Testhyperlink123
Globoside
term (main_entry) : Globoside
glycan_dictionary_accession : GSD000087
glytoucan_accession : G00061MO
term_in_sentence : Results of TLC immunostaining of neutral glycolipids from the cDNA-transfected cells also supported the identity of the newly synthesized component as globoside. [PMID:[https://pubmed.ncbi.nlm.nih.gov/0993897 0993897 10993897]]
publication : 10993897
definition :
term_xref : GlycoMotif:GGM.000070|GTC:G00061MO
synonyms : Cytolipin K|Gb4|Globoside I|Globotetraosylceramide|P antigen
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 47
Globotetraosylceramide
term (main_entry) : Globotetraosylceramide
glycan_dictionary_accession : GSD000088
glytoucan_accession : G00061MO
term_in_sentence : Here we report that PUGNAc treatment provokes globotetraosylceramide (Gb4Cer) accumulation in human umbilical vein endothelial cells (HUVEC).[PMID:[https://pubmed.ncbi.nlm.nih.gov/8392398 8392398 28392398]]
publication : 28392398|25787850|23471986|2559078|32455599|2663859|32796033|3517161|20082214|30853699|15279935|26104834|20732996|30224239|31142708|30338271|25033755|[https://pubmed.ncbi.nlm.nih.gov/30413389 30413389 30413389]|7104376|29866658|24983355|6794884|31361021|21740983|33168837|31752441|28123520|29068380|24841197|27932383|28535204|31691795|27916888|27558838|10227680|26464281|22348006|22279060|25156739|32314902|22718629|23701631|23906628|8613382|23555772|20059899|7868240
definition : An amino tetrasaccharide consisting of 2-acetamido-2-deoxy-β-D-galactopyranosyl, α-D-galactopyranosyl, β-D-galactopyranosyl, and β-D-glucopyranose units joined together in sequence by (1→3), (1→4), and (1→4) glycosidic linkages, respectively.[CHEBI:145578]
term_xref : GlycoMotif:GGM.000070|GlycoEpitope:EP0073|CID:5288889|CHEBI:145578|SugarBind_Ligand:18|MeSH:C024032
synonyms : Gb4Cer|Gb4|Globoside|P antigen|Cytolipin K
function :
disease_associations : Actinomycosis[SugarBind_Ligand:18]|Pyelonephritis[SugarBind_Ligand:18]|Acute cystitis[SugarBind_Ligand:18]|Shigellosis[SugarBind_Ligand:18]|Lazy leukocyte syndrome[SugarBind_Ligand:18]|Influenza[SugarBind_Ligand:18]
wikipedia :
essentials_of_glycobiology : Chapter 11
Globotriaosylceramide
term (main_entry) : Globotriaosylceramide
glycan_dictionary_accession : GSD000089
glytoucan_accession : G00059MO
term_in_sentence : Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) in various cell types.[PMID:32127409]
publication : 32127409|28674962|30875019|[https://pubmed.ncbi.nlm.nih.gov/30413389 30413389 30413389]|31778662|31101366|24335674|31241709|24158513|28947349|31566927|28672034|31939530|29530250|27851774|26426881|25031264|29982630|24496231|29983334|28756410|27190352|29274327|29099167|28402705|23680766|28625968|26960552|26797827|22742555|27756537|31630715|3827883|28384397|29523338|31010832|27195818|26661087|23093409|30879639|27081853|17409683|29921669|25575293|26291612|23146289|25857295|26070511
definition : Globotriaosylceramide is a type of globoside(glycosphingolipid) which is formed by alpha linkage of galactose to lactosylceramide. The reaction is catalyzed by enzyme A4GALT.[Wiki:Globotriaosylceramide]
term_xref : GlycoMotif:GGM.000068|GTC:G00059MO|GlycoEpitope:EP0071|CID:5279515|CHEBI:68485|MeSH:C018549|SugarBind_Ligand:27
synonyms : Gb3|GL3|Pk antigen|P^K antigen|Gb(3)|Gb_3|CD77|globotriaosylceramide|ceramide trihexoside|CTH|Trihexosylceramide
function :
disease_associations : Pyelonephritis[SugarBind_Ligand:27]|Acute cystitis[SugarBind_Ligand:27]|Shigellosis[SugarBind_Ligand:27]|Lyme disease[SugarBind_Ligand:27]|Cutaneous lesions[SugarBind_Ligand:27]|Diarrhea[SugarBind_Ligand:27]
wikipedia :
essentials_of_glycobiology :
Glucosylceramide
term (main_entry) : Glucosylceramide
glycan_dictionary_accession : GSD000090
glytoucan_accession : G71142DF
term_in_sentence : Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), is required for embryonic survival, but its role in the lung is unknown.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3126532 3126532 3126532]1]
