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===GSD000031===
===GSD000101===
  '''term (main_entry)''' : Blood group A1 (Type 3) <br>
  '''term (main_entry)''' : GT1b <br>
  '''glycan_dictionary_accession''' : GSD000031 <br>
  '''glycan_dictionary_accession''' : GSD000101 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G44060QH G44060QH] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G40183QN G40183QN] <br>
  '''term_in_sentence''' : The structure is essentially a repetitive A epitope attached to type 2 chain and is hereby called type 3 chain A. [PMID:[https://pubmed.ncbi.nlm.nih.gov/2579390 2579390]] <br>
  '''term_in_sentence''' : GT1b ganglioside is axonally transported to the spinal cord dorsal horn and contributes to characteristics of neuropathic pain such as mechanical and thermal hypersensitivity.[PMID: [https://pubmed.ncbi.nlm.nih.gov/32030804 32030804]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2579390 2579390]|[https://pubmed.ncbi.nlm.nih.gov/19756298 19756298] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/32030804 32030804]|[https://pubmed.ncbi.nlm.nih.gov/26370787 26370787]|[https://pubmed.ncbi.nlm.nih.gov/32046393 32046393]|[https://pubmed.ncbi.nlm.nih.gov/9712688 9712688]|[https://pubmed.ncbi.nlm.nih.gov/7636307 7636307]|[https://pubmed.ncbi.nlm.nih.gov/9931455 9931455]|[https://pubmed.ncbi.nlm.nih.gov/25520869 25520869]|[https://pubmed.ncbi.nlm.nih.gov/19605473 19605473]|[https://pubmed.ncbi.nlm.nih.gov/17188834 17188834]|[https://pubmed.ncbi.nlm.nih.gov/10233751 10233751]|[https://pubmed.ncbi.nlm.nih.gov/22735313 22735313]|[https://pubmed.ncbi.nlm.nih.gov/20540782 20540782]|[https://pubmed.ncbi.nlm.nih.gov/22746533 22746533]|[https://pubmed.ncbi.nlm.nih.gov/1861141 1861141]|[https://pubmed.ncbi.nlm.nih.gov/19490186 19490186]|[https://pubmed.ncbi.nlm.nih.gov/9521848 9521848]|[https://pubmed.ncbi.nlm.nih.gov/11921200 11921200]|[https://pubmed.ncbi.nlm.nih.gov/10731661 10731661]|[https://pubmed.ncbi.nlm.nih.gov/31431523 31431523]|[https://pubmed.ncbi.nlm.nih.gov/15274627 15274627]|[https://pubmed.ncbi.nlm.nih.gov/32726962 32726962]|[https://pubmed.ncbi.nlm.nih.gov/12573517 12573517]|[https://pubmed.ncbi.nlm.nih.gov/18277613 18277613]|[https://pubmed.ncbi.nlm.nih.gov/11370834 11370834]|[https://pubmed.ncbi.nlm.nih.gov/11234774 11234774]|[https://pubmed.ncbi.nlm.nih.gov/11123278 11123278]|[https://pubmed.ncbi.nlm.nih.gov/18704164 18704164]|[https://pubmed.ncbi.nlm.nih.gov/16291967 16291967]|[https://pubmed.ncbi.nlm.nih.gov/11411041 11411041]|[https://pubmed.ncbi.nlm.nih.gov/27549393 27549393]|[https://pubmed.ncbi.nlm.nih.gov/25253868 25253868]|[https://pubmed.ncbi.nlm.nih.gov/22720883 22720883]|[https://pubmed.ncbi.nlm.nih.gov/10686582 10686582]|[https://pubmed.ncbi.nlm.nih.gov/11511306 11511306]|[https://pubmed.ncbi.nlm.nih.gov/29904724 29904724]|[https://pubmed.ncbi.nlm.nih.gov/31472390 31472390]|[https://pubmed.ncbi.nlm.nih.gov/19156870 19156870] <br>
  '''definition''' : A branched amino heptasaccharide made up from two repeating (1→3)-linked N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl units that are in turn joined to an N-acetyl-β-D-glucosamine residue via a (1→4)-linkage.[CHEBI:85665] <br>
  '''definition''' : A branched amino heptasaccharide comprising a β-D-galactosyl-(1→4)-β-D-glucose disaccharide, the galactosyl residue of which carries an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl trisaccharide unit and an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl disaccharide unit through (2→4) and (2→3) linkages respectively. It corresponds to the carbohydrate portion of ganglioside GT1b.[CHEBI:59225] <br>
  '''term_xref''' : GTC:G44060QH|CHEBI:85665|CID:91825676|GlycoMotif:GGM.000040 <br>
  '''term_xref''' : GlycoMotif:GGM.000112|GTC:G40183QN|GlycoEpitopeEP0067|CID:[https://pubmed.ncbi.nlm.nih.gov/45266781 45266781]|CHEBI:59225| GlycoGlycoEpitope:130680|SugarBind_Ligand:26|KEGG:G00116 <br>
  '''synonyms''' : Blood group A1 (type 3)|Blood Group A1 <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : Toxoplasmosis[SugarBind_Ligand:26]|Lyme disease[SugarBind_Ligand:26]|Cholera[SugarBind_Ligand:26]|Botulism[SugarBind_Ligand:26]|Tetanus[SugarBind_Ligand:26]|Influenza[SugarBind_Ligand:26] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000032===
===GSD000102===
[[File:G62735WZ.png|thumb|G62735WZ]]
[[File:G78818SP.png|thumb|G78818SP]]
  '''term (main_entry)''' : Blood group A2 (A-associated H type 3) <br>
  '''term (main_entry)''' : GT1c <br>
  '''glycan_dictionary_accession''' : GSD000032 <br>
  '''glycan_dictionary_accession''' : GSD000102 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G62735WZ G62735WZ] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G78818SP G78818SP] <br>
  '''term_in_sentence''' : The H NMR spectrum of the associated H antigen (type 3 chain H) was characterized by the unusual presence of three n-anomeric resonances ('CJ'.~ = 3-4 Hz) in addition to five resonances from @-anomeric protons ("J1:2 = 7-9 Hz).[PMID: [https://pubmed.ncbi.nlm.nih.gov/3944091 3944091]]
  '''term_in_sentence''' : We show here that VVH associates with ganglioside GM1a, Fucosyl-GM1, GD1a, GT1c, and GD1b by glycan array.[PMID: [https://pubmed.ncbi.nlm.nih.gov/32228455 32228455]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/3944091 3944091]|[https://pubmed.ncbi.nlm.nih.gov/29000000 29000000]|[https://pubmed.ncbi.nlm.nih.gov/28658771 28658771] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28088450 28088450]|[https://pubmed.ncbi.nlm.nih.gov/30085356 30085356]|[https://pubmed.ncbi.nlm.nih.gov/32228455 32228455]|[https://pubmed.ncbi.nlm.nih.gov/2468656 2468656]|[https://pubmed.ncbi.nlm.nih.gov/19841910 19841910]|[https://pubmed.ncbi.nlm.nih.gov/23877172 23877172]|[https://pubmed.ncbi.nlm.nih.gov/1695858 1695858]|[https://pubmed.ncbi.nlm.nih.gov/10564776 10564776]|[https://pubmed.ncbi.nlm.nih.gov/1613492 1613492]|[https://pubmed.ncbi.nlm.nih.gov/8474578 8474578]|[https://pubmed.ncbi.nlm.nih.gov/7798936 7798936]|[https://pubmed.ncbi.nlm.nih.gov/11180643 11180643]|[https://pubmed.ncbi.nlm.nih.gov/2723647 2723647]|[https://pubmed.ncbi.nlm.nih.gov/7066685 7066685]|[https://pubmed.ncbi.nlm.nih.gov/9613831 9613831]|[https://pubmed.ncbi.nlm.nih.gov/7361620 7361620]|[https://pubmed.ncbi.nlm.nih.gov/10699494 10699494] <br>
  '''definition''' : A branched amino hexasaccharide in which an α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine linear pentasaccharide carries at the galactose residue proximal to the reducing end a second α-L-fucosyl residue via a (1→2) linkage.[CHEBI:152543] <br>
  '''definition''' : A branched amino heptasaccharide consisting of a linear tetrasaccharide of β-D-galactose, N-acetyl-β-D-galactosamine, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→4) and (1→4), to the galactose residue proximal to the reducing end is also linked (2→3) an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl trisaccharide side-chain. The carbohydrate moiety of ganglioside GT1c.[CHEBI:90509] <br>
  '''term_xref''' : CHEBI:152543|CID: 91852328|GlycoMotif:GGM.000041|GTC:G62735WZ <br>
  '''term_xref''' : GlycoMotif:GGM.000113|GTC:G78818SP|CID:[https://pubmed.ncbi.nlm.nih.gov/91846734 91846734]|CHEBI:90509|GlycoEpitope:EP0033|KEGG:G00120 <br>
  '''synonyms''' : Blood Group A2|Fuca1-2Galb1-3GalNAca1-3(Fuca1-2)Galb1-4GlcNAcb|Fuc(a1-2)Gal(b1-3)GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-4)b-GlcNAc|Fucalpha1-2Galbeta1-3GalNAcalpha1-3(Fucalpha1-2)Galbeta1-4GlcNAcbeta|6-deoxy-alpha-L-galacto-hexopyranosyl-(1→2)-beta-D-galacto-hexopyranosyl-(1→3)-2-acetamido-2-deoxy-alpha-D-galacto-hexopyranosyl-(1→3)-[6-deoxy-alpha-L-galacto-hexopyranosyl-(1→2)]-beta-D-galacto-hexopyranosyl-(1→4)-2-acetamido-2-deoxy-beta-D-gluco-hexopyranose|6-deoxy-alpha-L-galactopyranosyl-(1→2)-[6-deoxy-alpha-L-galactopyranosyl-(1→2)-beta-D-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-alpha-D-galactopyranosyl-(1→3)]-beta-D-galactopyranosyl-(1→4)-2-acetamido-2-deoxy-beta-D-glucopyranose <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
Line 31: Line 31:




===GSD000033===
===GSD000103===
[[File:G31734OS.png|thumb|G31734OS]]
  '''term (main_entry)''' : GT2 <br>
  '''term (main_entry)''' : Blood group B (Type 1) <br>
  '''glycan_dictionary_accession''' : GSD000103 <br>
  '''glycan_dictionary_accession''' : GSD000033 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G36476BA G36476BA] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G31734OS G31734OS] <br>
  '''term_in_sentence''' : Biosynthesis of the c-series gangliosides GT3, GT2 and GP1c was studied in Golgi derived from rat liver.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358] [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358]]] <br>
  '''term_in_sentence''' : The minimal binding epitope was identified as the blood group H type 1 determinant (Fucα2Galβ3GlcNAc), while an optimal binding epitope was created by addition of the terminal α3-linked galactose or N-acetylgalactosamine of the blood group B type 1 determinant (Galα3(Fucα2)Galβ3GlcNAc) and the blood group A type 1 determinant (GalNAcα3(Fucα2)-Galβ3GlcNAc). [PMID: [https://pubmed.ncbi.nlm.nih.gov/19208633 19208633]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358] [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358]]|[https://pubmed.ncbi.nlm.nih.gov/15498585 15498585]|[https://pubmed.ncbi.nlm.nih.gov/16005859 16005859]|[https://pubmed.ncbi.nlm.nih.gov/27540730 27540730]|[https://pubmed.ncbi.nlm.nih.gov/31533196 31533196]|[https://pubmed.ncbi.nlm.nih.gov/31201844 31201844] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/18701592 18701592]|[https://pubmed.ncbi.nlm.nih.gov/24749871 24749871]|[https://pubmed.ncbi.nlm.nih.gov/19387828 19387828]|[https://pubmed.ncbi.nlm.nih.gov/19208633 19208633]|[https://pubmed.ncbi.nlm.nih.gov/29562255 29562255] <br>
  '''definition''' : A branched amino hexasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4), to the galactosyl residue of which is also linked (1→4) an N-acetyl-β-D-galactosaminyl residue. The carbohydrate moiety of ganglioside GT2.[CHEBI:72446] <br>
  '''definition''' : α-D-Galp-(1→3)-[α-L-Fucp-(1→2)]-β-D-Galp-(1→3)-β-D-GlcpNAc with β configuration at the anomeric carbon of the GlcNAc residue at the reducing end.[CHEBI:63242] <br>
  '''term_xref''' : GlycoMotif:GGM.000109|GTC:G36476BA|CID:[https://pubmed.ncbi.nlm.nih.gov/70788971 70788971]|CHEBI:72446|KEGG:G00119  <br>
  '''term_xref''' : GlycoMotif:GGM.000043|GTC:G31734OS|CID:56927779|CHEBI:63242 <br>
  '''synonyms''' : <br>
  '''synonyms''' : blood group B type 1 tetrasaccharide <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>




===GSD000034===
===GSD000104===
  '''term (main_entry)''' : Blood group B (Type 2) <br>
  '''term (main_entry)''' : GT3 <br>
  '''glycan_dictionary_accession''' : GSD000034 <br>
  '''glycan_dictionary_accession''' : GSD000104 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G34881WK G34881WK] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G93899SO G93899SO] <br>
  '''term_in_sentence''' : The detection of a B type 2 determinant is the first chemical evidence for the presence of an autologous difucosyl blood group B type 2 antigen in human adenocarcinoma cells.[PMID: [https://pubmed.ncbi.nlm.nih.gov/2432062 2432062]] <br>
  '''term_in_sentence''' : The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound.[PMID: [https://pubmed.ncbi.nlm.nih.gov/28029115 28029115]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2432062 2432062]|[https://pubmed.ncbi.nlm.nih.gov/27196314 27196314]|[https://pubmed.ncbi.nlm.nih.gov/18701592 18701592] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28029115 28029115]|[https://pubmed.ncbi.nlm.nih.gov/31355968 31355968]|[https://pubmed.ncbi.nlm.nih.gov/30987413 30987413]|[https://pubmed.ncbi.nlm.nih.gov/27869747 27869747]|[https://pubmed.ncbi.nlm.nih.gov/27216753 27216753]|[https://pubmed.ncbi.nlm.nih.gov/8631981 8631981]|[https://pubmed.ncbi.nlm.nih.gov/29672891 29672891]|[https://pubmed.ncbi.nlm.nih.gov/10385047 10385047]|[https://pubmed.ncbi.nlm.nih.gov/29642403 29642403]|[https://pubmed.ncbi.nlm.nih.gov/10412028 10412028]|[https://pubmed.ncbi.nlm.nih.gov/27193023 27193023]|[https://pubmed.ncbi.nlm.nih.gov/30068561 30068561]|[https://pubmed.ncbi.nlm.nih.gov/23415908 23415908]|[https://pubmed.ncbi.nlm.nih.gov/8858920 8858920]|[https://pubmed.ncbi.nlm.nih.gov/2303428 2303428]|[https://pubmed.ncbi.nlm.nih.gov/27153057 27153057]|[https://pubmed.ncbi.nlm.nih.gov/27128741 27128741]|[https://pubmed.ncbi.nlm.nih.gov/2654294 2654294]|[https://pubmed.ncbi.nlm.nih.gov/26930378 26930378]|[https://pubmed.ncbi.nlm.nih.gov/7561885 7561885]|[https://pubmed.ncbi.nlm.nih.gov/25860286 25860286]|[https://pubmed.ncbi.nlm.nih.gov/30845647 30845647]|[https://pubmed.ncbi.nlm.nih.gov/24712339 24712339]|[https://pubmed.ncbi.nlm.nih.gov/30070965 30070965]|[https://pubmed.ncbi.nlm.nih.gov/8910600 8910600]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358] [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358]]|[https://pubmed.ncbi.nlm.nih.gov/27356050 27356050]|[https://pubmed.ncbi.nlm.nih.gov/8514740 8514740]|[https://pubmed.ncbi.nlm.nih.gov/18509108 18509108]|[https://pubmed.ncbi.nlm.nih.gov/23000517 23000517]|[https://pubmed.ncbi.nlm.nih.gov/29769046 29769046]|[https://pubmed.ncbi.nlm.nih.gov/29566611 29566611] <br>
  '''definition''' : <br>
  '''definition''' : A linear amino pentasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4).[CHEBI:72444] <br>
  '''term_xref''' : GlycoMotif:GGM.000037|GTC:G34881WK|GlycoEpitope:EP0262 <br>
  '''term_xref''' : GlycoEpitope:EP0070|KEGG:G00118|CID:[https://pubmed.ncbi.nlm.nih.gov/70788970 70788970]|GlycoMotif:GGM.000092|GTC:G93899SO|CHEBI:72444 <br>
  '''synonyms''' : blood group B type 2 <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>




===GSD000035===
===GSD000105===
  '''term (main_entry)''' : Blood group B (Type 4) <br>
[[File:G94435QH.png|thumb|G94435QH]]
  '''glycan_dictionary_accession''' : GSD000035 <br>
  '''term (main_entry)''' : Blood group H (Type 3) <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G25216QA G25216QA] <br>
  '''glycan_dictionary_accession''' : GSD000105 <br>
  '''term_in_sentence''' : The blood group B type-4 heptaglycosylceramide is a minor blood group B structure in human B kidneys in contrast to the corresponding A type-4 compound in A kidneys.[PMID:[https://pubmed.ncbi.nlm.nih.gov/1390942 1390942]] <br>
  '''glytoucan_accession ''' : [https://glygen.org/glycan/G94435QH G94435QH]<br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/1390942 1390942]|[https://pubmed.ncbi.nlm.nih.gov/1841684 1841684] <br>
  '''term_in_sentence''' : One particular lambody, VLRB.aGPA.23, was shown by glycan array analysis to be selective for the blood group H type 3 trisaccharide (BG-H3, Fucα1-2Galβ1-3GalNAcα), aGPA, and TFα (Galβ1-3GalNAcα), with affinity constants of 0.2, 1, and 8 nM, respectively.[PMID:[https://pubmed.ncbi.nlm.nih.gov/23030719 23030719]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/23030719 23030719]|[https://pubmed.ncbi.nlm.nih.gov/20466654 20466654]|[https://pubmed.ncbi.nlm.nih.gov/1563908 1563908]|[https://pubmed.ncbi.nlm.nih.gov/3944092 3944092]|[https://pubmed.ncbi.nlm.nih.gov/11218748 11218748]|[https://pubmed.ncbi.nlm.nih.gov/11101633 11101633]|[https://pubmed.ncbi.nlm.nih.gov/18842005 18842005]|[https://pubmed.ncbi.nlm.nih.gov/27550195 27550195]|[https://pubmed.ncbi.nlm.nih.gov/2469783 2469783]|[https://pubmed.ncbi.nlm.nih.gov/2433836 2433836]|[https://pubmed.ncbi.nlm.nih.gov/23118206 23118206]|[https://pubmed.ncbi.nlm.nih.gov/8445257 8445257]|[https://pubmed.ncbi.nlm.nih.gov/2664192 2664192]|[https://pubmed.ncbi.nlm.nih.gov/3063304 3063304] <br>
  '''definition''' :  <br>
  '''definition''' :  <br>
  '''term_xref''' : GlycoMotif:GGM.000087|GTC:G25216QA  <br>
  '''term_xref''' : GlycoMotif:GGM.000010|GTC:G94435QH<br>
  '''synonyms''' : <br>
  '''synonyms''' : H type 3|H antigen (type 3)|Type 3 chain H <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>




===GSD000036===
===GSD000106===
  '''term (main_entry)''' : Blood group H (Type 1) <br>
  '''term (main_entry)''' : Heparan sulfate <br>
  '''glycan_dictionary_accession''' : GSD000036 <br>
  '''glycan_dictionary_accession''' : GSD000106 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00294TN G00294TN] <br>
  '''glytoucan_accession ''' : <br>
  '''term_in_sentence''' : Blood group H type 1 [Fuc alpha (1,2)Gal beta (1,3)GlcNAc beta-->] is known as the precursor structure of the blood group determinant, Lewis b [Fuc alpha (1,2)Gal beta (1,3)(Fuc alpha (1,4))GlcNAc beta-->].[PMID:[https://pubmed.ncbi.nlm.nih.gov/7718581 7718581]] <br>
  '''term_in_sentence''' : In Niemann-Pick C-1 fibroblasts, where deaminative degradation of heparan sulfate is defective, carbonylated proteins were abundant.[PMID: 17540770] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/7718581 7718581]|[https://pubmed.ncbi.nlm.nih.gov/6309836 6309836]|[https://pubmed.ncbi.nlm.nih.gov/19208633 19208633]|[https://pubmed.ncbi.nlm.nih.gov/27431816 27431816]| [https://pubmed.ncbi.nlm.nih.gov/2432062 2432062]|[https://pubmed.ncbi.nlm.nih.gov/24219248 24219248]|[https://pubmed.ncbi.nlm.nih.gov/6352465 6352465]|[https://pubmed.ncbi.nlm.nih.gov/8499478 8499478]|[https://pubmed.ncbi.nlm.nih.gov/3348768 3348768]|[https://pubmed.ncbi.nlm.nih.gov/3718924 3718924] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/32266657 32266657]|[https://pubmed.ncbi.nlm.nih.gov/29554552 29554552]|[https://pubmed.ncbi.nlm.nih.gov/29032302 29032302]|[https://pubmed.ncbi.nlm.nih.gov/30003471 30003471]|[https://pubmed.ncbi.nlm.nih.gov/25197032 25197032]|[https://pubmed.ncbi.nlm.nih.gov/28538085 28538085]|[https://pubmed.ncbi.nlm.nih.gov/26236728 26236728]|[https://pubmed.ncbi.nlm.nih.gov/16917509 16917509]|[https://pubmed.ncbi.nlm.nih.gov/22899865 22899865]|[https://pubmed.ncbi.nlm.nih.gov/17080204 17080204]|[https://pubmed.ncbi.nlm.nih.gov/23042481 23042481]|[https://pubmed.ncbi.nlm.nih.gov/28982096 28982096]|[https://pubmed.ncbi.nlm.nih.gov/24146040 24146040]|[https://pubmed.ncbi.nlm.nih.gov/25081076 25081076]|[https://pubmed.ncbi.nlm.nih.gov/15719168 15719168]|[https://pubmed.ncbi.nlm.nih.gov/17453622 17453622]|[https://pubmed.ncbi.nlm.nih.gov/25325954 25325954]|[https://pubmed.ncbi.nlm.nih.gov/21110089 21110089]|[https://pubmed.ncbi.nlm.nih.gov/29797526 29797526]|[https://pubmed.ncbi.nlm.nih.gov/21967329 21967329]|[https://pubmed.ncbi.nlm.nih.gov/23313092 23313092]|[https://pubmed.ncbi.nlm.nih.gov/11212344 11212344]|[https://pubmed.ncbi.nlm.nih.gov/28465034 28465034]|[https://pubmed.ncbi.nlm.nih.gov/11746174 11746174]|[https://pubmed.ncbi.nlm.nih.gov/12512855 12512855]|[https://pubmed.ncbi.nlm.nih.gov/8836040 8836040]|[https://pubmed.ncbi.nlm.nih.gov/28394734 28394734]|[https://pubmed.ncbi.nlm.nih.gov/24182748 24182748]|[https://pubmed.ncbi.nlm.nih.gov/28264929 28264929]|[https://pubmed.ncbi.nlm.nih.gov/28745308 28745308]|[https://pubmed.ncbi.nlm.nih.gov/26555370 26555370]|[https://pubmed.ncbi.nlm.nih.gov/14718374 14718374]|[https://pubmed.ncbi.nlm.nih.gov/16767693 16767693]|[https://pubmed.ncbi.nlm.nih.gov/25246018 25246018]|[https://pubmed.ncbi.nlm.nih.gov/19584012 19584012]|[https://pubmed.ncbi.nlm.nih.gov/8274190 8274190]|[https://pubmed.ncbi.nlm.nih.gov/25034023 25034023]|[https://pubmed.ncbi.nlm.nih.gov/8370471 8370471]|[https://pubmed.ncbi.nlm.nih.gov/26571620 26571620]|[https://pubmed.ncbi.nlm.nih.gov/29920400 29920400]|[https://pubmed.ncbi.nlm.nih.gov/31731076 31731076]|[https://pubmed.ncbi.nlm.nih.gov/20816205 20816205]|[https://pubmed.ncbi.nlm.nih.gov/16880267 16880267]|[https://pubmed.ncbi.nlm.nih.gov/31547957 31547957]|[https://pubmed.ncbi.nlm.nih.gov/11457867 11457867]|[https://pubmed.ncbi.nlm.nih.gov/27241222 27241222]|[https://pubmed.ncbi.nlm.nih.gov/28718936 28718936]|[https://pubmed.ncbi.nlm.nih.gov/21204109 21204109]|[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]|[https://pubmed.ncbi.nlm.nih.gov/11166215 11166215]|[https://pubmed.ncbi.nlm.nih.gov/11457866 11457866] <br>
  '''definition''' : <br>
  '''definition''' : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815] <br>
  '''term_xref''' : GTC:G00294TN|GlycoMotif:GGM.000042|SugarBind_Ligand:153  <br>
  '''term_xref''' : CHEBI:28815|CID: [https://pubmed.ncbi.nlm.nih.gov/53477715 53477715]|GlycoEpitope: EP0086 <br>
  '''synonyms''' : H type 1 <br>
  '''synonyms''' : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate <br>
  '''function''' : <br>
  '''function''' : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[GlycoEpitope: EP0086] <br>
  '''disease_associations''' : Gastroenteritis[SugarBind_Ligand:153] <br>
  '''disease_associations''' : <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000037===
===GSD000107===
[[File:G70519XK.png|alt=|thumb|G70519XK]]
  '''term (main_entry)''' : Heparin <br>
  '''term (main_entry)''' : Blood group H (Type 2) <br>
  '''glycan_dictionary_accession''' : GSD000107 <br>
  '''glycan_dictionary_accession''' : GSD000037 <br>
  '''glytoucan_accession ''' : <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G70519XK G70519XK] <br>
  '''term_in_sentence''' : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:[https://pubmed.ncbi.nlm.nih.gov/6416324 6416324]] <br>
  '''term_in_sentence''' : We have examined the immunohistochemical distribution of H Type 1 and of H Type 2 substances of the ABO blood group system in human submandibular gland using either of the two anti-H monoclonal antibodies MAb 1E3 and MAb 3A5. MAb 3A5 was specific for H Type 2, and MAb 1E3 reacted with each of H Type 1-H Type 4 artificial antigens.[PMID: [https://pubmed.ncbi.nlm.nih.gov/9405495 9405495]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27100512 27100512]|[https://pubmed.ncbi.nlm.nih.gov/22566218 22566218]|[https://pubmed.ncbi.nlm.nih.gov/27264866 27264866]|[https://pubmed.ncbi.nlm.nih.gov/30094590 30094590]|[https://pubmed.ncbi.nlm.nih.gov/31077659 31077659]|[https://pubmed.ncbi.nlm.nih.gov/26975675 26975675]|[https://pubmed.ncbi.nlm.nih.gov/2083874 2083874]|[https://pubmed.ncbi.nlm.nih.gov/25088334 25088334]|[https://pubmed.ncbi.nlm.nih.gov/3333067 3333067]|[https://pubmed.ncbi.nlm.nih.gov/2191809 2191809]|[https://pubmed.ncbi.nlm.nih.gov/28118750 28118750]|[https://pubmed.ncbi.nlm.nih.gov/28224913 28224913]|[https://pubmed.ncbi.nlm.nih.gov/22495506 22495506]|[https://pubmed.ncbi.nlm.nih.gov/29385025 29385025]|[https://pubmed.ncbi.nlm.nih.gov/10332503 10332503]|[https://pubmed.ncbi.nlm.nih.gov/22393937 22393937]|[https://pubmed.ncbi.nlm.nih.gov/19947315 19947315]|[https://pubmed.ncbi.nlm.nih.gov/27655335 27655335]|[https://pubmed.ncbi.nlm.nih.gov/14529394 14529394]|[https://pubmed.ncbi.nlm.nih.gov/2419035 2419035]|[https://pubmed.ncbi.nlm.nih.gov/22048616 22048616]|[https://pubmed.ncbi.nlm.nih.gov/23849978 23849978]|[https://pubmed.ncbi.nlm.nih.gov/10204652 10204652]|[https://pubmed.ncbi.nlm.nih.gov/28958760 28958760]|[https://pubmed.ncbi.nlm.nih.gov/12627673 12627673]|[https://pubmed.ncbi.nlm.nih.gov/9042555 9042555]|[https://pubmed.ncbi.nlm.nih.gov/15639107 15639107]|[https://pubmed.ncbi.nlm.nih.gov/28880550 28880550]|[https://pubmed.ncbi.nlm.nih.gov/27238483 27238483]|[https://pubmed.ncbi.nlm.nih.gov/1964668 1964668]|[https://pubmed.ncbi.nlm.nih.gov/16716101 16716101]|[https://pubmed.ncbi.nlm.nih.gov/10796377 10796377]|[https://pubmed.ncbi.nlm.nih.gov/25981976 25981976]|[https://pubmed.ncbi.nlm.nih.gov/24680753 24680753]|[https://pubmed.ncbi.nlm.nih.gov/2191118 2191118]|[https://pubmed.ncbi.nlm.nih.gov/21166465 21166465]|[https://pubmed.ncbi.nlm.nih.gov/30582884 30582884]|[https://pubmed.ncbi.nlm.nih.gov/1322434 1322434]|[https://pubmed.ncbi.nlm.nih.gov/15330727 15330727]|[https://pubmed.ncbi.nlm.nih.gov/9752370 9752370]|[https://pubmed.ncbi.nlm.nih.gov/6416324 6416324]|[https://pubmed.ncbi.nlm.nih.gov/14996629 14996629]|[https://pubmed.ncbi.nlm.nih.gov/20452241 20452241]|[https://pubmed.ncbi.nlm.nih.gov/1340407 1340407]|[https://pubmed.ncbi.nlm.nih.gov/29050610 29050610]|345399|[https://pubmed.ncbi.nlm.nih.gov/6916469 6916469]|[https://pubmed.ncbi.nlm.nih.gov/6565376 6565376]|[https://pubmed.ncbi.nlm.nih.gov/26714061 26714061] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/9405495 9405495]|[https://pubmed.ncbi.nlm.nih.gov/8082855 8082855]|[https://pubmed.ncbi.nlm.nih.gov/6177241 6177241]|[https://pubmed.ncbi.nlm.nih.gov/3944092 3944092]|[https://pubmed.ncbi.nlm.nih.gov/21406562 21406562]|[https://pubmed.ncbi.nlm.nih.gov/2410664 2410664]|[https://pubmed.ncbi.nlm.nih.gov/8731502 8731502]|[https://pubmed.ncbi.nlm.nih.gov/6203846 6203846]|[https://pubmed.ncbi.nlm.nih.gov/2238560 2238560]| <br>
  '''definition''' : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304] <br>
  '''definition''' : <br>
  '''term_xref''' : CID:772|CHEBI:28304 <br>
  '''term_xref''' : GTC:G70519XK|GlycoMotif:GGM.000036 <br>
  '''synonyms''' : bemiparin|bemiparin|certoparin|Cy 222|enoxaparin|fluxum|Heparin|Heparinic acid|parnaparin|reviparin|sandoparin <br>
  '''synonyms''' : Blood group H (type 2)|H type 2|H type 2 chain|H type 2 antigen|type 2 chain H|blood group H type II <br>
  '''function''' : <br>
  '''function''' : <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000038===
===GSD000108===
[[File:G00052MO.png|alt=|thumb|G00052MO]]
  '''term (main_entry)''' : High mannose <br>
  '''term (main_entry)''' : Blood group H (Type 2) - Lewis y <br>
  '''glycan_dictionary_accession''' : GSD000108 <br>
  '''glycan_dictionary_accession''' : GSD000038 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G55220VL G55220VL] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00052MO G00052MO] <br>
  '''term_in_sentence''' : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:[https://pubmed.ncbi.nlm.nih.gov/11258925 11258925]] <br>
  '''term_in_sentence''' : The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes.[PMID: [https://pubmed.ncbi.nlm.nih.gov/11479278 11479278]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/11258925 11258925]|[https://pubmed.ncbi.nlm.nih.gov/17956937 17956937]|[https://pubmed.ncbi.nlm.nih.gov/2059624 2059624]|[https://pubmed.ncbi.nlm.nih.gov/2065054 2065054]|[https://pubmed.ncbi.nlm.nih.gov/26791533 26791533]|[https://pubmed.ncbi.nlm.nih.gov/4077844 4077844]|[https://pubmed.ncbi.nlm.nih.gov/7780197 7780197]|[https://pubmed.ncbi.nlm.nih.gov/9136890 9136890]|[https://pubmed.ncbi.nlm.nih.gov/30659065 30659065]|[https://pubmed.ncbi.nlm.nih.gov/30075362 30075362]|[https://pubmed.ncbi.nlm.nih.gov/21421994 21421994]|[https://pubmed.ncbi.nlm.nih.gov/31076349 31076349]|[https://pubmed.ncbi.nlm.nih.gov/29738673 29738673]|[https://pubmed.ncbi.nlm.nih.gov/29508223 29508223]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26747427 26747427] [https://pubmed.ncbi.nlm.nih.gov/26747427 26747427]]|[https://pubmed.ncbi.nlm.nih.gov/30634645 30634645]|[https://pubmed.ncbi.nlm.nih.gov/23007868 23007868]|[https://pubmed.ncbi.nlm.nih.gov/29051951 29051951]|[https://pubmed.ncbi.nlm.nih.gov/24549150 24549150]|[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]|[https://pubmed.ncbi.nlm.nih.gov/26724786 26724786]|[https://pubmed.ncbi.nlm.nih.gov/26956389 26956389]|[https://pubmed.ncbi.nlm.nih.gov/26493153 26493153]|[https://pubmed.ncbi.nlm.nih.gov/31102532 31102532]|[https://pubmed.ncbi.nlm.nih.gov/29673624 29673624]|[https://pubmed.ncbi.nlm.nih.gov/8348230 8348230]|[https://pubmed.ncbi.nlm.nih.gov/25586968 25586968]|[https://pubmed.ncbi.nlm.nih.gov/24975601 24975601]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29803109 29803109] [https://pubmed.ncbi.nlm.nih.gov/29803109 29803109]]|[https://pubmed.ncbi.nlm.nih.gov/28465212 28465212]|[https://pubmed.ncbi.nlm.nih.gov/25776945 25776945]|[https://pubmed.ncbi.nlm.nih.gov/30151520 30151520]|[https://pubmed.ncbi.nlm.nih.gov/21097542 21097542]|[https://pubmed.ncbi.nlm.nih.gov/24326091 24326091]|[https://pubmed.ncbi.nlm.nih.gov/27995699 27995699]|[https://pubmed.ncbi.nlm.nih.gov/26003537 26003537]|[https://pubmed.ncbi.nlm.nih.gov/6722291 6722291]|[https://pubmed.ncbi.nlm.nih.gov/2925680 2925680]|[https://pubmed.ncbi.nlm.nih.gov/25565276 25565276]|[https://pubmed.ncbi.nlm.nih.gov/21460211 21460211]|[https://pubmed.ncbi.nlm.nih.gov/25196214 25196214]|[https://pubmed.ncbi.nlm.nih.gov/27387600 27387600]|[https://pubmed.ncbi.nlm.nih.gov/22373601 22373601]|[https://pubmed.ncbi.nlm.nih.gov/3729933 3729933]|[https://pubmed.ncbi.nlm.nih.gov/16423983 16423983]|[https://pubmed.ncbi.nlm.nih.gov/24174266 24174266]|[https://pubmed.ncbi.nlm.nih.gov/30605318 30605318] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/11479278 11479278] <br>
  '''definition''' : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man . <br>
  '''definition''' : A branched amino tetrasaccharide consisting of N-acetyl-β-D-glucosamine at the reducing end having an α-L-fucosyl residue attached at the 3-position and an α-L-fucosyl-(1→2)-β-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure.[CHEBI:59045] <br>
  '''term_xref''' : GTC:G55220VL|CID:[https://pubmed.ncbi.nlm.nih.gov/70698382 70698382]|CHEBI:71514 <br>
  '''term_xref''' : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045|GlycoMotif:GGM.000045 <br>
  '''synonyms''' : oligomannose <br>
  '''synonyms''' : Lewis y|Blood group H (type 2) (Ley)|Lewis b (Leb)|Lewis a|Lewis b (Lewis b)|Blood group H (type 2) - Lewis y|H-Ley|H-Le^y|Lewis Y|H-Ley|H-Le^y|Lewis Y <br>
  '''function''' : Involved in promotion of protein folding in ER. [PMID:[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205] <br>
  '''function''' : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018] <br>
  '''disease_associations''' : Relative abundance changes in multiple CDGs [PMID: 30770376][PMID: 28484880] <br>
  '''disease_associations''' : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018]|Inappropriate tissue distribution of Ley blood-group antigens was observed in CCs(cholangiocarcinomas) and, much less frequently, in HCCs(hepatocellular carcinomas).[GlycoEpitope:EP0018]|Ley determinant is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC).[GlycoEpitope:EP0018] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17]<br>




