Testhyperlink123
Monosialylated
term (main_entry) : Monosialylated
glycan_dictionary_accession : GSD000123
glytoucan_accession :
term_in_sentence : The structures of the asparagine-linked sugar chains of U- CD59 were biantennary complex type , only 4.2% of which are monosialylated.[PMID:7514386]
publication : 7514386|8477709|8942648|29752599|31669586|29747818|16425369|12089170|31390883|1632647|29733234|31110965|31566965|30555678|28263871|29652662|25915761|16381065|29247593|28370937|23896595|26633899|32155999|25261856|2737211|26945091|27065039|26784838|26582205
definition : A glycan that have the addition of one sialic acid residues.
term_xref :
synonyms :
function : appears in bovine brain gangliosides.[PMID: 29752599]
disease_associations :
wikipedia :
essentials_of_glycobiology :
Monosialyl-biantennary
term (main_entry) : Monosialyl-biantennary
glycan_dictionary_accession : GSD000124
glytoucan_accession :
term_in_sentence : In contrast, the sugar chain structure of HCC highly specific AFP isoform was found to comprise a monosialyl-biantennary sugar chain with additional fucosylation of the proximal N-acetylglucosamine.[PMID:7686446]
publication : 7686446|1374031|9648261|10460833|19524219|10207016|15797573|15218190
definition : A biantennary glycan with two GlcNAc branches linked to the core and the addition of one sialic acid residues.
term_xref :
synonyms : monosialyl biantennary|sialylated diantennary|sialylated biantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Monosialyl-Gb5
term (main_entry) : Monosialyl-Gb5
glycan_dictionary_accession : GSD000125
glytoucan_accession : G32254QI
term_in_sentence : Thus, malignancy of MCF-7 is highly dependent on monosialyl-Gb5, and its activation of cSrc and FAK in GEM.[PMID:12401210]
publication : 12401210|16995838|[https://pubmed.ncbi.nlm.nih.gov/27318475 27318475 27318475]
definition : alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp is a linear amino hexasaccharide comprising β-D-glucose at the reducing end with at the 4-position a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-α-D-galactosyl-(1→4)-β-D-galactosyl moiety, α(2→3)-sialylated at the terminal galactosyl residue.[CHEBI:62313]
term_xref : GTC:G32254QI|GlycoEpitope:EP0099|GlycoMotif:GGM.000080|CID:73427363|CHEBI:62313
synonyms : GL-7 globoseries ganglioside (SSEA-4)|Monosialyl Gb5|Sialosyl galactosyl globoside|GL-7 globoseries ganglioside|SSEA-4
function :
disease_associations : renal cell carcinoma/RCC[GlycoEpitope:EP0099]
wikipedia :
essentials_of_glycobiology :
Mono-sulfated globopentaosylceramide
term (main_entry) : Mono-sulfated globopentaosylceramide
glycan_dictionary_accession : GSD000126
glytoucan_accession : G80193TN
term_in_sentence : Mono-sulfated globopentaosylceramide from human kidney.[PMID:2777788]
publication : 2777788
definition :
term_xref : GlycoMotif:GGM.000072|GTC:G80193TN
synonyms : Monosulfated globopentaosylceramide
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Mono-sulfated globotetraosylceramide
term (main_entry) : Mono-sulfated globotetraosylceramide
glycan_dictionary_accession : GSD000127
glytoucan_accession : G05297EK
term_in_sentence : Mono-sulfated globotetraosylceramide from human kidney.[PMID:2559078]
publication : 2559078
definition :
term_xref : GlycoMotif:GGM.000073|GTC:G05297EK
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
N-acetyl GM2
term (main_entry) : N-acetyl GM2
glycan_dictionary_accession : GSD000128
glytoucan_accession : G79389NT
term_in_sentence : The appearance of the N-acetyl GM2 antigen correlated well with the degree of differentiation of the cancer cells in patients with squamous cell carcinoma and adenocarcinoma of the lung.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]]
publication : [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]|2153431|[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107 25673107]
definition : beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp is a branched amino tetrasaccharide consisting of the linear sequence β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the galactose via an α-(2→3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2.[CHEBI:59220]
term_xref : GTC:G79389NT|GlycoEpitope:EP0051|CID:45266845|CHEBI:59220
synonyms :
function : The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.[CHEBI:59220]
disease_associations : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051]
wikipedia :
essentials_of_glycobiology :
N-acetyllactosamine (Type 1)
term (main_entry) : N-acetyllactosamine (Type 1)
glycan_dictionary_accession : GSD000181
glytoucan_accession : G00056MO
term_in_sentence : The N-acetyllactosamine type 1 (LacNAc type 1, Galβ1,3GlcNAc) is a well-known precursor of several important blood group epitopes, such as Lewis A, Lewis B, or sialyl Lewis A [1], which are involved in many biological processes, e.g., fertilization [2] and pathogen adhesion [3]. [PMID:28796164]
publication : [https://pubmed.ncbi.nlm.nih.gov/28796164 28796164 28796164]|[https://pubmed.ncbi.nlm.nih.gov/28167527 28167527 28167527]
definition :
term_xref : GTC:G00056MO|GlycoMotif:GGM.000005
synonyms : LacNAc type 1|Type 1 LN|Type-1 lactosamine
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
N-acetyllactosamine (Type 2)
term (main_entry) : N-acetyllactosamine (Type 2)
glycan_dictionary_accession : GSD000129
glytoucan_accession : G00055MO
term_in_sentence : Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial beta1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form N-acetyllactosamine in the presence of UDP.[PMID:31165848]
publication : 31165848|31126011|28796164|6236210|9751793|29740087|9151975|10567443|21472942|26477523|6548353|28167527|20056550|7737204|22052010|10223649|11323440|10420596|7766648|25257940|17977857|15556936|26541999|23650594|9692202|29429899|21062783|25034434|8985145|28503789|8720464/
definition : N-acetyllactosamine is a beta-D-galactopyranosyl-(1→4)-N-acetyl-D-glucosamine having beta-configuration at the reducing end anomeric centre. It is also known as galb1-4glcnacb or lacnac, belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group. N-Acetyllactosamine is an extremely weak basic (essentially neutral) compound (based on its pKa). N-Acetyllactosamine exists in all living organisms, ranging from bacteria to humans.[CHEBI:16153,HMDB0001542]