publication : [https://pubmed.ncbi.nlm.nih.gov/3126532 3126532 3126532]1|29290548|29627573|20919653|28427052|30550553|24415933|31914593|31051284|23073611|30146946|31619618|26840726|29750412|8065509|27412675|27840079|[https://pubmed.ncbi.nlm.nih.gov/3061174 30611744 30611744]|31353719|25661072|28686011|25803043|28865794|28154347|31466334|30242129|12531551|30639288|30864417|27711049|22764777|27905603|29077010|28744000|23555901|24115322|12803919|29204666|23628459|28851512|26136173|23563543|30110701|26572681|2193825|29926415|31727994|27479571
definition : Cerebrosides which contain as their polar head group a glucose moiety bound in glycosidic linkage to the hydroxyl group of ceramides. Their accumulation in tissue, due to a defect in beta-glucosidase, is the cause of Gaucher's disease.[MeSH:D005963]
term_xref : MeSH:D005963|GlycoMotif:GGM.000060|CHEBI:83264|GTC:G71142DF
synonyms : GlcCer|Glucocerebroside|Ceramide monohexoside|CMH
function : The structural characterization of mixed membranes made of cationic lipids and glucosylceramides may be important for developing novel immunotherapeutic tools such as vaccine adjuvants.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3061174 30611744 30611744]]|Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), is required for embryonic survival, but its role in the lung is unknown.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3126532 3126532 3126532]1]
disease_associations : Gaucher's Disease|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3]
wikipedia :
essentials_of_glycobiology : Chapter 31
GM1
term (main_entry) : GM1
glycan_dictionary_accession : GSD000091
glytoucan_accession : G48558GR
term_in_sentence : GM1-induced fluidization of the phospholipid membranes and probable physical contact between bulky sugar head group of GM1 and spectrin, may explain the modulatory role of GM1 on aminophospholipid interactions with nonerythroid brain spectrin.[PMID: [https://pubmed.ncbi.nlm.nih.gov/2992023 2992023 2992023]8]
publication : [https://pubmed.ncbi.nlm.nih.gov/8524657 8524657 18524657]|[https://pubmed.ncbi.nlm.nih.gov/1761138 1761138 31761138]|[https://pubmed.ncbi.nlm.nih.gov/6180805 6180805 36180805]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2992023 2992023 2992023]8 [https://pubmed.ncbi.nlm.nih.gov/2992023 2992023 2992023]8]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3859490 3859490 3859490] 3[https://pubmed.ncbi.nlm.nih.gov/3859490 3859490 3859490]]|[https://pubmed.ncbi.nlm.nih.gov/1937438 1937438 31937438]|[https://pubmed.ncbi.nlm.nih.gov/5762012 5762012 25762012]|[https://pubmed.ncbi.nlm.nih.gov/5931034 5931034 25931034]|[https://pubmed.ncbi.nlm.nih.gov/1776384 1776384 31776384]|[https://pubmed.ncbi.nlm.nih.gov/2013258 2013258 32013258]|[https://pubmed.ncbi.nlm.nih.gov/0776097 0776097 30776097]|[https://pubmed.ncbi.nlm.nih.gov/1048748 1048748 31048748]|[https://pubmed.ncbi.nlm.nih.gov/1447771 1447771 31447771]|[https://pubmed.ncbi.nlm.nih.gov/0292198 0292198 30292198]|[https://pubmed.ncbi.nlm.nih.gov/8796418 8796418 28796418]|[https://pubmed.ncbi.nlm.nih.gov/7806275 7806275 27806275]|[https://pubmed.ncbi.nlm.nih.gov/1076871 1076871 21076871]|[https://pubmed.ncbi.nlm.nih.gov/7552916 7552916 27552916]|[https://pubmed.ncbi.nlm.nih.gov/7986147 7986147 17986147]|[https://pubmed.ncbi.nlm.nih.gov/6960162 6960162 26960162]|[https://pubmed.ncbi.nlm.nih.gov/7815022 7815022 27815022]|[https://pubmed.ncbi.nlm.nih.gov/5851126 5851126 25851126]|[https://pubmed.ncbi.nlm.nih.gov/2916822 2916822 32916822]|[https://pubmed.ncbi.nlm.nih.gov/1462671 1462671 11462671]|[https://pubmed.ncbi.nlm.nih.gov/8236574 8236574 28236574]|[https://pubmed.ncbi.nlm.nih.gov/5911874 5911874 15911874]|[https://pubmed.ncbi.nlm.nih.gov/8577204 8577204 28577204]|[https://pubmed.ncbi.nlm.nih.gov/8497346 8497346 28497346]|1794005|[https://pubmed.ncbi.nlm.nih.gov/1934908 1934908 31934908]|[https://pubmed.ncbi.nlm.nih.gov/0267299 0267299 30267299]|[https://pubmed.ncbi.nlm.nih.gov/6902585 6902585 16902585]|[https://pubmed.ncbi.nlm.nih.gov/9439846 9439846 29439846]|[https://pubmed.ncbi.nlm.nih.gov/2325905 2325905 32325905]|[https://pubmed.ncbi.nlm.nih.gov/9747823 9747823 29747823]|[https://pubmed.ncbi.nlm.nih.gov/7576485 7576485 27576485]|[https://pubmed.ncbi.nlm.nih.gov/6338710 6338710 26338710]|[https://pubmed.ncbi.nlm.nih.gov/7858734 7858734 27858734]|[https://pubmed.ncbi.nlm.nih.gov/4501414 4501414 24501414]|[https://pubmed.ncbi.nlm.nih.gov/6818965 6818965 26818965]|[https://pubmed.ncbi.nlm.nih.gov/6629687 6629687 26629687]|[https://pubmed.ncbi.nlm.nih.gov/6958633 6958633 26958633]|1854596|[https://pubmed.ncbi.nlm.nih.gov/2134593 2134593 32134593]|[https://pubmed.ncbi.nlm.nih.gov/2198666 2198666 32198666]|6619101
