EGF)-like repeats of the Notch extracellular domain modulate Notch signaling.[PMID:12417415]
publication : 19594638|30690220|[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191 18952191]|22415200|12417415|16400812|18948267|21464368|20816394|30207383|20301232|27129198|17132502|22492969|30030822|30214079|26175457|25378397|18272537|28729422|11524432|31722217|23045360|24803430|28876865|25700513|32518939|30523691|18227520|20816217|24909690|17964136|12036964|27268051|15653671|19948734|31590629|32201074|15189151|17263732|32913123|12909620|[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176 28785176]|17132500|22949680|25053492|28939751
definition : Form of glycosylation where the protein is modified by a fucose residue and can be extended futher to form a tetrasaccharide in certain cases. alpha-linked o-fucose have a consensus motif of C2X4(s/T)C3 where C2 and C3 are conserved cysteines number 2 and 3 respectively of the EGFR like repeats. [Essentials of Glycobiology:Chapter13]
term_xref : GTC:G39294YF|GlycoEpitope:EP0005
synonyms :
function : modification of Notch signaling.[GlycoEpitope:EP0005]
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000138
term (main_entry) : O-GlcNAc
glycan_dictionary_accession : GSD000138
glytoucan_accession : G49108TO
term_in_sentence : A better understanding of the mechanisms of OGT/OGA action would enable us to derive therapeutic benefits of resetting cellular O-GlcNAc levels within an optimal range.[PMID:30464755]
publication : 30464755|29049853|29594839|31654859|29404877|30105004|30669087|29790000|28408483|26862193|30523150|30037904|28408480|29352075|29456783|29577901|29223644|28638491|30221662|29904918|32155042|30298013|31630803|31847126|29784830|30181664|28768194|30134155|25336654|30356792|30199580|32329777|28408494|29774032|29044951|23836420|20301273|29772801|28922739|30100348|30793403|30657688|31237748|29756380|29954943|30018219|32207184|25566193|30626734|24759912|
definition : Form of glycosylation which exclusively occurs in the mitochondrial, cytoplasmic or nuclear compartments of the cell where the protein is modified by a GlcNAc monosaccharide on the serine or threonine residues and is generally not modified or elongated further to form more complex structures. [Essentials of Glycobiology:Chapter19]
term_xref : GTC:G49108TO|GlycoEpitope:EP0004|CID:24139|HMDB:HMDB0000803
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000139
term (main_entry) : O-linked glycans
glycan_dictionary_accession : GSD000139
glytoucan_accession :
term_in_sentence : Among these, six fucosylated N-linked glycansand four O-linked glycans exhibited significantly increased expression levels in GC, while five fucosylated N-linked glycans and ten fucosylated O-linked glycans exhibited significantly decreased expression levels in GC.[PMID:[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]]
publication : [https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]|30952424|31611643|[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919 19577919]|32019882|19139197|26184710|11159917|21536259|25186198|19277556|22261557|24115046|18725413|[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855 15966855]|24256304|25477510|10359703|24406064|22259135|29279989|[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855 15966855]|30619255|9673446|[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555 31676555]|28745859|28196325|27975143|30591584|[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173 28518173]|17522109|[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495 26328495]|32178593|27529638|24663386|[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328 22474328]|28096352|27496768|[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191 18952191]|11135308|24917611|11532966|22786570|[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229 11891229]|18332077|26867212|26925665|16769205|23475718|16005634|[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176 28785176]
definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the hydroxyl oxygen of serine, threonine, hydroxylysine or hydroxyproline side-chains.[CHEBI:59521]