term_xref : GTC:G00055MO|CID:439271|CHEBI:16153|MeSH:C000458|GlycoMotif:GGM.000001
synonyms : LacNAc|Type 2 LN
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
N-Glycolyl-GM2
term (main_entry) : N-Glycolyl-GM2
glycan_dictionary_accession : GSD000130
glytoucan_accession : G56478LD
term_in_sentence : The monoclonal antibodies MK2-34 and MK1-16 (both IgM), which specifically detect N-glycolyl GM2 and N-acetyl GM2, respectively, were generated by immunizing mice with liposomes containing monophosphoryl lipid A, trehalose dimycolate, and the antigenic ganglioside.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]]
publication : [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]|11861662|17980710|3731079|[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107 25673107]
definition : (2S,4S,5R,6R)-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of carbohydrates and carbohydrate derivatives.[CHEBI:151464]
term_xref : GTC:G56478LD |GlycoEpitope:EP0052|CID:91845742|CHEBI:151464|GlycoEpitope:GGM.000096
synonyms :
function :
disease_associations : choriocarcinoma[GlycoEpitope:EP0052]|teratocarcinoma|[GlycoEpitope:EP0052]yolk sac tumor[GlycoEpitope:EP0052]
wikipedia :
essentials_of_glycobiology :
N-linked glycans
term (main_entry) : N-linked glycans
glycan_dictionary_accession : GSD000131
glytoucan_accession : G78059CC
term_in_sentence : Our study identifies extracellular N-linked glycans-and the glycoprotein neurexin 1β specifically-as key modulators of neuronal uptake of αSacetyl, drawing attention to the potential therapeutic value of αSacetyl-glycan interactions.[PMID:31211781]
publication : 31211781|28384382|30305477|31364612|26899268|29945790|29652253|29723274|30962676|29778448|25325701|31100702|28898525|22944671|19277537|24473128|17957771|27554083|15189166|11269317|[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919 19577919]|24303005|12042249|22191536|28324664|25965797|25434632|30484244|28110657|[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]|20129637|27346875|30280442|26911286|22491358|26582281|26398792|31548313|31066275|28331984|25482090|[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173 28518173]|30733536|22326428|30063825|30315103|21558494|[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555 31676555]|31256374
definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the nitrogen of an asparagine side-chain.[CHEBI:59520]
term_xref : GTC:G78059CC|CID:70679232|CHEBI:70967
synonyms :
function : N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374]|Affect transportation of the glycosylated proteins in the Golgi.[PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding.[PMID: 25151374]|extracellular N-glycans act as key modulators of neuronal uptake of αacetyl [PMID: 31211781].
disease_associations : Rheumatoid arthritis[PMID:17392038]|Type 1 Diabetes[PMID:29146600]|Lung Cancer[PMID: 23766031]
wikipedia :
essentials_of_glycobiology : Chapter 14
Nonfucosylated
term (main_entry) : Nonfucosylated
glycan_dictionary_accession : GSD000132
glytoucan_accession :
term_in_sentence : In the carbohydrate moiety , alpha-subunit from normal pregnancy hCG contained nonfucosylated , mono- and biantennary N-linked structures (49.3 and 36.7%, means); fucosylated biantennary and triantennary oligosaccharides were also identified (7.3 and 6.9%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]|30258536|23554380|16675584|26747427|22457527|24362443|19657637|8811881|19218011|20022111|17363544|17368483|20564614|27054024|28397880|[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688 31490688]|31860772|17012310|29633346|9442021|30350565|30296068|31800250|30021910|31133022|[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385 29224385]|[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087 28630087]|26444434|31697975|30991260
definition : glycans without a fucose component/monosaccharide residue.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Nonfucosylated biantennary
term (main_entry) : Nonfucosylated biantennary
glycan_dictionary_accession : GSD000133
glytoucan_accession :
term_in_sentence : Structural analysis combining methylation-mass spectrometry and 400 MHz 1H-n.m.r. spectrometry of oligosaccharide alditols released from human leucocyte lactotransferrin shows the presence of two disialylated and non-fucosylated biantennary glycans of the N-acetyl-lactosaminic type.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]]
publication : [https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]|1375510|9101715|[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]|2332109
definition : A biantennary glycan with two GlcNAc branches linked to the core and no fucose appears.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
Nonfucosylated biantennary N-Linked structures
term (main_entry) : Nonfucosylated biantennary N-Linked structures
glycan_dictionary_accession : GSD000134
glytoucan_accession :
term_in_sentence : The beta-subunit from normal pregnancy hCG contained fucosylated and nonfucosylated biantennary N-linked structures; however, mono- and triantennary oligosaccharides were also identified (4.6 and 13.7%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]
definition : A biantennary N-linked glycan with two GlcNAc branches linked to the core and no fucose appears.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Nonfucosylated triantennary
term (main_entry) : Nonfucosylated triantennary
glycan_dictionary_accession : GSD000135
glytoucan_accession :
term_in_sentence : Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.[PMID:7679920]
publication : 7679920|23274891
definition : A triantennary N-linked glycan with three GlcNAc branches linked to the core and no fucose appears.
term_xref :
synonyms :
function : Appears in human alpha-fetoprotein (AFP).[PMID:7679920]
disease_associations : hepatocellular carcinoma[PMID:7679920].