definition : A branched amino pentasaccharide consisting of the linear sequence β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the inner galactose via an α-(2→3) linkage. The oligosaccharide of ganglioside GM1a.[CHEBI:59208]
term_xref : GlycoMotif:GGM.000098|GTC:G48558GR|CID:196569|CHEBI:59208|GlycoEpitope:EP0050|SugarBind_Ligand:13|KEGG:G00110
synonyms : GM1 ganglioside|GM1-ganglioside
function : The branched pentasaccharide chain of ganglioside GM1 is a prominent cell surface ligand, for example, for cholera toxin or tumor growth-regulatory homodimeric galectins.[PMID:[https://pubmed.ncbi.nlm.nih.gov/6267866 6267866/ 16267866]]
disease_associations : GM1 gangliosidosis (GM1) [PMID: [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3859490 3859490 3859490]/ 3[https://pubmed.ncbi.nlm.nih.gov/3859490 3859490 3859490]]]|Gastroenteritis[SugarBind_Ligand:13]|Actinomycosis[SugarBind_Ligand:13]|Lazy leukocyte syndrome[SugarBind_Ligand:13]|Toxoplasmosis[SugarBind_Ligand:13]|Cholera[SugarBind_Ligand:13]|Botulism[SugarBind_Ligand:13]
wikipedia : https://en.wikipedia.org/wiki/GM1
essentials_of_glycobiology : Chapter 11| Chapter 14
GM2
term (main_entry) : GM2
glycan_dictionary_accession : GSD000092
glytoucan_accession : G79389NT
term_in_sentence : GM1 gangliosidosis has both central nervous system and systemic findings; while, GM2 gangliosidosis is restricted primarily to the central nervous system.[PMID: [https://pubmed.ncbi.nlm.nih.gov/2749121 2749121 2749121]4]
publication : [https://pubmed.ncbi.nlm.nih.gov/9618308 9618308 29618308]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2749121 2749121 2749121]4 [https://pubmed.ncbi.nlm.nih.gov/2749121 2749121 2749121]4]|[https://pubmed.ncbi.nlm.nih.gov/2867370 2867370 32867370]|[https://pubmed.ncbi.nlm.nih.gov/0030044 0030044 30030044]|[https://pubmed.ncbi.nlm.nih.gov/7499644 7499644 27499644]|[https://pubmed.ncbi.nlm.nih.gov/1097363 1097363 31097363]|[https://pubmed.ncbi.nlm.nih.gov/9100724 9100724 29100724]|[https://pubmed.ncbi.nlm.nih.gov/7402091 7402091 27402091]|[https://pubmed.ncbi.nlm.nih.gov/1852956 1852956 31852956]|[https://pubmed.ncbi.nlm.nih.gov/0389374 0389374 30389374]|[https://pubmed.ncbi.nlm.nih.gov/0988135 0988135 30988135]|8786814|[https://pubmed.ncbi.nlm.nih.gov/4533808 4533808 14533808]|[https://pubmed.ncbi.nlm.nih.gov/3370522 3370522 23370522]|[https://pubmed.ncbi.nlm.nih.gov/8192816 8192816 28192816]|[https://pubmed.ncbi.nlm.nih.gov/2692591 2692591 32692591]|[https://pubmed.ncbi.nlm.nih.gov/9106755 9106755 29106755]|[https://pubmed.ncbi.nlm.nih.gov/8833537 8833537 28833537]|[https://pubmed.ncbi.nlm.nih.gov/1339652 1339652 11339652]|9728335|[https://pubmed.ncbi.nlm.nih.gov/7270764 7270764 27270764]|9714704|[https://pubmed.ncbi.nlm.nih.gov/6175473 6175473 26175473]|[https://pubmed.ncbi.nlm.nih.gov/7018595 7018595 27018595]|[https://pubmed.ncbi.nlm.nih.gov/8615102 8615102 28615102]|[https://pubmed.ncbi.nlm.nih.gov/8974375 8974375 28974375]|[https://pubmed.ncbi.nlm.nih.gov/2951593 2951593 32951593]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1146267 1146267 1146267]2 [https://pubmed.ncbi.nlm.nih.gov/1146267 1146267 1146267]2]|[https://pubmed.ncbi.nlm.nih.gov/8955902 8955902 28955902]|[https://pubmed.ncbi.nlm.nih.gov/7192692 7192692 17192692]|[https://pubmed.ncbi.nlm.nih.gov/6538065 6538065 26538065]|[https://pubmed.ncbi.nlm.nih.gov/5421609 5421609 25421609]|9572057|[https://pubmed.ncbi.nlm.nih.gov/1596983 1596983 11596983]|[https://pubmed.ncbi.nlm.nih.gov/5264019 5264019 15264019]|[https://pubmed.ncbi.nlm.nih.gov/3236285 3236285 23236285]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1159698 1159698 1159698]4 [https://pubmed.ncbi.nlm.nih.gov/1159698 1159698 1159698]4]|[https://pubmed.ncbi.nlm.nih.gov/1261761 1261761 31261761]|[https://pubmed.ncbi.nlm.nih.gov/0113798 0113798 30113798]|[https://pubmed.ncbi.nlm.nih.gov/4391178 4391178 24391178]|[https://pubmed.ncbi.nlm.nih.gov/4309906 4309906 24309906]|[https://pubmed.ncbi.nlm.nih.gov/2224667 2224667 22224667]|7980537|[https://pubmed.ncbi.nlm.nih.gov/8272501 8272501 18272501]|9006924|