===GSD000039===
===GSD000109===
  '''term (main_entry)''' : Blood group H (Type 4) <br>
  '''term (main_entry)''' : HNK-1 <br>
  '''glycan_dictionary_accession''' : GSD000039 <br>
  '''glycan_dictionary_accession''' : GSD000109 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G98465JN G98465JN] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G54406UD G54406UD] <br>
  '''term_in_sentence''' : In addition, the blood group H type 4 chain structure was present together with Le(a) and Le(b) compounds.[PMID:[https://pubmed.ncbi.nlm.nih.gov/1841684 1841684]] <br>
  '''term_in_sentence''' : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:[https://pubmed.ncbi.nlm.nih.gov/28709864 28709864]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/11261842 11261842]| [https://pubmed.ncbi.nlm.nih.gov/1841684 1841684]|[https://pubmed.ncbi.nlm.nih.gov/11101633 11101633]|[https://pubmed.ncbi.nlm.nih.gov/9405495 9405495] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28709864 28709864]|[https://pubmed.ncbi.nlm.nih.gov/31738061 31738061]|[https://pubmed.ncbi.nlm.nih.gov/26738850 26738850]|[https://pubmed.ncbi.nlm.nih.gov/30306736 30306736]|[https://pubmed.ncbi.nlm.nih.gov/11070366 11070366]|[https://pubmed.ncbi.nlm.nih.gov/20855890 20855890]|[https://pubmed.ncbi.nlm.nih.gov/18024472 18024472]|[https://pubmed.ncbi.nlm.nih.gov/22669261 22669261]|[https://pubmed.ncbi.nlm.nih.gov/19729452 19729452]|[https://pubmed.ncbi.nlm.nih.gov/19796667 19796667]|[https://pubmed.ncbi.nlm.nih.gov/26850637 26850637]|[https://pubmed.ncbi.nlm.nih.gov/11769463 11769463]|[https://pubmed.ncbi.nlm.nih.gov/18263654 18263654]|[https://pubmed.ncbi.nlm.nih.gov/15843379 15843379]|[https://pubmed.ncbi.nlm.nih.gov/26659409 26659409]|[https://pubmed.ncbi.nlm.nih.gov/9003039 9003039]|[https://pubmed.ncbi.nlm.nih.gov/22087768 22087768]|[https://pubmed.ncbi.nlm.nih.gov/21771787 21771787]|[https://pubmed.ncbi.nlm.nih.gov/15173636 15173636]|[https://pubmed.ncbi.nlm.nih.gov/9210489 9210489]|[https://pubmed.ncbi.nlm.nih.gov/15258996 15258996]|[https://pubmed.ncbi.nlm.nih.gov/17924534 17924534]|[https://pubmed.ncbi.nlm.nih.gov/26382082 26382082]|[https://pubmed.ncbi.nlm.nih.gov/16171882 16171882]|[https://pubmed.ncbi.nlm.nih.gov/18802400 18802400]|[https://pubmed.ncbi.nlm.nih.gov/9800516 9800516]|[https://pubmed.ncbi.nlm.nih.gov/7504418 7504418]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229] [https://pubmed.ncbi.nlm.nih.gov/11891229 11891229]]|[https://pubmed.ncbi.nlm.nih.gov/15232286 15232286]|[https://pubmed.ncbi.nlm.nih.gov/9013478 9013478]|[https://pubmed.ncbi.nlm.nih.gov/21621858 21621858]|[https://pubmed.ncbi.nlm.nih.gov/11677051 11677051]|[https://pubmed.ncbi.nlm.nih.gov/18668221 18668221]|[https://pubmed.ncbi.nlm.nih.gov/11414798 11414798]|[https://pubmed.ncbi.nlm.nih.gov/19265195 19265195]|[https://pubmed.ncbi.nlm.nih.gov/8982638 8982638]|[https://pubmed.ncbi.nlm.nih.gov/8798480 8798480]|[https://pubmed.ncbi.nlm.nih.gov/28403522 28403522]|[https://pubmed.ncbi.nlm.nih.gov/17935701 17935701]|[https://pubmed.ncbi.nlm.nih.gov/1691305 1691305]|[https://pubmed.ncbi.nlm.nih.gov/10998116 10998116]|[https://pubmed.ncbi.nlm.nih.gov/9364602 9364602]|[https://pubmed.ncbi.nlm.nih.gov/7528651 7528651]|[https://pubmed.ncbi.nlm.nih.gov/12472892 12472892]|[https://pubmed.ncbi.nlm.nih.gov/21176892 21176892]|[https://pubmed.ncbi.nlm.nih.gov/28416698 28416698]|[https://pubmed.ncbi.nlm.nih.gov/19389918 19389918]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937] [https://pubmed.ncbi.nlm.nih.gov/28427937 28427937]]|[https://pubmed.ncbi.nlm.nih.gov/25450311 25450311] <br>
  '''definition''' : An amino hexasaccharide consisting of α-L-fucose, β-D-galactose, N-acetyl-α-D-galactosamine, α-D-galactose, β-D-galactose and β-D-glucose residues joined in sequence with (1→2)-, (1→3)-, (1→3)-, (1→4)- and (1→4)-linkages, respectively.[CHEBI:65245] <br>
  '''definition''' : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322] <br>
  '''term_xref''' : GlycoMotif:GGM.000086|GTC:G98465JN|CID:10260428|SugarBind_Ligand:61|CHEBI:65245<br>
  '''term_xref''' : GTC:G54406UD|GlycoEpitope:EP0001|CID:[https://pubmed.ncbi.nlm.nih.gov/46906103 46906103]|CHEBI:60322|GlycoMotif:GGM.000058 <br>
  '''synonyms''' : <br>
  '''synonyms''' : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen <br>
  '''function''' : <br>
  '''function''' : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001] <br>
  '''disease_associations''' : Pyelonephritis[SugarBind_Ligand:61] <br>
  '''disease_associations''' : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001] <br>
  '''wikipedia''' : <br>
  '''wikipedia''' : https://en.wikipedia.org/wiki/N-linked_glycosylation <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17]<br>




===GSD000040===
===GSD000110===
  '''term (main_entry)''' : C2-O-sLex <br>
  '''term (main_entry)''' : Hybrid <br>
  '''glycan_dictionary_accession''' : GSD000040 <br>
  '''glycan_dictionary_accession''' : GSD000110 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G97345NY G97345NY] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G16828VN G16828VN] <br>
  '''term_in_sentence''' : PSGL-1 lacks 6-sulfo-sLex but contains sulfated tyrosine residues (Tyr-SO3)at positions 46, 48, and 51 and sLex in a core 2-based O-glycan (C2-O-sLex) on Thr at position 57.[PMID:[https://pubmed.ncbi.nlm.nih.gov/12736247 12736247]] <br>
  '''term_in_sentence''' : A hybrid-type N-glycan was accessed by total synthesis, converted to an oxazoline, and used as a donor substrate with both wild type Endo M and an N175Q glycosynthase Endo M mutant allowing the convergent synthesis of a glycosylated amino acid bearing a hybrid N-glycan structure. [PMID:[https://pubmed.ncbi.nlm.nih.gov/27058295 27058295]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/12736247 12736247]|[https://pubmed.ncbi.nlm.nih.gov/19267921 19267921]|[https://pubmed.ncbi.nlm.nih.gov/21283832 21283832]|[https://pubmed.ncbi.nlm.nih.gov/15596301 15596301]|[https://pubmed.ncbi.nlm.nih.gov/17072011 17072011] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27058295 27058295]|[https://pubmed.ncbi.nlm.nih.gov/15044398 15044398]|[https://pubmed.ncbi.nlm.nih.gov/28714086 28714086]|[https://pubmed.ncbi.nlm.nih.gov/29578688 29578688]|[https://pubmed.ncbi.nlm.nih.gov/26999365 26999365] <br>
  '''definition''' : A seven-membered branched galactosamine oligosaccharide that consists of a branched tetrasaccharide unit α-Neu5Ac-(2→3)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc, attached by a glycosidic linkage to position 6 of the GalNAc residue of the trisaccharide α-Neu5Ac-(2→3)-β-D-Gal-(1→3)-D-GalNAc.[CHEBI:65192] <br>
  '''definition''' : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1–Asn-X-Ser/Thr is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the α-linked Man residue.[Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]] <br>
  '''term_xref''' : GlycoMotif:GGM.000053|GTC:G97345NY|CID:91860725|KEGG:G10899|CHEBI:155160  <br>
  '''term_xref''' : GTC:G16828VN|CID:[https://pubmed.ncbi.nlm.nih.gov/91847108 91847108]|CHEBI:147471 <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]<br>




===GSD000041===
===GSD000111===
[[File:G04416BG.png|thumb|G04416BG]]
  '''term (main_entry)''' : i antigen <br>
  '''term (main_entry)''' : Ceramide dihexosyl sulfate <br>
  '''glycan_dictionary_accession''' : GSD000111 <br>
  '''glycan_dictionary_accession''' : GSD000041 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00058MO G00058MO]|[https://www.glygen.org/glycan/G46055MA G46055MA] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G04416BG G04416BG] <br>
  '''term_in_sentence''' : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]] <br>
  '''term_in_sentence''' : Although it has been reported that ceramide dihexosyl sulfate is present in human kidney, it is unlikely that it is present in equine kidney.[PMID:818074] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458] [https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254] [https://pubmed.ncbi.nlm.nih.gov/21912254 21912254]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428] [https://pubmed.ncbi.nlm.nih.gov/12468428 12468428]]|[https://pubmed.ncbi.nlm.nih.gov/28508465 28508465]|[https://pubmed.ncbi.nlm.nih.gov/6203982 6203982]|[https://pubmed.ncbi.nlm.nih.gov/30728302 30728302]|[https://pubmed.ncbi.nlm.nih.gov/8449405 8449405]|[https://pubmed.ncbi.nlm.nih.gov/9122902 9122902]|[https://pubmed.ncbi.nlm.nih.gov/10360315 10360315]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787] [https://pubmed.ncbi.nlm.nih.gov/6159787 6159787]]|[https://pubmed.ncbi.nlm.nih.gov/6183759 6183759]|518539|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951] [https://pubmed.ncbi.nlm.nih.gov/6715951 6715951]]|[https://pubmed.ncbi.nlm.nih.gov/21933024 21933024] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/818074 818074] <br>
'''definition''' :  <br>
'''definition''' : A sulfatide with two hexose moieties (glucose and galactose) has been isolated from human kidney (Martensson E, Acta Chem Scand 1963, 17, 1174). Equimolar amounts of ceramide, glucose, galactose, and sulfate are found in the molecule. The sulfate group is esterified, as in sulfatides, with carbon 3 of the galactose moiety. The linkage between galactose and glucose is identical to lactose (b-1-4). Its fatty acid composition is similar to that of sulfatides. [http://cyberlipid.gerli.com/description/complex-lipids/glycolipids/glycosphingolipids/sulfosphingolipids/<nowiki>] </nowiki><br>
  '''term_xref''' : GlycoMotif:GGM.000004|GlycoMotif:GGM.000002|GTC:G46055MA|GTC:G00058MO <br>
  '''term_xref''' : GTC:G04416BG|GlycoMotif:GGM.000065 <br>
  '''synonyms''' : Type 2 LN2 <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
Line 170: Line 167:




===GSD000043===
===GSD000112===
  '''term (main_entry)''' : Chondroitin sulfate <br>
  '''term (main_entry)''' : I antigen <br>
  '''glycan_dictionary_accession''' : GSD000043 <br>
  '''glycan_dictionary_accession''' : GSD000112 <br>
  '''glytoucan_accession ''' : <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G56045WU G56045WU] <br>
  '''term_in_sentence''' : The industrial production of chondroitin sulfate (CS) uses animal tissue sources as raw material derived from different terrestrial or marine species of animals.[PMID: [https://pubmed.ncbi.nlm.nih.gov/31013685 31013685]] <br>
  '''term_in_sentence''' : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458] [https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/31013685 31013685]|[https://pubmed.ncbi.nlm.nih.gov/27526113 27526113]|[https://pubmed.ncbi.nlm.nih.gov/27194526 27194526]|[https://pubmed.ncbi.nlm.nih.gov/26980567 26980567]|[https://pubmed.ncbi.nlm.nih.gov/28847361 28847361]|[https://pubmed.ncbi.nlm.nih.gov/24413804 24413804]|[https://pubmed.ncbi.nlm.nih.gov/29891297 29891297]|[https://pubmed.ncbi.nlm.nih.gov/29600622 29600622]|[https://pubmed.ncbi.nlm.nih.gov/25129732 25129732]|[https://pubmed.ncbi.nlm.nih.gov/31317901 31317901]|[https://pubmed.ncbi.nlm.nih.gov/29181550 29181550]|[https://pubmed.ncbi.nlm.nih.gov/31250530 31250530]|[https://pubmed.ncbi.nlm.nih.gov/22265655 22265655]|[https://pubmed.ncbi.nlm.nih.gov/25756648 25756648]|[https://pubmed.ncbi.nlm.nih.gov/29402610 29402610]|[https://pubmed.ncbi.nlm.nih.gov/17928217 17928217]|[https://pubmed.ncbi.nlm.nih.gov/20236040 20236040]|[https://pubmed.ncbi.nlm.nih.gov/28091940 28091940]|[https://pubmed.ncbi.nlm.nih.gov/30824935 30824935]|[https://pubmed.ncbi.nlm.nih.gov/26572336 26572336]|[https://pubmed.ncbi.nlm.nih.gov/31207331 31207331]|[https://pubmed.ncbi.nlm.nih.gov/21110089 21110089]|[https://pubmed.ncbi.nlm.nih.gov/30599999 30599999]|[https://pubmed.ncbi.nlm.nih.gov/20399897 20399897]|[https://pubmed.ncbi.nlm.nih.gov/27226567 27226567]|[https://pubmed.ncbi.nlm.nih.gov/19388612 19388612]|[https://pubmed.ncbi.nlm.nih.gov/23186102 23186102]|[https://pubmed.ncbi.nlm.nih.gov/31494830 31494830]|[https://pubmed.ncbi.nlm.nih.gov/28982096 28982096]|[https://pubmed.ncbi.nlm.nih.gov/30241863 30241863]|[https://pubmed.ncbi.nlm.nih.gov/30295666 30295666]|[https://pubmed.ncbi.nlm.nih.gov/25366475 25366475]|[https://pubmed.ncbi.nlm.nih.gov/20521042 20521042]|[https://pubmed.ncbi.nlm.nih.gov/29456007 29456007]|[https://pubmed.ncbi.nlm.nih.gov/31304829 31304829]|[https://pubmed.ncbi.nlm.nih.gov/18661362 18661362]|[https://pubmed.ncbi.nlm.nih.gov/28576008 28576008]|[https://pubmed.ncbi.nlm.nih.gov/29494632 29494632]|[https://pubmed.ncbi.nlm.nih.gov/30016441 30016441]|[https://pubmed.ncbi.nlm.nih.gov/26906924 26906924]|[https://pubmed.ncbi.nlm.nih.gov/24861964 24861964]|[https://pubmed.ncbi.nlm.nih.gov/23774590 23774590]|[https://pubmed.ncbi.nlm.nih.gov/31887904 31887904]|[https://pubmed.ncbi.nlm.nih.gov/31339761 31339761]| [https://pubmed.ncbi.nlm.nih.gov/12512856 12512856]|[https://pubmed.ncbi.nlm.nih.gov/26957048 26957048]|[https://pubmed.ncbi.nlm.nih.gov/29625000 29625000] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458] [https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254] [https://pubmed.ncbi.nlm.nih.gov/21912254 21912254]]|[https://pubmed.ncbi.nlm.nih.gov/30705292 30705292]|[https://pubmed.ncbi.nlm.nih.gov/33403394 33403394]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951] [https://pubmed.ncbi.nlm.nih.gov/6715951 6715951]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428] [https://pubmed.ncbi.nlm.nih.gov/12468428 12468428]]|[https://pubmed.ncbi.nlm.nih.gov/6088627 6088627]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787] [https://pubmed.ncbi.nlm.nih.gov/6159787 6159787]] <br>
'''definition''' : Any of a class of 10—60 kDa glycosaminoglycan sulfates, widely distributed in cartilage and other mammalian connective tissues.[CHEBI:37397] <br>
'''definition''' : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390] <br>
  '''term_xref''' : CHEBI:37397|CID:24766 <br>
'''term_xref''' : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:[https://pubmed.ncbi.nlm.nih.gov/91852915 91852915]|CHEBI:151390 <br>
  '''synonyms''' : chondroitin polysulfate|chondroitin sulfate|chondroitin sulfates|chondroitin sulfuric acid|chondroitin sulphate|Chondroitinsulfate <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]<br>




===GSD000044===
===GSD000113===
  '''term (main_entry)''' : cisGM1 <br>
  '''term (main_entry)''' : Isoglobotetraosylceramide <br>
  '''glycan_dictionary_accession''' : GSD000044 <br>
  '''glycan_dictionary_accession''' : GSD000113 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G03277YI G03277YI] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G57710SU G57710SU] <br>
  '''term_in_sentence''' : Macrophage ganglioside patterns dramatically increase in complexity when murine peritoneal macrophages are stimulated in vivo with the appearance of the sialidase-sensitive monosialoganglioside GM1b (cisGM1) as a major component.[PMID: [https://pubmed.ncbi.nlm.nih.gov/9455923 9455923]] <br>
  '''term_in_sentence''' : Furthermore, isoglobotetraosylceramide seems to play a direct role in the metastatic process since the blocking of exposed antigen with monoclonal antibodies, or their Fab fragments, results in a highly significant decrease in lung colony formation.[PMID:[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/9455923 9455923] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/1396705 1396705]|[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]|[https://pubmed.ncbi.nlm.nih.gov/2713378 2713378]|[https://pubmed.ncbi.nlm.nih.gov/3489485 3489485]|[https://pubmed.ncbi.nlm.nih.gov/18997175 18997175]|[https://pubmed.ncbi.nlm.nih.gov/7053385 7053385]|[https://pubmed.ncbi.nlm.nih.gov/3379797 3379797]|[https://pubmed.ncbi.nlm.nih.gov/2465279 2465279]|[https://pubmed.ncbi.nlm.nih.gov/3743633 3743633]|[https://pubmed.ncbi.nlm.nih.gov/11479210 11479210] <br>
'''definition''' : A member of the class of neuraminic acids that is neuraminic acid attached in sequence to β-D-galactopyranosyl, 2-acetamido-2-deoxy-β-D-galactopyranosyl, β-D-galactopyranosyl, and β-D-gucoopyranose units by (2→3), (1→3), (1→4), and (1→4) glycosidic linkages, respectively. It corresponds to the carbohydrate portion of ganglioside GM1b.[CHEBI:145580] <br>
'''definition''' : <br>
'''term_xref''' : GlycoMotif:GGM.000100|GTC:G03277YI|CID:91850212|CHEBI:145580|GlycoEpitope:EP0048|SugarBind_Ligand:92|KEGG:G00125 <br>
'''term_xref''' : GlycoMotif:GGM.000071|GTC:G57710SU|CID:[https://pubmed.ncbi.nlm.nih.gov/91849719 91849719]|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17 <br>
'''synonyms''' : GM1b <br>
'''function''' :  <br>
'''disease_associations''' : Influenza[SugarBind_Ligand:92] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453054/ Chapter 23]<br>
 
 
===GSD000045===
'''term (main_entry)''' : Complex-type N-glycans <br>
'''glycan_dictionary_accession''' : GSD000045 <br>
'''glytoucan_accession ''' :  <br>
'''term_in_sentence''' : In this study, 32 new complex-type glycans are characterized containing the Le(x), Le(Y), and sialyl-Le(x) determinants, the bloodgroup A and H antigens, as well as the ALe(Y) determinant.[PMID:[https://pubmed.ncbi.nlm.nih.gov/10988252 10988252] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29902282 29902282]|[https://pubmed.ncbi.nlm.nih.gov/29212795 29212795]|[https://pubmed.ncbi.nlm.nih.gov/29343819 29343819]|[https://pubmed.ncbi.nlm.nih.gov/27705835 27705835]|[https://pubmed.ncbi.nlm.nih.gov/26745022 26745022]|[https://pubmed.ncbi.nlm.nih.gov/18399796 18399796]|[https://pubmed.ncbi.nlm.nih.gov/16825488 16825488]|[https://pubmed.ncbi.nlm.nih.gov/21964725 21964725]|[https://pubmed.ncbi.nlm.nih.gov/15864431 15864431]|[https://pubmed.ncbi.nlm.nih.gov/22890903 22890903]|[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]|[https://pubmed.ncbi.nlm.nih.gov/28039392 28039392]|[https://pubmed.ncbi.nlm.nih.gov/19426135 19426135]|[https://pubmed.ncbi.nlm.nih.gov/30253927 30253927]|[https://pubmed.ncbi.nlm.nih.gov/16794314 16794314]|[https://pubmed.ncbi.nlm.nih.gov/19806620 19806620]|[https://pubmed.ncbi.nlm.nih.gov/22975979 22975979]|[https://pubmed.ncbi.nlm.nih.gov/25931033 25931033]|[https://pubmed.ncbi.nlm.nih.gov/15201278 15201278]|[https://pubmed.ncbi.nlm.nih.gov/19129634 19129634]|[https://pubmed.ncbi.nlm.nih.gov/19129628 19129628]|[https://pubmed.ncbi.nlm.nih.gov/24032650 24032650]|[https://pubmed.ncbi.nlm.nih.gov/22530754 22530754]|[https://pubmed.ncbi.nlm.nih.gov/31021709 31021709]|[https://pubmed.ncbi.nlm.nih.gov/30973186 30973186]|[https://pubmed.ncbi.nlm.nih.gov/28091941 28091941]|[https://pubmed.ncbi.nlm.nih.gov/23115339 23115339]|[https://pubmed.ncbi.nlm.nih.gov/20829342 20829342]|[https://pubmed.ncbi.nlm.nih.gov/27304954 27304954]|[https://pubmed.ncbi.nlm.nih.gov/29090617 29090617]|[https://pubmed.ncbi.nlm.nih.gov/21802690 21802690]|[https://pubmed.ncbi.nlm.nih.gov/29725121 29725121]|[https://pubmed.ncbi.nlm.nih.gov/30471292 30471292]|[https://pubmed.ncbi.nlm.nih.gov/16581187 16581187]|[https://pubmed.ncbi.nlm.nih.gov/26098720 26098720]|[https://pubmed.ncbi.nlm.nih.gov/31080188 31080188]|[https://pubmed.ncbi.nlm.nih.gov/1930135 1930135]|[https://pubmed.ncbi.nlm.nih.gov/31888963 31888963]|[https://pubmed.ncbi.nlm.nih.gov/30844485 30844485]|[https://pubmed.ncbi.nlm.nih.gov/24014058 24014058]|[https://pubmed.ncbi.nlm.nih.gov/11129583 11129583] <br>
'''definition''' : Type of N-linked glycan in which at least two antenna are present on the trimannosyl core, each initiated by GlcNAc additions catalyzed by position-specific N-acetylglucosaminyltransferases (GlcNAcTs). Each antenna can be exteneded or capped with HexNAc, deoxyHex, Hex, or sialic acid residues.  <br>
'''term_xref''' :  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' : Involved in protein stability.[PMID:[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]] <br>
  '''function''' : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]] <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : Actinomycosis[SugarBind_Ligand:17] <br>
  '''wikipedia''' : <br>
  '''wikipedia''' : https://en.wikipedia.org/wiki/Ii_antigen_system <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17]<br>
  '''essentials_of_glycobiology''' : <br>