wikipedia :
essentials_of_glycobiology :
Nonsialylated
term (main_entry) : Nonsialylated
glycan_dictionary_accession : GSD000136
glytoucan_accession :
term_in_sentence : The pattern of nonsialylated oligosaccharides was used for interpretation of the fully sialylated species using bioinformatics tools. From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively. Glycan structures carry dominantly between 15 and 16 sialic acids indicating an almost complete termination of all antenae with sialic acid.[PMID:30295034]
publication : 14533820|1377689|9705949|30788437|28090561|12498371|26839900|[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688 31490688]|2656426|30295034|31545048|12381155|25730103|26787879|25646460|[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385 29224385]|26063435|26954852|32889432|2825412|27504786|22431161
definition : A glycan which is not sialylated.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
O-fucose glycans
term (main_entry) : O-fucose glycans
glycan_dictionary_accession : GSD000137
glytoucan_accession : G39294YF
term_in_sentence : Recently, a number of laboratories have shown that O-fucose glycans on the epidermal growth factor (EGF)-like repeats of the Notch extracellular domain modulate Notch signaling.[PMID:12417415]
publication : 19594638|30690220|[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191 18952191]|22415200|12417415|16400812|18948267|21464368|20816394|30207383|20301232|27129198|17132502|22492969|30030822|30214079|26175457|25378397|18272537|28729422|11524432|31722217|23045360|24803430|28876865|25700513|32518939|30523691|18227520|20816217|24909690|17964136|12036964|27268051|15653671|19948734|31590629|32201074|15189151|17263732|32913123|12909620|[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176 28785176]|17132500|22949680|25053492|28939751
definition : Form of glycosylation where the protein is modified by a fucose residue and can be extended futher to form a tetrasaccharide in certain cases. alpha-linked o-fucose have a consensus motif of C2X4(s/T)C3 where C2 and C3 are conserved cysteines number 2 and 3 respectively of the EGFR like repeats. [Essentials of Glycobiology:Chapter13]
term_xref : GTC:G39294YF|GlycoEpitope:EP0005
synonyms :
function : modification of Notch signaling.[GlycoEpitope:EP0005]
disease_associations :
wikipedia :
essentials_of_glycobiology :
O-GlcNAc
term (main_entry) : O-GlcNAc
glycan_dictionary_accession : GSD000138
glytoucan_accession : G49108TO
term_in_sentence : A better understanding of the mechanisms of OGT/OGA action would enable us to derive therapeutic benefits of resetting cellular O-GlcNAc levels within an optimal range.[PMID:30464755]
publication : 30464755|29049853|29594839|31654859|29404877|30105004|30669087|29790000|28408483|26862193|30523150|30037904|28408480|29352075|29456783|29577901|29223644|28638491|30221662|29904918|32155042|30298013|31630803|31847126|29784830|30181664|28768194|30134155|25336654|30356792|30199580|32329777|28408494|29774032|29044951|23836420|20301273|29772801|28922739|30100348|30793403|30657688|31237748|29756380|29954943|30018219|32207184|25566193|30626734|24759912|
definition : Form of glycosylation which exclusively occurs in the mitochondrial, cytoplasmic or nuclear compartments of the cell where the protein is modified by a GlcNAc monosaccharide on the serine or threonine residues and is generally not modified or elongated further to form more complex structures. [Essentials of Glycobiology:Chapter19]
term_xref : GTC:G49108TO|GlycoEpitope:EP0004|CID:24139|HMDB:HMDB0000803
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
O-linked glycans
term (main_entry) : O-linked glycans
glycan_dictionary_accession : GSD000139
glytoucan_accession :
term_in_sentence : Among these, six fucosylated N-linked glycansand four O-linked glycans exhibited significantly increased expression levels in GC, while five fucosylated N-linked glycans and ten fucosylated O-linked glycans exhibited significantly decreased expression levels in GC.[PMID:[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]]
publication : [https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]|30952424|31611643|[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919 19577919]|32019882|19139197|26184710|11159917|21536259|25186198|19277556|22261557|24115046|18725413|[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855 15966855]|24256304|25477510|10359703|24406064|22259135|29279989|[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855 15966855]|30619255|9673446|[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555 31676555]|28745859|28196325|27975143|30591584|[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173 28518173]|17522109|[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495 26328495]|32178593|27529638|24663386|22474328|28096352|27496768|[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191 18952191]|11135308|24917611|11532966|22786570|11891229|18332077|26867212|26925665|16769205|23475718|16005634|[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176 28785176]
definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the hydroxyl oxygen of serine, threonine, hydroxylysine or hydroxyproline side-chains.[CHEBI:59521]
term_xref : CHEBI:59521
synonyms :
function : Affects several important activities like protein stability, modulation of signaling molecules and enzyme activity.[PMID:9673446]
disease_associations :
wikipedia :
essentials_of_glycobiology :
O-linked mannose
term (main_entry) : O-linked mannose
glycan_dictionary_accession : GSD000140
glytoucan_accession : G59126YU