definition : A branched amino tetrasaccharide consisting of the linear sequence β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the galactose via an α-(2→3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2.[CHEBI:59220]
term_xref : GlycoMotif:GGM.000095|GTC:G79389NT|CID:45266845|CHEBI:59220|GlycoEpitope:EP0051|SugarBind_Ligand:39|KEGG:G00109|KEGG:G10351
synonyms :
function :
disease_associations : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051]|Gastroenteritis[SugarBind_Ligand:39]|Cholera[SugarBind_Ligand:39]|Clostridial myonecrosis[SugarBind_Ligand:39]|Tetanus[SugarBind_Ligand:39]
wikipedia : https://en.wikipedia.org/wiki/GM1_gangliosidoses
essentials_of_glycobiology : Chapter 11
GM3
term (main_entry) : GM3
glycan_dictionary_accession : GSD000093
glytoucan_accession : G91237TK
term_in_sentence : We also demonstrated an essential role of GM3 in murine and human auditory systems; a common pathological feature of GM3S deficiency is deafness. [PMID: [https://pubmed.ncbi.nlm.nih.gov/2974781 2974781 2974781]3]
publication : [https://pubmed.ncbi.nlm.nih.gov/9376491 9376491 29376491]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2974781 2974781 2974781]3 [https://pubmed.ncbi.nlm.nih.gov/2974781 2974781 2974781]3]|[https://pubmed.ncbi.nlm.nih.gov/5613425 5613425 25613425]|[https://pubmed.ncbi.nlm.nih.gov/0318083 0318083 30318083]|[https://pubmed.ncbi.nlm.nih.gov/1526872 1526872 31526872]|[https://pubmed.ncbi.nlm.nih.gov/1004109 1004109 31004109]|[https://pubmed.ncbi.nlm.nih.gov/8019668 8019668 28019668]|[https://pubmed.ncbi.nlm.nih.gov/6434718 6434718 26434718]|[https://pubmed.ncbi.nlm.nih.gov/7313500 7313500 27313500]|[https://pubmed.ncbi.nlm.nih.gov/7539856 7539856 27539856]|[https://pubmed.ncbi.nlm.nih.gov/0111401 0111401 30111401]|[https://pubmed.ncbi.nlm.nih.gov/8544772 8544772 28544772]|[https://pubmed.ncbi.nlm.nih.gov/9407985 9407985 29407985]|[https://pubmed.ncbi.nlm.nih.gov/9364317 9364317 19364317]|[https://pubmed.ncbi.nlm.nih.gov/0190430 0190430 30190430]|[https://pubmed.ncbi.nlm.nih.gov/1297734 1297734 31297734]|[https://pubmed.ncbi.nlm.nih.gov/0091781 0091781 30091781]|[https://pubmed.ncbi.nlm.nih.gov/6043887 6043887 26043887]|[https://pubmed.ncbi.nlm.nih.gov/2183071 2183071 32183071]|[https://pubmed.ncbi.nlm.nih.gov/0665141 0665141 30665141]|[https://pubmed.ncbi.nlm.nih.gov/7873002 7873002 27873002]|[https://pubmed.ncbi.nlm.nih.gov/5801320 5801320 25801320]|[https://pubmed.ncbi.nlm.nih.gov/0209782 0209782 30209782]|[https://pubmed.ncbi.nlm.nih.gov/2378734 2378734 32378734]|[https://pubmed.ncbi.nlm.nih.gov/3050851 3050851 23050851]|[https://pubmed.ncbi.nlm.nih.gov/2768242 2768242 22768242]|[https://pubmed.ncbi.nlm.nih.gov/4993837 4993837 14993837]|[https://pubmed.ncbi.nlm.nih.gov/4934090 4934090 24934090]|[https://pubmed.ncbi.nlm.nih.gov/7638075 7638075 17638075]|[https://pubmed.ncbi.nlm.nih.gov/1518140 1518140 21518140]|[https://pubmed.ncbi.nlm.nih.gov/6102277 6102277 26102277]|[https://pubmed.ncbi.nlm.nih.gov/9759399 9759399 19759399]|[https://pubmed.ncbi.nlm.nih.gov/4502144 4502144 24502144]|[https://pubmed.ncbi.nlm.nih.gov/5303960 5303960 25303960]|[https://pubmed.ncbi.nlm.nih.gov/3564406 3564406 23564406]|[https://pubmed.ncbi.nlm.nih.gov/6636105 6636105 16636105]|[https://pubmed.ncbi.nlm.nih.gov/6491123 6491123 16491123]|[https://pubmed.ncbi.nlm.nih.gov/1259118 1259118 11259118]|[https://pubmed.ncbi.nlm.nih.gov/5102521 5102521 15102521]|[https://pubmed.ncbi.nlm.nih.gov/2724312 2724312 12724312]|[https://pubmed.ncbi.nlm.nih.gov/4985965 4985965 24985965]|8496625|[https://pubmed.ncbi.nlm.nih.gov/5403557 5403557 25403557]|[https://pubmed.ncbi.nlm.nih.gov/5690123 5690123 15690123]|[https://pubmed.ncbi.nlm.nih.gov/5939439 5939439 15939439]|[https://pubmed.ncbi.nlm.nih.gov/5893133 5893133 25893133]|[https://pubmed.ncbi.nlm.nih.gov/3591593 3591593 23591593]|[https://pubmed.ncbi.nlm.nih.gov/0634908 0634908 20634908]|2004380|739008|