===GSD000046===
===GSD000114===
  '''term (main_entry)''' : Core 2 <br>
  '''term (main_entry)''' : Keratan sulfate <br>
  '''glycan_dictionary_accession''' : GSD000046 <br>
  '''glycan_dictionary_accession''' : GSD000114 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00033MO G00033MO] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G82109MW G82109MW] <br>
  '''term_in_sentence''' : To investigate the biological roles of core 2 O-glycans, we produced and characterized mice deficient in one or more of the three known glycosyltransferases that generate core 2 O-glycans (C2GnT1, C2GnT2, and C2GnT3).[PMID: [https://pubmed.ncbi.nlm.nih.gov/19349303 19349303]] <br>
  '''term_in_sentence''' : Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties.[PMID: [https://pubmed.ncbi.nlm.nih.gov/30578672 30578672]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/19349303 19349303]|[https://pubmed.ncbi.nlm.nih.gov/30315106 30315106]|[https://pubmed.ncbi.nlm.nih.gov/23640779 23640779]|[https://pubmed.ncbi.nlm.nih.gov/26677400 26677400] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29340594 29340594]|[https://pubmed.ncbi.nlm.nih.gov/30578672 30578672]|[https://pubmed.ncbi.nlm.nih.gov/12512857 12512857]|[https://pubmed.ncbi.nlm.nih.gov/29625490 29625490]|[https://pubmed.ncbi.nlm.nih.gov/25325967 25325967]|[https://pubmed.ncbi.nlm.nih.gov/30025865 30025865]|[https://pubmed.ncbi.nlm.nih.gov/29924315 29924315]|[https://pubmed.ncbi.nlm.nih.gov/9549787 9549787]|[https://pubmed.ncbi.nlm.nih.gov/11030741 11030741]|[https://pubmed.ncbi.nlm.nih.gov/28078490 28078490]|[https://pubmed.ncbi.nlm.nih.gov/8298243 8298243]|[https://pubmed.ncbi.nlm.nih.gov/29096187 29096187]|[https://pubmed.ncbi.nlm.nih.gov/30059256 30059256]|[https://pubmed.ncbi.nlm.nih.gov/26958998 26958998]|[https://pubmed.ncbi.nlm.nih.gov/26773479 26773479]|[https://pubmed.ncbi.nlm.nih.gov/22840010 22840010]|[https://pubmed.ncbi.nlm.nih.gov/15597951 15597951]|[https://pubmed.ncbi.nlm.nih.gov/28110685 28110685]|[https://pubmed.ncbi.nlm.nih.gov/28535934 28535934]|[https://pubmed.ncbi.nlm.nih.gov/2942429 2942429]|[https://pubmed.ncbi.nlm.nih.gov/18234072 18234072]|[https://pubmed.ncbi.nlm.nih.gov/8641829 8641829]|[https://pubmed.ncbi.nlm.nih.gov/8940154 8940154]|[https://pubmed.ncbi.nlm.nih.gov/2027120 2027120]|[https://pubmed.ncbi.nlm.nih.gov/30849116 30849116]|41589|[https://pubmed.ncbi.nlm.nih.gov/6238957 6238957]|[https://pubmed.ncbi.nlm.nih.gov/1907283 1907283]|[https://pubmed.ncbi.nlm.nih.gov/7722002 7722002]|[https://pubmed.ncbi.nlm.nih.gov/29275050 29275050]|[https://pubmed.ncbi.nlm.nih.gov/24274541 24274541]|[https://pubmed.ncbi.nlm.nih.gov/2527236 2527236]|[https://pubmed.ncbi.nlm.nih.gov/1731862 1731862]|[https://pubmed.ncbi.nlm.nih.gov/8991509 8991509]|[https://pubmed.ncbi.nlm.nih.gov/24291704 24291704]|[https://pubmed.ncbi.nlm.nih.gov/10517185 10517185]|[https://pubmed.ncbi.nlm.nih.gov/6451953 6451953]|[https://pubmed.ncbi.nlm.nih.gov/7688312 7688312]|[https://pubmed.ncbi.nlm.nih.gov/8663590 8663590]|139406|[https://pubmed.ncbi.nlm.nih.gov/25770829 25770829]|[https://pubmed.ncbi.nlm.nih.gov/25036480 25036480]|[https://pubmed.ncbi.nlm.nih.gov/9275006 9275006]|[https://pubmed.ncbi.nlm.nih.gov/25179279 25179279]|[https://pubmed.ncbi.nlm.nih.gov/32627425 32627425]|[https://pubmed.ncbi.nlm.nih.gov/26903438 26903438]|[https://pubmed.ncbi.nlm.nih.gov/27941632 27941632]|[https://pubmed.ncbi.nlm.nih.gov/12807022 12807022]|[https://pubmed.ncbi.nlm.nih.gov/32266652 32266652]|[https://pubmed.ncbi.nlm.nih.gov/21624346 21624346] <br>
  '''definition''' : The trisaccharide β-D-Gal-(1→3)-[β-D-GlcNAc-(1→6)]-D-GalNAc with α configuration at the anomeric centre of the N-acetylglucosamine residue at the reducing end.[CHEBI:62158] <br>
  '''definition''' : A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions.[CHEBI:60924] <br>
  '''term_xref''' : GTC:G00033MO|CID: 52921656|CHEBI:62158 <br>
  '''term_xref''' : CHEBI:60924|CID:446715|GlycoEpitope: EP0085|GTC: G82109MW <br>
  '''synonyms''' : <br>
  '''synonyms''' : keratan| Kerato sulphate|Kerato sulfate|Keratan sulphate|kerato 6'-sulfate|keratan 6'-sulfate|Kerato 6'-sulphate|Keratan 6'-sulphate <br>
  '''function''' : <br>
  '''function''' : Tissue hydration.[PMID: [https://pubmed.ncbi.nlm.nih.gov/11030741 11030741]] <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
Line 230: Line 212:




===GSD000047===
===GSD000115===
  '''term (main_entry)''' : Core 3 <br>
  '''term (main_entry)''' : LacdiNac <br>
  '''glycan_dictionary_accession''' : GSD000047 <br>
  '''glycan_dictionary_accession''' : GSD000115 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00035MO G00035MO] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G31736BK G31736BK] <br>
  '''term_in_sentence''' : Mechanically, we revealed that mucin-type core 3 O-glycan was synthesized at the membrane-tethered MUC1 N terminus because of core 3 synthase expression in colon cancer cells.[PMID: [https://pubmed.ncbi.nlm.nih.gov/28745318 28745318]] <br>
  '''term_in_sentence''' : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:[https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28745318 28745318]|[https://pubmed.ncbi.nlm.nih.gov/27259834 27259834]|[https://pubmed.ncbi.nlm.nih.gov/27143302 27143302]| <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]|[https://pubmed.ncbi.nlm.nih.gov/31711843 31711843]|[https://pubmed.ncbi.nlm.nih.gov/31145522 31145522]|[https://pubmed.ncbi.nlm.nih.gov/27601469 27601469]|[https://pubmed.ncbi.nlm.nih.gov/30669833 30669833]|[https://pubmed.ncbi.nlm.nih.gov/25210040 25210040]|[https://pubmed.ncbi.nlm.nih.gov/24633693 24633693]|[https://pubmed.ncbi.nlm.nih.gov/24755437 24755437]|[https://pubmed.ncbi.nlm.nih.gov/22653491 22653491]|[https://pubmed.ncbi.nlm.nih.gov/30898876 30898876]|[https://pubmed.ncbi.nlm.nih.gov/7758724 7758724]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328] [https://pubmed.ncbi.nlm.nih.gov/22474328 22474328]]|[https://pubmed.ncbi.nlm.nih.gov/21305673 21305673]|[https://pubmed.ncbi.nlm.nih.gov/31558607 31558607]|[https://pubmed.ncbi.nlm.nih.gov/31271862 31271862]|[https://pubmed.ncbi.nlm.nih.gov/28549117 28549117]|[https://pubmed.ncbi.nlm.nih.gov/26213980 26213980]|[https://pubmed.ncbi.nlm.nih.gov/9134425 9134425]|[https://pubmed.ncbi.nlm.nih.gov/25561735 25561735]|[https://pubmed.ncbi.nlm.nih.gov/31756927 31756927]|[https://pubmed.ncbi.nlm.nih.gov/31170332 31170332]|[https://pubmed.ncbi.nlm.nih.gov/16282603 16282603]|[https://pubmed.ncbi.nlm.nih.gov/15265923 15265923]|[https://pubmed.ncbi.nlm.nih.gov/32267274 32267274]|[https://pubmed.ncbi.nlm.nih.gov/23015818 23015818]|[https://pubmed.ncbi.nlm.nih.gov/32676595 32676595]|[https://pubmed.ncbi.nlm.nih.gov/16728562 16728562]|[https://pubmed.ncbi.nlm.nih.gov/10814702 10814702]|[https://pubmed.ncbi.nlm.nih.gov/9591048 9591048]|[https://pubmed.ncbi.nlm.nih.gov/22245701 22245701]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628] [https://pubmed.ncbi.nlm.nih.gov/29751628 29751628]]|[https://pubmed.ncbi.nlm.nih.gov/22997242 22997242]|[https://pubmed.ncbi.nlm.nih.gov/15535969 15535969]|[https://pubmed.ncbi.nlm.nih.gov/31911241 31911241]|[https://pubmed.ncbi.nlm.nih.gov/30622255 30622255]|[https://pubmed.ncbi.nlm.nih.gov/29888905 29888905]|[https://pubmed.ncbi.nlm.nih.gov/30236114 30236114]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790] [https://pubmed.ncbi.nlm.nih.gov/30298790 30298790]]|[https://pubmed.ncbi.nlm.nih.gov/29373511 29373511]|[https://pubmed.ncbi.nlm.nih.gov/22298779 22298779]|[https://pubmed.ncbi.nlm.nih.gov/19179461 19179461]|[https://pubmed.ncbi.nlm.nih.gov/31606752 31606752]|[https://pubmed.ncbi.nlm.nih.gov/15653684 15653684]|[https://pubmed.ncbi.nlm.nih.gov/16403022 16403022]|[https://pubmed.ncbi.nlm.nih.gov/11162373 11162373]|[https://pubmed.ncbi.nlm.nih.gov/32005658 32005658]|[https://pubmed.ncbi.nlm.nih.gov/30529570 30529570] <br>
  '''definition''' : An amino disaccharide comprising an N-acetyl-β-D-glucosamine residue linked (1→3) to an N-acetyl-β-D-galactosamine residue at the reducing end.[CHEBI:71344] <br>
  '''definition''' : An amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a β-linkage.[CHEBI:61190] <br>
  '''term_xref''' : GTC:G00035MO|CID:25061208|CHEBI:71344  <br>
  '''term_xref''' : GTC:G31736BK|GlycoEpitope:P0150|CID:[https://pubmed.ncbi.nlm.nih.gov/25257164 25257164]|CHEBI:61190|GlycoMotif:GGM.000016 <br>
  '''synonyms''' : <br>
  '''synonyms''' : LDN <br>
  '''function''' : <br>
  '''function''' : Has a role of epitope.[CHEBI:61190] <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9] <br>
  '''essentials_of_glycobiology''' : <br>




===GSD000048===
===GSD000116===
  '''term (main_entry)''' : Core 4 <br>
  '''term (main_entry)''' : Lactosylceramide <br>
  '''glycan_dictionary_accession''' : GSD000048 <br>
  '''glycan_dictionary_accession''' : GSD000116 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00037MO G00037MO] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G84224TW G84224TW] <br>
  '''term_in_sentence''' : The results confirm the predicted existence of a beta1,6GlcNAc-transferase that functions in both core 2 and core 4 O-glycan branch formation.[PMID: [https://pubmed.ncbi.nlm.nih.gov/9988682 9988682]] <br>
  '''term_in_sentence''' : In the 1970s, a neutral glycosphingolipid lactosylceramide (LacCer) was found to bind specifically to several kinds of microorganisms.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30175814 30175814]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/9988682 9988682]|[https://pubmed.ncbi.nlm.nih.gov/10747980 10747980]| <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/30175814 30175814]|[https://pubmed.ncbi.nlm.nih.gov/26900161 26900161]|[https://pubmed.ncbi.nlm.nih.gov/30502090 30502090]|[https://pubmed.ncbi.nlm.nih.gov/29624959 29624959]|[https://pubmed.ncbi.nlm.nih.gov/28444900 28444900]|[https://pubmed.ncbi.nlm.nih.gov/25408340 25408340]|[https://pubmed.ncbi.nlm.nih.gov/31801289 31801289]|[https://pubmed.ncbi.nlm.nih.gov/29099167 29099167]|[https://pubmed.ncbi.nlm.nih.gov/25595946 25595946]|[https://pubmed.ncbi.nlm.nih.gov/32592089 32592089]|[https://pubmed.ncbi.nlm.nih.gov/27729551 27729551]|[https://pubmed.ncbi.nlm.nih.gov/24658420 24658420]|[https://pubmed.ncbi.nlm.nih.gov/25216636 25216636]|[https://pubmed.ncbi.nlm.nih.gov/25638276 25638276]|[https://pubmed.ncbi.nlm.nih.gov/9499377 9499377]|[https://pubmed.ncbi.nlm.nih.gov/17986153 17986153]|[https://pubmed.ncbi.nlm.nih.gov/8143857 8143857]|[https://pubmed.ncbi.nlm.nih.gov/23801329 23801329]|[https://pubmed.ncbi.nlm.nih.gov/18077097 18077097]|[https://pubmed.ncbi.nlm.nih.gov/32708181 32708181]|[https://pubmed.ncbi.nlm.nih.gov/15346887 15346887]|[https://pubmed.ncbi.nlm.nih.gov/19015977 19015977]|[https://pubmed.ncbi.nlm.nih.gov/18393821 18393821]|[https://pubmed.ncbi.nlm.nih.gov/25279740 25279740]|[https://pubmed.ncbi.nlm.nih.gov/21057870 21057870]|[https://pubmed.ncbi.nlm.nih.gov/11915327 11915327]|[https://pubmed.ncbi.nlm.nih.gov/25212460 25212460]|[https://pubmed.ncbi.nlm.nih.gov/23882130 23882130]|[https://pubmed.ncbi.nlm.nih.gov/11915329 11915329]|[https://pubmed.ncbi.nlm.nih.gov/8195125 8195125]|[https://pubmed.ncbi.nlm.nih.gov/8808768 8808768]|[https://pubmed.ncbi.nlm.nih.gov/3396945 3396945]|[https://pubmed.ncbi.nlm.nih.gov/22128256 22128256]|[https://pubmed.ncbi.nlm.nih.gov/6733104 6733104]|[https://pubmed.ncbi.nlm.nih.gov/24968752 24968752]|[https://pubmed.ncbi.nlm.nih.gov/32518749 32518749]|[https://pubmed.ncbi.nlm.nih.gov/30688114 30688114]|[https://pubmed.ncbi.nlm.nih.gov/7666005 7666005]|[https://pubmed.ncbi.nlm.nih.gov/8200356 8200356]|[https://pubmed.ncbi.nlm.nih.gov/24718572 24718572]|[https://pubmed.ncbi.nlm.nih.gov/6193809 6193809]|[https://pubmed.ncbi.nlm.nih.gov/25781947 25781947]|[https://pubmed.ncbi.nlm.nih.gov/12383912 12383912]|[https://pubmed.ncbi.nlm.nih.gov/26086247 26086247]|[https://pubmed.ncbi.nlm.nih.gov/30606995 30606995]|[https://pubmed.ncbi.nlm.nih.gov/12419803 12419803] <br>
  '''definition''' : A branched amino trisaccharide comprising an N -acetyl-α-D-galactosamine residue at the reducing end, to which are (1→3)- and (1→6)-linked two N -acetyl-α-D-glucosamine residues.[CHEBI:71341] <br>
  '''definition''' : Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.[MeSH:D007790] <br>
  '''term_xref''' : GTC:G00037MO| CID:25229562|CHEBI:71341 <br>
  '''term_xref''' : GTC:G84224TW|MeSH:D007790|GlycoMotif:GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3 <br>
  '''synonyms''' : <br>
  '''synonyms''' : LacCer|Lc2|CDH <br>
  '''function''' : <br>
  '''function''' : mammalian cell receptors for Neisseria gonorrhoeae recognized by Helicobacter pylori[GlycoEpitope:EP0078] <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : chronic gastritis[GlycoEpitope:EP0078,SugarBind_Ligand:3]|duodenal ulcers[GlycoEpitope:EP0078]|gastric adenocarcinoma[GlycoEpitope:EP0078,SugarBind_Ligand:3]|gastric ulcers[GlycoEpitope:EP0078]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Actinomycosis[SugarBind_Ligand:3]|Pertussis[SugarBind_Ligand:3]|Candidiasis[SugarBind_Ligand:3]|Cryptococcosis[SugarBind_Ligand:3]|Hemorrhagic colitis[SugarBind_Ligand:3]|Peptic ulcers[SugarBind_Ligand:3]|Histoplasmosis[SugarBind_Ligand:3]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Gonorrhea[SugarBind_Ligand:3]|Sporotrichosis[SugarBind_Ligand:3]|Plague[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK20721/ Chapter 8]<br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17]<br>