term_in_sentence : Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the first step toward the functional matriglycan structure on alpha-dystroglycan that is responsible for binding extracellular matrix proteins and certain arenaviruses.[PMID: 27932460]
publication : 27932460|24526361|25381909|26644575|23851827|28810660|19054127|23929950|21684258|22608994|28973932|24733390|31851597|29884773|28711406|14577328|21089343|14617637|9838223|17072003|[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495 26328495]|11181560|31949166|31988979|20362685|27733679|27493216|20044576|30643095|29732660|10580142|14568618|28079948|15467391|27812179|23761899|25737452|32930586|25381372|23434682|16857188|21452199|19429925|25361541|24297939|30322079|23428289|28427937|22746206|27533452|17502374|20816174|27496765
definition : O-linked glycans that are initiated by the addtion of a Man residue to Ser or Thr. Subsequent extension of the Man defines the O-Man core type, either M1, M2, or M3. The M1 type is initated by addition of a GlcNAc in β-linkage to the 2 position of the Man residue. M2 is initiated by addition of another GlcNAc to the 6 position of the M1 core. M3 is initiated by the addition of a GlcNAc in β-linkage to the 4 position of the Man residue. M1 and M2 type core glycans can be extended and branched with Gal, Fuc, Sialic Acid, and GlcA. The M3 core is uniquely extended by a multienzyme system to generate the matriglycan polysaccharide, a protein-specific modification found only on alpha-dystroglycan. [CHEBI:87761]
term_xref : GlycoMotif:GGM.000055|GTC:G59126YU|CHEBI:87761|GlycoEpitope:EP0002|CID:91859038
synonyms : O-mannosyl glycan
function :
disease_associations : MEB/muscle-eye-brain disease[GlycoEpitope:EP0002]|WWS/walker-warburg syndrome |muscular dystrophy[GlycoEpitope:EP0002]|neuronal migration disorder[GlycoEpitope:EP0002]|Muscle-Eye-Brain disease (MEB) and Walker-Warburg Syndrome (WWS) have mutations in genes encoding glycosyltransferases needed for O -mannosyl oligosaccharide synthesis[GlycoEpitope:EP0002]|Muscular dystrophy and neuronal migration disorder are caused by mutations in a glycosyltransferase, POMGnT1.[GlycoEpitope:EP0002]
wikipedia :
essentials_of_glycobiology :
P1 antigen
term (main_entry) : P1 antigen
glycan_dictionary_accession : GSD000141
glytoucan_accession : G12460DL
term_in_sentence : The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively.[PMID: 24046920]
publication : 29622537|26773500|24046920|6207232|8550516|6609976|6375319|817855|2428855|3312011|15364312|1937801|7729906
definition : An amino pentasaccharide consisting of α-D-galactose, β-D-galactose N-acetyl-α-D-glucosamine, β-D-galactose, and β-D-glucose residues joined in sequence with ((1→4)-, (1→4)-, (1→3)- and (1→4)-linkages, respectively.[CHEBI:68484]
term_xref : GlycoMotif:GGM.000069|GTC:G12460DL|CID:71296137|CHEBI:68484|SugarBind_Ligand:160
synonyms :
function :
disease_associations : Shigellosis[SugarBind_Ligand:160]
wikipedia :
essentials_of_glycobiology : Chapter 23
Para-Forssman glycolipid
term (main_entry) : Para-Forssman glycolipid
glycan_dictionary_accession : GSD000142
glytoucan_accession : G51699SI
term_in_sentence : A novel pentaglycosyl ceramide containing di-beta-N-acetylgalactos-aminyl residue (Para-Forssman glycolipid) isolated from human erythrocyte membrane. [PMID:6814203]
publication : 6814203
definition : GalNAcβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1→1Cer [https://doi.org/10.1016/S0040-4039(01)93814-6]
term_xref : GlycoMotif:GGM.000085|GTC:G51699SI|CID:56836111|KEGG:G00096|SugarBind_Ligand:19|CHEBI:151565
synonyms :
function :
disease_associations : Actinomycosis[SugarBind_Ligand:19]
wikipedia : https://en.wikipedia.org/wiki/P1PK_blood_group_system
essentials_of_glycobiology :
Paragloboside
term (main_entry) : Paragloboside
glycan_dictionary_accession : GSD000143
glytoucan_accession : G58896AZ
term_in_sentence : Galactosyltransferase activities in sera of cancer patients were determined by assaying the formation of paragloboside from UDP-galactose and lactotriaosylceramide immobilized on microtiter plates by means of the enzyme-linked immunosorbent assay using a monoclonal antibody, H-11, directed to paragloboside. [PMID: 1551117]
publication : 3345524|850070|10569746|30624951|29438961|6816790|1551117|6865961|25039255
definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→3)-D-GalpNAc in which the configuration at the GalNAc anomeric carbon is α.[CHEBI:65257]
term_xref : GlycoMotif:GGM.000077|GTC:G58896AZ|CID:21670519|CHEBI:65257|GlycoEpitope:EP0075|SugarBind_Ligand:15
synonyms :
function :
disease_associations : Pharyngitis[SugarBind_Ligand:15]|Tracheobronchitis[SugarBind_Ligand:15]|Gonorrhea[SugarBind_Ligand:15]|Actinomycosis[SugarBind_Ligand:15]|Diarrhea[SugarBind_Ligand:15]|Hemorrhagic colitis[SugarBind_Ligand:15]|Chronic gastritis[SugarBind_Ligand:15]|Peptic ulcers[SugarBind_Ligand:15]|Gastric cancer[SugarBind_Ligand:15]|Influenza[SugarBind_Ligand:15]
wikipedia :
essentials_of_glycobiology : Chapter 14
Paucimannose
term (main_entry) : Paucimannose
glycan_dictionary_accession : GSD000144
glytoucan_accession :
term_in_sentence : The galactosylation of core fucose (GalFuc epitope) in paucimannose and complex-type N-glycans is characteristic of protostome organisms, including flatworms (planarians).[PMID:29475940]
publication : 29475940|29803109|12603202|31817246|31719144|21057214|31932305|17132514|30382146|27731363|31325506|25746926|26513758|16522637|21169367|25190359|27928741|22496646|27384337|16897177|15228383|27379103|27189951|23475714|24907509|20558211|28060516|20441997|27720757|28817611|24550396|19494052|19515361|[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087 28630087]|31320997|30651366|30253927|25922361|31655162|18056652|24467287|32367383