term_xref : CHEBI:59521
synonyms :
function : Affects several important activities like protein stability, modulation of signaling molecules and enzyme activity.[PMID:9673446]
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000140
term (main_entry) : O-linked mannose
glycan_dictionary_accession : GSD000140
glytoucan_accession : G59126YU
term_in_sentence : Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the first step toward the functional matriglycan structure on alpha-dystroglycan that is responsible for binding extracellular matrix proteins and certain arenaviruses.[PMID: 27932460]
publication : 27932460|24526361|25381909|26644575|23851827|28810660|19054127|23929950|21684258|22608994|28973932|24733390|31851597|29884773|28711406|14577328|21089343|14617637|9838223|17072003|[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495 26328495]|11181560|31949166|31988979|20362685|27733679|27493216|20044576|30643095|29732660|10580142|14568618|28079948|15467391|27812179|23761899|25737452|32930586|25381372|23434682|16857188|21452199|19429925|25361541|24297939|30322079|23428289|[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937 28427937]|22746206|27533452|17502374|20816174|27496765
definition : O-linked glycans that are initiated by the addtion of a Man residue to Ser or Thr. Subsequent extension of the Man defines the O-Man core type, either M1, M2, or M3. The M1 type is initated by addition of a GlcNAc in β-linkage to the 2 position of the Man residue. M2 is initiated by addition of another GlcNAc to the 6 position of the M1 core. M3 is initiated by the addition of a GlcNAc in β-linkage to the 4 position of the Man residue. M1 and M2 type core glycans can be extended and branched with Gal, Fuc, Sialic Acid, and GlcA. The M3 core is uniquely extended by a multienzyme system to generate the matriglycan polysaccharide, a protein-specific modification found only on alpha-dystroglycan. [CHEBI:87761]
term_xref : GlycoMotif:GGM.000055|GTC:G59126YU|CHEBI:87761|GlycoEpitope:EP0002|CID:91859038
synonyms : O-mannosyl glycan
function :
disease_associations : MEB/muscle-eye-brain disease[GlycoEpitope:EP0002]|WWS/walker-warburg syndrome |muscular dystrophy[GlycoEpitope:EP0002]|neuronal migration disorder[GlycoEpitope:EP0002]|Muscle-Eye-Brain disease (MEB) and Walker-Warburg Syndrome (WWS) have mutations in genes encoding glycosyltransferases needed for O -mannosyl oligosaccharide synthesis[GlycoEpitope:EP0002]|Muscular dystrophy and neuronal migration disorder are caused by mutations in a glycosyltransferase, POMGnT1.[GlycoEpitope:EP0002]
wikipedia :
essentials_of_glycobiology :
GSD000141
term (main_entry) : P1 antigen
glycan_dictionary_accession : GSD000141
glytoucan_accession : G12460DL
term_in_sentence : The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively.[PMID: 24046920]
publication : 29622537|26773500|24046920|6207232|8550516|6609976|6375319|817855|2428855|3312011|15364312|1937801|7729906
definition : An amino pentasaccharide consisting of α-D-galactose, β-D-galactose N-acetyl-α-D-glucosamine, β-D-galactose, and β-D-glucose residues joined in sequence with ((1→4)-, (1→4)-, (1→3)- and (1→4)-linkages, respectively.[CHEBI:68484]
term_xref : GlycoMotif:GGM.000069|GTC:G12460DL|CID:71296137|CHEBI:68484|SugarBind_Ligand:160
synonyms :
function :
disease_associations : Shigellosis[SugarBind_Ligand:160]
wikipedia :
essentials_of_glycobiology : Chapter 23
GSD000142
term (main_entry) : Para-Forssman glycolipid
glycan_dictionary_accession : GSD000142
glytoucan_accession : G51699SI
term_in_sentence : A novel pentaglycosyl ceramide containing di-beta-N-acetylgalactos-aminyl residue (Para-Forssman glycolipid) isolated from human erythrocyte membrane. [PMID:6814203]
publication : 6814203
definition : GalNAcβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1→1Cer [https://doi.org/10.1016/S0040-4039(01)93814-6]
term_xref : GlycoMotif:GGM.000085|GTC:G51699SI|CID:56836111|KEGG:G00096|SugarBind_Ligand:19|CHEBI:151565
synonyms :
function :
disease_associations : Actinomycosis[SugarBind_Ligand:19]