===GSD000049===
===GSD000117===
[[File:G78059CC.png|thumb|G78059CC]]
  '''term (main_entry)''' : Lactotriaosylceramide <br>
  '''term (main_entry)''' : Core-fucosylated <br>
  '''glycan_dictionary_accession''' : GSD000117 <br>
  '''glycan_dictionary_accession''' : GSD000049 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G06239NA G06239NA] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G78059CC G78059CC] <br>
  '''term_in_sentence''' : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br>
  '''term_in_sentence''' : The approach was validated for selective capture and analysis of core fucosylated N-glycans present in complex glycan mixtures derived from mammalian serum IgG.[PMID:[https://pubmed.ncbi.nlm.nih.gov/27678371 27678371]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]|[https://pubmed.ncbi.nlm.nih.gov/20693232 20693232]|[https://pubmed.ncbi.nlm.nih.gov/26104834 26104834]|[https://pubmed.ncbi.nlm.nih.gov/27435676 27435676]|[https://pubmed.ncbi.nlm.nih.gov/26405105 26405105]|[https://pubmed.ncbi.nlm.nih.gov/32340400 32340400]|[https://pubmed.ncbi.nlm.nih.gov/25241919 25241919]|[https://pubmed.ncbi.nlm.nih.gov/23404501 23404501]|[https://pubmed.ncbi.nlm.nih.gov/32452379 32452379]|[https://pubmed.ncbi.nlm.nih.gov/2960671 2960671]|272643|[https://pubmed.ncbi.nlm.nih.gov/27711049 27711049]|[https://pubmed.ncbi.nlm.nih.gov/33202844 33202844]|[https://pubmed.ncbi.nlm.nih.gov/4060695 4060695]|[https://pubmed.ncbi.nlm.nih.gov/27638607 27638607]|[https://pubmed.ncbi.nlm.nih.gov/20547865 20547865]|[https://pubmed.ncbi.nlm.nih.gov/2277039 2277039]|[https://pubmed.ncbi.nlm.nih.gov/6238026 6238026]|[https://pubmed.ncbi.nlm.nih.gov/8448388 8448388]|[https://pubmed.ncbi.nlm.nih.gov/8489255 8489255]|[https://pubmed.ncbi.nlm.nih.gov/9363437 9363437]|[https://pubmed.ncbi.nlm.nih.gov/11836161 11836161]|[https://pubmed.ncbi.nlm.nih.gov/6892925 6892925]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117] [https://pubmed.ncbi.nlm.nih.gov/1551117 1551117]]|[https://pubmed.ncbi.nlm.nih.gov/6811267 6811267]|[https://pubmed.ncbi.nlm.nih.gov/8059935 8059935]|[https://pubmed.ncbi.nlm.nih.gov/7861954 7861954]|[https://pubmed.ncbi.nlm.nih.gov/11283017 11283017]|[https://pubmed.ncbi.nlm.nih.gov/8514762 8514762]|[https://pubmed.ncbi.nlm.nih.gov/1291049 1291049]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3805024 3805024] [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]]|[https://pubmed.ncbi.nlm.nih.gov/10816509 10816509]|[https://pubmed.ncbi.nlm.nih.gov/12393713 12393713]|[https://pubmed.ncbi.nlm.nih.gov/6417117 6417117]|[https://pubmed.ncbi.nlm.nih.gov/11054095 11054095]|[https://pubmed.ncbi.nlm.nih.gov/8781973 8781973]|[https://pubmed.ncbi.nlm.nih.gov/1692829 1692829] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27678371 27678371]|[https://pubmed.ncbi.nlm.nih.gov/26514868 26514868]|[https://pubmed.ncbi.nlm.nih.gov/15538974 15538974]|[https://pubmed.ncbi.nlm.nih.gov/24914453 24914453]| [https://pubmed.ncbi.nlm.nih.gov/17049014 17049014]|[https://pubmed.ncbi.nlm.nih.gov/32078267 32078267]|[https://pubmed.ncbi.nlm.nih.gov/31268672 31268672]|[https://pubmed.ncbi.nlm.nih.gov/28674882 28674882]|[https://pubmed.ncbi.nlm.nih.gov/29956878 29956878]|[https://pubmed.ncbi.nlm.nih.gov/27798819 27798819]|[https://pubmed.ncbi.nlm.nih.gov/32044029 32044029]|[https://pubmed.ncbi.nlm.nih.gov/30962950 30962950]|[https://pubmed.ncbi.nlm.nih.gov/31548313 31548313]|[https://pubmed.ncbi.nlm.nih.gov/30907281 30907281]|[https://pubmed.ncbi.nlm.nih.gov/29090617 29090617]|[https://pubmed.ncbi.nlm.nih.gov/29571940 29571940]|[https://pubmed.ncbi.nlm.nih.gov/28800497 28800497]|[https://pubmed.ncbi.nlm.nih.gov/27629418 27629418]|[https://pubmed.ncbi.nlm.nih.gov/29733746 29733746]|[https://pubmed.ncbi.nlm.nih.gov/31623829 31623829]|[https://pubmed.ncbi.nlm.nih.gov/28768188 28768188]|[https://pubmed.ncbi.nlm.nih.gov/26897254 26897254]|[https://pubmed.ncbi.nlm.nih.gov/31451706 31451706]|[https://pubmed.ncbi.nlm.nih.gov/26514868 26514868]]|[https://pubmed.ncbi.nlm.nih.gov/29427759 29427759]|[https://pubmed.ncbi.nlm.nih.gov/28982386 28982386]|[https://pubmed.ncbi.nlm.nih.gov/26587313 26587313]|[https://pubmed.ncbi.nlm.nih.gov/30940702 30940702]| [https://pubmed.ncbi.nlm.nih.gov/15538974 15538974]|[https://pubmed.ncbi.nlm.nih.gov/31249452 31249452]|[https://pubmed.ncbi.nlm.nih.gov/27282921 27282921]|[https://pubmed.ncbi.nlm.nih.gov/31229844 31229844]|[https://pubmed.ncbi.nlm.nih.gov/30445455 30445455]|[https://pubmed.ncbi.nlm.nih.gov/31325506 31325506]|[https://pubmed.ncbi.nlm.nih.gov/24732908 24732908]|[https://pubmed.ncbi.nlm.nih.gov/29209018 29209018]|[https://pubmed.ncbi.nlm.nih.gov/26965517 26965517]|[https://pubmed.ncbi.nlm.nih.gov/28609658 28609658]| [https://pubmed.ncbi.nlm.nih.gov/24914453 24914453]|[https://pubmed.ncbi.nlm.nih.gov/25573275 25573275]|[https://pubmed.ncbi.nlm.nih.gov/17049014 17049014]|[https://pubmed.ncbi.nlm.nih.gov/19218400 19218400]|[https://pubmed.ncbi.nlm.nih.gov/27012207 27012207]|[https://pubmed.ncbi.nlm.nih.gov/27139574 27139574]| [https://pubmed.ncbi.nlm.nih.gov/32078267 32078267]|[https://pubmed.ncbi.nlm.nih.gov/25861849 25861849]|[https://pubmed.ncbi.nlm.nih.gov/32561391 32561391]|[https://pubmed.ncbi.nlm.nih.gov/21374780 21374780]|[https://pubmed.ncbi.nlm.nih.gov/31669139 31669139]|[https://pubmed.ncbi.nlm.nih.gov/25732060 25732060]|[https://pubmed.ncbi.nlm.nih.gov/29408166 29408166]|[https://pubmed.ncbi.nlm.nih.gov/31268672 31268672]|[https://pubmed.ncbi.nlm.nih.gov/30472795 30472795]|[https://pubmed.ncbi.nlm.nih.gov/30614075 30614075]|[https://pubmed.ncbi.nlm.nih.gov/19003000 19003000]|[https://pubmed.ncbi.nlm.nih.gov/25664929 25664929] <br>
  '''definition''' : A linear amino trisaccharide consisting of β-D-glucose at the reducing end having an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl group attached at the 4-position.[CHEBI:61758] <br>
  '''definition''' : Modification of the N-glycan core structure with fucose moiety attached at the innermost GlcNAc by FUT8 enzyme. Core Fuc is found on paucimannose, hybrid and complex type N-glycans. [https://doi.org/10.1016/bs.acr.2014.11.006<nowiki>]. </nowiki><br>
  '''term_xref''' : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:[https://pubmed.ncbi.nlm.nih.gov/10230777 10230777]|CHEBI:61758|SugarBind_Ligand:20<br>
  '''term_xref''' : GTC:G78059CC|CID: 70679232|CHEBI:70967|CHEBI:156499 <br>
  '''synonyms''' : Lc3|Lc(3)Cer|Lc_3 <br>
  '''synonyms''' : Core Fuc|6-linked Fuc|Fuca6 to chitobiose core|a6-linked Fuc|a1-6 Fuc|Fuca6 to chitobiose core|Fuc a1-6 to chitobiose core|Fuca6 to internal GlcNAc|Fuc a1-6 to internal GlcNAc <br>
  '''function''' : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br>
  '''function''' : Required for signaling through TCR [PMID: 29434598]|VGF, PDGFr, and EGFr and TGFbeta receptor dysregulation in Fut8 KO mice [PMID:17132494]|IgG-Fcg receptor interactions destabilized by core Fuc [PMID:29062024] <br>
  '''disease_associations''' : Pharyngitis[SugarBind_Ligand:20]|Tracheobronchitis[SugarBind_Ligand:20]|Gonorrhea[SugarBind_Ligand:20]|Actinomycosis[SugarBind_Ligand:20]|Diarrhea[SugarBind_Ligand:20] <br>
  '''disease_associations''' : Emphysema|systemic lupus erythematosuslung cancer|autoimmunity|tumor metastasis <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK20721/ Chapter 8] <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000050===
===GSD000118===
  '''term (main_entry)''' : Core-fucosylated biantennary <br>
  '''term (main_entry)''' : LcGg4 <br>
  '''glycan_dictionary_accession''' : GSD000050 <br>
  '''glycan_dictionary_accession''' : GSD000118 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G78059CC G78059CC] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G62554JH G62554JH] <br>
  '''term_in_sentence''' : The IFN-alpha14c N-glycans were shown to exhibit core-fucosylated biantennary glycans , with about 10% carrying an additional alpha1,3-linked fucose unit at the antennae.[PMID:[https://pubmed.ncbi.nlm.nih.gov/9654101 9654101]] <br>
  '''term_in_sentence''' : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3805024 3805024] [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/9654101 9654101]|[https://pubmed.ncbi.nlm.nih.gov/15819890 15819890]|[https://pubmed.ncbi.nlm.nih.gov/28263871 28263871]|[https://pubmed.ncbi.nlm.nih.gov/26763099 26763099]|[https://pubmed.ncbi.nlm.nih.gov/22256781 22256781]|[https://pubmed.ncbi.nlm.nih.gov/23681398 23681398]|[https://pubmed.ncbi.nlm.nih.gov/25855029 25855029]|[https://pubmed.ncbi.nlm.nih.gov/10529240 10529240]|[https://pubmed.ncbi.nlm.nih.gov/26544759 26544759]|[https://pubmed.ncbi.nlm.nih.gov/8206921 8206921]|[https://pubmed.ncbi.nlm.nih.gov/33149259 33149259]|[https://pubmed.ncbi.nlm.nih.gov/8547276 8547276] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3805024 3805024] [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]]|[https://pubmed.ncbi.nlm.nih.gov/33395290 33395290] <br>
  '''definition''' : A biantennary glycan with two GlcNAc branches linked to the core and fucosylation on the core GlcNAc. <br>
  '''definition''' : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521] <br>
  '''term_xref''' : GTC:G78059CC|CID:70679232|CHEBI:70967|CHEBI:156499 <br>
  '''term_xref''' : GlycoMotif:GGM.000075|GTC:G62554JH|CID:[https://pubmed.ncbi.nlm.nih.gov/91850076 91850076]|CHEBI:152521|GlycoEpitope:EP0035  <br>
  '''synonyms''' : core-fucosylated diantennary <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK20721/ Chapter 8] <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000051===
===GSD000119===
  '''term (main_entry)''' : Core-fucosylated biantennary complex-type <br>
  '''term (main_entry)''' : Lewis a <br>
  '''glycan_dictionary_accession''' : GSD000051 <br>
  '''glycan_dictionary_accession''' : GSD000119 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G78059CC G78059CC] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00047MO G00047MO] <br>
  '''term_in_sentence''' : The oligosaccharide structure at Asn(32 ) is a mixture of the monosialo and asialo forms of a core fucosylated biantennary complex-type oligosaccharide.[PMID:[https://pubmed.ncbi.nlm.nih.gov/10731668 10731668]] <br>
  '''term_in_sentence''' : Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). [PMID:[https://pubmed.ncbi.nlm.nih.gov/29367698 29367698]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/10731668 10731668] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29367698 29367698]|[https://pubmed.ncbi.nlm.nih.gov/27187324 27187324]|[https://pubmed.ncbi.nlm.nih.gov/30562693 30562693]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625] [https://pubmed.ncbi.nlm.nih.gov/27646625 27646625]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286] [https://pubmed.ncbi.nlm.nih.gov/26911286 26911286]]|[https://pubmed.ncbi.nlm.nih.gov/30225822 30225822]|[https://pubmed.ncbi.nlm.nih.gov/28600306 28600306]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016] [https://pubmed.ncbi.nlm.nih.gov/32527016 32527016]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097] [https://pubmed.ncbi.nlm.nih.gov/2385097 2385097]]|[https://pubmed.ncbi.nlm.nih.gov/11064310 11064310]|[https://pubmed.ncbi.nlm.nih.gov/23809433 23809433]|[https://pubmed.ncbi.nlm.nih.gov/30050155 30050155]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929] [https://pubmed.ncbi.nlm.nih.gov/1615929 1615929]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514] [https://pubmed.ncbi.nlm.nih.gov/29527514 29527514]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264] [https://pubmed.ncbi.nlm.nih.gov/9207264 9207264]]|[https://pubmed.ncbi.nlm.nih.gov/1675497 1675497]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023] [https://pubmed.ncbi.nlm.nih.gov/3677023 3677023]]|[https://pubmed.ncbi.nlm.nih.gov/27705835 27705835]|[https://pubmed.ncbi.nlm.nih.gov/7593252 7593252]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997] [https://pubmed.ncbi.nlm.nih.gov/2579997 2579997]]|[https://pubmed.ncbi.nlm.nih.gov/17630273 17630273]|[https://pubmed.ncbi.nlm.nih.gov/9350993 9350993]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001] [https://pubmed.ncbi.nlm.nih.gov/9098001 9098001]] <br>
  '''definition''' : A biantennary complex glycan with two GlcNAc branches linked to the core and fucosylation on the core GlcNAc. <br>
  '''definition''' : A lewis blood group antigen with structure beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcpNAc consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an alpha-linkage and a galactosyl residue attached at the 3-position via a beta-linkage. It has a role as an epitope and an antigen. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:62265] <br>
  '''term_xref''' : GTC:G78059CC|CID:70679232|CHEBI:70967|CHEBI:156499 <br>
  '''term_xref''' : GTC:G00047MO|CID:[https://pubmed.ncbi.nlm.nih.gov/22806751 22806751]|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155 <br>
  '''synonyms''' : core fucosylated diantennary complex-type <br>
  '''synonyms''' : Le(a)|Lea-3|Lea|Le^a <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : Gastroenteritis[SugarBind_Ligand:155] <br>
  '''wikipedia''' : <br>
  '''wikipedia''' : https://www.wikidata.org/wiki/Q[https://pubmed.ncbi.nlm.nih.gov/50687009 50687009] <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000052===
===GSD000120===
[[File:G11148DZ.png|thumb|G11148DZ]]
[[File:G39211DH.png|thumb|G39211DH]]
  '''term (main_entry)''' : Cyclic sialyl 6-sulfo Lewis x <br>
  '''term (main_entry)''' : Lewis b <br>
  '''glycan_dictionary_accession''' : GSD000052 <br>
  '''glycan_dictionary_accession''' : GSD000120 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G11148DZ G11148DZ]<br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G39211DH G39211DH] <br>
  '''term_in_sentence''' : Stimulation of the sialyl 6-sulfo Lewis X-positive colon cancer cell line with a calcium ionophore ionomycin markedly reduced sialyl 6-sulfo Lewis X and induced cyclic sialyl 6-sulfo Lewis X expression.[PMID:[https://pubmed.ncbi.nlm.nih.gov/10728707 10728707]] <br>
  '''term_in_sentence''' : Human mannose-binding lectin preferentially binds to human colon adenocarcinoma cell lines expressing high amount of Lewis A and Lewis B antigens.[PMID:[https://pubmed.ncbi.nlm.nih.gov/10328552 10328552]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/10728707 10728707]|[https://pubmed.ncbi.nlm.nih.gov/31222115 31222115]|[https://pubmed.ncbi.nlm.nih.gov/9990070 9990070]|[https://pubmed.ncbi.nlm.nih.gov/23088960 23088960] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/10328552 10328552]|[https://pubmed.ncbi.nlm.nih.gov/23408949 23408949]|[https://pubmed.ncbi.nlm.nih.gov/31927399 31927399]|[https://pubmed.ncbi.nlm.nih.gov/26601230 26601230]|[https://pubmed.ncbi.nlm.nih.gov/28279343 28279343]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016] [https://pubmed.ncbi.nlm.nih.gov/32527016 32527016]]|[https://pubmed.ncbi.nlm.nih.gov/30831115 30831115]|[https://pubmed.ncbi.nlm.nih.gov/27318698 27318698]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264] [https://pubmed.ncbi.nlm.nih.gov/9207264 9207264]]|[https://pubmed.ncbi.nlm.nih.gov/23828675 23828675]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514] [https://pubmed.ncbi.nlm.nih.gov/29527514 29527514]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929] [https://pubmed.ncbi.nlm.nih.gov/1615929 1615929]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097] [https://pubmed.ncbi.nlm.nih.gov/2385097 2385097]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997] [https://pubmed.ncbi.nlm.nih.gov/2579997 2579997]]|[https://pubmed.ncbi.nlm.nih.gov/25516619 25516619]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023] [https://pubmed.ncbi.nlm.nih.gov/3677023 3677023]]|[https://pubmed.ncbi.nlm.nih.gov/8509439 8509439]|[https://pubmed.ncbi.nlm.nih.gov/19832116 19832116]|[https://pubmed.ncbi.nlm.nih.gov/15270746 15270746]|[https://pubmed.ncbi.nlm.nih.gov/3166398 3166398]|[https://pubmed.ncbi.nlm.nih.gov/30909206 30909206]|[https://pubmed.ncbi.nlm.nih.gov/7718581 7718581]|[https://pubmed.ncbi.nlm.nih.gov/18400963 18400963]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628] [https://pubmed.ncbi.nlm.nih.gov/29751628 29751628]]|[https://pubmed.ncbi.nlm.nih.gov/8982241 8982241]|[https://pubmed.ncbi.nlm.nih.gov/30284922 30284922]|[https://pubmed.ncbi.nlm.nih.gov/24576035 24576035]|[https://pubmed.ncbi.nlm.nih.gov/30974776 30974776]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001] [https://pubmed.ncbi.nlm.nih.gov/9098001 9098001]]|[https://pubmed.ncbi.nlm.nih.gov/31768613 31768613]|[https://pubmed.ncbi.nlm.nih.gov/1651804 1651804]|[https://pubmed.ncbi.nlm.nih.gov/25428879 25428879]|[https://pubmed.ncbi.nlm.nih.gov/15946883 15946883]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790] [https://pubmed.ncbi.nlm.nih.gov/30298790 30298790]]|[https://pubmed.ncbi.nlm.nih.gov/30544260 30544260]|[https://pubmed.ncbi.nlm.nih.gov/29197783 29197783]|[https://pubmed.ncbi.nlm.nih.gov/8632739 8632739]|[https://pubmed.ncbi.nlm.nih.gov/7679772 7679772]|[https://pubmed.ncbi.nlm.nih.gov/18666312 18666312]|[https://pubmed.ncbi.nlm.nih.gov/20231766 20231766]|[https://pubmed.ncbi.nlm.nih.gov/29922666 29922666]|95124|[https://pubmed.ncbi.nlm.nih.gov/2247887 2247887]|[https://pubmed.ncbi.nlm.nih.gov/21519121 21519121]|[https://pubmed.ncbi.nlm.nih.gov/25153235 25153235]|[https://pubmed.ncbi.nlm.nih.gov/28751211 28751211] <br>
  '''definition''' :  <br>
  '''definition''' :  <br>
  '''term_xref''' : GlycoEpitope:EP0017|CID: 91858084|CHEBI:147484<br>
  '''term_xref''' : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:[https://pubmed.ncbi.nlm.nih.gov/45480568 45480568]|CHEBI:59440 <br>
  '''synonyms''' : <br>
  '''synonyms''' : Le(b)|Lewis(b)|Le^b <br>
  '''function''' : The accumulated intracellular cyclic sialyl 6-sulfo Lex determinant may function as a dormant pool of selectin ligands.[GlycoEpitope:EP0017] <br>
  '''function''' : possible receptor for Helicobacter pylori[https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/blood-group-lewis-system<nowiki>] </nowiki><br>
  '''disease_associations''' : <br>
  '''disease_associations''' : Gastroenteritis[SugarBind_Ligand:146] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000053===
===GSD000121===
  '''term (main_entry)''' : Cytolipin R <br>
  '''term (main_entry)''' : Lewis x <br>
  '''glycan_dictionary_accession''' : GSD000053 <br>
  '''glycan_dictionary_accession''' : GSD000121 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G57710SU G57710SU] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00051MO G00051MO] <br>
  '''term_in_sentence''' : The reaction can be inhibited completely by pure cytolipin R showing that (a) immune hemolysis can be mediated through lipid determinants in the membrane, and (b) that cytolipin R determinants are present in the intact erythrocyte membrane and exposed on the surface.[PMID:[https://pubmed.ncbi.nlm.nih.gov/4110375 4110375]] <br>
  '''term_in_sentence''' : In particular, the observation of oxonium ions at m/z 512.2 and 803.2 is useful for probing outer non-reducing terminal fucosylation, which represented carbohydrate structures consisting of Hex Hex , dHex Hex , and HexNAc , and NeuNAc , Hex Hex , dHex Hex , and HexNAc , respectively, from which the Lewis X structure (Galbeta1-4(Fucalpha1-3)GlcNAc) was readily deduced.[PMID:[https://pubmed.ncbi.nlm.nih.gov/15536627 15536627]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/893368 893368]|[https://pubmed.ncbi.nlm.nih.gov/4375678 4375678]|[https://pubmed.ncbi.nlm.nih.gov/51702 51702]|[https://pubmed.ncbi.nlm.nih.gov/186204 186204]|[https://pubmed.ncbi.nlm.nih.gov/4110375 4110375]|[https://pubmed.ncbi.nlm.nih.gov/5068000 5068000]|[https://pubmed.ncbi.nlm.nih.gov/24174198 24174198]|[https://pubmed.ncbi.nlm.nih.gov/6072378 6072378]|[https://pubmed.ncbi.nlm.nih.gov/389925 389925|[https://pubmed.ncbi.nlm.nih.gov/7054174 7054174] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/15536627 15536627]|[https://pubmed.ncbi.nlm.nih.gov/31666308 31666308]|[https://pubmed.ncbi.nlm.nih.gov/29019053 29019053]|[https://pubmed.ncbi.nlm.nih.gov/28296340 28296340]|[https://pubmed.ncbi.nlm.nih.gov/29593094 29593094]|[https://pubmed.ncbi.nlm.nih.gov/17607374 17607374]|[https://pubmed.ncbi.nlm.nih.gov/16581086 16581086]|[https://pubmed.ncbi.nlm.nih.gov/20858014 20858014]|[https://pubmed.ncbi.nlm.nih.gov/19962782 19962782]|[https://pubmed.ncbi.nlm.nih.gov/7912739 7912739]|[https://pubmed.ncbi.nlm.nih.gov/25121780 25121780]|[https://pubmed.ncbi.nlm.nih.gov/24059473 24059473]|[https://pubmed.ncbi.nlm.nih.gov/29210428 29210428]|[https://pubmed.ncbi.nlm.nih.gov/31276881 31276881]|[https://pubmed.ncbi.nlm.nih.gov/9015359 9015359]|[https://pubmed.ncbi.nlm.nih.gov/7628844 7628844]|[https://pubmed.ncbi.nlm.nih.gov/7499837 7499837]|[https://pubmed.ncbi.nlm.nih.gov/16850248 16850248]|[https://pubmed.ncbi.nlm.nih.gov/28425129 28425129]|[https://pubmed.ncbi.nlm.nih.gov/28869691 28869691]|[https://pubmed.ncbi.nlm.nih.gov/19576189 19576189]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/10223649 10223649] [https://pubmed.ncbi.nlm.nih.gov/10223649 10223649]]|[https://pubmed.ncbi.nlm.nih.gov/22593503 22593503]|[https://pubmed.ncbi.nlm.nih.gov/15632313 15632313]|[https://pubmed.ncbi.nlm.nih.gov/27198630 27198630]|[https://pubmed.ncbi.nlm.nih.gov/26582608 26582608]|[https://pubmed.ncbi.nlm.nih.gov/11500392 11500392]|[https://pubmed.ncbi.nlm.nih.gov/31256373 31256373]|[https://pubmed.ncbi.nlm.nih.gov/23399157 23399157]|[https://pubmed.ncbi.nlm.nih.gov/21984435 21984435]|[https://pubmed.ncbi.nlm.nih.gov/26244810 26244810]|[https://pubmed.ncbi.nlm.nih.gov/26162743 26162743]|[https://pubmed.ncbi.nlm.nih.gov/17335083 17335083]|[https://pubmed.ncbi.nlm.nih.gov/15388363 15388363]|[https://pubmed.ncbi.nlm.nih.gov/9556613 9556613]|[https://pubmed.ncbi.nlm.nih.gov/10760152 10760152]|[https://pubmed.ncbi.nlm.nih.gov/11267844 11267844]|[https://pubmed.ncbi.nlm.nih.gov/20876654 20876654]|[https://pubmed.ncbi.nlm.nih.gov/12131290 12131290] <br>
  '''definition''' : A ceramide tetrahexoside isolated from rat lymphosarcoma. The structure of cytolipin R to be N-acetylgalactosaminyl(beta1-->3)galactosyl(alpha1-->3) galactosyl(beta1-->4)glucosyl ceramide.[PMID:[https://pubmed.ncbi.nlm.nih.gov/5068000 5068000]] <br>
  '''definition''' : A Lewis blood group antigen with structure α-L-Fucp-(1→3)-[β-D-Galp-(1→4)]-D-GlcpNAc where the glucosamine at the reducing end has β-configuration at its anomeric centre. Commonly known as Lewis x trisaccharide or Lex.[CHEBI:59294] <br>
  '''term_xref''' : GlycoMotif:GGM.000083|GTC:G57710SU|CID:91855936|KEGG:G00392|CHEBI:152175|SugarBind_Ligand:17  <br>
  '''term_xref''' : GTC:G00051MO |GlycoEpitope:EP0011|CID:[https://pubmed.ncbi.nlm.nih.gov/44611539 44611539]|CHEBI:59294|GlycoMotif:GGM.000018 <br>
  '''synonyms''' : <br>
  '''synonyms''' : Lex|Galbeta1-4(Fucalpha1-3)GlcNAc|Lewis x trisaccharide|Le(X)|Le^x|SSEA-1 <br>
  '''function''' : <br>
  '''function''' : Involved in carbohydrate-carbohydrate interaction[Glycoepitope:EP0011].|Also implicated in apoptosis.[Glycoepitope:EP0011]|influence antigenic presentation and interfere with pathogen transfer in breastfed infants.[Glycoepitope:EP0011] <br>
  '''disease_associations''' : Actinomycosis[SugarBind_Ligand:17] <br>
  '''disease_associations''' : acute leukemia[GlycoEpitope:EP0011]|lymphoma[GlycoEpitope:EP0011] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000054===
===GSD000122===
  '''term (main_entry)''' : Dermatan sulfate <br>
[[File:G00052MO.png|alt=|thumb|G00052MO]]
  '''glycan_dictionary_accession''' : GSD000054 <br>
  '''term (main_entry)''' : Lewis y <br>
  '''glytoucan_accession ''' : <br>
  '''glycan_dictionary_accession''' : GSD000122 <br>
  '''term_in_sentence''' : By utilizing sophisticated separation methods followed by compositional analysis, domain mapping, and tandem mass spectrometry coupled with analysis by a modified genetic algorithm approach, the structural motif for the decorin dermatan sulfate chain was determined.[PMID:[https://pubmed.ncbi.nlm.nih.gov/29111696 29111696]] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00052MO G00052MO] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27526113 27526113]]|[https://pubmed.ncbi.nlm.nih.gov/29111696 29111696]|[https://pubmed.ncbi.nlm.nih.gov/29891297 29891297]|[https://pubmed.ncbi.nlm.nih.gov/26164146 26164146]|[https://pubmed.ncbi.nlm.nih.gov/30869126 30869126]|[https://pubmed.ncbi.nlm.nih.gov/7789716 7789716]|[https://pubmed.ncbi.nlm.nih.gov/8597249 8597249]|[https://pubmed.ncbi.nlm.nih.gov/12512856 12512856]| [https://pubmed.ncbi.nlm.nih.gov/31250530 31250530]| [https://pubmed.ncbi.nlm.nih.gov/17928217 17928217]|[https://pubmed.ncbi.nlm.nih.gov/12213784 12213784]|[https://pubmed.ncbi.nlm.nih.gov/27226567 27226567]|[https://pubmed.ncbi.nlm.nih.gov/31455633 31455633]|[https://pubmed.ncbi.nlm.nih.gov/28091940 28091940]|[https://pubmed.ncbi.nlm.nih.gov/19075609 19075609]|[https://pubmed.ncbi.nlm.nih.gov/31071403 31071403]|[https://pubmed.ncbi.nlm.nih.gov/15078125 15078125]|[https://pubmed.ncbi.nlm.nih.gov/18661328 18661328]|[https://pubmed.ncbi.nlm.nih.gov/20581662 20581662]|[https://pubmed.ncbi.nlm.nih.gov/17239765 17239765]|[https://pubmed.ncbi.nlm.nih.gov/15749837 15749837]|[https://pubmed.ncbi.nlm.nih.gov/2777747 2777747]|[https://pubmed.ncbi.nlm.nih.gov/20632047 20632047]|[https://pubmed.ncbi.nlm.nih.gov/8930750 8930750]|[https://pubmed.ncbi.nlm.nih.gov/7762784 7762784]|[https://pubmed.ncbi.nlm.nih.gov/31006321 31006321]|[https://pubmed.ncbi.nlm.nih.gov/26876822 26876822]|[https://pubmed.ncbi.nlm.nih.gov/1522290 1522290]|131009|[https://pubmed.ncbi.nlm.nih.gov/26986023 26986023]|[https://pubmed.ncbi.nlm.nih.gov/8161353 8161353]|[https://pubmed.ncbi.nlm.nih.gov/15315969 15315969]|[https://pubmed.ncbi.nlm.nih.gov/12543559 12543559]|[https://pubmed.ncbi.nlm.nih.gov/30637950 30637950]|[https://pubmed.ncbi.nlm.nih.gov/2525357 2525357]|[https://pubmed.ncbi.nlm.nih.gov/18156656 18156656]|[https://pubmed.ncbi.nlm.nih.gov/9692613 9692613]|[https://pubmed.ncbi.nlm.nih.gov/9200333 9200333]|[https://pubmed.ncbi.nlm.nih.gov/19661164 19661164]|[https://pubmed.ncbi.nlm.nih.gov/2299256 2299256]|[https://pubmed.ncbi.nlm.nih.gov/16075147 16075147]|[https://pubmed.ncbi.nlm.nih.gov/1126924 1126924]|[https://pubmed.ncbi.nlm.nih.gov/9774430 9774430]|[https://pubmed.ncbi.nlm.nih.gov/8537360 8537360]|[https://pubmed.ncbi.nlm.nih.gov/15563459 15563459]|[https://pubmed.ncbi.nlm.nih.gov/21077227 21077227]|[https://pubmed.ncbi.nlm.nih.gov/23275130 23275130]|[https://pubmed.ncbi.nlm.nih.gov/17137817 17137817]|[https://pubmed.ncbi.nlm.nih.gov/6447930 6447930]|[https://pubmed.ncbi.nlm.nih.gov/6209270 6209270] <br>
  '''term_in_sentence''' : In conclusion, Lewis y antigen and CD147 were significantly upregulated in ovarian tumors, and the altered expression of Lewis y may cause changes in CD147.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446] [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446]]] <br>
  '''definition''' : Any of a group of glycosaminoglycans with repeating units consisting of variously sulfated β1→4-linked L-iduronyl-(α1→3)-N-acetyl-D-galactosamine units.[CHEBI:18376] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446] [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467] [https://pubmed.ncbi.nlm.nih.gov/20003467 20003467]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145] [https://pubmed.ncbi.nlm.nih.gov/24692145 24692145]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328] [https://pubmed.ncbi.nlm.nih.gov/24998328 24998328]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913] [https://pubmed.ncbi.nlm.nih.gov/25726913 25726913]]|[https://pubmed.ncbi.nlm.nih.gov/29299130 29299130]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446] [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467] [https://pubmed.ncbi.nlm.nih.gov/20003467 20003467]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145] [https://pubmed.ncbi.nlm.nih.gov/24692145 24692145]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328] [https://pubmed.ncbi.nlm.nih.gov/24998328 24998328]]|[https://pubmed.ncbi.nlm.nih.gov/20127027 20127027]|[https://pubmed.ncbi.nlm.nih.gov/22138668 22138668]|[https://pubmed.ncbi.nlm.nih.gov/23894390 23894390]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913] [https://pubmed.ncbi.nlm.nih.gov/25726913 25726913]]|[https://pubmed.ncbi.nlm.nih.gov/25416440 25416440]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625] [https://pubmed.ncbi.nlm.nih.gov/27646625 27646625]]|[https://pubmed.ncbi.nlm.nih.gov/23725446 23725446]|[https://pubmed.ncbi.nlm.nih.gov/21294926 21294926]|[https://pubmed.ncbi.nlm.nih.gov/22312289 22312289]|[https://pubmed.ncbi.nlm.nih.gov/25973320 25973320]|[https://pubmed.ncbi.nlm.nih.gov/23242548 23242548]|[https://pubmed.ncbi.nlm.nih.gov/30328452 30328452]|[https://pubmed.ncbi.nlm.nih.gov/21119363 21119363]|[https://pubmed.ncbi.nlm.nih.gov/29130097 29130097]|[https://pubmed.ncbi.nlm.nih.gov/23443083 23443083]|[https://pubmed.ncbi.nlm.nih.gov/23708102 23708102]|[https://pubmed.ncbi.nlm.nih.gov/28671040 28671040]|[https://pubmed.ncbi.nlm.nih.gov/19715603 19715603]|[https://pubmed.ncbi.nlm.nih.gov/23468946 23468946]|[https://pubmed.ncbi.nlm.nih.gov/27723168 27723168]|[https://pubmed.ncbi.nlm.nih.gov/21747684 21747684]|[https://pubmed.ncbi.nlm.nih.gov/19771739 19771739] <br>
  '''term_xref''' : CHEBI:18376|CID:32756 <br>
  '''definition''' : A Lewis blood group antigen which is a branched amino tetrasaccharide with structure alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, consisting of consisting of N-acetyl-beta-D-glucosamine at the reducing end having an alpha-L-fucosyl residue attached at the 3-position and an alpha-L-fucosyl-(1→2)-beta-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure. It has a role as an antigen and an epitope. [CHEBI:59045]] <br>
  '''synonyms''' : beta-Heparin|Chondroitin sulfate B|Dermatan L-iduronate <br>
  '''term_xref''' : GTC:G00052MO|GlycoEpitope:EP0018|CID:[https://pubmed.ncbi.nlm.nih.gov/45266908 45266908]|CHEBI:59045|GlycoMotif:GGM.000019  <br>
  '''function''' : Wound healing[Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453034/ Chapter 7]]|maintain the structure of the dermis.[Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453056/ Chapter 41]] <br>
  '''synonyms''' : LeY|Le(y)|Ley|Le^y <br>
  '''disease_associations''' : <br>
  '''function''' : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018] <br>
  '''disease_associations''' : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000055===
===GSD000123===
  '''term (main_entry)''' : Desialylated <br>
  '''term (main_entry)''' : Monosialylated <br>
  '''glycan_dictionary_accession''' : GSD000055 <br>
  '''glycan_dictionary_accession''' : GSD000123 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : Furthermore, we found no evidence for "desialylated" apoB100 glycans in any of the samples analyzed.[PMID:11588155] <br>
  '''term_in_sentence''' : The structures of the asparagine-linked sugar chains of U- CD59 were biantennary complex type , only 4.2% of which are monosialylated.[PMID:[https://pubmed.ncbi.nlm.nih.gov/7514386 7514386]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/30015642 30015642]|[https://pubmed.ncbi.nlm.nih.gov/26168491 26168491]|[https://pubmed.ncbi.nlm.nih.gov/29492899 29492899]|[https://pubmed.ncbi.nlm.nih.gov/31774586 31774586]|[https://pubmed.ncbi.nlm.nih.gov/32321401 32321401]|[https://pubmed.ncbi.nlm.nih.gov/23780974 23780974]|[https://pubmed.ncbi.nlm.nih.gov/7600681 7600681]|[https://pubmed.ncbi.nlm.nih.gov/18045697 18045697]|[https://pubmed.ncbi.nlm.nih.gov/1450583 1450583]|[https://pubmed.ncbi.nlm.nih.gov/4137057 4137057]|[https://pubmed.ncbi.nlm.nih.gov/28911304 28911304]|[https://pubmed.ncbi.nlm.nih.gov/27562992 27562992]|[https://pubmed.ncbi.nlm.nih.gov/29950245 29950245]|[https://pubmed.ncbi.nlm.nih.gov/31978220 31978220]|[https://pubmed.ncbi.nlm.nih.gov/2408573 2408573]|[https://pubmed.ncbi.nlm.nih.gov/8612720 8612720]|[https://pubmed.ncbi.nlm.nih.gov/10910970 10910970]|[https://pubmed.ncbi.nlm.nih.gov/27195066 27195066]|[https://pubmed.ncbi.nlm.nih.gov/1434544 1434544]|[https://pubmed.ncbi.nlm.nih.gov/22175031 22175031]|[https://pubmed.ncbi.nlm.nih.gov/24517196 24517196]|[https://pubmed.ncbi.nlm.nih.gov/29794068 29794068]|[https://pubmed.ncbi.nlm.nih.gov/30101537 30101537]|[https://pubmed.ncbi.nlm.nih.gov/18972200 18972200]|[https://pubmed.ncbi.nlm.nih.gov/1478792 1478792]|[https://pubmed.ncbi.nlm.nih.gov/4440781 4440781]|[https://pubmed.ncbi.nlm.nih.gov/21229239 21229239]|[https://pubmed.ncbi.nlm.nih.gov/30844664 30844664]|[https://pubmed.ncbi.nlm.nih.gov/31351722 31351722]|[https://pubmed.ncbi.nlm.nih.gov/31330845 31330845]|[https://pubmed.ncbi.nlm.nih.gov/1872910 1872910] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/7514386 7514386]|[https://pubmed.ncbi.nlm.nih.gov/8477709 8477709]|[https://pubmed.ncbi.nlm.nih.gov/8942648 8942648]|[https://pubmed.ncbi.nlm.nih.gov/29752599 29752599]|[https://pubmed.ncbi.nlm.nih.gov/31669586 31669586]|[https://pubmed.ncbi.nlm.nih.gov/29747818 29747818]|[https://pubmed.ncbi.nlm.nih.gov/16425369 16425369]|[https://pubmed.ncbi.nlm.nih.gov/12089170 12089170]|[https://pubmed.ncbi.nlm.nih.gov/31390883 31390883]|[https://pubmed.ncbi.nlm.nih.gov/1632647 1632647]|[https://pubmed.ncbi.nlm.nih.gov/29733234 29733234]|[https://pubmed.ncbi.nlm.nih.gov/31110965 31110965]|[https://pubmed.ncbi.nlm.nih.gov/31566965 31566965]|[https://pubmed.ncbi.nlm.nih.gov/30555678 30555678]|[https://pubmed.ncbi.nlm.nih.gov/28263871 28263871]|[https://pubmed.ncbi.nlm.nih.gov/29652662 29652662]|[https://pubmed.ncbi.nlm.nih.gov/25915761 25915761]|[https://pubmed.ncbi.nlm.nih.gov/16381065 16381065]|[https://pubmed.ncbi.nlm.nih.gov/29247593 29247593]|[https://pubmed.ncbi.nlm.nih.gov/28370937 28370937]|[https://pubmed.ncbi.nlm.nih.gov/23896595 23896595]|[https://pubmed.ncbi.nlm.nih.gov/26633899 26633899]|[https://pubmed.ncbi.nlm.nih.gov/32155999 32155999]|[https://pubmed.ncbi.nlm.nih.gov/25261856 25261856]|[https://pubmed.ncbi.nlm.nih.gov/2737211 2737211]|[https://pubmed.ncbi.nlm.nih.gov/26945091 26945091]|[https://pubmed.ncbi.nlm.nih.gov/27065039 27065039]|[https://pubmed.ncbi.nlm.nih.gov/26784838 26784838]|[https://pubmed.ncbi.nlm.nih.gov/26582205 26582205] <br>
  '''definition''' : A glycan from which sialyl groups have been removed. [https://en.wiktionary.org/wiki/desialylated<nowiki>] </nowiki><br>
  '''definition''' : A glycan that have the addition of one sialic acid residues. <br>
  '''term_xref''' :  <br>
  '''term_xref''' :  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' : <br>
  '''function''' : appears in bovine brain gangliosides.[PMID: [https://pubmed.ncbi.nlm.nih.gov/29752599 29752599]] <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
Line 367: Line 349:




===GSD000056===
===GSD000124===
  '''term (main_entry)''' : Desialylated tetrasaccharide <br>
  '''term (main_entry)''' : Monosialyl-biantennary <br>
  '''glycan_dictionary_accession''' : GSD000056 <br>
  '''glycan_dictionary_accession''' : GSD000124 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : The structures of a desialylated tetrasaccharide , two monosialylated trisaccharides , and five other minor products were defined.[PMID:[https://pubmed.ncbi.nlm.nih.gov/8384526 8384526]] <br>
  '''term_in_sentence''' : In contrast, the sugar chain structure of HCC highly specific AFP isoform was found to comprise a monosialyl-biantennary sugar chain with additional fucosylation of the proximal N-acetylglucosamine.[PMID:[https://pubmed.ncbi.nlm.nih.gov/7686446 7686446]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/8384526 8384526] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/7686446 7686446]|[https://pubmed.ncbi.nlm.nih.gov/1374031 1374031]|[https://pubmed.ncbi.nlm.nih.gov/9648261 9648261]|[https://pubmed.ncbi.nlm.nih.gov/10460833 10460833]|[https://pubmed.ncbi.nlm.nih.gov/19524219 19524219]|[https://pubmed.ncbi.nlm.nih.gov/10207016 10207016]|[https://pubmed.ncbi.nlm.nih.gov/15797573 15797573]|[https://pubmed.ncbi.nlm.nih.gov/15218190 15218190] <br>
  '''definition''' : A tetrasachharide (four branches) glycan from which sialyl groups have been removed. <br>
  '''definition''' : A biantennary glycan with two GlcNAc branches linked to the core and the addition of one sialic acid residues. <br>
  '''term_xref''' :  <br>
  '''term_xref''' :  <br>
  '''synonyms''' : <br>
  '''synonyms''' : monosialyl biantennary|sialylated diantennary|sialylated biantennary <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17]<br>
  '''essentials_of_glycobiology''' : <br>