definition : Any N-linked glycan derivative with composition Man1-4Fuc0-1 GlcNAc2, in which the chitobiose core (GlcNAc2) is intact. Found in relatively large amounts in invertebrates and plants, they are formed by removal of the non-reducing terminal GlcNAc (\added by GlcNAcT1) from GlcNAcMan3-5GlcNAc2 by a Golgi hexosaminidase and subsequent removal of Man residues by Golgi mannosidases. Pauscimannose glycans have also been detected in vertebrates.[CHEBI:144386]
term_xref : CHEBI:144386
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Polysialic acid
term (main_entry) : Polysialic acid
glycan_dictionary_accession : GSD000182
glytoucan_accession :
term_in_sentence : Polysialic acid (PSA) is a carbohydrate composed of a linear polymer of α2,8-linked sialic acids, primarily attached to the Neural Cell Adhesion Molecule (NCAM). [PMID:36076963]
publication : 36076963|35222358
definition :
term_xref : GlycoMotif:GGM.000252
synonyms : polySia|PSA
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sd(A)/Cad
term (main_entry) : Sd(A)/Cad
glycan_dictionary_accession : GSD000145
glytoucan_accession : G41052GC
term_in_sentence : The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2.[PMID:24112972]
publication : 24112972|11577689|30067891|15361072
definition : A branched amino tetrasaccharide comprised of a trisaccharide chain of N-acetyl-α-neuraminic acid, β-D-galactose and N-acetyl-β-D-glucosamine residues linked sequentially (2→3) and (1→4), to the galactose residue of which is also linked (1→4) an N-acetyl-β-L-galactosamine residue. [CHEBI:71561]
term_xref : GlycoMotif:GGM.000051|GTC:G41052GC|CID:70698375|CHEBI:71561
synonyms : Sd^a /Cad
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
SDlex
term (main_entry) : SDlex
glycan_dictionary_accession : GSD000146
glytoucan_accession : G19619KS
term_in_sentence : Hepatic expression of sialylated difucosyl Lex antigen (SDLex, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-) was studied with monoclonal antibody FH6, which defines this structure.[PMID: 3341453]
publication : 30226570|3341453|12725333
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-5-acetamido-6-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CHEBI:148203]
term_xref : GlycoMotif:GGM.000032|GTC:G19619KS|CID:91856705|CHEBI:148203
synonyms : Sdlex|SDLe^x|SDLex
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
Seminolipid
term (main_entry) : Seminolipid
glycan_dictionary_accession : GSD000147
glytoucan_accession : G72548RZ
term_in_sentence : A concise total synthesis of seminolipid, a sulfoglycolipid, has been achieved; key features include regioselective, tin-free sulfation of allyl β-d-galactopyranoside using 2,6-bis(trifluoromethyl)phenylboronic acid as protective reagent, stereoselective epoxidation, and site-selective acylation. [PMID: 31353379]
publication : 31353379|31736776|12810822|19582571|19542524|20670037|15659616|20817833|870059|10801776|21965315|8095813|1280685|4690236|34199863|4207869|2373957|845131
definition :
term_xref : GlycoMotif:GGM.000062|GTC:G72548RZ
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
Sialopentaosylceramide
term (main_entry) : Sialopentaosylceramide
glycan_dictionary_accession : GSD000148
glytoucan_accession : G13224CR
term_in_sentence : Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosap[PMID: 2139874]
publication : 2139874
definition : A ganglioside in which the oligosaccharide portion is composed of a pentasaccharide containing one or more sialic acid residues.[CHEBI:36542]
term_xref : GlycoMotif:GGM.000097|GTC:G13224CR|CID:91859576|CHEBI:148045|KEGG:G00883|CHEBI:36542
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sialosyl paragloboside
term (main_entry) : Sialosyl paragloboside
glycan_dictionary_accession : GSD000149
glytoucan_accession : G50123ZO
term_in_sentence : Unlike CNS myelin, human peripheral nerve myelin has the acidic glycosphingolipids sialosyl paragloboside (SPG), sialosyl lactosaminyl paragloboside (SLPG), and sulfated glucuronyl paragloboside (SGPG).[PMID:8862128]
publication : 8862128|7236652|2370108|3133978|2905604|1749114|1573418
definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-D-GlcpNAc with β configuration at the anomeric position of the reducing-end N-acetyl-D-glucosamine residue.[CHEBI:71612]
term_xref : GlycoMotif:GGM.000081|GTC:G50123ZO|CID:91845504|KEGG:G01429|CHEBI:151914
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sialyl Lewis a
term (main_entry) : Sialyl Lewis a
glycan_dictionary_accession : GSD000150
glytoucan_accession : G00053MO
term_in_sentence : By comparing the serum O-glycan profiles from healthy controls with those of cancer patients, we identified a marker candidate, core 1 sialyl Lewis A (NeuAcα2-3Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal) (abbreviated C1SLA), whose concentration appeared to be weakly correlated with CA19-9 values.[PMID:[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]]
publication : [https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]|31424423|26530370|17760270|18343410|16033091|8829184|11907351|20592391|[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]|24128856|30249386|10773785|16149606|10996727|10436809|10667238|7720892|7630017|10612415|9836451|12511721|22623153
definition : A sialyated version of Lewis A with a branched structure of amino tetrasaccharide consisting of a sialyl residue, linked (2→3) to a galactosyl residue that in turn is linked (1→3) to a glucosaminyl residue at the reducing end, which is also carrying a fucosyl residue at the 4-position.[CHEBI:62681]
term_xref : GTC:G00053MO|GlycoEpitope:EP0008|CID:53356732|CHEBI:62681|GlycoMotif:GGM.000024