definition : Ganglioside GM3 (d18:1/16:0) is a glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GM3 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissuesGangliosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Gangliosides are very similar to globosides except that they also contain N-acetyl neuraminic acid (NANA) in varying amounts. The specific names for the gangliosides provide information about their structure. The letter G refers to ganglioside, and the subscripts M, D, T and Q indicate that the molecule contains mono-, di-, tri and quatra-sialic acid. The numbered subscripts 1, 2 and 3 refer to the carbohydrate sequence that is attached to the ceramide. In particular, 1 stands for GalGalNAcGalGlc-ceramide, 2 stands for GalNAcGalGlc-ceramide and 3 stands for GalGlc-ceramide. Deficiencies in lysosomal enzymes that degrade the carbohydrate portions of various gangliosides are responsible for a number of lysosomal storage diseases such as Tay-Sachs disease, Sandhoff disease, and GM1 gangliosidosis. The carbohydrate portion of the ganglioside GM1 is the site of attachment of cholera toxin, the protein secreted by Vibrio cholerae.[HMDB0004844]
term_xref : GlycoMotif:GGM.000090|GTC:G91237TK|CID:5288424|CHEBI:59226|GlycoEpitope:EP0053|SugarBind_Ligand:35
synonyms :
function : Membrane stabilizer|Energy source|Energy storage|Molecular messenger:|Signaling molecule[HMDB0004844]
disease_associations : Gastroenteritis[SugarBind_Ligand:35]|Chronic gastritis[SugarBind_Ligand:35]|Toxoplasmosis[SugarBind_Ligand:35]|Peptic ulcerSugarBind_Ligand:35]|Gastric cancer[SugarBind_Ligand:35]|Influenza[SugarBind_Ligand:35]|Diarrhea[SugarBind_Ligand:35]|Botulism[SugarBind_Ligand:35]
wikipedia :
essentials_of_glycobiology : Chapter 37
GM4
term (main_entry) : GM4
glycan_dictionary_accession : GSD000094
glytoucan_accession : G30207PZ
term_in_sentence : GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3999868 3999868 3999868] 2[https://pubmed.ncbi.nlm.nih.gov/3999868 3999868 3999868]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3999868 3999868 3999868] 2[https://pubmed.ncbi.nlm.nih.gov/3999868 3999868 3999868]]|2332419|[https://pubmed.ncbi.nlm.nih.gov/2091485 2091485 12091485]|[https://pubmed.ncbi.nlm.nih.gov/9542236 9542236 19542236]|8407875|[https://pubmed.ncbi.nlm.nih.gov/3320941 3320941 23320941]|[https://pubmed.ncbi.nlm.nih.gov/8808804 8808804 28808804]|3621237|[https://pubmed.ncbi.nlm.nih.gov/3203271 3203271 23203271]|7057115|[https://pubmed.ncbi.nlm.nih.gov/6362868 6362868 26362868]|6170387|[https://pubmed.ncbi.nlm.nih.gov/8034482 8034482 18034482]|7076644|2391348|[https://pubmed.ncbi.nlm.nih.gov/5464080 5464080 25464080]|3701369|[https://pubmed.ncbi.nlm.nih.gov/1217952 1217952 11217952]|6201236|[https://pubmed.ncbi.nlm.nih.gov/0744426 0744426 30744426]|9388026|[https://pubmed.ncbi.nlm.nih.gov/7177620 7177620 27177620]|[https://pubmed.ncbi.nlm.nih.gov/0246056 0246056 30246056]|[https://pubmed.ncbi.nlm.nih.gov/5979459 5979459 15979459]|7586078|6779816|[https://pubmed.ncbi.nlm.nih.gov/9402905 9402905 29402905]|7335153|3306476|[https://pubmed.ncbi.nlm.nih.gov/7499534 7499534 17499534]|7074082|9668345|3701884|[https://pubmed.ncbi.nlm.nih.gov/6862430 6862430 26862430]|6831238|[https://pubmed.ncbi.nlm.nih.gov/7311552 7311552 27311552]|[https://pubmed.ncbi.nlm.nih.gov/6831445 6831445 26831445]|[https://pubmed.ncbi.nlm.nih.gov/4417799 4417799 24417799]|7097284|4169231|[https://pubmed.ncbi.nlm.nih.gov/6854400 6854400 16854400]|[https://pubmed.ncbi.nlm.nih.gov/6483798 6483798 26483798]
definition : An amino disaccharide consisting of β-D-galactose having an α-N-acetylneuraminyl residue attached at the 3-position [CHEBI:63155]
term_xref : GlycoMotif:GGM.000089|GTC:G30207PZ|CID:5289366|CHEBI:63155|KEGG:G00317|SugarBind_Ligand:110
synonyms : Sialylated GalCer
function :
disease_associations : Chronic gastritis[SugarBind_Ligand:110]|Peptic ulcers[SugarBind_Ligand:110]|Gastric cancer[SugarBind_Ligand:110]
wikipedia :
essentials_of_glycobiology : Chapter 11|Chapter 15|Chapter 44|Appendix 45A