===GSD000057===
===GSD000125===
  '''term (main_entry)''' : Difucosylated tetra-antennary N-glycans <br>
  '''term (main_entry)''' : Monosialyl-Gb5 <br>
  '''glycan_dictionary_accession''' : GSD000057 <br>
  '''glycan_dictionary_accession''' : GSD000125 <br>
  '''glytoucan_accession ''' : <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G32254QI G32254QI] <br>
  '''term_in_sentence''' : While fucosylated N-glycans derived from serum haptoglobin of patients with CP slightly increased, di-fucosylated tetra-antennary N-glycans were observed only at this site in PC patients, and were absent in the haptoglobin of normal controls and individuals with CP.[PMID: [https://pubmed.ncbi.nlm.nih.gov/18214858 18214858]] <br>
  '''term_in_sentence''' : Thus, malignancy of MCF-7 is highly dependent on monosialyl-Gb5, and its activation of cSrc and FAK in GEM.[PMID:[https://pubmed.ncbi.nlm.nih.gov/12401210 12401210]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/18214858 18214858] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/12401210 12401210]|[https://pubmed.ncbi.nlm.nih.gov/16995838 16995838]|[https://pubmed.ncbi.nlm.nih.gov/27318475 27318475] <br>
  '''definition''' : The tetra-antennary N-linked glycans that have four GlcNAc branches linked to the core and two fucose added. <br>
  '''definition''' : alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp is a linear amino hexasaccharide comprising β-D-glucose at the reducing end with at the 4-position a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-α-D-galactosyl-(1→4)-β-D-galactosyl moiety, α(2→3)-sialylated at the terminal galactosyl residue.[CHEBI:62313] <br>
  '''term_xref''' :  <br>
  '''term_xref''' : GTC:G32254QI|GlycoEpitope:EP0099|GlycoMotif:GGM.000080|CID:[https://pubmed.ncbi.nlm.nih.gov/73427363 73427363]|CHEBI:62313 <br>
  '''synonyms''' : <br>
  '''synonyms''' : GL-7 globoseries ganglioside (SSEA-4)|Monosialyl Gb5|Sialosyl galactosyl globoside|GL-7 globoseries ganglioside|SSEA-4 <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : pancreatic cancer[PMID:[https://pubmed.ncbi.nlm.nih.gov/18214858 18214858]] <br>
  '''disease_associations''' : renal cell carcinoma/RCC[GlycoEpitope:EP0099] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000058===
===GSD000126===
'''term (main_entry)''' : Dimeric Lewis x <br>
[[File:G80193TN.png|thumb|G80193TN]]
'''glycan_dictionary_accession''' : GSD000058 <br>
  '''term (main_entry)''' : Mono-sulfated globopentaosylceramide <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G79535HZ G79535HZ] <br>
  '''glycan_dictionary_accession''' : GSD000126 <br>
'''term_in_sentence''' : The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics.[PMID:[https://pubmed.ncbi.nlm.nih.gov/32957489 32957489]] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G80193TN G80193TN] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/32957489 32957489]|[https://pubmed.ncbi.nlm.nih.gov/31276881 31276881]|[https://pubmed.ncbi.nlm.nih.gov/12062524 12062524]|[https://pubmed.ncbi.nlm.nih.gov/15488731 15488731]|[https://pubmed.ncbi.nlm.nih.gov/1979361 1979361]|[https://pubmed.ncbi.nlm.nih.gov/8737237 8737237]|[https://pubmed.ncbi.nlm.nih.gov/17939723 17939723]|[https://pubmed.ncbi.nlm.nih.gov/7683631 7683631]|[https://pubmed.ncbi.nlm.nih.gov/11384108 11384108]|[https://pubmed.ncbi.nlm.nih.gov/11133015 11133015]|[https://pubmed.ncbi.nlm.nih.gov/17388629 17388629]|[https://pubmed.ncbi.nlm.nih.gov/15483381 15483381]|[https://pubmed.ncbi.nlm.nih.gov/12662048 12662048]|[https://pubmed.ncbi.nlm.nih.gov/3233598 3233598]|[https://pubmed.ncbi.nlm.nih.gov/18618154 18618154]|[https://pubmed.ncbi.nlm.nih.gov/21892456 21892456] <br>
  '''term_in_sentence''' : Mono-sulfated globopentaosylceramide from human kidney.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2777788 2777788]] <br>
'''definition''' : A six-membered glucosamine oligosaccharide consisting of two repeating units of β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc joined by a (1→3)-linkage.[CHEBI:61325] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2777788 2777788] <br>
'''term_xref''' : GTC:G79535HZ|GlycoEpitope:EP0093|CID:50909845|CHEBI:61325|GlycoMotif:GGM.000031 <br>
'''synonyms''' : DimLex^x|dimeric Le(x)|Lex-Lex|diLe(x)|Lewisx-Lewisx <br>
'''function''' : cancer-associated antigen[GlycoEpitope:EP0093] <br>
'''disease_associations''' : colonic cancer[GlycoEpitope:EP0093]|liver cancer[GlycoEpitope:EP0093] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>
 
 
===GSD000059===
  '''term (main_entry)''' : Diphosphorylated Man6 <br>
  '''glycan_dictionary_accession''' : GSD000059 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G54792LL G54792LL] <br>
  '''term_in_sentence''' : Here we report that the single-chain variable domain (scFv) M6P-1 is a unique antibody fragment with specificity for Man6P monosaccharide that, through an array-screening approach against a number of phosphorylated N-glycans, is shown to bind mono- and diphosphorylated Man6 and Man7 glycans that contain terminal αMan6P(1 → 2)αMan(1 → 3)αMan.[PMID:[https://pubmed.ncbi.nlm.nih.gov/26503547 26503547]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/26503547 26503547] <br>
  '''definition''' :  <br>
  '''definition''' :  <br>
  '''term_xref''' : GTC:G54792LL|GlycoMotif:GGM.000054<br>
  '''term_xref''' : GlycoMotif:GGM.000072|GTC:G80193TN <br>
  '''synonyms''' : Diphosphorylated Man_6 <br>
  '''synonyms''' : Monosulfated globopentaosylceramide <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
Line 427: Line 395:




===GSD000060===
===GSD000127===
  '''term (main_entry)''' : Disialosyl globopentaosylceramide <br>
  '''term (main_entry)''' : Mono-sulfated globotetraosylceramide <br>
  '''glycan_dictionary_accession''' : GSD000060 <br>
  '''glycan_dictionary_accession''' : GSD000127 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G97932OH G97932OH] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G05297EK G05297EK] <br>
  '''term_in_sentence''' : Disialosyl globopentaosylceramide (DSGb5) is often expressed by renal cell carcinomas.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31339142 31339142]] <br>
  '''term_in_sentence''' : Mono-sulfated globotetraosylceramide from human kidney.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2559078 2559078]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/31339142 31339142]|[https://pubmed.ncbi.nlm.nih.gov/24637536 24637536]|[https://pubmed.ncbi.nlm.nih.gov/25864532 25864532]|[https://pubmed.ncbi.nlm.nih.gov/27344728 27344728]| [https://pubmed.ncbi.nlm.nih.gov/12084983 12084983] [https://pubmed.ncbi.nlm.nih.gov/12084983 12084983]| [https://pubmed.ncbi.nlm.nih.gov/32567311 32567311]|[https://pubmed.ncbi.nlm.nih.gov/28205070 28205070]|[https://pubmed.ncbi.nlm.nih.gov/20663960 20663960]|[https://pubmed.ncbi.nlm.nih.gov/18214042 18214042] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2559078 2559078] <br>
'''definition''' : Disialosyl globopentaosylceramide (DSGb5) is a ganglioside originally isolated from tissue extracts of renal cell carcinoma (RCC) with metastasis.[PMID:[https://pubmed.ncbi.nlm.nih.gov/28205070 28205070]] <br>
'''term_xref''' : GlycoMotif:GGM.000082|GTC:G97932OH|GlycoEpitope:EP0098|CID:91860287|KEGG:G00181|SugarBind_Ligand:57  <br>
'''synonyms''' : DSGb5|Disialosyl Gb5|V3NeuAcIV6NeuAc-Gb5Cer|Disialosylgalactosylgloboside <br>
'''function''' : promotes metastasis[PMID:[https://pubmed.ncbi.nlm.nih.gov/28205070 28205070]] <br>
'''disease_associations''' : prostate cancer[PMID:[https://pubmed.ncbi.nlm.nih.gov/24637536 24637536]]|renal cell carcinoma/RCC[GlycoEpitope:EP0098]|Pyelonephritis[SugarBind_Ligand:57] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' :  <br>
 
 
===GSD000061===
'''term (main_entry)''' : Disialyl Gb5 <br>
'''glycan_dictionary_accession''' : GSD000061 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G97932OH G97932OH] <br>
'''term_in_sentence''' : The major disialoganglioside antigen isolated from ACHN cells, showing specific reactivity with 5F3, was characterized unequivocally as disialosyl Gb5 (V(3)NeuAcIV(6)NeuAcGb5) by identification of the core structure as globopentaosylceramide (Gb5) after enzymatic and acid hydrolysis, and by 2-dimensional (1)H-NMR spectroscopy.[PMID: [https://pubmed.ncbi.nlm.nih.gov/12084983 12084983]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/12084983 12084983] [https://pubmed.ncbi.nlm.nih.gov/12084983 12084983] <br>
  '''definition''' :  <br>
  '''definition''' :  <br>
  '''term_xref''' : GlycoEpitope:EP0098|GTC:G97932OH|CID:  91860287|SugarBind_Ligand:57|KEGG:G00181  <br>
  '''term_xref''' : GlycoMotif:GGM.000073|GTC:G05297EK<br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
'''function''' :  <br>
'''disease_associations''' : renal cell carcinoma/RCC[GlycoEpitope:EP0098]|Pyelonephritis[SugarBind_Ligand:57] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' :  <br>
===GSD000062===
'''term (main_entry)''' : Disialyl I <br>
'''glycan_dictionary_accession''' : GSD000062 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G54937EM G54937EM] <br>
'''term_in_sentence''' : Here we present an example of promotion of binding of soluble-form FN from placenta or from hepatoma cells, having a specific carbohydrate epitope termed "disialyl-I," to K562 or VA13 cell surface in the presence of glycosphingolipid Gg3, which interacts specifically with disialyl-I[PMID:[https://pubmed.ncbi.nlm.nih.gov/10640401 10640401]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/10640401 10640401] <br>
'''definition''' :  <br>
'''term_xref''' : GlycoEpitope:EP0095|GTC:G54937EM|CID:91849523  <br>
'''synonyms''' : disialyl-I <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
Line 472: Line 410:




===GSD000063===
===GSD000128===
  '''term (main_entry)''' : Disialyl Lewis a <br>
  '''term (main_entry)''' : N-acetyl GM2 <br>
  '''glycan_dictionary_accession''' : GSD000063 <br>
  '''glycan_dictionary_accession''' : GSD000128 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G93400AK G93400AK] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G79389NT G79389NT] <br>
  '''term_in_sentence''' : Biosynthesis of disialyl Lewis a (Lea) was analyzed using previously cloned ST6GalNAc V and ST6GalNAc VI, which were responsible for the synthesis of alpha-series gangliosides.[PMID:[https://pubmed.ncbi.nlm.nih.gov/12668675 12668675]] <br>
  '''term_in_sentence''' : The appearance of the N-acetyl GM2 antigen correlated well with the degree of differentiation of the cancer cells in patients with squamous cell carcinoma and adenocarcinoma of the lung.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861] [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861]]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/12668675 12668675]|[https://pubmed.ncbi.nlm.nih.gov/17760270 17760270]|[https://pubmed.ncbi.nlm.nih.gov/15231659 15231659]|[https://pubmed.ncbi.nlm.nih.gov/12668106 12668106]|[https://pubmed.ncbi.nlm.nih.gov/30716533 30716533]|[https://pubmed.ncbi.nlm.nih.gov/32050430 32050430]|[https://pubmed.ncbi.nlm.nih.gov/22467657 22467657] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861] [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861]]|[https://pubmed.ncbi.nlm.nih.gov/2153431 2153431]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107] [https://pubmed.ncbi.nlm.nih.gov/25673107 25673107]] <br>
  '''definition''' : Disialyl Lewis is a sialyl Lewis a with an additional sialic acid attached at the C-6 position of penultimate GlcNAc. [PMID:[https://pubmed.ncbi.nlm.nih.gov/15231659 15231659]] <br>
  '''definition''' : beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp is a branched amino tetrasaccharide consisting of the linear sequence β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the galactose via an α-(2→3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2.[CHEBI:59220] <br>
  '''term_xref''' : GTC:G93400AK |GlycoEpitope:EP0040|CID:91854138|CHEBI:155549 <br>
  '''term_xref''' : GTC:G79389NT|GlycoEpitope:EP0051|CID:[https://pubmed.ncbi.nlm.nih.gov/45266845 45266845]|CHEBI:59220 <br>
  '''synonyms''' : disialyl Lea <br>
  '''synonyms''' : <br>
  '''function''' : The 2-3,2-6 disialyl Lea determinant on epithelial cells may play a role in protecting normal epithelial cells.[GlycoEpitope:EP0040] <br>
  '''function''' : The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.[CHEBI:59220] <br>
  '''disease_associations''' : Mucin antigen carrying 2-3 sialylated Le a antigen or 2-3, 2-6 disialylated Lc4 antigen in cancer patients had the lowest carbohydrate/protein ratio. Thus, the carbohydrate/protein ratio in the type 1 chain mucin antigens in sera of normal subjects is higher than that in sera of cancer patients.[GlycoEpitope:EP0040] <br>
  '''disease_associations''' : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000064===
===GSD000129===
  '''term (main_entry)''' : Disialyl T antigen <br>
  '''term (main_entry)''' : N-acetyllactosamine (Type 2)<br>
  '''glycan_dictionary_accession''' : GSD000064 <br>
  '''glycan_dictionary_accession''' : GSD000129 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G01614ZM G01614ZM] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00055MO G00055MO] <br>
  '''term_in_sentence''' : The most potent glycoside was disialyl T antigen (NeuAcalpha2-3Galbeta1-3[NeuAcalpha2-6]GalNAc-R), followed by 3-sialyl T antigen (NeuAcalpha2-3Galbeta1-3GalNAc-R), structures expressed on O-linked glycoproteins as well as on gangliosides.[PMID: [https://pubmed.ncbi.nlm.nih.gov/15701648 15701648]] <br>
  '''term_in_sentence''' : Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial beta1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form N-acetyllactosamine in the presence of UDP.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31165848 31165848]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29113555 29113555]|[https://pubmed.ncbi.nlm.nih.gov/17974963 17974963]|[https://pubmed.ncbi.nlm.nih.gov/33242079 33242079]|[https://pubmed.ncbi.nlm.nih.gov/12645620 12645620]|[https://pubmed.ncbi.nlm.nih.gov/15701648 15701648]|[https://pubmed.ncbi.nlm.nih.gov/26598643 26598643] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/31165848 31165848]|[https://pubmed.ncbi.nlm.nih.gov/31126011 31126011]|[https://pubmed.ncbi.nlm.nih.gov/28796164 28796164]|[https://pubmed.ncbi.nlm.nih.gov/6236210 6236210]|[https://pubmed.ncbi.nlm.nih.gov/9751793 9751793]|[https://pubmed.ncbi.nlm.nih.gov/29740087 29740087]|[https://pubmed.ncbi.nlm.nih.gov/9151975 9151975]|[https://pubmed.ncbi.nlm.nih.gov/10567443 10567443]|[https://pubmed.ncbi.nlm.nih.gov/21472942 21472942]|[https://pubmed.ncbi.nlm.nih.gov/26477523 26477523]|[https://pubmed.ncbi.nlm.nih.gov/6548353 6548353]|[https://pubmed.ncbi.nlm.nih.gov/28167527 28167527]|[https://pubmed.ncbi.nlm.nih.gov/20056550 20056550]|[https://pubmed.ncbi.nlm.nih.gov/7737204 7737204]|[https://pubmed.ncbi.nlm.nih.gov/22052010 22052010]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/10223649 10223649] [https://pubmed.ncbi.nlm.nih.gov/10223649 10223649]]|[https://pubmed.ncbi.nlm.nih.gov/11323440 11323440]|[https://pubmed.ncbi.nlm.nih.gov/10420596 10420596]|[https://pubmed.ncbi.nlm.nih.gov/7766648 7766648]|[https://pubmed.ncbi.nlm.nih.gov/25257940 25257940]|[https://pubmed.ncbi.nlm.nih.gov/17977857 17977857]|[https://pubmed.ncbi.nlm.nih.gov/15556936 15556936]|[https://pubmed.ncbi.nlm.nih.gov/26541999 26541999]|[https://pubmed.ncbi.nlm.nih.gov/23650594 23650594]|[https://pubmed.ncbi.nlm.nih.gov/9692202 9692202]|[https://pubmed.ncbi.nlm.nih.gov/29429899 29429899]|[https://pubmed.ncbi.nlm.nih.gov/21062783 21062783]|[https://pubmed.ncbi.nlm.nih.gov/25034434 25034434]|[https://pubmed.ncbi.nlm.nih.gov/8985145 8985145]|[https://pubmed.ncbi.nlm.nih.gov/28503789 28503789]|[https://pubmed.ncbi.nlm.nih.gov/8720464 8720464]/ <br>
  '''definition''' : α-Neup5Ac-(2→6)-[α-Neup5Ac-(2→3)-β-D-Galp-(1→3)]-α-D-GalpNAc in which the anomeric configuration of the reducing-end N-acetyl-D-glucosamine residue is α.[CHEBI:71602] <br>
  '''definition''' : N-acetyllactosamine is a beta-D-galactopyranosyl-(1→4)-N-acetyl-D-glucosamine having beta-configuration at the reducing end anomeric centre. It is also known as galb1-4glcnacb or lacnac, belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group. N-Acetyllactosamine is an extremely weak basic (essentially neutral) compound (based on its pKa). N-Acetyllactosamine exists in all living organisms, ranging from bacteria to humans.[CHEBI:16153,HMDB0001542] <br>
  '''term_xref''' : GlycoMotif:GGM.000014|GTC:G01614ZM|CID: 70698317|CHEBI:71602|GlycoEpitope:EP0023|KEGG:G00027 <br>
  '''term_xref''' : GTC:G00055MO|CID:439271|CHEBI:16153|MeSH:C000458|GlycoMotif:GGM.000001 <br>
  '''synonyms''' : di-sialyl T antigen|disialyl-T antigen|disialylated T-antigen <br>
  '''synonyms''' : LacNAc|Type 2 LN <br>
  '''function''' : associated with von Willebrand factor(VWF) plasma levels[GlycoEpitope:EP0023] <br>
  '''function''' : <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
Line 502: Line 440:




===GSD000065===
===GSD000130===
  '''term (main_entry)''' : Disialylated biantennary <br>
  '''term (main_entry)''' : N-Glycolyl-GM2 <br>
  '''glycan_dictionary_accession''' : GSD000065 <br>
  '''glycan_dictionary_accession''' : GSD000130 <br>
  '''glytoucan_accession ''' : <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G56478LD G56478LD] <br>
  '''term_in_sentence''' : FAB-MS, electrospray-mass spectrometry, and linkage analysis demonstrated that each monomer of rat CRP contained one oligosaccharide chain , predominantly a disialylated biantennary structure , attached to Asn-128.[PMID:[https://pubmed.ncbi.nlm.nih.gov/8486673 8486673]] <br>
  '''term_in_sentence''' : The monoclonal antibodies MK2-34 and MK1-16 (both IgM), which specifically detect N-glycolyl GM2 and N-acetyl GM2, respectively, were generated by immunizing mice with liposomes containing monophosphoryl lipid A, trehalose dimycolate, and the antigenic ganglioside.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861] [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861]]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/22426998 22426998]|[https://pubmed.ncbi.nlm.nih.gov/17171781 17171781]|[https://pubmed.ncbi.nlm.nih.gov/25022802 25022802]|[https://pubmed.ncbi.nlm.nih.gov/24812685 24812685]|[https://pubmed.ncbi.nlm.nih.gov/24780636 24780636]|[https://pubmed.ncbi.nlm.nih.gov/26582205 26582205]|[https://pubmed.ncbi.nlm.nih.gov/9499382 9499382]|[https://pubmed.ncbi.nlm.nih.gov/22978794 22978794]|[https://pubmed.ncbi.nlm.nih.gov/22594947 22594947]|[https://pubmed.ncbi.nlm.nih.gov/8486673 8486673]|[https://pubmed.ncbi.nlm.nih.gov/20356825 20356825]|[https://pubmed.ncbi.nlm.nih.gov/1634621 1634621]|[https://pubmed.ncbi.nlm.nih.gov/9244386 9244386]|[https://pubmed.ncbi.nlm.nih.gov/12966096 12966096]|[https://pubmed.ncbi.nlm.nih.gov/1472054 1472054]| [https://pubmed.ncbi.nlm.nih.gov/24243045 24243045]|[https://pubmed.ncbi.nlm.nih.gov/19579232 19579232]|[https://pubmed.ncbi.nlm.nih.gov/27943633 27943633] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861] [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861]]|[https://pubmed.ncbi.nlm.nih.gov/11861662 11861662]|[https://pubmed.ncbi.nlm.nih.gov/17980710 17980710]|[https://pubmed.ncbi.nlm.nih.gov/3731079 3731079]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107] [https://pubmed.ncbi.nlm.nih.gov/25673107 25673107]] <br>
  '''definition''' : A biantennary glycan with two GlcNAc branches linked to the core and the addition of two sialic acid residues. <br>
  '''definition''' : (2S,4S,5R,6R)-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of carbohydrates and carbohydrate derivatives.[CHEBI:151464] <br>
  '''term_xref''' :  <br>
  '''term_xref''' : GTC:G56478LD |GlycoEpitope:EP0052|CID:[https://pubmed.ncbi.nlm.nih.gov/91845742 91845742]|CHEBI:151464|GlycoEpitope:GGM.000096 <br>
  '''synonyms''' : disialylated diantennary <br>
  '''synonyms''' : <br>
  '''function''' : appears in human transferrin[PMID:  [https://pubmed.ncbi.nlm.nih.gov/24243045 24243045]]|Appears in human apolipoprotein (apo) B-100.[PMID:2344297] <br>
  '''function''' :  <br>
  '''disease_associations''' : galactosemia.[PMID: [https://pubmed.ncbi.nlm.nih.gov/9499382 9499382]] <br>
  '''disease_associations''' : choriocarcinoma[GlycoEpitope:EP0052]|teratocarcinoma|[GlycoEpitope:EP0052]yolk sac tumor[GlycoEpitope:EP0052] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000066===
===GSD000131===
  '''term (main_entry)''' : Disialylated biantennary complex-type <br>
  '''term (main_entry)''' : N-linked glycans <br>
  '''glycan_dictionary_accession''' : GSD000066 <br>
  '''glycan_dictionary_accession''' : GSD000131 <br>
  '''glytoucan_accession ''' : <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G78059CC G78059CC] <br>
  '''term_in_sentence''' : The glycan was shown to be a disialylated biantennary complex type oligosaccharide N-linked to 318 Asn.[PMID:[https://pubmed.ncbi.nlm.nih.gov/11738084 11738084]] <br>
  '''term_in_sentence''' : Our study identifies extracellular N-linked glycans-and the glycoprotein neurexin 1β specifically-as key modulators of neuronal uptake of αSacetyl, drawing attention to the potential therapeutic value of αSacetyl-glycan interactions.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31211781 31211781]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/11738084 11738084]|[https://pubmed.ncbi.nlm.nih.gov/9499382 9499382]|[https://pubmed.ncbi.nlm.nih.gov/9244386 9244386]|[https://pubmed.ncbi.nlm.nih.gov/24243045 24243045]|[https://pubmed.ncbi.nlm.nih.gov/12966096 12966096]|[https://pubmed.ncbi.nlm.nih.gov/25124522 25124522]|[https://pubmed.ncbi.nlm.nih.gov/19371135 19371135] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/31211781 31211781]|[https://pubmed.ncbi.nlm.nih.gov/28384382 28384382]|[https://pubmed.ncbi.nlm.nih.gov/30305477 30305477]|[https://pubmed.ncbi.nlm.nih.gov/31364612 31364612]|[https://pubmed.ncbi.nlm.nih.gov/26899268 26899268]|[https://pubmed.ncbi.nlm.nih.gov/29945790 29945790]|[https://pubmed.ncbi.nlm.nih.gov/29652253 29652253]|[https://pubmed.ncbi.nlm.nih.gov/29723274 29723274]|[https://pubmed.ncbi.nlm.nih.gov/30962676 30962676]|[https://pubmed.ncbi.nlm.nih.gov/29778448 29778448]|[https://pubmed.ncbi.nlm.nih.gov/25325701 25325701]|[https://pubmed.ncbi.nlm.nih.gov/31100702 31100702]|[https://pubmed.ncbi.nlm.nih.gov/28898525 28898525]|[https://pubmed.ncbi.nlm.nih.gov/22944671 22944671]|[https://pubmed.ncbi.nlm.nih.gov/19277537 19277537]|[https://pubmed.ncbi.nlm.nih.gov/24473128 24473128]|[https://pubmed.ncbi.nlm.nih.gov/17957771 17957771]|[https://pubmed.ncbi.nlm.nih.gov/27554083 27554083]|[https://pubmed.ncbi.nlm.nih.gov/15189166 15189166]|[https://pubmed.ncbi.nlm.nih.gov/11269317 11269317]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919] [https://pubmed.ncbi.nlm.nih.gov/19577919 19577919]]|[https://pubmed.ncbi.nlm.nih.gov/24303005 24303005]|[https://pubmed.ncbi.nlm.nih.gov/12042249 12042249]|[https://pubmed.ncbi.nlm.nih.gov/22191536 22191536]|[https://pubmed.ncbi.nlm.nih.gov/28324664 28324664]|[https://pubmed.ncbi.nlm.nih.gov/25965797 25965797]|[https://pubmed.ncbi.nlm.nih.gov/25434632 25434632]|[https://pubmed.ncbi.nlm.nih.gov/30484244 30484244]|[https://pubmed.ncbi.nlm.nih.gov/28110657 28110657]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036] [https://pubmed.ncbi.nlm.nih.gov/29865036 29865036]]|[https://pubmed.ncbi.nlm.nih.gov/20129637 20129637]|[https://pubmed.ncbi.nlm.nih.gov/27346875 27346875]|[https://pubmed.ncbi.nlm.nih.gov/30280442 30280442]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286] [https://pubmed.ncbi.nlm.nih.gov/26911286 26911286]]|[https://pubmed.ncbi.nlm.nih.gov/22491358 22491358]|[https://pubmed.ncbi.nlm.nih.gov/26582281 26582281]|[https://pubmed.ncbi.nlm.nih.gov/26398792 26398792]|[https://pubmed.ncbi.nlm.nih.gov/31548313 31548313]|[https://pubmed.ncbi.nlm.nih.gov/31066275 31066275]|[https://pubmed.ncbi.nlm.nih.gov/28331984 28331984]|[https://pubmed.ncbi.nlm.nih.gov/25482090 25482090]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173] [https://pubmed.ncbi.nlm.nih.gov/28518173 28518173]]|[https://pubmed.ncbi.nlm.nih.gov/30733536 30733536]|[https://pubmed.ncbi.nlm.nih.gov/22326428 22326428]|[https://pubmed.ncbi.nlm.nih.gov/30063825 30063825]|[https://pubmed.ncbi.nlm.nih.gov/30315103 30315103]|[https://pubmed.ncbi.nlm.nih.gov/21558494 21558494]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555] [https://pubmed.ncbi.nlm.nih.gov/31676555 31676555]]|[https://pubmed.ncbi.nlm.nih.gov/31256374 31256374] <br>
  '''definition''' : A biantennary complex glycan with two GlcNAc branches linked to the core and the addition of two sialic acid residues. <br>
  '''definition''' : The carbohydrate portion of a glycoprotein that has a glycan linked through the nitrogen of an asparagine side-chain.[CHEBI:59520] <br>
  '''term_xref''' : <br>
  '''term_xref''' : GTC:G78059CC|CID:[https://pubmed.ncbi.nlm.nih.gov/70679232 70679232]|CHEBI:70967 <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' : appears in human transferrin[PMID:[https://pubmed.ncbi.nlm.nih.gov/24243045 24243045]]|Appears in human apolipoprotein (apo) B-100.[PMID:2344297] <br>
  '''function''' : N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374]|Affect transportation of the glycosylated proteins in the Golgi.[PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding.[PMID: 25151374]|extracellular N-glycans act as key modulators of neuronal uptake of αacetyl [PMID: [https://pubmed.ncbi.nlm.nih.gov/31211781 31211781]]. <br>
  '''disease_associations''' : galactosemia.[PMID:[https://pubmed.ncbi.nlm.nih.gov/9499382 9499382]] <br>
  '''disease_associations''' : Rheumatoid arthritis[PMID:17392038]|Type 1 Diabetes[PMID:29146600]|Lung Cancer[PMID: 23766031] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000067===
===GSD000132===
  '''term (main_entry)''' : Disialylated fucosylated <br>
  '''term (main_entry)''' : Nonfucosylated <br>
  '''glycan_dictionary_accession''' : GSD000067 <br>
  '''glycan_dictionary_accession''' : GSD000132 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : Disialylated fucosylated and monosialylated non-fucosylated oligosaccharides were also identified.[PMID:[https://pubmed.ncbi.nlm.nih.gov/17591618 17591618]] <br>
  '''term_in_sentence''' : In the carbohydrate moiety , alpha-subunit from normal pregnancy hCG contained nonfucosylated , mono- and biantennary N-linked structures (49.3 and 36.7%, means); fucosylated biantennary and triantennary oligosaccharides were also identified (7.3 and 6.9%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]] [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]]]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/17591618 17591618] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]] [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]]]|[https://pubmed.ncbi.nlm.nih.gov/30258536 30258536]|[https://pubmed.ncbi.nlm.nih.gov/23554380 23554380]|[https://pubmed.ncbi.nlm.nih.gov/16675584 16675584]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26747427 26747427] [https://pubmed.ncbi.nlm.nih.gov/26747427 26747427]]|[https://pubmed.ncbi.nlm.nih.gov/22457527 22457527]|[https://pubmed.ncbi.nlm.nih.gov/24362443 24362443]|[https://pubmed.ncbi.nlm.nih.gov/19657637 19657637]|[https://pubmed.ncbi.nlm.nih.gov/8811881 8811881]|[https://pubmed.ncbi.nlm.nih.gov/19218011 19218011]|[https://pubmed.ncbi.nlm.nih.gov/20022111 20022111]|[https://pubmed.ncbi.nlm.nih.gov/17363544 17363544]|[https://pubmed.ncbi.nlm.nih.gov/17368483 17368483]|[https://pubmed.ncbi.nlm.nih.gov/20564614 20564614]|[https://pubmed.ncbi.nlm.nih.gov/27054024 27054024]|[https://pubmed.ncbi.nlm.nih.gov/28397880 28397880]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688] [https://pubmed.ncbi.nlm.nih.gov/31490688 31490688]]|[https://pubmed.ncbi.nlm.nih.gov/31860772 31860772]|[https://pubmed.ncbi.nlm.nih.gov/17012310 17012310]|[https://pubmed.ncbi.nlm.nih.gov/29633346 29633346]|[https://pubmed.ncbi.nlm.nih.gov/9442021 9442021]|[https://pubmed.ncbi.nlm.nih.gov/30350565 30350565]|[https://pubmed.ncbi.nlm.nih.gov/30296068 30296068]|[https://pubmed.ncbi.nlm.nih.gov/31800250 31800250]|[https://pubmed.ncbi.nlm.nih.gov/30021910 30021910]|[https://pubmed.ncbi.nlm.nih.gov/31133022 31133022]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385] [https://pubmed.ncbi.nlm.nih.gov/29224385 29224385]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087] [https://pubmed.ncbi.nlm.nih.gov/28630087 28630087]]|[https://pubmed.ncbi.nlm.nih.gov/26444434 26444434]|[https://pubmed.ncbi.nlm.nih.gov/31697975 31697975]|[https://pubmed.ncbi.nlm.nih.gov/30991260 30991260] <br>
  '''definition''' : A fucosylated glycan with two sialic acid components. <br>
  '''definition''' : glycans without a fucose component/monosaccharide residue. <br>
  '''term_xref''' :  <br>
  '''term_xref''' :  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
Line 544: Line 482:
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453041/ Chapter 45]<br>
  '''essentials_of_glycobiology''' :  <br>
 