synonyms : SLea|CA19-9|CA19-9 antigen|SLe^a|Slea
function : The carbohydrate determinants,Sialyl Lea and Sialyl Lex,which are frequently expressed on human cancer cells,serve as ligands for a cell adhesion molecule of the selectin family,E-selectin,which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0008]
disease_associations : pancreatic adenocarcinoma[GlycoEpitope:EP0008]|hepatocellular cancer[GlycoEpitope:EP0008]|cholangiocellular cancer[GlycoEpitope:EP0008]|gastric cancer|[GlycoEpitope:EP0008]colorectal cancer[GlycoEpitope:EP0008]|ovarian cancer[GlycoEpitope:EP0008]|lung cancer[GlycoEpitope:EP0008]|breast cancer[GlycoEpitope:EP0008]|uterine cancer[GlycoEpitope:EP0008]
wikipedia :
essentials_of_glycobiology :
Sialyl Lewis x
term (main_entry) : Sialyl Lewis x
glycan_dictionary_accession : GSD000151
glytoucan_accession : G00054MO
term_in_sentence : As sialyl Lewis X is a lignad of the selectin family, it has been proposed that sialyl Lewis X-rich colon cancer cells metastasize to the liver by adhesion to selectins on hepatic endothelial cells.[PMID:12828079]
publication : 12828079|[https://pubmed.ncbi.nlm.nih.gov/8940172 8940172 8940172]|10075923|19054801|[https://pubmed.ncbi.nlm.nih.gov/9642161 9642161 9642161]|31054033|15229399|29061785|16033070|10728707|9556613|[https://pubmed.ncbi.nlm.nih.gov/8940172 8940172 8940172]|9298692|18607721|22593503|25944902|[https://pubmed.ncbi.nlm.nih.gov/9642161 9642161 9642161]|15780091|20401888
definition : A sialylated version of Lewis X antigen expressed on cell surfaces with structure alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAcis α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-D-GlcpNAc in which the anomeric configuration of the reducing-end N-acetyl-beta-D-glucosamine residue is beta. It is a ligand for selectins. [MESH:[https://pubmed.ncbi.nlm.nih.gov/2030970 2030970 2030970],CHEI:71622]
term_xref : GTC:G00054MO |GlycoEpitope:EP0012|CID:44456859|CHEBI:71622|MESH:[https://pubmed.ncbi.nlm.nih.gov/2030970 2030970 2030970]|GlycoMotif:GGM.000022
synonyms : SLe(x)|SLe^x|SLex|Slex
function : Sialyl Lex was shown to be a specific ligand on human leukocytes for vascular E- and P-selectins,and was shown to mediate leukocyte recruitment.[GlycoEpitope:EP0012]|The determinant is also frequently expressed on human cancer cells,and is involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0012]
disease_associations : colon cancer[GlycoEpitope:EP0012]|colorectal cancer[GlycoEpitope:EP0012]
wikipedia :
essentials_of_glycobiology :
Sialyl Lewis x-i
term (main_entry) : Sialyl Lewis x-i
glycan_dictionary_accession : GSD000152
glytoucan_accession : G06597DS
term_in_sentence : Univariate analysis showed that survival of NSCLC patients with high (more than 100 units/ml) sialyl Lewis X-i antigen levels was significantly poorer than that of patients with low antigen levels (P = 0.0001).[PMID:9815711]
publication : 9815711|9730796|11867833|9713476|2819663|9372327|9615762|1352835|2575680|9330526|8753037|2210805|12680155|11974864|10453898|2565704|17144590
definition :
term_xref : GTC:G06597DS|GlycoEpitope:EP0043|CID:91855346|CHEBI:147019
synonyms :
function : hematogenous metastasis[GlycoEpitope:EP0043]|the progression of inflammation[GlycoEpitope:EP0043]
disease_associations : lung cancer[GlycoEpitope:EP0043]|ovarian cancer[GlycoEpitope:EP0043]|pancreatic adenocarcinoma[GlycoEpitope:EP0043]
wikipedia :
essentials_of_glycobiology :
Sialyl T antigen
term (main_entry) : Sialyl T antigen
glycan_dictionary_accession : GSD000153
glytoucan_accession : G65562ZE
term_in_sentence : The expression and functional analysis of the sialyl-T antigen in prostate cancer.[PMID:32583304]
publication : 32583304|31897478|31719620|[https://pubmed.ncbi.nlm.nih.gov/10365852 10365852 10365852]|25727149|11523928|20407596|25464017|30864133|26391208|19811634|29796594|23725156|8905873|11192238|18275089|27037304|11949946|15604091|24118321
definition : Alpha-Neup5Ac-(2→3)-beta-D-Galp-(1→3)-alpha-D-GalpNAc is alpha-Neup5Ac-(2→3)-beta-D-Galp-(1→3)-D-GalpNAc in which the configuration at the GalNAc anomeric carbon is alpha. It has a role as an epitope.[CHEBI:65257]
term_xref : GlycoMotif:GGM.000013|GTC:G65562ZE|CID:44611726|CHEBI:65257
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sialylated biantennary
term (main_entry) : Sialylated biantennary
glycan_dictionary_accession : GSD000154
glytoucan_accession :
term_in_sentence : Simbucus nigra agglutinin or an antibody specific to sialylated lactosamine with a preference for Neu5Acalpha2-6Gal rather than Neu5Acalpha2-3Gal reduced sperm binding to oviduct isthmic cells, as did occupying putative receptors on sperm with sialylated biantennary glycans.[PMID:23115267]
publication : 23115267|31510952|29265394|31589880|3979568|26045275|29029079|30252064
definition : A binantennary glycan with one or two sialic acid residues as non-reducing terminal residues on one or both antennae. [RN]
term_xref :
synonyms : sialyl biantennary
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sialylated complex-type
term (main_entry) : Sialylated complex-type
glycan_dictionary_accession : GSD000155
glytoucan_accession :
term_in_sentence : By using 1H-NMR spectroscopy we were able to establish that our product contains a single N-linked biantennary , fully sialylated complex-type oligosaccharide , typical of human hepatomas.[PMID:1694115]
publication : 1694115|15201278|30471292|30969765|11058758|28342150
definition : Complex N-linked glycan that have added GlcNAc residues at both the α-3 and α-6 mannose sites and do not contain mannose residues apart from the core structure but with sialic acid residues.