wikipedia : https://en.wikipedia.org/wiki/P1PK_blood_group_system
essentials_of_glycobiology :
GSD000143
term (main_entry) : Paragloboside
glycan_dictionary_accession : GSD000143
glytoucan_accession : G58896AZ
term_in_sentence : Galactosyltransferase activities in sera of cancer patients were determined by assaying the formation of paragloboside from UDP-galactose and lactotriaosylceramide immobilized on microtiter plates by means of the enzyme-linked immunosorbent assay using a monoclonal antibody, H-11, directed to paragloboside. [PMID: [https://pubmed.ncbi.nlm.nih.gov/1551117 1551117 1551117]]
publication : 3345524|850070|10569746|30624951|29438961|6816790|[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117 1551117]|6865961|25039255
definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→3)-D-GalpNAc in which the configuration at the GalNAc anomeric carbon is α.[CHEBI:65257]
term_xref : GlycoMotif:GGM.000077|GTC:G58896AZ|CID:21670519|CHEBI:65257|GlycoEpitope:EP0075|SugarBind_Ligand:15
synonyms :
function :
disease_associations : Pharyngitis[SugarBind_Ligand:15]|Tracheobronchitis[SugarBind_Ligand:15]|Gonorrhea[SugarBind_Ligand:15]|Actinomycosis[SugarBind_Ligand:15]|Diarrhea[SugarBind_Ligand:15]|Hemorrhagic colitis[SugarBind_Ligand:15]|Chronic gastritis[SugarBind_Ligand:15]|Peptic ulcers[SugarBind_Ligand:15]|Gastric cancer[SugarBind_Ligand:15]|Influenza[SugarBind_Ligand:15]
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000144
term (main_entry) : Paucimannose
glycan_dictionary_accession : GSD000144
glytoucan_accession :
term_in_sentence : The galactosylation of core fucose (GalFuc epitope) in paucimannose and complex-type N-glycans is characteristic of protostome organisms, including flatworms (planarians).[PMID:29475940]
publication : 29475940|[https://pubmed.ncbi.nlm.nih.gov/29803109 29803109 29803109]|12603202|31817246|31719144|21057214|31932305|17132514|30382146|27731363|31325506|25746926|26513758|16522637|21169367|25190359|27928741|22496646|27384337|16897177|15228383|27379103|27189951|23475714|24907509|20558211|28060516|20441997|27720757|28817611|24550396|19494052|19515361|[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087 28630087]|31320997|30651366|30253927|25922361|31655162|18056652|24467287|32367383
definition : Any N-linked glycan derivative with composition Man1-4Fuc0-1 GlcNAc2, in which the chitobiose core (GlcNAc2) is intact. Found in relatively large amounts in invertebrates and plants, they are formed by removal of the non-reducing terminal GlcNAc (\added by GlcNAcT1) from GlcNAcMan3-5GlcNAc2 by a Golgi hexosaminidase and subsequent removal of Man residues by Golgi mannosidases. Pauscimannose glycans have also been detected in vertebrates.[CHEBI:144386]
term_xref : CHEBI:144386
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000145
term (main_entry) : Sd(A)/Cad
glycan_dictionary_accession : GSD000145
glytoucan_accession : G41052GC
term_in_sentence : The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2.[PMID:24112972]
publication : 24112972|11577689|30067891|15361072
definition : A branched amino tetrasaccharide comprised of a trisaccharide chain of N-acetyl-α-neuraminic acid, β-D-galactose and N-acetyl-β-D-glucosamine residues linked sequentially (2→3) and (1→4), to the galactose residue of which is also linked (1→4) an N-acetyl-β-L-galactosamine residue. [CHEBI:71561]
term_xref : GlycoMotif:GGM.000051|GTC:G41052GC|CID:70698375|CHEBI:71561
synonyms : Sd^a /Cad
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
GSD000146
term (main_entry) : SDlex
glycan_dictionary_accession : GSD000146
glytoucan_accession : G19619KS
term_in_sentence : Hepatic expression of sialylated difucosyl Lex antigen (SDLex, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-) was studied with monoclonal antibody FH6, which defines this structure.[PMID: 3341453]
publication : 30226570|3341453|12725333
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-5-acetamido-6-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CHEBI:148203]