 
===GSD000068===
  '''term (main_entry)''' : Forssman antigen <br>
'''glycan_dictionary_accession''' : GSD000068 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G80062GG G80062GG] <br>
'''term_in_sentence''' : Here we report the crystal structure of the complex between SLL-2 and Forssman antigen tetrasaccharide (GalNAcα1-3GalNAcβ1-3 Galα1-4 Galβ at 3.4 √Ö resolution).[PMID:[https://pubmed.ncbi.nlm.nih.gov/28510705 28510705]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28510705 28510705]|[https://pubmed.ncbi.nlm.nih.gov/31933576 31933576]| [https://pubmed.ncbi.nlm.nih.gov/28134301 28134301]|[https://pubmed.ncbi.nlm.nih.gov/7021748 7021748]|[https://pubmed.ncbi.nlm.nih.gov/1802714 1802714]|[https://pubmed.ncbi.nlm.nih.gov/7512587 7512587]|[https://pubmed.ncbi.nlm.nih.gov/7747818 7747818]|[https://pubmed.ncbi.nlm.nih.gov/23325748 23325748]|[https://pubmed.ncbi.nlm.nih.gov/268649 268649]|[https://pubmed.ncbi.nlm.nih.gov/31816281 31816281]|[https://pubmed.ncbi.nlm.nih.gov/22015168 22015168]|[https://pubmed.ncbi.nlm.nih.gov/4147161 4147161]|[https://pubmed.ncbi.nlm.nih.gov/2857159 2857159]|[https://pubmed.ncbi.nlm.nih.gov/6267170 6267170]|[https://pubmed.ncbi.nlm.nih.gov/7293775 7293775]|[https://pubmed.ncbi.nlm.nih.gov/13367419 13367419]|[https://pubmed.ncbi.nlm.nih.gov/20636540 20636540]| [https://pubmed.ncbi.nlm.nih.gov/10460829 10460829]  [https://pubmed.ncbi.nlm.nih.gov/10460829 10460829]|[https://pubmed.ncbi.nlm.nih.gov/23255552 23255552]|[https://pubmed.ncbi.nlm.nih.gov/2675268 2675268]|[https://pubmed.ncbi.nlm.nih.gov/18955372 18955372]|[https://pubmed.ncbi.nlm.nih.gov/7020692 7020692]|[https://pubmed.ncbi.nlm.nih.gov/31784953 31784953]|[https://pubmed.ncbi.nlm.nih.gov/4114942 4114942]|[https://pubmed.ncbi.nlm.nih.gov/31273262 31273262]|[https://pubmed.ncbi.nlm.nih.gov/6257673 6257673]|[https://pubmed.ncbi.nlm.nih.gov/7696847 7696847]|[https://pubmed.ncbi.nlm.nih.gov/1916901 1916901]|[https://pubmed.ncbi.nlm.nih.gov/11169215 11169215]|[https://pubmed.ncbi.nlm.nih.gov/48262 48262]|[https://pubmed.ncbi.nlm.nih.gov/26022515 26022515]|[https://pubmed.ncbi.nlm.nih.gov/6175621 6175621]|[https://pubmed.ncbi.nlm.nih.gov/31404475 31404475]|[https://pubmed.ncbi.nlm.nih.gov/6983878 6983878]|[https://pubmed.ncbi.nlm.nih.gov/8381954 8381954]| [https://pubmed.ncbi.nlm.nih.gov/10431785 10431785]|[https://pubmed.ncbi.nlm.nih.gov/3257757 3257757]|[https://pubmed.ncbi.nlm.nih.gov/6792413 6792413]|[https://pubmed.ncbi.nlm.nih.gov/25039359 25039359] <br>
'''definition''' : A linear amino pentasaccharide comprising N-acetyl-α-D-galactosamine, N-acetyl-β-D-galactosamine, α-D-galactose, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→3), (1→4) and (1→4).CHEBI:85789 <br>
'''term_xref''' : GTC:G80062GG |GlycoEpitope:EP0037|CID 91825690|CHEBI:85789 <br>
'''synonyms''' :  <br>
'''function''' :  <br>
'''disease_associations''' :  <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453041/ Chapter 45]<br>
 
 
===GSD000069===
'''term (main_entry)''' : Forssman glycolipid <br>
'''glycan_dictionary_accession''' : GSD000069 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G80062GG G80062GG] <br>
'''term_in_sentence''' : Analysis of metabolically labeled glycolipids released into the apical and basal culture medium, either as shed membrane vesicles or in budding viruses, also demonstrated the presence of the Forssman glycolipid on both apical and basolateral membranes of polarized cells.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3040119 3040119]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/3040119 3040119]|268649|[https://pubmed.ncbi.nlm.nih.gov/23240079 23240079]|[https://pubmed.ncbi.nlm.nih.gov/28134301 28134301]|[https://pubmed.ncbi.nlm.nih.gov/3495590 3495590]|[https://pubmed.ncbi.nlm.nih.gov/1138893 1138893]| [https://pubmed.ncbi.nlm.nih.gov/10460829 10460829]|[https://pubmed.ncbi.nlm.nih.gov/10506200 10506200]|[https://pubmed.ncbi.nlm.nih.gov/8855242 8855242]|[https://pubmed.ncbi.nlm.nih.gov/1955453 1955453]|[https://pubmed.ncbi.nlm.nih.gov/1933935 1933935]|[https://pubmed.ncbi.nlm.nih.gov/3355161 3355161]|[https://pubmed.ncbi.nlm.nih.gov/6773959 6773959]|[https://pubmed.ncbi.nlm.nih.gov/14573676 14573676]|[https://pubmed.ncbi.nlm.nih.gov/29898878 29898878]|[https://pubmed.ncbi.nlm.nih.gov/10431785 10431785]|[https://pubmed.ncbi.nlm.nih.gov/1747956 1747956]|[https://pubmed.ncbi.nlm.nih.gov/11214737 11214737]|[https://pubmed.ncbi.nlm.nih.gov/7423202 7423202]|[https://pubmed.ncbi.nlm.nih.gov/389939 389939]|[https://pubmed.ncbi.nlm.nih.gov/3871816 3871816]|[https://pubmed.ncbi.nlm.nih.gov/6187373 6187373]|[https://pubmed.ncbi.nlm.nih.gov/16133832 16133832]|[https://pubmed.ncbi.nlm.nih.gov/469271 469271]|[https://pubmed.ncbi.nlm.nih.gov/3753492 3753492]|[https://pubmed.ncbi.nlm.nih.gov/2695680 2695680]|[https://pubmed.ncbi.nlm.nih.gov/7037611 7037611]|[https://pubmed.ncbi.nlm.nih.gov/25703376 25703376]|[https://pubmed.ncbi.nlm.nih.gov/23798992 23798992]|[https://pubmed.ncbi.nlm.nih.gov/414913 414913]|[https://pubmed.ncbi.nlm.nih.gov/1868069 1868069]| [https://pubmed.ncbi.nlm.nih.gov/7960243 7960243] <br>
'''definition''' : A linear amino pentasaccharide comprising N-acetyl-α-D-galactosamine, N-acetyl-β-D-galactosamine, α-D-galactose, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→3), (1→4) and (1→4).[CHEBI:85789] <br>
'''term_xref''' : GlycoMotif:GGM.000084|GTC:G80062GG|CID:91825690|KEGG:G00095|CHEBI:85789|GlycoEpitope:EP0037|SugarBind_Ligand:86 <br>
'''synonyms''' : Forssman antigen|Globopentosylceramide <br>
'''function''' : an antigenic marker for a major subpopulation of macrophages from murine spleen and peripheral lymph nodes[PMID:[https://pubmed.ncbi.nlm.nih.gov/3495590 3495590]] <br>
'''disease_associations''' : Pyelonephritis[SugarBind_Ligand:86]|Acute cystitis[SugarBind_Ligand:86] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453041/ Chapter 45]<br>




===GSD000070===
===GSD000133===
  '''term (main_entry)''' : Fucose-containing tetraantennary <br>
  '''term (main_entry)''' : Nonfucosylated biantennary <br>
  '''glycan_dictionary_accession''' : GSD000070 <br>
  '''glycan_dictionary_accession''' : GSD000133 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : The two major N-linked oligosaccharides of Namalwa EPO were fucose-containing tetraantennary and fucose-containing triantennary structures.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2550193 2550193]] <br>
  '''term_in_sentence''' : Structural analysis combining methylation-mass spectrometry and 400 MHz 1H-n.m.r. spectrometry of oligosaccharide alditols released from human leucocyte lactotransferrin shows the presence of two disialylated and non-fucosylated biantennary glycans of the N-acetyl-lactosaminic type.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069] [https://pubmed.ncbi.nlm.nih.gov/2390069 2390069]]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2550193 2550193] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069] [https://pubmed.ncbi.nlm.nih.gov/2390069 2390069]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]] [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]]]|[https://pubmed.ncbi.nlm.nih.gov/1375510 1375510]|[https://pubmed.ncbi.nlm.nih.gov/9101715 9101715]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069] [https://pubmed.ncbi.nlm.nih.gov/2390069 2390069]]|[https://pubmed.ncbi.nlm.nih.gov/2332109 2332109] <br>
  '''definition''' : A tetraantennary glycan with four GlcNAc branches linked to the core and the addition of fucose. <br>
  '''definition''' : A biantennary glycan with two GlcNAc branches linked to the core and no fucose appears. <br>
  '''term_xref''' :  <br>
  '''term_xref''' :  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
'''wikipedia''' : https://en.wikipedia.org/wiki/Forssman_antigen <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>
===GSD000071===
'''term (main_entry)''' : Fucosyl GM1 <br>
'''glycan_dictionary_accession''' : GSD000071 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G91532KA G91532KA] <br>
'''term_in_sentence''' : Unique localization of fucosyl GM1 implicates its possible role in cell adhesion and recognition in the nervous system.[PMID:[https://pubmed.ncbi.nlm.nih.gov/8068725 8068725]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/6619101 6619101]|[https://pubmed.ncbi.nlm.nih.gov/16880505 16880505]|[https://pubmed.ncbi.nlm.nih.gov/9089399 9089399]|[https://pubmed.ncbi.nlm.nih.gov/29789847 29789847]|[https://pubmed.ncbi.nlm.nih.gov/8068725 8068725]|[https://pubmed.ncbi.nlm.nih.gov/19556222 19556222]|[https://pubmed.ncbi.nlm.nih.gov/1660040 1660040]|[https://pubmed.ncbi.nlm.nih.gov/2420639 2420639]|[https://pubmed.ncbi.nlm.nih.gov/9076515 9076515]|[https://pubmed.ncbi.nlm.nih.gov/15926079 15926079]|[https://pubmed.ncbi.nlm.nih.gov/19555091 19555091]|[https://pubmed.ncbi.nlm.nih.gov/2541996 2541996]|[https://pubmed.ncbi.nlm.nih.gov/16211870 16211870]|[https://pubmed.ncbi.nlm.nih.gov/1336587 1336587]|[https://pubmed.ncbi.nlm.nih.gov/21174147 21174147]|[https://pubmed.ncbi.nlm.nih.gov/14967068 14967068]|[https://pubmed.ncbi.nlm.nih.gov/18923900 18923900]|[https://pubmed.ncbi.nlm.nih.gov/30021910 30021910]|[https://pubmed.ncbi.nlm.nih.gov/16941490 16941490]|[https://pubmed.ncbi.nlm.nih.gov/27070150 27070150]|[https://pubmed.ncbi.nlm.nih.gov/8305235 8305235]|[https://pubmed.ncbi.nlm.nih.gov/10602885 10602885]|[https://pubmed.ncbi.nlm.nih.gov/2645049 2645049]|[https://pubmed.ncbi.nlm.nih.gov/7993838 7993838]|[https://pubmed.ncbi.nlm.nih.gov/10537341 10537341]|[https://pubmed.ncbi.nlm.nih.gov/3002616 3002616]|[https://pubmed.ncbi.nlm.nih.gov/8336147 8336147]|[https://pubmed.ncbi.nlm.nih.gov/15447995 15447995]|[https://pubmed.ncbi.nlm.nih.gov/8905401 8905401]|[https://pubmed.ncbi.nlm.nih.gov/11714535 11714535]|[https://pubmed.ncbi.nlm.nih.gov/9260862 9260862]|[https://pubmed.ncbi.nlm.nih.gov/32228455 32228455]|[https://pubmed.ncbi.nlm.nih.gov/3315641 3315641]|[https://pubmed.ncbi.nlm.nih.gov/8076384 8076384]|[https://pubmed.ncbi.nlm.nih.gov/2317201 2317201]|[https://pubmed.ncbi.nlm.nih.gov/3680254 3680254]|[https://pubmed.ncbi.nlm.nih.gov/6403518 6403518] <br>
'''definition''' : A branched amino hexasaccharide consisting of the linear sequence α-L-Fuc-(1→2)-β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-D-Glc having a Neu5Ac residue attached to the inner galactose via an α-(2→3) linkage.[CHEBI:62686] <br>
'''term_xref''' : GTC:G91532KA |GlycoEpitope:EP0049|CID: 53356699|CHEBI:62686 <br>
'''synonyms''' :  <br>
'''function''' :  <br>
'''disease_associations''' : small-cell lung cancer(SCLC)[GlycoEpitope:EP0049]|hepatoma[GlycoEpitope:EP0049] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]<br>




===GSD000072===
===GSD000134===
  '''term (main_entry)''' : Fucosylated asialo-biantennary <br>
  '''term (main_entry)''' : Nonfucosylated biantennary N-Linked structures <br>
  '''glycan_dictionary_accession''' : GSD000072 <br>
  '''glycan_dictionary_accession''' : GSD000134 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : We found that approximately 63% of the total N-linked oligosaccharides were of the complex type, with bisialo-biantennary (28%), asialo-biantennary (7%), fucosylated bisialo-biantennary (25%), and fucosylated asialo-biantennary (3%) oligosaccharides representing the major complex-type carbohydrate species.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2065054 2065054]] <br>
  '''term_in_sentence''' : The beta-subunit from normal pregnancy hCG contained fucosylated and nonfucosylated biantennary N-linked structures; however, mono- and triantennary oligosaccharides were also identified (4.6 and 13.7%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]] [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]]]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2065054 2065054]|[https://pubmed.ncbi.nlm.nih.gov/17013932 17013932] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]] [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027]]] <br>
  '''definition''' : Describing a biantennary oligosaccharide that has no sialic acid component but has fucose. <br>
  '''definition''' : A biantennary N-linked glycan with two GlcNAc branches linked to the core and no fucose appears. <br>
  '''term_xref''' :  <br>
  '''term_xref''' :  <br>
  '''synonyms''' : fucosylated asialo-diantennary <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
Line 622: Line 515:




===GSD000073===
===GSD000135===
  '''term (main_entry)''' : Fucosylated biantennary <br>
  '''term (main_entry)''' : Nonfucosylated triantennary <br>
  '''glycan_dictionary_accession''' : GSD000073 <br>
  '''glycan_dictionary_accession''' : GSD000135 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : The profiles of the PSA N-glycans from the free and complexed molecules were quite similar to each other and consisted of fucosylated biantennary oligosaccharides as the major class.[PMID:[https://pubmed.ncbi.nlm.nih.gov/17956937 17956937]] <br>
  '''term_in_sentence''' : Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.[PMID:[https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/17956937 17956937]|[https://pubmed.ncbi.nlm.nih.gov/30525457 30525457]|[https://pubmed.ncbi.nlm.nih.gov/1933856 1933856] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]|[https://pubmed.ncbi.nlm.nih.gov/23274891 23274891] <br>
  '''definition''' : a biantennary glycan with two GlcNAc branches linked to the core and the addition of fucose. <br>
  '''definition''' : A triantennary N-linked glycan with three GlcNAc branches linked to the core and no fucose appears. <br>
  '''term_xref''' :  <br>
  '''term_xref''' :  <br>
  '''synonyms''' : fucosylated bisialo-diantennary <br>
  '''synonyms''' : <br>
  '''function''' : <br>
  '''function''' : Appears in human alpha-fetoprotein (AFP).[PMID:[https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]] <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : hepatocellular carcinoma[PMID:[https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]]. <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000074===
===GSD000136===
  '''term (main_entry)''' : Fucosylated bisialo-biantennary <br>
  '''term (main_entry)''' : Nonsialylated <br>
  '''glycan_dictionary_accession''' : GSD000074 <br>
  '''glycan_dictionary_accession''' : GSD000136 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : We found that approximately 63% of the total N-linked oligosaccharides were of the complex type, with bisialo-biantennary (28%), asialo-biantennary (7%), fucosylated bisialo-biantennary (25%), and fucosylated asialo-biantennary (3%) oligosaccharides representing the major complex-type carbohydrate species.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2065054 2065054]] <br>
  '''term_in_sentence''' : The pattern of nonsialylated oligosaccharides was used for interpretation of the fully sialylated species using bioinformatics tools. From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively. Glycan structures carry dominantly between 15 and 16 sialic acids indicating an almost complete termination of all antenae with sialic acid.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30295034 30295034]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2065054 2065054] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/14533820 14533820]|[https://pubmed.ncbi.nlm.nih.gov/1377689 1377689]|[https://pubmed.ncbi.nlm.nih.gov/9705949 9705949]|[https://pubmed.ncbi.nlm.nih.gov/30788437 30788437]|[https://pubmed.ncbi.nlm.nih.gov/28090561 28090561]|[https://pubmed.ncbi.nlm.nih.gov/12498371 12498371]|[https://pubmed.ncbi.nlm.nih.gov/26839900 26839900]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688] [https://pubmed.ncbi.nlm.nih.gov/31490688 31490688]]|[https://pubmed.ncbi.nlm.nih.gov/2656426 2656426]|[https://pubmed.ncbi.nlm.nih.gov/30295034 30295034]|[https://pubmed.ncbi.nlm.nih.gov/31545048 31545048]|[https://pubmed.ncbi.nlm.nih.gov/12381155 12381155]|[https://pubmed.ncbi.nlm.nih.gov/25730103 25730103]|[https://pubmed.ncbi.nlm.nih.gov/26787879 26787879]|[https://pubmed.ncbi.nlm.nih.gov/25646460 25646460]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385] [https://pubmed.ncbi.nlm.nih.gov/29224385 29224385]]|[https://pubmed.ncbi.nlm.nih.gov/26063435 26063435]|[https://pubmed.ncbi.nlm.nih.gov/26954852 26954852]|[https://pubmed.ncbi.nlm.nih.gov/32889432 32889432]|[https://pubmed.ncbi.nlm.nih.gov/2825412 2825412]|[https://pubmed.ncbi.nlm.nih.gov/27504786 27504786]|[https://pubmed.ncbi.nlm.nih.gov/22431161 22431161] <br>
  '''definition''' : Describing a biantennary oligosaccharide that has two sialic acid component and fucose added. <br>
  '''definition''' : A glycan which is not sialylated. <br>
  '''term_xref''' :  <br>
  '''term_xref''' :  <br>
  '''synonyms''' : Fucosylated biantennary <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
Line 652: Line 545:




===GSD000075===
===GSD000137===
  '''term (main_entry)''' : Fucosylated LDN <br>
  '''term (main_entry)''' : O-fucose glycans <br>
  '''glycan_dictionary_accession''' : GSD000075 <br>
  '''glycan_dictionary_accession''' : GSD000137 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G02240AO G02240AO] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G39294YF G39294YF] <br>
  '''term_in_sentence''' : To date, oligomeric LDN and oligomeric fucosylated LDN (LDNF) have been found only on N-glycans from mammalian cells engineered to express Caenorhabditis elegansbeta4-GalNAc transferase and human alpha3-fucosyltransferase IX [Z. S. Kawar et al. (2005) J Biol Chem280, 12810-12819]. [PMID:[https://pubmed.ncbi.nlm.nih.gov/16403022 16403022]] <br>
  '''term_in_sentence''' : Recently, a number of laboratories have shown that O-fucose glycans on the epidermal growth factor (EGF)-like repeats of the Notch extracellular domain modulate Notch signaling.[PMID:[https://pubmed.ncbi.nlm.nih.gov/12417415 12417415]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/16403022 16403022]|[https://pubmed.ncbi.nlm.nih.gov/28151933 28151933]|[https://pubmed.ncbi.nlm.nih.gov/19545571 19545571]|[https://pubmed.ncbi.nlm.nih.gov/22448293 22448293] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/19594638 19594638]|[https://pubmed.ncbi.nlm.nih.gov/30690220 30690220]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191] [https://pubmed.ncbi.nlm.nih.gov/18952191 18952191]]|[https://pubmed.ncbi.nlm.nih.gov/22415200 22415200]|[https://pubmed.ncbi.nlm.nih.gov/12417415 12417415]|[https://pubmed.ncbi.nlm.nih.gov/16400812 16400812]|[https://pubmed.ncbi.nlm.nih.gov/18948267 18948267]|[https://pubmed.ncbi.nlm.nih.gov/21464368 21464368]|[https://pubmed.ncbi.nlm.nih.gov/20816394 20816394]|[https://pubmed.ncbi.nlm.nih.gov/30207383 30207383]|[https://pubmed.ncbi.nlm.nih.gov/20301232 20301232]|[https://pubmed.ncbi.nlm.nih.gov/27129198 27129198]|[https://pubmed.ncbi.nlm.nih.gov/17132502 17132502]|[https://pubmed.ncbi.nlm.nih.gov/22492969 22492969]|[https://pubmed.ncbi.nlm.nih.gov/30030822 30030822]|[https://pubmed.ncbi.nlm.nih.gov/30214079 30214079]|[https://pubmed.ncbi.nlm.nih.gov/26175457 26175457]|[https://pubmed.ncbi.nlm.nih.gov/25378397 25378397]|[https://pubmed.ncbi.nlm.nih.gov/18272537 18272537]|[https://pubmed.ncbi.nlm.nih.gov/28729422 28729422]|[https://pubmed.ncbi.nlm.nih.gov/11524432 11524432]|[https://pubmed.ncbi.nlm.nih.gov/31722217 31722217]|[https://pubmed.ncbi.nlm.nih.gov/23045360 23045360]|[https://pubmed.ncbi.nlm.nih.gov/24803430 24803430]|[https://pubmed.ncbi.nlm.nih.gov/28876865 28876865]|[https://pubmed.ncbi.nlm.nih.gov/25700513 25700513]|[https://pubmed.ncbi.nlm.nih.gov/32518939 32518939]|[https://pubmed.ncbi.nlm.nih.gov/30523691 30523691]|[https://pubmed.ncbi.nlm.nih.gov/18227520 18227520]|[https://pubmed.ncbi.nlm.nih.gov/20816217 20816217]|[https://pubmed.ncbi.nlm.nih.gov/24909690 24909690]|[https://pubmed.ncbi.nlm.nih.gov/17964136 17964136]|[https://pubmed.ncbi.nlm.nih.gov/12036964 12036964]|[https://pubmed.ncbi.nlm.nih.gov/27268051 27268051]|[https://pubmed.ncbi.nlm.nih.gov/15653671 15653671]|[https://pubmed.ncbi.nlm.nih.gov/19948734 19948734]|[https://pubmed.ncbi.nlm.nih.gov/31590629 31590629]|[https://pubmed.ncbi.nlm.nih.gov/32201074 32201074]|[https://pubmed.ncbi.nlm.nih.gov/15189151 15189151]|[https://pubmed.ncbi.nlm.nih.gov/17263732 17263732]|[https://pubmed.ncbi.nlm.nih.gov/32913123 32913123]|[https://pubmed.ncbi.nlm.nih.gov/12909620 12909620]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176] [https://pubmed.ncbi.nlm.nih.gov/28785176 28785176]]|[https://pubmed.ncbi.nlm.nih.gov/17132500 17132500]|[https://pubmed.ncbi.nlm.nih.gov/22949680 22949680]|[https://pubmed.ncbi.nlm.nih.gov/25053492 25053492]|[https://pubmed.ncbi.nlm.nih.gov/28939751 28939751] <br>
  '''definition''' : An amino trisaccharide comprising an acetamido-β-D-galactose and an α-L-fucose attached to an acetamidoglucose by 1→4 and 1→3 linkages, respectively.[CHEBI:61864] <br>
  '''definition''' : Form of glycosylation where the protein is modified by a fucose residue and can be extended futher to form a tetrasaccharide in certain cases. alpha-linked o-fucose have a consensus motif of C2X4(s/T)C3 where C2 and C3 are conserved cysteines number 2 and 3 respectively of the EGFR like repeats. [Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453017/ Chapter13]]<br>
  '''term_xref''' : GlycoMotif:GGM.000017|GTC:G02240AO|GlycoEpitope:EP0151|CID: 52921591|CHEBI:61864|MeSH:C488538|KEGG:G01594 <br>
  '''term_xref''' : GTC:G39294YF|GlycoEpitope:EP0005  <br>
  '''synonyms''' : LDNF|Fucosylated lacdiNAc|LDN-F|(GalNAc)1 (GlcNAc)1 (LFuc)1 <br>
  '''synonyms''' : <br>
  '''function''' : <br>
  '''function''' : modification of Notch signaling.[GlycoEpitope:EP0005] <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
Line 667: Line 560:




===GSD000076===
===GSD000138===
  '''term (main_entry)''' : Fucosylated N-glycans <br>
  '''term (main_entry)''' : O-GlcNAc <br>
  '''glycan_dictionary_accession''' : GSD000076 <br>
  '''glycan_dictionary_accession''' : GSD000138 <br>
  '''glytoucan_accession ''' : <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G49108TO G49108TO] <br>
  '''term_in_sentence''' : Haptoglobin , an acute phase protein , has four potential N-glycosylation sites , although it remains unknown which site is responsible for the change in fucosylated N-glycans.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/18214858 18214858] [https://pubmed.ncbi.nlm.nih.gov/18214858 18214858]]] <br>
  '''term_in_sentence''' : A better understanding of the mechanisms of OGT/OGA action would enable us to derive therapeutic benefits of resetting cellular O-GlcNAc levels within an optimal range.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30464755 30464755]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/18214858 18214858]|[https://pubmed.ncbi.nlm.nih.gov/31141660 31141660]|[https://pubmed.ncbi.nlm.nih.gov/26869352 26869352]|[https://pubmed.ncbi.nlm.nih.gov/29790113 29790113]|[https://pubmed.ncbi.nlm.nih.gov/31931062 31931062] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/30464755 30464755]|[https://pubmed.ncbi.nlm.nih.gov/29049853 29049853]|[https://pubmed.ncbi.nlm.nih.gov/29594839 29594839]|[https://pubmed.ncbi.nlm.nih.gov/31654859 31654859]|[https://pubmed.ncbi.nlm.nih.gov/29404877 29404877]|[https://pubmed.ncbi.nlm.nih.gov/30105004 30105004]|[https://pubmed.ncbi.nlm.nih.gov/30669087 30669087]|[https://pubmed.ncbi.nlm.nih.gov/29790000 29790000]|[https://pubmed.ncbi.nlm.nih.gov/28408483 28408483]|[https://pubmed.ncbi.nlm.nih.gov/26862193 26862193]|[https://pubmed.ncbi.nlm.nih.gov/30523150 30523150]|[https://pubmed.ncbi.nlm.nih.gov/30037904 30037904]|[https://pubmed.ncbi.nlm.nih.gov/28408480 28408480]|[https://pubmed.ncbi.nlm.nih.gov/29352075 29352075]|[https://pubmed.ncbi.nlm.nih.gov/29456783 29456783]|[https://pubmed.ncbi.nlm.nih.gov/29577901 29577901]|[https://pubmed.ncbi.nlm.nih.gov/29223644 29223644]|[https://pubmed.ncbi.nlm.nih.gov/28638491 28638491]|[https://pubmed.ncbi.nlm.nih.gov/30221662 30221662]|[https://pubmed.ncbi.nlm.nih.gov/29904918 29904918]|[https://pubmed.ncbi.nlm.nih.gov/32155042 32155042]|[https://pubmed.ncbi.nlm.nih.gov/30298013 30298013]|[https://pubmed.ncbi.nlm.nih.gov/31630803 31630803]|[https://pubmed.ncbi.nlm.nih.gov/31847126 31847126]|[https://pubmed.ncbi.nlm.nih.gov/29784830 29784830]|[https://pubmed.ncbi.nlm.nih.gov/30181664 30181664]|[https://pubmed.ncbi.nlm.nih.gov/28768194 28768194]|[https://pubmed.ncbi.nlm.nih.gov/30134155 30134155]|[https://pubmed.ncbi.nlm.nih.gov/25336654 25336654]|[https://pubmed.ncbi.nlm.nih.gov/30356792 30356792]|[https://pubmed.ncbi.nlm.nih.gov/30199580 30199580]|[https://pubmed.ncbi.nlm.nih.gov/32329777 32329777]|[https://pubmed.ncbi.nlm.nih.gov/28408494 28408494]|[https://pubmed.ncbi.nlm.nih.gov/29774032 29774032]|[https://pubmed.ncbi.nlm.nih.gov/29044951 29044951]|[https://pubmed.ncbi.nlm.nih.gov/23836420 23836420]|[https://pubmed.ncbi.nlm.nih.gov/20301273 20301273]|[https://pubmed.ncbi.nlm.nih.gov/29772801 29772801]|[https://pubmed.ncbi.nlm.nih.gov/28922739 28922739]|[https://pubmed.ncbi.nlm.nih.gov/30100348 30100348]|[https://pubmed.ncbi.nlm.nih.gov/30793403 30793403]|[https://pubmed.ncbi.nlm.nih.gov/30657688 30657688]|[https://pubmed.ncbi.nlm.nih.gov/31237748 31237748]|[https://pubmed.ncbi.nlm.nih.gov/29756380 29756380]|[https://pubmed.ncbi.nlm.nih.gov/29954943 29954943]|[https://pubmed.ncbi.nlm.nih.gov/30018219 30018219]|[https://pubmed.ncbi.nlm.nih.gov/32207184 32207184]|[https://pubmed.ncbi.nlm.nih.gov/25566193 25566193]|[https://pubmed.ncbi.nlm.nih.gov/30626734 30626734]|[https://pubmed.ncbi.nlm.nih.gov/24759912 24759912]| <br>
  '''definition''' : The fucose from GDP-fucose is transferred to N-linked glycans. <br>
  '''definition''' : Form of glycosylation which exclusively occurs in the mitochondrial, cytoplasmic or nuclear compartments of the cell where the protein is modified by a GlcNAc monosaccharide on the serine or threonine residues and is generally not modified or elongated further to form more complex structures. [Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453063/ Chapter19]] <br>
  '''term_xref''' :  <br>
  '''term_xref''' : GTC:G49108TO|GlycoEpitope:EP0004|CID:24139|HMDB:HMDB[https://pubmed.ncbi.nlm.nih.gov/0000803 0000803] <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : pancreatic cancer.[PMID: [https://pubmed.ncbi.nlm.nih.gov/26869352 26869352]] <br>
  '''disease_associations''' : <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000077===
===GSD000139===
  '''term (main_entry)''' : Fucosylated triantennary <br>
  '''term (main_entry)''' : O-linked glycans <br>
  '''glycan_dictionary_accession''' : GSD000077 <br>
  '''glycan_dictionary_accession''' : GSD000139 <br>
  '''glytoucan_accession ''' :  <br>
  '''glytoucan_accession ''' :  <br>
  '''term_in_sentence''' : Asn184 is only partially glycosylated and substituted by fucosylated triantennary and small amounts of diantennary N-acetyllactosaminic glycans.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2513186 2513186]] <br>
  '''term_in_sentence''' : Among these, six fucosylated N-linked glycansand four O-linked glycans exhibited significantly increased expression levels in GC, while five fucosylated N-linked glycans and ten fucosylated O-linked glycans exhibited significantly decreased expression levels in GC.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036] [https://pubmed.ncbi.nlm.nih.gov/29865036 29865036]]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2513186 2513186]|[https://pubmed.ncbi.nlm.nih.gov/29642865 29642865]|[https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]|[https://pubmed.ncbi.nlm.nih.gov/31110965 31110965]|[https://pubmed.ncbi.nlm.nih.gov/2551687 2551687]|[https://pubmed.ncbi.nlm.nih.gov/15051952 15051952]|[https://pubmed.ncbi.nlm.nih.gov/12943224 12943224] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036] [https://pubmed.ncbi.nlm.nih.gov/29865036 29865036]]|[https://pubmed.ncbi.nlm.nih.gov/30952424 30952424]|[https://pubmed.ncbi.nlm.nih.gov/31611643 31611643]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919] [https://pubmed.ncbi.nlm.nih.gov/19577919 19577919]]|[https://pubmed.ncbi.nlm.nih.gov/32019882 32019882]|[https://pubmed.ncbi.nlm.nih.gov/19139197 19139197]|[https://pubmed.ncbi.nlm.nih.gov/26184710 26184710]|[https://pubmed.ncbi.nlm.nih.gov/11159917 11159917]|[https://pubmed.ncbi.nlm.nih.gov/21536259 21536259]|[https://pubmed.ncbi.nlm.nih.gov/25186198 25186198]|[https://pubmed.ncbi.nlm.nih.gov/19277556 19277556]|[https://pubmed.ncbi.nlm.nih.gov/22261557 22261557]|[https://pubmed.ncbi.nlm.nih.gov/24115046 24115046]|[https://pubmed.ncbi.nlm.nih.gov/18725413 18725413]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855] [https://pubmed.ncbi.nlm.nih.gov/15966855 15966855]]|[https://pubmed.ncbi.nlm.nih.gov/24256304 24256304]|[https://pubmed.ncbi.nlm.nih.gov/25477510 25477510]|[https://pubmed.ncbi.nlm.nih.gov/10359703 10359703]|[https://pubmed.ncbi.nlm.nih.gov/24406064 24406064]|[https://pubmed.ncbi.nlm.nih.gov/22259135 22259135]|[https://pubmed.ncbi.nlm.nih.gov/29279989 29279989]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855] [https://pubmed.ncbi.nlm.nih.gov/15966855 15966855]]|[https://pubmed.ncbi.nlm.nih.gov/30619255 30619255]|[https://pubmed.ncbi.nlm.nih.gov/9673446 9673446]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555] [https://pubmed.ncbi.nlm.nih.gov/31676555 31676555]]|[https://pubmed.ncbi.nlm.nih.gov/28745859 28745859]|[https://pubmed.ncbi.nlm.nih.gov/28196325 28196325]|[https://pubmed.ncbi.nlm.nih.gov/27975143 27975143]|[https://pubmed.ncbi.nlm.nih.gov/30591584 30591584]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173] [https://pubmed.ncbi.nlm.nih.gov/28518173 28518173]]|[https://pubmed.ncbi.nlm.nih.gov/17522109 17522109]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495] [https://pubmed.ncbi.nlm.nih.gov/26328495 26328495]]|[https://pubmed.ncbi.nlm.nih.gov/32178593 32178593]|[https://pubmed.ncbi.nlm.nih.gov/27529638 27529638]|[https://pubmed.ncbi.nlm.nih.gov/24663386 24663386]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328] [https://pubmed.ncbi.nlm.nih.gov/22474328 22474328]]|[https://pubmed.ncbi.nlm.nih.gov/28096352 28096352]|[https://pubmed.ncbi.nlm.nih.gov/27496768 27496768]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191] [https://pubmed.ncbi.nlm.nih.gov/18952191 18952191]]|[https://pubmed.ncbi.nlm.nih.gov/11135308 11135308]|[https://pubmed.ncbi.nlm.nih.gov/24917611 24917611]|[https://pubmed.ncbi.nlm.nih.gov/11532966 11532966]|[https://pubmed.ncbi.nlm.nih.gov/22786570 22786570]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229] [https://pubmed.ncbi.nlm.nih.gov/11891229 11891229]]|[https://pubmed.ncbi.nlm.nih.gov/18332077 18332077]|[https://pubmed.ncbi.nlm.nih.gov/26867212 26867212]|[https://pubmed.ncbi.nlm.nih.gov/26925665 26925665]|[https://pubmed.ncbi.nlm.nih.gov/16769205 16769205]|[https://pubmed.ncbi.nlm.nih.gov/23475718 23475718]|[https://pubmed.ncbi.nlm.nih.gov/16005634 16005634]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176] [https://pubmed.ncbi.nlm.nih.gov/28785176 28785176]] <br>
  '''definition''' : A triantennary glycan with three GlcNAc branches linked to the core and the addition of fucose. <br>
  '''definition''' : The carbohydrate portion of a glycoprotein that has a glycan linked through the hydroxyl oxygen of serine, threonine, hydroxylysine or hydroxyproline side-chains.[CHEBI:59521] <br>
  '''term_xref''' : <br>
  '''term_xref''' : CHEBI:59521 <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' : appears in human alpha-fetoprotein (AFP).[PMID: [https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]] <br>
  '''function''' : Affects several important activities like protein stability, modulation of signaling molecules and enzyme activity.[PMID:[https://pubmed.ncbi.nlm.nih.gov/9673446 9673446]] <br>
'''disease_associations''' : neoplastic diseases of the liver[PMID: [https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]] |hepatocellular carcinoma[PMID:  [https://pubmed.ncbi.nlm.nih.gov/7679920 7679920]]. <br>
  '''disease_associations''' : <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453068/ Chapter 43]<br>
 