term_xref :
synonyms : sialo-complex type
function : enhance the signaling activity of soluble intercellular adhesion molecule-1 in mouse astrocytes [PMID: 15201278] Appears in IgG-Fc.[PMID:20647032 ]
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 10
Sialylated LacdiNAc
term (main_entry) : Sialylated LacdiNAc
glycan_dictionary_accession : GSD000192
glytoucan_accession : G55583HW
term_in_sentence : The major non-reducing epitopes in the complex-type glycans are: Gal beta 1-4GlcNAc (lacNAc), GalNAc beta 1-4GlcNAc (lacdiNAc), NeuAc alpha 2-6Gal beta 1-4GlcNAc (sialylated lacNAc), NeuAc alpha 2-6Gal beta 1-4GlcNAc (sialylated lacdiNAc), Gal beta 1-4(Fuc alpha 1-3)GlcNAc (Lewisx), and GalNAc beta 1-4(Fuc alpha 1-3)GlcNAc (lacdiNAc analogue of Lewisx).[PMID:7592613]
publication : 7592613|34192302|19756298|16286643
definition :
term_xref : GlycoMotif:GGM.000050
synonyms : sialylated-LacdiNAc|Sialylated LDN
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sialylated tetraantennary
term (main_entry) : Sialylated tetraantennary
glycan_dictionary_accession : GSD000156
glytoucan_accession :
term_in_sentence : A small amount of sialylated tetraantennary oligosaccharide was detected.[PMID:16321355]
publication : 16321355|1940447|27501865
definition : A tetraantennary glycan with four GlcNAc branches linked to the core and the addition of one sialic acid residues.
term_xref :
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sialyl-Tn antigen
term (main_entry) : Sialyl-Tn antigen
glycan_dictionary_accession : GSD000157
glytoucan_accession : G36123IU
term_in_sentence : The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.[PMID:23035012]
publication : 23035012|29273237|15770530|31595388|26617889|1720922|15466199|10971172|14652017|8616877|1543361|16965854|21566901|9269833|9834267|24970145|22367369|10778170|30018351|28628803|16149605|32134186|28632300|11308020|[https://pubmed.ncbi.nlm.nih.gov/10365852 10365852 10365852]|17195456|23567325|11014575|2342728|8575847|1851822|11735169|20960853|7846011
definition : N-acetyl-alpha-neuraminyl-(2→6)-N-acetyl-alpha-D-galactosamine is an N-acetyl-alpha-neuraminyl-(2→6)-N-acetyl-D-galactosamine in which the carbon bearing the anomeric hydroxy group has alpha configuration. It has a role as an epitope. It derives from a N-acetyl-alpha-D-galactosamine and a N-acetyl-alpha-neuraminic acid.[CHEBI:61818]
term_xref : GTC:G36123IU|GlycoEpitope:EP0022|CID:51351800|CHEBI:61818
synonyms :
function : apoptosis of monocyte-derived dendritic cells[GlycoEpitope:EP0022]|decrease of adhesion and increase of migration[GlycoEpitope:EP0022]|increase of tumor growth[GlycoEpitope:EP0022]|associated with morphological changes, decreased growth and increased migration of MDA-MB-231 cells.[GlycoEpitope:EP0022]
disease_associations : anaplastic meningioma[GlycoEpitope:EP0022]|Barrett's esophagus[GlycoEpitope:EP0022]|bladder cancer[GlycoEpitope:EP0022]|breast cancer[GlycoEpitope:EP0022]|colon cancer[GlycoEpitope:EP0022]|colorectal cancer[GlycoEpitope:EP0022]|erythroblastic leukemia[GlycoEpitope:EP0022]|esophageal cancer[GlycoEpitope:EP0022]|gastric cancer[GlycoEpitope:EP0022]|helicobacter pylori chronic gastritis(HpCG)[GlycoEpitope:EP0022]|liver cancer[GlycoEpitope:EP0022]|iterome cancer[GlycoEpitope:EP0022]|ovary tumor[GlycoEpitope:EP0022]|pancreas cancer[GlycoEpitope:EP0022]
wikipedia :
essentials_of_glycobiology : Chapter 56
SLex Core 2 O-glycan
term (main_entry) : SLex Core 2 O-glycan
glycan_dictionary_accession : GSD000158
glytoucan_accession : G97345NY
term_in_sentence : In particular, the sLeX-modified core 2 O-glycan structure C2-O-sLeX has been directly demonstrated to confer significantly higher affinity selectin binding than sLeX.[PMID:15596301]
publication : 15596301
definition :
term_xref : GlycoMotif:GGM.000053|GTC:G97345NY
synonyms : SLe^x Core 2 O-glycan
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
SSEA-1
term (main_entry) : SSEA-1
glycan_dictionary_accession : GSD000159
glytoucan_accession : G85497PI
term_in_sentence : Our findings suggest that expression of SSEA-1 immunoreactivity in thyroid neoplasms was associated with more aggressive thyroid carcinomas.[PMID:27550342]
publication : 27550342|25564944|30987116|10778174|19427293|24923741|28092949|16499901|10470652|18787210|2885312|16149609|17003364|27363517|15505339|27990704|2568298|20491542|23572256|1977666|9553168|[https://pubmed.ncbi.nlm.nih.gov/20458727 20458727 20458727]|2566639|14577357|20960856|15547746|9096265|30639212|1357195|1359630|20181261|20508065|2907526|22624699|22988836|17183690|27188587|7908065|10400391|6137429|1979260|2898921|14736812|30919971
definition :
term_xref : GTC:G85497PI |GlycoEpitope:EP0042|CID:91851144|CHEBI:154343
synonyms :
function : This determinant is specifically recognized by the antibody raised against stage-specific embryonic antigen-1 (SSEA-1)[GlycoEpitope:EP0042]. The SSEA-1 antibody requires Lex hapten carried by i-antigenic structure (e.g.,nor-nLc6Cer).[GlycoEpitope:EP0042]
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 10