term_xref : GlycoMotif:GGM.000032|GTC:G19619KS|CID:91856705|CHEBI:148203
synonyms : Sdlex|SDLe^x|SDLex
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000147
term (main_entry) : Seminolipid
glycan_dictionary_accession : GSD000147
glytoucan_accession : G72548RZ
term_in_sentence : A concise total synthesis of seminolipid, a sulfoglycolipid, has been achieved; key features include regioselective, tin-free sulfation of allyl β-d-galactopyranoside using 2,6-bis(trifluoromethyl)phenylboronic acid as protective reagent, stereoselective epoxidation, and site-selective acylation. [PMID: 31353379]
publication : 31353379|31736776|12810822|19582571|19542524|20670037|15659616|20817833|870059|10801776|21965315|8095813|1280685|4690236|34199863|4207869|2373957|845131
definition :
term_xref : GlycoMotif:GGM.000062|GTC:G72548RZ
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
GSD000148
term (main_entry) : Sialopentaosylceramide
glycan_dictionary_accession : GSD000148
glytoucan_accession : G13224CR
term_in_sentence : Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosap[PMID: 2139874]
publication : 2139874
definition : A ganglioside in which the oligosaccharide portion is composed of a pentasaccharide containing one or more sialic acid residues.[CHEBI:36542]
term_xref : GlycoMotif:GGM.000097|GTC:G13224CR|CID:91859576|CHEBI:148045|KEGG:G00883|CHEBI:36542
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000149
term (main_entry) : Sialosyl paragloboside
glycan_dictionary_accession : GSD000149
glytoucan_accession : G50123ZO
term_in_sentence : Unlike CNS myelin, human peripheral nerve myelin has the acidic glycosphingolipids sialosyl paragloboside (SPG), sialosyl lactosaminyl paragloboside (SLPG), and sulfated glucuronyl paragloboside (SGPG).[PMID:8862128]
publication : 8862128|7236652|2370108|3133978|2905604|1749114|1573418
definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-D-GlcpNAc with β configuration at the anomeric position of the reducing-end N-acetyl-D-glucosamine residue.[CHEBI:71612]
term_xref : GlycoMotif:GGM.000081|GTC:G50123ZO|CID:91845504|KEGG:G01429|CHEBI:151914
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GSD000150
term (main_entry) : Sialyl Lewis a
glycan_dictionary_accession : GSD000150
glytoucan_accession : G00053MO
term_in_sentence : By comparing the serum O-glycan profiles from healthy controls with those of cancer patients, we identified a marker candidate, core 1 sialyl Lewis A (NeuAcα2-3Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal) (abbreviated C1SLA), whose concentration appeared to be weakly correlated with CA19-9 values.[PMID:[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]]
publication : [https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]|31424423|26530370|17760270|18343410|16033091|8829184|11907351|20592391|[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]|24128856|30249386|10773785|16149606|10996727|10436809|10667238|7720892|7630017|10612415|9836451|12511721|22623153
definition : A sialyated version of Lewis A with a branched structure of amino tetrasaccharide consisting of a sialyl residue, linked (2→3) to a galactosyl residue that in turn is linked (1→3) to a glucosaminyl residue at the reducing end, which is also carrying a fucosyl residue at the 4-position.[CHEBI:62681]
term_xref : GTC:G00053MO|GlycoEpitope:EP0008|CID:53356732|CHEBI:62681|GlycoMotif:GGM.000024
synonyms : SLea|CA19-9|CA19-9 antigen|SLe^a|Slea
function : The carbohydrate determinants,Sialyl Lea and Sialyl Lex,which are frequently expressed on human cancer cells,serve as ligands for a cell adhesion molecule of the selectin family,E-selectin,which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0008]
disease_associations : pancreatic adenocarcinoma[GlycoEpitope:EP0008]|hepatocellular cancer[GlycoEpitope:EP0008]|cholangiocellular cancer[GlycoEpitope:EP0008]|gastric cancer|[GlycoEpitope:EP0008]colorectal cancer[GlycoEpitope:EP0008]|ovarian cancer[GlycoEpitope:EP0008]|lung cancer[GlycoEpitope:EP0008]|breast cancer[GlycoEpitope:EP0008]|uterine cancer[GlycoEpitope:EP0008]
wikipedia :
essentials_of_glycobiology :