 
===GSD000078===
'''term (main_entry)''' : Galabiosylceramide <br>
'''glycan_dictionary_accession''' : GSD000078 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G67988RO G67988RO] <br>
'''term_in_sentence''' : LacCer and its structural isomer, galabiosylceramide (Gb2, Galβ(1,4)Galβ-ceramide), are classified as ceramide dihexosides (CDH).[PMID:[https://pubmed.ncbi.nlm.nih.gov/33360824 33360824]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/33360824 33360824]|[https://pubmed.ncbi.nlm.nih.gov/29099167 29099167]|[https://pubmed.ncbi.nlm.nih.gov/25582508 25582508]|[https://pubmed.ncbi.nlm.nih.gov/2824515 2824515]|[https://pubmed.ncbi.nlm.nih.gov/4027258 4027258]|[https://pubmed.ncbi.nlm.nih.gov/32854306 32854306]|[https://pubmed.ncbi.nlm.nih.gov/32868283 32868283]|[https://pubmed.ncbi.nlm.nih.gov/31319156 31319156]|[https://pubmed.ncbi.nlm.nih.gov/29530250 29530250]|[https://pubmed.ncbi.nlm.nih.gov/27367163 27367163]|[https://pubmed.ncbi.nlm.nih.gov/2564247 2564247]|[https://pubmed.ncbi.nlm.nih.gov/27727434 27727434]|[https://pubmed.ncbi.nlm.nih.gov/10216186 10216186]| [https://pubmed.ncbi.nlm.nih.gov/10460829 10460829]|[https://pubmed.ncbi.nlm.nih.gov/24992926 24992926]|[https://pubmed.ncbi.nlm.nih.gov/23590301 23590301]|[https://pubmed.ncbi.nlm.nih.gov/15702404 15702404]|[https://pubmed.ncbi.nlm.nih.gov/1854798 1854798]|[https://pubmed.ncbi.nlm.nih.gov/14761135 14761135]|[https://pubmed.ncbi.nlm.nih.gov/3600200 3600200]|[https://pubmed.ncbi.nlm.nih.gov/8603914 8603914]|[https://pubmed.ncbi.nlm.nih.gov/8601603 8601603]|[https://pubmed.ncbi.nlm.nih.gov/1965141 1965141]|[https://pubmed.ncbi.nlm.nih.gov/17400502 17400502]|[https://pubmed.ncbi.nlm.nih.gov/3840690 3840690]|[https://pubmed.ncbi.nlm.nih.gov/15959771 15959771]|[https://pubmed.ncbi.nlm.nih.gov/7930586 7930586]|[https://pubmed.ncbi.nlm.nih.gov/7721812 7721812]|[https://pubmed.ncbi.nlm.nih.gov/17095952 17095952]|[https://pubmed.ncbi.nlm.nih.gov/2500499 2500499]|[https://pubmed.ncbi.nlm.nih.gov/3815386 3815386]|[https://pubmed.ncbi.nlm.nih.gov/8842706 8842706]|[https://pubmed.ncbi.nlm.nih.gov/10746023 10746023]|[https://pubmed.ncbi.nlm.nih.gov/3928791 3928791]|[https://pubmed.ncbi.nlm.nih.gov/3782065 3782065]|[https://pubmed.ncbi.nlm.nih.gov/6440894 6440894] <br>
'''definition''' : A disaccharide consisting of β-D-galactopyranose having a D-galactopyranosyl residue attached at the 4-position via an α-linkage.[CHEBI:59314] <br>
'''term_xref''' : GlycoEpitope:EP0113|GTC:G67988RO|CID: 5288350|KEGG:G00497|KEGG:G10645|CHEBI:59314 <br>
'''synonyms''' :  <br>
'''function''' :  <br>
  '''disease_associations''' : tumor/lung[GlycoEpitope:EP0113]|tumor/gallbladder[GlycoEpitope:EP0113]|tumor/kidney[GlycoEpitope:EP0113]|tumor/pancreas[GlycoEpitope:EP0113] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>


 
===GSD000140===
===GSD000079===
  '''term (main_entry)''' : O-linked mannose <br>
  '''term (main_entry)''' : Galactosylceramide <br>
  '''glycan_dictionary_accession''' : GSD000140 <br>
  '''glycan_dictionary_accession''' : GSD000079 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G59126YU G59126YU] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G65889KE G65889KE] <br>
  '''term_in_sentence''' : Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the first step toward the functional matriglycan structure on alpha-dystroglycan that is responsible for binding extracellular matrix proteins and certain arenaviruses.[PMID: [https://pubmed.ncbi.nlm.nih.gov/27932460 27932460]] <br>
  '''term_in_sentence''' : Galactosylceramide improved behavioral, neuropathological, and biochemical parameters in Cln3 Cln3 Δex7/8 mice, paving the way for effective therapy for CLN3 disease and use of serum ceramide as a potential biomarker to track impact of therapies.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31393621 31393621]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27932460 27932460]|[https://pubmed.ncbi.nlm.nih.gov/24526361 24526361]|[https://pubmed.ncbi.nlm.nih.gov/25381909 25381909]|[https://pubmed.ncbi.nlm.nih.gov/26644575 26644575]|[https://pubmed.ncbi.nlm.nih.gov/23851827 23851827]|[https://pubmed.ncbi.nlm.nih.gov/28810660 28810660]|[https://pubmed.ncbi.nlm.nih.gov/19054127 19054127]|[https://pubmed.ncbi.nlm.nih.gov/23929950 23929950]|[https://pubmed.ncbi.nlm.nih.gov/21684258 21684258]|[https://pubmed.ncbi.nlm.nih.gov/22608994 22608994]|[https://pubmed.ncbi.nlm.nih.gov/28973932 28973932]|[https://pubmed.ncbi.nlm.nih.gov/24733390 24733390]|[https://pubmed.ncbi.nlm.nih.gov/31851597 31851597]|[https://pubmed.ncbi.nlm.nih.gov/29884773 29884773]|[https://pubmed.ncbi.nlm.nih.gov/28711406 28711406]|[https://pubmed.ncbi.nlm.nih.gov/14577328 14577328]|[https://pubmed.ncbi.nlm.nih.gov/21089343 21089343]|[https://pubmed.ncbi.nlm.nih.gov/14617637 14617637]|[https://pubmed.ncbi.nlm.nih.gov/9838223 9838223]|[https://pubmed.ncbi.nlm.nih.gov/17072003 17072003]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495] [https://pubmed.ncbi.nlm.nih.gov/26328495 26328495]]|[https://pubmed.ncbi.nlm.nih.gov/11181560 11181560]|[https://pubmed.ncbi.nlm.nih.gov/31949166 31949166]|[https://pubmed.ncbi.nlm.nih.gov/31988979 31988979]|[https://pubmed.ncbi.nlm.nih.gov/20362685 20362685]|[https://pubmed.ncbi.nlm.nih.gov/27733679 27733679]|[https://pubmed.ncbi.nlm.nih.gov/27493216 27493216]|[https://pubmed.ncbi.nlm.nih.gov/20044576 20044576]|[https://pubmed.ncbi.nlm.nih.gov/30643095 30643095]|[https://pubmed.ncbi.nlm.nih.gov/29732660 29732660]|[https://pubmed.ncbi.nlm.nih.gov/10580142 10580142]|[https://pubmed.ncbi.nlm.nih.gov/14568618 14568618]|[https://pubmed.ncbi.nlm.nih.gov/28079948 28079948]|[https://pubmed.ncbi.nlm.nih.gov/15467391 15467391]|[https://pubmed.ncbi.nlm.nih.gov/27812179 27812179]|[https://pubmed.ncbi.nlm.nih.gov/23761899 23761899]|[https://pubmed.ncbi.nlm.nih.gov/25737452 25737452]|[https://pubmed.ncbi.nlm.nih.gov/32930586 32930586]|[https://pubmed.ncbi.nlm.nih.gov/25381372 25381372]|[https://pubmed.ncbi.nlm.nih.gov/23434682 23434682]|[https://pubmed.ncbi.nlm.nih.gov/16857188 16857188]|[https://pubmed.ncbi.nlm.nih.gov/21452199 21452199]|[https://pubmed.ncbi.nlm.nih.gov/19429925 19429925]|[https://pubmed.ncbi.nlm.nih.gov/25361541 25361541]|[https://pubmed.ncbi.nlm.nih.gov/24297939 24297939]|[https://pubmed.ncbi.nlm.nih.gov/30322079 30322079]|[https://pubmed.ncbi.nlm.nih.gov/23428289 23428289]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937] [https://pubmed.ncbi.nlm.nih.gov/28427937 28427937]]|[https://pubmed.ncbi.nlm.nih.gov/22746206 22746206]|[https://pubmed.ncbi.nlm.nih.gov/27533452 27533452]|[https://pubmed.ncbi.nlm.nih.gov/17502374 17502374]|[https://pubmed.ncbi.nlm.nih.gov/20816174 20816174]|[https://pubmed.ncbi.nlm.nih.gov/27496765 27496765] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/31393621 31393621]|[https://pubmed.ncbi.nlm.nih.gov/19941861 19941861]|[https://pubmed.ncbi.nlm.nih.gov/9883654 9883654]|[https://pubmed.ncbi.nlm.nih.gov/33006978 33006978]|[https://pubmed.ncbi.nlm.nih.gov/26735924 26735924]|[https://pubmed.ncbi.nlm.nih.gov/22032265 22032265]|[https://pubmed.ncbi.nlm.nih.gov/18035062 18035062]|[https://pubmed.ncbi.nlm.nih.gov/25129050 25129050]|[https://pubmed.ncbi.nlm.nih.gov/2802541 2802541]|[https://pubmed.ncbi.nlm.nih.gov/1761517 1761517]|[https://pubmed.ncbi.nlm.nih.gov/28660574 28660574]|475780|[https://pubmed.ncbi.nlm.nih.gov/2302222 2302222] <br>
  '''definition''' : O-linked glycans that are initiated by the addtion of a Man residue to Ser or Thr. Subsequent extension of the Man defines the O-Man core type, either M1, M2, or M3. The M1 type is initated by addition of a GlcNAc in β-linkage to the 2 position of the Man residue. M2 is initiated by addition of another GlcNAc to the 6 position of the M1 core. M3 is initiated by the addition of a GlcNAc in β-linkage to the 4 position of the Man residue. M1 and M2 type core glycans can be extended and branched with Gal, Fuc, Sialic Acid, and GlcA. The M3 core is uniquely extended by a multienzyme system to generate the matriglycan polysaccharide, a protein-specific modification found only on alpha-dystroglycan. [CHEBI:87761] <br>
  '''definition''' : <br>
  '''term_xref''' : GlycoMotif:GGM.000055|GTC:G59126YU|CHEBI:87761|GlycoEpitope:EP0002|CID:[https://pubmed.ncbi.nlm.nih.gov/91859038 91859038] <br>
  '''term_xref''' : GTC:G65889KE|GlycoEpitope:EP0074|SugarBind_Ligand:1|GlycoMotif:GGM.000061<br>
  '''synonyms''' : O-mannosyl glycan <br>
  '''synonyms''' : GalCer|Galactocerebroside|LC <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : Pleuropneumonia[SugarBind_Ligand:1]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:1]|Lyme disease[SugarBind_Ligand:1]|Plague[SugarBind_Ligand:1]|Acquired immune deficiency syndrome[SugarBind_Ligand:1] <br>
  '''disease_associations''' : MEB/muscle-eye-brain disease[GlycoEpitope:EP0002]|WWS/walker-warburg syndrome |muscular dystrophy[GlycoEpitope:EP0002]|neuronal migration disorder[GlycoEpitope:EP0002]|Muscle-Eye-Brain disease (MEB) and Walker-Warburg Syndrome (WWS) have mutations in genes encoding glycosyltransferases needed for O -mannosyl oligosaccharide synthesis[GlycoEpitope:EP0002]|Muscular dystrophy and neuronal migration disorder are caused by mutations in a glycosyltransferase, POMGnT1.[GlycoEpitope:EP0002] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000080===
===GSD000141===
  '''term (main_entry)''' : Galnac disialyl Lc4 (Hexasaccharide) <br>
  '''term (main_entry)''' : P1 antigen <br>
  '''glycan_dictionary_accession''' : GSD000080 <br>
  '''glycan_dictionary_accession''' : GSD000141 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G33532XU G33532XU] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G12460DL G12460DL] <br>
  '''term_in_sentence''' : Therefore, a new marker for prostate cancer is urgently required. We examined expression of a novel carbohydrate antigen, beta1,4-GalNAc-disialyl-Lc(4), defined by the monoclonal antibody RM2, in prostate cancer using 75 cases of radical prostatectomy specimens.[PMID: [https://pubmed.ncbi.nlm.nih.gov/12084983 12084983]] <br>
  '''term_in_sentence''' : The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively.[PMID: [https://pubmed.ncbi.nlm.nih.gov/24046920 24046920]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/15704108 15704108]|[https://pubmed.ncbi.nlm.nih.gov/11278988 11278988]|[https://pubmed.ncbi.nlm.nih.gov/12084983 12084983]|[https://pubmed.ncbi.nlm.nih.gov/7509790 7509790] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29622537 29622537]|[https://pubmed.ncbi.nlm.nih.gov/26773500 26773500]|[https://pubmed.ncbi.nlm.nih.gov/24046920 24046920]|[https://pubmed.ncbi.nlm.nih.gov/6207232 6207232]|[https://pubmed.ncbi.nlm.nih.gov/8550516 8550516]|[https://pubmed.ncbi.nlm.nih.gov/6609976 6609976]|[https://pubmed.ncbi.nlm.nih.gov/6375319 6375319]|817855|[https://pubmed.ncbi.nlm.nih.gov/2428855 2428855]|[https://pubmed.ncbi.nlm.nih.gov/3312011 3312011]|[https://pubmed.ncbi.nlm.nih.gov/15364312 15364312]|[https://pubmed.ncbi.nlm.nih.gov/1937801 1937801]|[https://pubmed.ncbi.nlm.nih.gov/7729906 7729906] <br>
  '''definition''' : (2R,4S,5R,6R)-5-Acetamido-2-[[(2R,3S,4R,5R,6S)-5-acetamido-4-[(2R,3R,4R,5S,6R)-4-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxy-6-[(3R,4S,5S,6R)-2,3,5-trihydroxy-6-(hydroxymethyl)oxan-4-yl]oxyoxan-2-yl]methoxy]-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CID: 91857945] <br>
  '''definition''' : An amino pentasaccharide consisting of α-D-galactose, β-D-galactose N-acetyl-α-D-glucosamine, β-D-galactose, and β-D-glucose residues joined in sequence with ((1→4)-, (1→4)-, (1→3)- and (1→4)-linkages, respectively.[CHEBI:68484] <br>
  '''term_xref''' : GlycoEpitope:EP0097|GTC:G33532XU|CID: 91857945|CHEBI:149360 <br>
  '''term_xref''' : GlycoMotif:GGM.000069|GTC:G12460DL|CID:[https://pubmed.ncbi.nlm.nih.gov/71296137 71296137]|CHEBI:68484|SugarBind_Ligand:160  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : prostate cancer[GlycoEpitope:EP0097]|renal cell carcinoma/RCC[GlycoEpitope:EP0097] <br>
  '''disease_associations''' : Shigellosis[SugarBind_Ligand:160] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453054/ Chapter 23]<br>




===GSD000081===
===GSD000142===
  '''term (main_entry)''' : Gb5 <br>
[[File:G51699SI.png|thumb|G51699SI]]
  '''glycan_dictionary_accession''' : GSD000081 <br>
  '''term (main_entry)''' : Para-Forssman glycolipid <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G99053DY G99053DY] <br>
  '''glycan_dictionary_accession''' : GSD000142 <br>
  '''term_in_sentence''' : LnbB, a member of the glycoside hydrolase family 20 isolated from Bifidobacterium bifidum, was shown to release GNB from Gb5 and GA1 oligosaccharides.[PMID:[https://pubmed.ncbi.nlm.nih.gov/25839135 25839135]] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G51699SI G51699SI] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/12401210 12401210]|[https://pubmed.ncbi.nlm.nih.gov/25839135 25839135]|[https://pubmed.ncbi.nlm.nih.gov/31540393 31540393]|[https://pubmed.ncbi.nlm.nih.gov/31140679 31140679]|[https://pubmed.ncbi.nlm.nih.gov/3028540 3028540]|[https://pubmed.ncbi.nlm.nih.gov/3674263 3674263]|[https://pubmed.ncbi.nlm.nih.gov/31339142 31339142]|[https://pubmed.ncbi.nlm.nih.gov/30026902 30026902]|[https://pubmed.ncbi.nlm.nih.gov/10721708 10721708]|[https://pubmed.ncbi.nlm.nih.gov/30671362 30671362]|[https://pubmed.ncbi.nlm.nih.gov/26176557 26176557]|[https://pubmed.ncbi.nlm.nih.gov/25039255 25039255]|[https://pubmed.ncbi.nlm.nih.gov/24044869 24044869]|[https://pubmed.ncbi.nlm.nih.gov/32567311 32567311]|[https://pubmed.ncbi.nlm.nih.gov/27857717 27857717]|[https://pubmed.ncbi.nlm.nih.gov/21491978 21491978]|[https://pubmed.ncbi.nlm.nih.gov/24910250 24910250]|[https://pubmed.ncbi.nlm.nih.gov/29077212 29077212]|[https://pubmed.ncbi.nlm.nih.gov/8014006 8014006]|[https://pubmed.ncbi.nlm.nih.gov/27107335 27107335]|[https://pubmed.ncbi.nlm.nih.gov/32679486 32679486]|[https://pubmed.ncbi.nlm.nih.gov/1747956 1747956]|[https://pubmed.ncbi.nlm.nih.gov/8679447 8679447]|[https://pubmed.ncbi.nlm.nih.gov/28352526 28352526]|[https://pubmed.ncbi.nlm.nih.gov/11341836 11341836]|[https://pubmed.ncbi.nlm.nih.gov/10837462 10837462]| [https://pubmed.ncbi.nlm.nih.gov/7960243 7960243]|[https://pubmed.ncbi.nlm.nih.gov/16158941 16158941]|[https://pubmed.ncbi.nlm.nih.gov/3297853 3297853]|[https://pubmed.ncbi.nlm.nih.gov/2431136 2431136]|[https://pubmed.ncbi.nlm.nih.gov/21734356 21734356]|[https://pubmed.ncbi.nlm.nih.gov/8625206 8625206]|[https://pubmed.ncbi.nlm.nih.gov/30732055 30732055]|[https://pubmed.ncbi.nlm.nih.gov/12716912 12716912]|[https://pubmed.ncbi.nlm.nih.gov/20128040 20128040]|[https://pubmed.ncbi.nlm.nih.gov/2582447 2582447]|[https://pubmed.ncbi.nlm.nih.gov/14659673 14659673] <br>
  '''term_in_sentence''' : A novel pentaglycosyl ceramide containing di-beta-N-acetylgalactos-aminyl residue (Para-Forssman glycolipid) isolated from human erythrocyte membrane. [PMID:[https://pubmed.ncbi.nlm.nih.gov/6814203 6814203]] <br>
'''definition''' : A linear amino pentasaccharide comprising D-glucose at the reducing end with a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-α-D-galactosyl-(1→4)-β-D-galactosyl moiety at the 4-position.[CHEBI:141842] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/6814203 6814203] <br>
'''term_xref''' : GlycoMotif:GGM.000076|GTC:G99053DY|CID:[https://pubmed.ncbi.nlm.nih.gov/53239691 53239691]|KEGG:G00097|CHEBI:62311|SugarBind_Ligand:12<br>
  '''definition''' : GalNAcβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1→1Cer [https://doi.org/10.1016/S0040-4039(01)93814-6<nowiki>] </nowiki><br>
'''synonyms''' : Globopentaosylceramide <br>
  '''term_xref''' : GlycoMotif:GGM.000085|GTC:G51699SI|CID:[https://pubmed.ncbi.nlm.nih.gov/56836111 56836111]|KEGG:G00096|SugarBind_Ligand:19|CHEBI:151565 <br>
'''function''' :  <br>
  '''synonyms''' :  <br>
'''disease_associations''' : Pyelonephritis[SugarBind_Ligand:12]|Actinomycosis[SugarBind_Ligand:12|Influenza[SugarBind_Ligand:12] <br>
  '''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>
 
 
===GSD000082===
  '''term (main_entry)''' : GD1 <br>
'''glycan_dictionary_accession''' : GSD000082 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G81983KG G81983KG] <br>
'''term_in_sentence''' : Hormonal and metabolic disturbances observed in both adult and paediatric patients with Gaucher disease type 1 (GD1) are discussed in this review. The PubMed database was used to identify articles on endocrine and metabolic disorders in GD1.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31791361 31791361]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/5652802 5652802]|[https://pubmed.ncbi.nlm.nih.gov/25345088 25345088]|[https://pubmed.ncbi.nlm.nih.gov/31791361 31791361]|[https://pubmed.ncbi.nlm.nih.gov/29361370 29361370]|[https://pubmed.ncbi.nlm.nih.gov/31234327 31234327]|[https://pubmed.ncbi.nlm.nih.gov/30264864 30264864]|[https://pubmed.ncbi.nlm.nih.gov/25250137 25250137]|[https://pubmed.ncbi.nlm.nih.gov/7528216 7528216]|[https://pubmed.ncbi.nlm.nih.gov/31669751 31669751]|[https://pubmed.ncbi.nlm.nih.gov/20684311 20684311]|[https://pubmed.ncbi.nlm.nih.gov/16306603 16306603]|[https://pubmed.ncbi.nlm.nih.gov/10420586 10420586]|[https://pubmed.ncbi.nlm.nih.gov/7766692 7766692]|[https://pubmed.ncbi.nlm.nih.gov/31614613 31614613]|[https://pubmed.ncbi.nlm.nih.gov/26384672 26384672]|[https://pubmed.ncbi.nlm.nih.gov/31613991 31613991]|[https://pubmed.ncbi.nlm.nih.gov/19210136 19210136]|[https://pubmed.ncbi.nlm.nih.gov/8926633 8926633]|[https://pubmed.ncbi.nlm.nih.gov/29696051 29696051]|[https://pubmed.ncbi.nlm.nih.gov/32300455 32300455]|[https://pubmed.ncbi.nlm.nih.gov/7513313 7513313]|[https://pubmed.ncbi.nlm.nih.gov/26674302 26674302]|[https://pubmed.ncbi.nlm.nih.gov/20336376 20336376]|[https://pubmed.ncbi.nlm.nih.gov/24259734 24259734]|[https://pubmed.ncbi.nlm.nih.gov/31704237 31704237]|[https://pubmed.ncbi.nlm.nih.gov/21067946 21067946]|[https://pubmed.ncbi.nlm.nih.gov/30516933 30516933]|[https://pubmed.ncbi.nlm.nih.gov/27979707 27979707]|[https://pubmed.ncbi.nlm.nih.gov/26345314 26345314]|[https://pubmed.ncbi.nlm.nih.gov/30516941 30516941]|[https://pubmed.ncbi.nlm.nih.gov/31849452 31849452]|[https://pubmed.ncbi.nlm.nih.gov/27789132 27789132]|[https://pubmed.ncbi.nlm.nih.gov/30218706 30218706]|[https://pubmed.ncbi.nlm.nih.gov/29388611 29388611]|[https://pubmed.ncbi.nlm.nih.gov/20177787 20177787] <br>
'''definition''' :  <br>
  '''term_xref''' : GlycoMotif:GGM.000105|GTC:G81983KG|CID: 91859783|KEGG:G00126  <br>
'''synonyms''' : GD1c <br>
'''function''' :  <br>
'''disease_associations''' :  <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' :  <br>
 