SSEA-3
term (main_entry) : SSEA-3
glycan_dictionary_accession : GSD000160
glytoucan_accession : G25129BT
term_in_sentence : Glycosphingolipids (GSLs), such as the globo-series GSLs stage-specific embryonic antigen 3 (SSEA-3), SSEA-4, and Globo-H, are specifically expressed on pluripotent stem cells and cancer cells, and are known to be associated with various biological processes such as cell recognition, cell adhesion, and signal transduction.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31817926 31817926 31817926]]
publication : [https://pubmed.ncbi.nlm.nih.gov/31817926 31817926 31817926]|30271856|32684574|26677875|23175153|32525407|[https://pubmed.ncbi.nlm.nih.gov/29227830 29227830 29227830]|[https://pubmed.ncbi.nlm.nih.gov/18773292 18773292 18773292]|25561682|10837462|[https://pubmed.ncbi.nlm.nih.gov/2412924 2412924 2412924]|[https://pubmed.ncbi.nlm.nih.gov/21149348 21149348 21149348]|[https://pubmed.ncbi.nlm.nih.gov/17008424 17008424 17008424]|[https://pubmed.ncbi.nlm.nih.gov/2874662 2874662 2874662]|[https://pubmed.ncbi.nlm.nih.gov/25171543 25171543 25171543]|31304790|31642560|30484221|30525067|21161592|27325407|28170296|29637816|[https://pubmed.ncbi.nlm.nih.gov/27318475 27318475 27318475]|31346146|7648586|24236059|21964054|27456773|30558911|21559451|29312455|27549315|30599359|6141938|28883415|30733757|26041528|16643871
definition : An amino trisaccharide consisting of β-D-galactopyranose, 2-acetamido-2-deoxy-β-D-galactopyranose and α-D-galactopyranose residues joined in sequence by (1→3) glycosidic linkages.[CHEBI:149071]
term_xref : GTC:G25129BT|GlycoEpitope:EP0039|CID:91855781|CHEBI:149071|GlycoMotif:GGM.000079
synonyms :
function :
disease_associations : embryonal carcinoma[GlycoEpitope:EP0039]|teratocarcinoma[GlycoEpitope:EP0039]|yolk sac carcinoma[GlycoEpitope:EP0039]
wikipedia :
essentials_of_glycobiology :
SSEA-4
term (main_entry) : SSEA-4
glycan_dictionary_accession : GSD000161
glytoucan_accession : G84263XI
term_in_sentence : Glycosphingolipids (GSLs), such as the globo-series GSLs stage-specific embryonic antigen 3 (SSEA-3), SSEA-4, and Globo-H, are specifically expressed on pluripotent stem cells and cancer cells, and are known to be associated with various biological processes such as cell recognition, cell adhesion, and signal transduction.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31817926 31817926 31817926]]
publication : 27845370|[https://pubmed.ncbi.nlm.nih.gov/31817926 31817926 31817926]|26295543|[https://pubmed.ncbi.nlm.nih.gov/25171543 25171543 25171543]|25978997|30296654|25853231|24862940|31243630|28736232|22895512|24578244|29478902|23574147|23768762|27797400|[https://pubmed.ncbi.nlm.nih.gov/29227830 29227830 29227830]|[https://pubmed.ncbi.nlm.nih.gov/18773292 18773292 18773292]|25123923|22924692|22665977|23330736|31831622|31916611|[https://pubmed.ncbi.nlm.nih.gov/2412924 2412924 2412924]|16033656|24866102|[https://pubmed.ncbi.nlm.nih.gov/20458727 20458727 20458727]|[https://pubmed.ncbi.nlm.nih.gov/21149348 21149348 21149348]|26940129|[https://pubmed.ncbi.nlm.nih.gov/17008424 17008424 17008424]|[https://pubmed.ncbi.nlm.nih.gov/2874662 2874662 2874662]|23301556|27836003|19118716|24550271|32988880|22743677|20683402|17062733|23570331|30310530|31545316|23509763|24364909|18273440|28985528|22266579
definition :
term_xref : GTC:G84263XI|GlycoEpitope:EP0044|CID:91845478|CHEBI:154843
synonyms :
function :
disease_associations : teratocarcinoma[GlycoEpitope:EP0044]
wikipedia :
essentials_of_glycobiology : Chapter 47
Sulfated LacdiNAc
term (main_entry) : Sulfated LacdiNAc
glycan_dictionary_accession : GSD000191
glytoucan_accession : G18464VS
term_in_sentence : The mRNA expression of the enzymes related to the formation of sulfated LacdiNAc:β(1,4)-N-acetylgalactosaminyltransferases 3 (B4GALNT3) and 4 (B4GALNT4), carbohydrate sulfotransferases 8 (CHST8) and 9 (CHST9); and β(1,4)-galactosyltransferase 1 (B4GALT1) in these cells was confirmed by RT-PCR (Fig. S4).[PMID:31558607]
publication : 31558607|27318476|19756298|11279168|26688390
definition :
term_xref : GlycoMotif:GGM.000049
synonyms : 4'-O-sulfated LacdiNAc|4'-sulfated LDN|sulfated LDN
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Sulfatide
term (main_entry) : Sulfatide
glycan_dictionary_accession : GSD000162
glytoucan_accession : G72548RZ
term_in_sentence : In a previous study we found that sulfatide was efficient in lowering HIV-1 viral loads in SCID mice engrafted with human fetal liver/thymus tissues (SCID-hu).[PMID:23550344]
publication : 23550344|18465098|26542149|15158666|10434709|22619219|29676479|30196830|16143863|1052451|30400820|29887538|26981544|17986152|31739035|19941861|24578319|30531843|25645724|31197846|22821828|27861899|31037952|23593400|23604989|17855742|25966258|25989600|9657940|29497057|12838515|25170267|9878314|20554435|1410493|26585924|17257892|17044925|21089387|11445552|22977233|21437360|17179664|6273571|8370675
definition :
term_xref : GlycoMotif:GGM.000063|GTC:G72548RZ
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 47