GP1c
term (main_entry) : GP1c
glycan_dictionary_accession : GSD000095
glytoucan_accession : G93805MV
term_in_sentence : n this report, we describe an efficient convergent synthesis of the GP1c glycolipid epitope, which is one of the most complex c-series gangliosides. [PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9053458 9053458 9053458] 1[https://pubmed.ncbi.nlm.nih.gov/9053458 9053458 9053458]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358] [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9053458 9053458 9053458] 1[https://pubmed.ncbi.nlm.nih.gov/9053458 9053458 9053458]]|[https://pubmed.ncbi.nlm.nih.gov/1695858 1695858 1695858]|4091974|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/0775425 0775425 0775425] 1[https://pubmed.ncbi.nlm.nih.gov/0775425 0775425 0775425]]|[https://pubmed.ncbi.nlm.nih.gov/2468656 2468656 2468656]|[https://pubmed.ncbi.nlm.nih.gov/2299350 2299350 2299350]|3064875|[https://pubmed.ncbi.nlm.nih.gov/1432974 1432974 11432974]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9613831 9613831 9613831] [https://pubmed.ncbi.nlm.nih.gov/9613831 9613831 9613831]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1831845 1831845 1831845] 1[https://pubmed.ncbi.nlm.nih.gov/1831845 1831845 1831845]]|1879553|[https://pubmed.ncbi.nlm.nih.gov/0699494 0699494 10699494]|8969459|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/8474578 8474578 8474578] [https://pubmed.ncbi.nlm.nih.gov/8474578 8474578 8474578]]|[https://pubmed.ncbi.nlm.nih.gov/2031286 2031286 12031286]|1304332|[https://pubmed.ncbi.nlm.nih.gov/9153001 9153001 9153001]|[https://pubmed.ncbi.nlm.nih.gov/0564776 0564776 10564776]
definition :
term_xref : GlycoMotif:GGM.000118|GTC:G93805MV
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 11|Chapter 14|Chapter 27|Chapter 35|Chapter 45 |Chapter 47|Chapter 49
GQ1b
term (main_entry) : GQ1b
glycan_dictionary_accession : GSD000096
glytoucan_accession : G18625KA
term_in_sentence : Bilateral infusion of GQ1b into the hippocampus ameliorates cognitive deficits in the triple-transgenic AD mouse model (3xTg-AD).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1186474 1186474 1186474] 3[https://pubmed.ncbi.nlm.nih.gov/1186474 1186474 1186474]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/0798387 0798387 30798387]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1186474 1186474 1186474] 3[https://pubmed.ncbi.nlm.nih.gov/1186474 1186474 1186474]]|[https://pubmed.ncbi.nlm.nih.gov/6704905 6704905 26704905]|[https://pubmed.ncbi.nlm.nih.gov/3677659 3677659 23677659]|[https://pubmed.ncbi.nlm.nih.gov/6984947 6984947 26984947]|[https://pubmed.ncbi.nlm.nih.gov/4184316 4184316 24184316]|[https://pubmed.ncbi.nlm.nih.gov/3804237 3804237 23804237]|9819299|[https://pubmed.ncbi.nlm.nih.gov/8514410 8514410 18514410]|[https://pubmed.ncbi.nlm.nih.gov/2189683 2189683 22189683]|[https://pubmed.ncbi.nlm.nih.gov/4859332 4859332 24859332]
definition : An amino oligosaccharide that is a branched octasaccharide derivative consisting of four sialyl residues, two galactose residues, one N-acetylglucosamine and a glucose residue at the reducing end.[CHEBI:59212]
term_xref : GlycoMotif:GGM.000115|GTC:G18625KA|GlycoEpitope:EP0069|CID:45266843|KEGG:G00117|CHEBI:59212
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 11
GQ1ba
term (main_entry) : GQ1ba
glycan_dictionary_accession : GSD000097
glytoucan_accession : G54733XO
term_in_sentence : A few studies have reported the association of autoantibodies to GM1 or GQ1bα with Alzheimer's disease (AD) or vascular dementia.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/5024341 5024341 5024341] 2[https://pubmed.ncbi.nlm.nih.gov/5024341 5024341 5024341]]]
publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/5024341 5024341 5024341] 2[https://pubmed.ncbi.nlm.nih.gov/5024341 5024341 5024341]]|[https://pubmed.ncbi.nlm.nih.gov/3717411 3717411 23717411]|[https://pubmed.ncbi.nlm.nih.gov/7870542 7870542 17870542]|[https://pubmed.ncbi.nlm.nih.gov/0702226 0702226 10702226]|[https://pubmed.ncbi.nlm.nih.gov/1137678 1137678 21137678]|[https://pubmed.ncbi.nlm.nih.gov/6748510 6748510 26748510]|8662799|[https://pubmed.ncbi.nlm.nih.gov/1274438 1274438 21274438]|[https://pubmed.ncbi.nlm.nih.gov/4649890 4649890 24649890]|[https://pubmed.ncbi.nlm.nih.gov/6580208 6580208 16580208]|[https://pubmed.ncbi.nlm.nih.gov/8124591 8124591 28124591]|[https://pubmed.ncbi.nlm.nih.gov/0095613 0095613 20095613]|[https://pubmed.ncbi.nlm.nih.gov/7507233 7507233 17507233]|[https://pubmed.ncbi.nlm.nih.gov/3565921 3565921 23565921]|[https://pubmed.ncbi.nlm.nih.gov/4505645 4505645 14505645]|[https://pubmed.ncbi.nlm.nih.gov/0930939 0930939 20930939]|9201997
definition :
term_xref : GlycoMotif:GGM.000116|GTC:G54733XO
synonyms : GQ1balpha
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GQ1c
term (main_entry) : GQ1c
glycan_dictionary_accession : GSD000098
glytoucan_accession : G99524KA
term_in_sentence : The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with Gq1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1.[PMID: 6640289]
publication : 6640289|[https://pubmed.ncbi.nlm.nih.gov/1695858 1695858 1695858]|[https://pubmed.ncbi.nlm.nih.gov/7798936 7798936 7798936]|1729139|[https://pubmed.ncbi.nlm.nih.gov/2468656 2468656 2468656]|[https://pubmed.ncbi.nlm.nih.gov/0368669 0368669 20368669]|[https://pubmed.ncbi.nlm.nih.gov/2723647 2723647 2723647]|1814411|3064875|6085330|[https://pubmed.ncbi.nlm.nih.gov/1613492 1613492 1613492]|[https://pubmed.ncbi.nlm.nih.gov/7883393 7883393 17883393]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1831845 1831845 1831845] 1[https://pubmed.ncbi.nlm.nih.gov/1831845 1831845 1831845]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/0775425 0775425 0775425] 1[https://pubmed.ncbi.nlm.nih.gov/0775425 0775425 0775425]]|8219015|8804704|1384262|[https://pubmed.ncbi.nlm.nih.gov/7066685 7066685 7066685]|2299192|[https://pubmed.ncbi.nlm.nih.gov/9613831 9613831 9613831]|10350354|1304337|9153001|11959025|[https://pubmed.ncbi.nlm.nih.gov/8474578 8474578 8474578]|2299350|10564776|10699494|3942818|12031286|[https://pubmed.ncbi.nlm.nih.gov/7361620 7361620 7361620]
definition : Alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-[alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)]-beta-D-Galp-(1->4)-beta-D-Glcp is a member of neuraminic acids and an amino octasaccharide.[CID:91860352]
term_xref : GlycoMotif:GGM.000117|GTC:G99524KA|CID:91860352|CHEBI:145645|KEGG:G00121
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 46
GT1a
term (main_entry) : GT1a
glycan_dictionary_accession : GSD000099
glytoucan_accession : G68110IF
term_in_sentence : GT1a mimicry was found in the lipo-oligosaccharides of strain ICDCCJ07002 and ICDCCJ07004; but a combination of GM3/GD3 mimics was observed in ICDCCJ07001, although this patient had anti-GT1a IgG antibodies.[PMID:26197476]
publication : 12023422|32623212|26197476|9585812|29747820|23804237|11993188|31683059|19631994|9742882|29709941|8971119|8706663|893404|31829433|[https://pubmed.ncbi.nlm.nih.gov/8910600 8910600 8910600]|30600291|29319803|26176883|29063860|6766128|31602715|29808463|30711390|29847988|30116054|28187751
definition : A branched heptasaccharide derivative consisting of three sialyl residues, two galactose residues, one N-acetylglucosamine and a glucose residue at the reducing end.[CHEBI:59215]
term_xref : CID:45266863|GlycoMotif:GGM.000110|GTC:G68110IF|GlycoEpitope:EP0066|KEGG:G00112|CHEBI:59215
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GT1a alpha
term (main_entry) : GT1a alpha
glycan_dictionary_accession : GSD000100
glytoucan_accession : G02149VR
term_in_sentence : A new class of gangliosides, GT1a alpha and GQ1b alpha, were initially identified as cholinergic neuron-specific antigens in bovine brain. [PMID:8082783]
publication : 7710562|8082783|10972137|9468624|9143254|8221098|9679279|11368158|11878808
definition :
term_xref : GlycoMotif:GGM.000111|GTC:G02149VR|GlycoEpitope:EP0111|CID:91851751|CHEBI:156678|KEGG:G00128
synonyms : GT1aa
function : GT1a alpha was a cholinerginic-specific antigen.[GlycoEpitope:EP0111]
disease_associations :
wikipedia :
essentials_of_glycobiology :
GT1b
term (main_entry) : GT1b
glycan_dictionary_accession : GSD000101
glytoucan_accession : G40183QN
term_in_sentence : GT1b ganglioside is axonally transported to the spinal cord dorsal horn and contributes to characteristics of neuropathic pain such as mechanical and thermal hypersensitivity.[PMID: 32030804]
publication : 32030804|26370787|32046393|9712688|7636307|9931455|25520869|19605473|17188834|10233751|22735313|20540782|22746533|1861141|19490186|9521848|11921200|10731661|31431523|15274627|32726962|12573517|18277613|11370834|11234774|11123278|18704164|16291967|11411041|27549393|25253868|22720883|10686582|11511306|29904724|31472390|19156870
definition : A branched amino heptasaccharide comprising a β-D-galactosyl-(1→4)-β-D-glucose disaccharide, the galactosyl residue of which carries an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl trisaccharide unit and an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl disaccharide unit through (2→4) and (2→3) linkages respectively. It corresponds to the carbohydrate portion of ganglioside GT1b.[CHEBI:59225]
term_xref : GlycoMotif:GGM.000112|GTC:G40183QN|GlycoEpitopeEP0067|CID:45266781|CHEBI:59225| GlycoGlycoEpitope:130680|SugarBind_Ligand:26|KEGG:G00116
synonyms :
function :
disease_associations : Toxoplasmosis[SugarBind_Ligand:26]|Lyme disease[SugarBind_Ligand:26]|Cholera[SugarBind_Ligand:26]|Botulism[SugarBind_Ligand:26]|Tetanus[SugarBind_Ligand:26]|Influenza[SugarBind_Ligand:26]
wikipedia :
essentials_of_glycobiology :
GT1c
term (main_entry) : GT1c
glycan_dictionary_accession : GSD000102
glytoucan_accession : G78818SP
term_in_sentence : We show here that VVH associates with ganglioside GM1a, Fucosyl-GM1, GD1a, GT1c, and GD1b by glycan array.[PMID: 32228455]
publication : 28088450|30085356|32228455|2468656|19841910|23877172|1695858|10564776|1613492|[https://pubmed.ncbi.nlm.nih.gov/8474578 8474578 8474578]|7798936|11180643|2723647|[https://pubmed.ncbi.nlm.nih.gov/7066685 7066685 7066685]|[https://pubmed.ncbi.nlm.nih.gov/9613831 9613831 9613831]|[https://pubmed.ncbi.nlm.nih.gov/7361620 7361620 7361620]|10699494
definition : A branched amino heptasaccharide consisting of a linear tetrasaccharide of β-D-galactose, N-acetyl-β-D-galactosamine, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→4) and (1→4), to the galactose residue proximal to the reducing end is also linked (2→3) an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl trisaccharide side-chain. The carbohydrate moiety of ganglioside GT1c.[CHEBI:90509]
term_xref : GlycoMotif:GGM.000113|GTC:G78818SP|CID:91846734|CHEBI:90509|GlycoEpitope:EP0033|KEGG:G00120
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
GT2
term (main_entry) : GT2
glycan_dictionary_accession : GSD000103
glytoucan_accession : G36476BA
term_in_sentence : Biosynthesis of the c-series gangliosides GT3, GT2 and GP1c was studied in Golgi derived from rat liver.[PMID:[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]]
publication : [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]|15498585|16005859|27540730|31533196|31201844
definition : A branched amino hexasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4), to the galactosyl residue of which is also linked (1→4) an N-acetyl-β-D-galactosaminyl residue. The carbohydrate moiety of ganglioside GT2.[CHEBI:72446]
term_xref : GlycoMotif:GGM.000109|GTC:G36476BA|CID:70788971|CHEBI:72446|KEGG:G00119
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 11
GT3
term (main_entry) : GT3
glycan_dictionary_accession : GSD000104
glytoucan_accession : G93899SO
term_in_sentence : The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound.[PMID: 28029115]
publication : 28029115|31355968|30987413|27869747|27216753|8631981|29672891|10385047|29642403|10412028|27193023|30068561|23415908|8858920|2303428|27153057|27128741|2654294|26930378|7561885|25860286|30845647|24712339|30070965|[https://pubmed.ncbi.nlm.nih.gov/8910600 8910600 8910600]|[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]|27356050|8514740|18509108|23000517|29769046|29566611
definition : A linear amino pentasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4).[CHEBI:72444]
term_xref : GlycoEpitope:EP0070|KEGG:G00118|CID:70788970|GlycoMotif:GGM.000092|GTC:G93899SO|CHEBI:72444
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 11