 
===GSD000083===
'''term (main_entry)''' : GD1a <br>
'''glycan_dictionary_accession''' : GSD000083 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G46677TE G46677TE] | [https://glygen.org/glycan/G45714BQ G45714BQ]<br>
'''term_in_sentence''' : Exclusive exposure of rat oligodendrocytes to GD1a, but not other gangliosides, overcomes aggregated fibronectin-induced inhibition of myelin membrane formation, in vitro, and OPC differentiation in fibronectin aggregate containing cuprizone-induced demyelinated lesions in male mice. [PMID: [https://pubmed.ncbi.nlm.nih.gov/28899916 28899916]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28899916 28899916]|[https://pubmed.ncbi.nlm.nih.gov/26860251 26860251]|[https://pubmed.ncbi.nlm.nih.gov/21930390 21930390]|[https://pubmed.ncbi.nlm.nih.gov/32906699 32906699]|[https://pubmed.ncbi.nlm.nih.gov/26054879 26054879]|[https://pubmed.ncbi.nlm.nih.gov/29951721 29951721]|[https://pubmed.ncbi.nlm.nih.gov/11745410 11745410]|[https://pubmed.ncbi.nlm.nih.gov/17653976 17653976]|[https://pubmed.ncbi.nlm.nih.gov/26119566 26119566]|[https://pubmed.ncbi.nlm.nih.gov/21554929 21554929]|[https://pubmed.ncbi.nlm.nih.gov/18435913 18435913]|[https://pubmed.ncbi.nlm.nih.gov/15342262 15342262]|[https://pubmed.ncbi.nlm.nih.gov/26865725 26865725]|[https://pubmed.ncbi.nlm.nih.gov/21151139 21151139]|[https://pubmed.ncbi.nlm.nih.gov/15716397 15716397]|[https://pubmed.ncbi.nlm.nih.gov/21492147 21492147]|[https://pubmed.ncbi.nlm.nih.gov/16942752 16942752]|[https://pubmed.ncbi.nlm.nih.gov/26973195 26973195]|[https://pubmed.ncbi.nlm.nih.gov/24449473 24449473]|[https://pubmed.ncbi.nlm.nih.gov/14999485 14999485]|[https://pubmed.ncbi.nlm.nih.gov/22735313 22735313]|[https://pubmed.ncbi.nlm.nih.gov/20589721 20589721]|[https://pubmed.ncbi.nlm.nih.gov/10521808 10521808]|[https://pubmed.ncbi.nlm.nih.gov/22929125 22929125]|[https://pubmed.ncbi.nlm.nih.gov/7827024 7827024]|[https://pubmed.ncbi.nlm.nih.gov/16897174 16897174]|[https://pubmed.ncbi.nlm.nih.gov/25062498 25062498]|[https://pubmed.ncbi.nlm.nih.gov/17227759 17227759] <br>
'''definition''' : A branched amino hexasaccharide consisting of the linear sequence α-Neu5Ac-(2→3)-β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to a galactose via an α-(2→3) linkage. The oligosaccharide of ganglioside GD1a.[CHEBI:59209] <br>
  '''term_xref''' : GlycoMotif:GGM.000106|GlycoMotif:GGM.000107|GTC:G46677TE|GTC:G45714BQ|CID:45266861|CHEBI:59209|GlycoEpitope:EP0056|SugarBind_Ligand:22|KEGG:G00111 <br>
'''synonyms''' : GD1alpha <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : Gastroenteritis[SugarBind_Ligand:22]|Actinomycosis[SugarBind_Ligand:22]|Lazy leukocyte syndrome[SugarBind_Ligand:22]|Toxoplasmosis[SugarBind_Ligand:22]|Lyme disease[SugarBind_Ligand:22]|Botulism[SugarBind_Ligand:22]|Keratoconjunctivitis[SugarBind_Ligand:22]|Influenza[SugarBind_Ligand:22] <br>
  '''disease_associations''' : Actinomycosis[SugarBind_Ligand:19] <br>
  '''wikipedia''' : <br>
  '''wikipedia''' : https://en.wikipedia.org/wiki/P1PK_blood_group_system <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000084===
===GSD000143===
[[File:G37184KW.png|thumb|G37184KW]]
  '''term (main_entry)''' : Paragloboside <br>
  '''term (main_entry)''' : GD1b <br>
  '''glycan_dictionary_accession''' : GSD000143 <br>
  '''glycan_dictionary_accession''' : GSD000084 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G58896AZ G58896AZ] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G37184KW G37184KW] <br>
  '''term_in_sentence''' : Galactosyltransferase activities in sera of cancer patients were determined by assaying the formation of paragloboside from UDP-galactose and lactotriaosylceramide immobilized on microtiter plates by means of the enzyme-linked immunosorbent assay using a monoclonal antibody, H-11, directed to paragloboside. [PMID: [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117] [https://pubmed.ncbi.nlm.nih.gov/1551117 1551117]]] <br>
  '''term_in_sentence''' : Gangliosides have been known to play a role in the regulation of apoptosis in cancer cells. This study has employed disialyl-ganglioside GD1b to apoptosis in human breast cancer MCF-7 cells using exogenous treatment of the cells with GD1b and endogenous expression of GD1b in MCF-7 cells.[PMID: [https://pubmed.ncbi.nlm.nih.gov/27144558 27144558]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/3345524 3345524]|850070|[https://pubmed.ncbi.nlm.nih.gov/10569746 10569746]|[https://pubmed.ncbi.nlm.nih.gov/30624951 30624951]|[https://pubmed.ncbi.nlm.nih.gov/29438961 29438961]|[https://pubmed.ncbi.nlm.nih.gov/6816790 6816790]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117] [https://pubmed.ncbi.nlm.nih.gov/1551117 1551117]]|[https://pubmed.ncbi.nlm.nih.gov/6865961 6865961]|[https://pubmed.ncbi.nlm.nih.gov/25039255 25039255] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27144558 27144558]|[https://pubmed.ncbi.nlm.nih.gov/24859332 24859332]|[https://pubmed.ncbi.nlm.nih.gov/18625966 18625966]|[https://pubmed.ncbi.nlm.nih.gov/7945223 7945223]|[https://pubmed.ncbi.nlm.nih.gov/32518172 32518172]|[https://pubmed.ncbi.nlm.nih.gov/26710925 26710925]|[https://pubmed.ncbi.nlm.nih.gov/31837178 31837178]|[https://pubmed.ncbi.nlm.nih.gov/20594196 20594196]|[https://pubmed.ncbi.nlm.nih.gov/30985655 30985655]|[https://pubmed.ncbi.nlm.nih.gov/11511306 11511306]|[https://pubmed.ncbi.nlm.nih.gov/1742806 1742806]|[https://pubmed.ncbi.nlm.nih.gov/11123278 11123278]|[https://pubmed.ncbi.nlm.nih.gov/7685064 7685064]|[https://pubmed.ncbi.nlm.nih.gov/2709011 2709011]|[https://pubmed.ncbi.nlm.nih.gov/33279873 33279873]|[https://pubmed.ncbi.nlm.nih.gov/22929125 22929125]|[https://pubmed.ncbi.nlm.nih.gov/9179156 9179156]|[https://pubmed.ncbi.nlm.nih.gov/17964572 17964572]|[https://pubmed.ncbi.nlm.nih.gov/8821498 8821498]|[https://pubmed.ncbi.nlm.nih.gov/32726962 32726962]|[https://pubmed.ncbi.nlm.nih.gov/26560950 26560950]|[https://pubmed.ncbi.nlm.nih.gov/2611779 2611779]|[https://pubmed.ncbi.nlm.nih.gov/10072058 10072058]|[https://pubmed.ncbi.nlm.nih.gov/20030259 20030259]|[https://pubmed.ncbi.nlm.nih.gov/16415013 16415013]|[https://pubmed.ncbi.nlm.nih.gov/10797556 10797556]|[https://pubmed.ncbi.nlm.nih.gov/11342695 11342695]|[https://pubmed.ncbi.nlm.nih.gov/8619520 8619520]|[https://pubmed.ncbi.nlm.nih.gov/21519903 21519903]|[https://pubmed.ncbi.nlm.nih.gov/16199892 16199892]|[https://pubmed.ncbi.nlm.nih.gov/23777091 23777091]|[https://pubmed.ncbi.nlm.nih.gov/30246056 30246056]|[https://pubmed.ncbi.nlm.nih.gov/10481046 10481046] <br>
  '''definition''' : α-Neup5Ac-(2→3)-β-D-Galp-(1→3)-D-GalpNAc in which the configuration at the GalNAc anomeric carbon is α.[CHEBI:65257] <br>
  '''definition''' : A branched amino hexasaccharide comprising a β-D-galactosyl-(1→4)-β-D-glucose disaccharide, the galactosyl residue of which carries β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl and N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl disaccharide units through (2→4) and (2→3) linkages respectively. It is the carbohydrate portion of ganglioside GD1b.[CHEBI:59222] <br>
  '''term_xref''' : GlycoMotif:GGM.000077|GTC:G58896AZ|CID:[https://pubmed.ncbi.nlm.nih.gov/21670519 21670519]|CHEBI:65257|GlycoEpitope:EP0075|SugarBind_Ligand:15 <br>
  '''term_xref''' : GlycoMotif:GGM.000108|GTC:G37184KW|CID:45266846|CHEBI:59222|GlycoEpitope:EP0059|SugarBind_Ligand:14  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : Pharyngitis[SugarBind_Ligand:15]|Tracheobronchitis[SugarBind_Ligand:15]|Gonorrhea[SugarBind_Ligand:15]|Actinomycosis[SugarBind_Ligand:15]|Diarrhea[SugarBind_Ligand:15]|Hemorrhagic colitis[SugarBind_Ligand:15]|Chronic gastritis[SugarBind_Ligand:15]|Peptic ulcers[SugarBind_Ligand:15]|Gastric cancer[SugarBind_Ligand:15]|Influenza[SugarBind_Ligand:15] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453023/ Chapter 47]<br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000085===
===GSD000144===
  '''term (main_entry)''' : GD2 <br>
  '''term (main_entry)''' : Paucimannose <br>
  '''glycan_dictionary_accession''' : GSD000085 <br>
  '''glycan_dictionary_accession''' : GSD000144 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G02657AK G02657AK] <br>
  '''glytoucan_accession ''' : <br>
  '''term_in_sentence''' : Ganglioside GD2 is a tumor-associated surface antigen found in a broad spectrum of human cancers and stem cells. [PMID: [https://pubmed.ncbi.nlm.nih.gov/25440605 25440605]] <br>
  '''term_in_sentence''' : The galactosylation of core fucose (GalFuc epitope) in paucimannose and complex-type N-glycans is characteristic of protostome organisms, including flatworms (planarians).[PMID:[https://pubmed.ncbi.nlm.nih.gov/29475940 29475940]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28154831 28154831]|[https://pubmed.ncbi.nlm.nih.gov/32002293 32002293]|[https://pubmed.ncbi.nlm.nih.gov/32733795 32733795]|[https://pubmed.ncbi.nlm.nih.gov/28145567 28145567]|[https://pubmed.ncbi.nlm.nih.gov/31500597 31500597]|[https://pubmed.ncbi.nlm.nih.gov/31903906 31903906]|[https://pubmed.ncbi.nlm.nih.gov/29180536 29180536]|[https://pubmed.ncbi.nlm.nih.gov/28415563 28415563]|[https://pubmed.ncbi.nlm.nih.gov/25440605 25440605]|[https://pubmed.ncbi.nlm.nih.gov/30617136 30617136]|[https://pubmed.ncbi.nlm.nih.gov/25604432 25604432]|[https://pubmed.ncbi.nlm.nih.gov/30198960 30198960]|[https://pubmed.ncbi.nlm.nih.gov/31075227 31075227]|[https://pubmed.ncbi.nlm.nih.gov/31721713 31721713]|[https://pubmed.ncbi.nlm.nih.gov/30955398 30955398]|[https://pubmed.ncbi.nlm.nih.gov/32195035 32195035]|[https://pubmed.ncbi.nlm.nih.gov/27304202 27304202]|[https://pubmed.ncbi.nlm.nih.gov/31015228 31015228]|[https://pubmed.ncbi.nlm.nih.gov/31653037 31653037]|[https://pubmed.ncbi.nlm.nih.gov/31016728 31016728]|[https://pubmed.ncbi.nlm.nih.gov/30670592 30670592]|[https://pubmed.ncbi.nlm.nih.gov/30613134 30613134]|[https://pubmed.ncbi.nlm.nih.gov/29221154 29221154]|[https://pubmed.ncbi.nlm.nih.gov/30027525 30027525]|[https://pubmed.ncbi.nlm.nih.gov/29442009 29442009]|[https://pubmed.ncbi.nlm.nih.gov/31762628 31762628]|[https://pubmed.ncbi.nlm.nih.gov/30485077 30485077]|[https://pubmed.ncbi.nlm.nih.gov/25642322 25642322]| [https://pubmed.ncbi.nlm.nih.gov/29436609 29436609]|[https://pubmed.ncbi.nlm.nih.gov/29151270 29151270]|[https://pubmed.ncbi.nlm.nih.gov/24773917 24773917]|[https://pubmed.ncbi.nlm.nih.gov/30612272 30612272]|[https://pubmed.ncbi.nlm.nih.gov/27654028 27654028]|[https://pubmed.ncbi.nlm.nih.gov/26298772 26298772] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29475940 29475940]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29803109 29803109] [https://pubmed.ncbi.nlm.nih.gov/29803109 29803109]]|[https://pubmed.ncbi.nlm.nih.gov/12603202 12603202]|[https://pubmed.ncbi.nlm.nih.gov/31817246 31817246]|[https://pubmed.ncbi.nlm.nih.gov/31719144 31719144]|[https://pubmed.ncbi.nlm.nih.gov/21057214 21057214]|[https://pubmed.ncbi.nlm.nih.gov/31932305 31932305]|[https://pubmed.ncbi.nlm.nih.gov/17132514 17132514]|[https://pubmed.ncbi.nlm.nih.gov/30382146 30382146]|[https://pubmed.ncbi.nlm.nih.gov/27731363 27731363]|[https://pubmed.ncbi.nlm.nih.gov/31325506 31325506]|[https://pubmed.ncbi.nlm.nih.gov/25746926 25746926]|[https://pubmed.ncbi.nlm.nih.gov/26513758 26513758]|[https://pubmed.ncbi.nlm.nih.gov/16522637 16522637]|[https://pubmed.ncbi.nlm.nih.gov/21169367 21169367]|[https://pubmed.ncbi.nlm.nih.gov/25190359 25190359]|[https://pubmed.ncbi.nlm.nih.gov/27928741 27928741]|[https://pubmed.ncbi.nlm.nih.gov/22496646 22496646]|[https://pubmed.ncbi.nlm.nih.gov/27384337 27384337]|[https://pubmed.ncbi.nlm.nih.gov/16897177 16897177]|[https://pubmed.ncbi.nlm.nih.gov/15228383 15228383]|[https://pubmed.ncbi.nlm.nih.gov/27379103 27379103]|[https://pubmed.ncbi.nlm.nih.gov/27189951 27189951]|[https://pubmed.ncbi.nlm.nih.gov/23475714 23475714]|[https://pubmed.ncbi.nlm.nih.gov/24907509 24907509]|[https://pubmed.ncbi.nlm.nih.gov/20558211 20558211]|[https://pubmed.ncbi.nlm.nih.gov/28060516 28060516]|[https://pubmed.ncbi.nlm.nih.gov/20441997 20441997]|[https://pubmed.ncbi.nlm.nih.gov/27720757 27720757]|[https://pubmed.ncbi.nlm.nih.gov/28817611 28817611]|[https://pubmed.ncbi.nlm.nih.gov/24550396 24550396]|[https://pubmed.ncbi.nlm.nih.gov/19494052 19494052]|[https://pubmed.ncbi.nlm.nih.gov/19515361 19515361]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087] [https://pubmed.ncbi.nlm.nih.gov/28630087 28630087]]|[https://pubmed.ncbi.nlm.nih.gov/31320997 31320997]|[https://pubmed.ncbi.nlm.nih.gov/30651366 30651366]|[https://pubmed.ncbi.nlm.nih.gov/30253927 30253927]|[https://pubmed.ncbi.nlm.nih.gov/25922361 25922361]|[https://pubmed.ncbi.nlm.nih.gov/31655162 31655162]|[https://pubmed.ncbi.nlm.nih.gov/18056652 18056652]|[https://pubmed.ncbi.nlm.nih.gov/24467287 24467287]|[https://pubmed.ncbi.nlm.nih.gov/32367383 32367383] <br>
'''definition''' : A branched amino pentasaccharide consisting of a linear sequence of two α-sialyl residues, a β-D-galactosyl residue and an N-acetyl-β-D-glucosamine residue linked respectively (2→8), (2→8) and (1→4), to the galactosyl residue of which is also linked (1→4) an N-acetyl-β-D-glucosaminyl residue. It is the carbohydrate portion of ganglioside GD2.[CHEBI:59218] <br>
  '''definition''' : Any N-linked glycan derivative with composition Man1-4Fuc0-1 GlcNAc2, in which the chitobiose core (GlcNAc2) is intact. Found in relatively large amounts in invertebrates and plants, they are formed by removal of the non-reducing terminal GlcNAc (\added by GlcNAcT1) from GlcNAcMan3-5GlcNAc2 by a Golgi hexosaminidase and subsequent removal of Man residues by Golgi mannosidases. Pauscimannose glycans have also been detected in vertebrates.[CHEBI:144386] <br>
'''term_xref''' : GlycoMotif:GGM.000094|GTC:G02657AK|CID:45266844|CHEBI:59218|GlycoEpitope:EP0061|SugarBind_Ligand:88  <br>
  '''term_xref''' : CHEBI:144386 <br>
'''synonyms''' :  <br>
'''function''' :  <br>
'''disease_associations''' : breast cancer[PMID:[https://pubmed.ncbi.nlm.nih.gov/28415563 28415563]] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]|[https://www.ncbi.nlm.nih.gov/books/NBK453073/ Chatper 35]<br>
 
 
===GSD000086===
'''term (main_entry)''' : GD3 <br>
'''glycan_dictionary_accession''' : GSD000086 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G98544DH G98544DH] <br>
'''term_in_sentence''' : In mammalian cells, the intracellular accumulation of ganglioside GD3, an acidic glycosphingolipid, contributes to mitochondrial damage, a crucial event during the apoptopic program. [PMID: [https://pubmed.ncbi.nlm.nih.gov/12531552 12531552]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/30245960 30245960]|[https://pubmed.ncbi.nlm.nih.gov/27591028 27591028]|[https://pubmed.ncbi.nlm.nih.gov/12531552 12531552]|[https://pubmed.ncbi.nlm.nih.gov/29069780 29069780]|[https://pubmed.ncbi.nlm.nih.gov/12470841 12470841]|[https://pubmed.ncbi.nlm.nih.gov/29436609 29436609]|[https://pubmed.ncbi.nlm.nih.gov/28295752 28295752]|[https://pubmed.ncbi.nlm.nih.gov/27304202 27304202]]|[https://pubmed.ncbi.nlm.nih.gov/31138648 31138648]|[https://pubmed.ncbi.nlm.nih.gov/27288875 27288875]|[https://pubmed.ncbi.nlm.nih.gov/30446565 30446565]|[https://pubmed.ncbi.nlm.nih.gov/8721669 8721669]|[https://pubmed.ncbi.nlm.nih.gov/3903474 3903474]|[https://pubmed.ncbi.nlm.nih.gov/16081368 16081368]|[https://pubmed.ncbi.nlm.nih.gov/32743804 32743804]|[https://pubmed.ncbi.nlm.nih.gov/24372645 24372645]|[https://pubmed.ncbi.nlm.nih.gov/26792897 26792897]|[https://pubmed.ncbi.nlm.nih.gov/20890432 20890432]|[https://pubmed.ncbi.nlm.nih.gov/25330147 25330147]|[https://pubmed.ncbi.nlm.nih.gov/20581115 20581115]|[https://pubmed.ncbi.nlm.nih.gov/11174200 11174200]|[https://pubmed.ncbi.nlm.nih.gov/16040804 16040804]|[https://pubmed.ncbi.nlm.nih.gov/23783008 23783008]|[https://pubmed.ncbi.nlm.nih.gov/17368571 17368571]|[https://pubmed.ncbi.nlm.nih.gov/11023989 11023989]|[https://pubmed.ncbi.nlm.nih.gov/12901230 12901230]|[https://pubmed.ncbi.nlm.nih.gov/21807667 21807667]|[https://pubmed.ncbi.nlm.nih.gov/7061953 7061953]|[https://pubmed.ncbi.nlm.nih.gov/2231782 2231782]|[https://pubmed.ncbi.nlm.nih.gov/19423750 19423750]|[https://pubmed.ncbi.nlm.nih.gov/22632091 22632091]|[https://pubmed.ncbi.nlm.nih.gov/18202973 18202973]|[https://pubmed.ncbi.nlm.nih.gov/6392333 6392333]|[https://pubmed.ncbi.nlm.nih.gov/15896784 15896784]|[https://pubmed.ncbi.nlm.nih.gov/8261439 8261439]|[https://pubmed.ncbi.nlm.nih.gov/20052288 20052288]|[https://pubmed.ncbi.nlm.nih.gov/12847141 12847141]|[https://pubmed.ncbi.nlm.nih.gov/12486096 12486096]|[https://pubmed.ncbi.nlm.nih.gov/12118012 12118012]|[https://pubmed.ncbi.nlm.nih.gov/19912988 19912988]|[https://pubmed.ncbi.nlm.nih.gov/22795094 22795094]|[https://pubmed.ncbi.nlm.nih.gov/18655184 18655184]|[https://pubmed.ncbi.nlm.nih.gov/17043769 17043769]|[https://pubmed.ncbi.nlm.nih.gov/21395555 21395555]|[https://pubmed.ncbi.nlm.nih.gov/2472199 2472199]|[https://pubmed.ncbi.nlm.nih.gov/19776077 19776077] <br>
  '''definition''' : A linear amino tetrasaccharide consisting of two sialyl, one galactose and one glucose residue (at the reducing end) connected by sequential α-(2→8)-, α-(2→3)- and β-(1→4)-linkages. The oligosaccharide of ganglioside GD3.[CHEBI:59210] <br>
  '''term_xref''' : GlycoMotif:GGM.000091|GTC:G98544DH|CID:45266862|CHEBI:59210|GlycoEpitope:EP0062|SugarBind_Ligand:89|MeSH:C509062  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
'''function''' :  <br>
'''disease_associations''' : Cholera[SugarBind_Ligand:89]|Influenza[SugarBind_Ligand:89] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>
===GSD000087===
'''term (main_entry)''' : Globoside <br>
'''glycan_dictionary_accession''' : GSD000087 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00061MO G00061MO] <br>
'''term_in_sentence''' : Results of TLC immunostaining of neutral glycolipids from the cDNA-transfected cells also supported the identity of the newly synthesized component as globoside. [PMID:[https://pubmed.ncbi.nlm.nih.gov/10993897 10993897]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/10993897 10993897] <br>
'''definition''' :  <br>
'''term_xref''' : GlycoMotif:GGM.000070|GTC:G00061MO  <br>
'''synonyms''' : Cytolipin K|Gb4|Globoside I|Globotetraosylceramide|P antigen <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453023/ Chapter 47]<br>
===GSD000088===
'''term (main_entry)''' : Globotetraosylceramide <br>
'''glycan_dictionary_accession''' : GSD000088 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00061MO G00061MO] <br>
'''term_in_sentence''' : Here we report that PUGNAc treatment provokes globotetraosylceramide (Gb4Cer) accumulation in human umbilical vein endothelial cells (HUVEC).[PMID:[https://pubmed.ncbi.nlm.nih.gov/28392398 28392398]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28392398 28392398]|[https://pubmed.ncbi.nlm.nih.gov/25787850 25787850]|[https://pubmed.ncbi.nlm.nih.gov/23471986 23471986]|[https://pubmed.ncbi.nlm.nih.gov/2559078 2559078]|[https://pubmed.ncbi.nlm.nih.gov/32455599 32455599]|[https://pubmed.ncbi.nlm.nih.gov/2663859 2663859]|[https://pubmed.ncbi.nlm.nih.gov/32796033 32796033]|[https://pubmed.ncbi.nlm.nih.gov/3517161 3517161]|[https://pubmed.ncbi.nlm.nih.gov/20082214 20082214]|[https://pubmed.ncbi.nlm.nih.gov/30853699 30853699]|[https://pubmed.ncbi.nlm.nih.gov/15279935 15279935]|[https://pubmed.ncbi.nlm.nih.gov/26104834 26104834]|[https://pubmed.ncbi.nlm.nih.gov/20732996 20732996]|[https://pubmed.ncbi.nlm.nih.gov/30224239 30224239]|[https://pubmed.ncbi.nlm.nih.gov/31142708 31142708]|[https://pubmed.ncbi.nlm.nih.gov/30338271 30338271]|[https://pubmed.ncbi.nlm.nih.gov/25033755 25033755]|[https://pubmed.ncbi.nlm.nih.gov/30413389 30413389]|[https://pubmed.ncbi.nlm.nih.gov/7104376 7104376]|[https://pubmed.ncbi.nlm.nih.gov/29866658 29866658]|[https://pubmed.ncbi.nlm.nih.gov/24983355 24983355]|[https://pubmed.ncbi.nlm.nih.gov/6794884 6794884]|[https://pubmed.ncbi.nlm.nih.gov/31361021 31361021]|[https://pubmed.ncbi.nlm.nih.gov/21740983 21740983]|[https://pubmed.ncbi.nlm.nih.gov/33168837 33168837]|[https://pubmed.ncbi.nlm.nih.gov/31752441 31752441]|[https://pubmed.ncbi.nlm.nih.gov/28123520 28123520]|[https://pubmed.ncbi.nlm.nih.gov/29068380 29068380]|[https://pubmed.ncbi.nlm.nih.gov/24841197 24841197]|[https://pubmed.ncbi.nlm.nih.gov/27932383 27932383]|[https://pubmed.ncbi.nlm.nih.gov/28535204 28535204]|[https://pubmed.ncbi.nlm.nih.gov/31691795 31691795]|[https://pubmed.ncbi.nlm.nih.gov/27916888 27916888]|[https://pubmed.ncbi.nlm.nih.gov/27558838 27558838]|[https://pubmed.ncbi.nlm.nih.gov/10227680 10227680]|[https://pubmed.ncbi.nlm.nih.gov/26464281 26464281]|[https://pubmed.ncbi.nlm.nih.gov/22348006 22348006]|[https://pubmed.ncbi.nlm.nih.gov/22279060 22279060]|[https://pubmed.ncbi.nlm.nih.gov/25156739 25156739]|[https://pubmed.ncbi.nlm.nih.gov/32314902 32314902]|[https://pubmed.ncbi.nlm.nih.gov/22718629 22718629]|[https://pubmed.ncbi.nlm.nih.gov/23701631 23701631]|[https://pubmed.ncbi.nlm.nih.gov/23906628 23906628]|[https://pubmed.ncbi.nlm.nih.gov/8613382 8613382]|[https://pubmed.ncbi.nlm.nih.gov/23555772 23555772]|[https://pubmed.ncbi.nlm.nih.gov/20059899 20059899]|[https://pubmed.ncbi.nlm.nih.gov/7868240 7868240] <br>
'''definition''' : An amino tetrasaccharide consisting of 2-acetamido-2-deoxy-β-D-galactopyranosyl, α-D-galactopyranosyl, β-D-galactopyranosyl, and β-D-glucopyranose units joined together in sequence by (1→3), (1→4), and (1→4) glycosidic linkages, respectively.[CHEBI:145578] <br>
'''term_xref''' : GlycoMotif:GGM.000070|GlycoEpitope:EP0073|CID: 5288889|CHEBI:145578|SugarBind_Ligand:18|MeSH:C024032<br>
'''synonyms''' : Gb4Cer|Gb4|Globoside|P antigen|Cytolipin K <br>
'''function''' :  <br>
'''disease_associations''' : Actinomycosis[SugarBind_Ligand:18]|Pyelonephritis[SugarBind_Ligand:18]|Acute cystitis[SugarBind_Ligand:18]|Shigellosis[SugarBind_Ligand:18]|Lazy leukocyte syndrome[SugarBind_Ligand:18]|Influenza[SugarBind_Ligand:18] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' :  [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>
===GSD000089===
[[File:G00061MO.png|thumb|G00061MO]]
'''term (main_entry)''' : Globotriaosylceramide <br>
'''glycan_dictionary_accession''' : GSD000089 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00059MO G00059MO] <br>
'''term_in_sentence''' : Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) in various cell types.[PMID:[https://pubmed.ncbi.nlm.nih.gov/32127409 32127409]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/32127409 32127409]|[https://pubmed.ncbi.nlm.nih.gov/28674962 28674962]|[https://pubmed.ncbi.nlm.nih.gov/30875019 30875019]|[https://pubmed.ncbi.nlm.nih.gov/30413389 30413389]|[https://pubmed.ncbi.nlm.nih.gov/31778662 31778662]|[https://pubmed.ncbi.nlm.nih.gov/31101366 31101366]|[https://pubmed.ncbi.nlm.nih.gov/24335674 24335674]|[https://pubmed.ncbi.nlm.nih.gov/31241709 31241709]|[https://pubmed.ncbi.nlm.nih.gov/24158513 24158513]|[https://pubmed.ncbi.nlm.nih.gov/28947349 28947349]|[https://pubmed.ncbi.nlm.nih.gov/31566927 31566927]|[https://pubmed.ncbi.nlm.nih.gov/28672034 28672034]|[https://pubmed.ncbi.nlm.nih.gov/31939530 31939530]|[https://pubmed.ncbi.nlm.nih.gov/29530250 29530250]|[https://pubmed.ncbi.nlm.nih.gov/27851774 27851774]|[https://pubmed.ncbi.nlm.nih.gov/26426881 26426881]|[https://pubmed.ncbi.nlm.nih.gov/25031264 25031264]|[https://pubmed.ncbi.nlm.nih.gov/29982630 29982630]|[https://pubmed.ncbi.nlm.nih.gov/24496231 24496231]|[https://pubmed.ncbi.nlm.nih.gov/29983334 29983334]|[https://pubmed.ncbi.nlm.nih.gov/28756410 28756410]|[https://pubmed.ncbi.nlm.nih.gov/27190352 27190352]|[https://pubmed.ncbi.nlm.nih.gov/29274327 29274327]|[https://pubmed.ncbi.nlm.nih.gov/29099167 29099167]|[https://pubmed.ncbi.nlm.nih.gov/28402705 28402705]|[https://pubmed.ncbi.nlm.nih.gov/23680766 23680766]|[https://pubmed.ncbi.nlm.nih.gov/28625968 28625968]|[https://pubmed.ncbi.nlm.nih.gov/26960552 26960552]|[https://pubmed.ncbi.nlm.nih.gov/26797827 26797827]|[https://pubmed.ncbi.nlm.nih.gov/22742555 22742555]|[https://pubmed.ncbi.nlm.nih.gov/27756537 27756537]|[https://pubmed.ncbi.nlm.nih.gov/31630715 31630715]|[https://pubmed.ncbi.nlm.nih.gov/3827883 3827883]|[https://pubmed.ncbi.nlm.nih.gov/28384397 28384397]|[https://pubmed.ncbi.nlm.nih.gov/29523338 29523338]|[https://pubmed.ncbi.nlm.nih.gov/31010832 31010832]|[https://pubmed.ncbi.nlm.nih.gov/27195818 27195818]|[https://pubmed.ncbi.nlm.nih.gov/26661087 26661087]|[https://pubmed.ncbi.nlm.nih.gov/23093409 23093409]|[https://pubmed.ncbi.nlm.nih.gov/30879639 30879639]|[https://pubmed.ncbi.nlm.nih.gov/27081853 27081853]|[https://pubmed.ncbi.nlm.nih.gov/17409683 17409683]|[https://pubmed.ncbi.nlm.nih.gov/29921669 29921669]|[https://pubmed.ncbi.nlm.nih.gov/25575293 25575293]|[https://pubmed.ncbi.nlm.nih.gov/26291612 26291612]|[https://pubmed.ncbi.nlm.nih.gov/23146289 23146289]|[https://pubmed.ncbi.nlm.nih.gov/25857295 25857295]|[https://pubmed.ncbi.nlm.nih.gov/26070511 26070511] <br>
'''definition''' : Globotriaosylceramide is a type of globoside(glycosphingolipid) which is formed by alpha linkage of galactose to lactosylceramide. The reaction is catalyzed by enzyme A4GALT.[Wiki:Globotriaosylceramide] <br>
'''term_xref''' : GlycoMotif:GGM.000068|GTC:G00059MO|GlycoEpitope:EP0071|CID: 5279515|CHEBI:68485|MeSH:C018549|SugarBind_Ligand:27  <br>
'''synonyms''' : Gb3|GL3|Pk antigen|P^K antigen|Gb(3)|Gb_3|CD77|globotriaosylceramide|ceramide trihexoside|CTH|Trihexosylceramide <br>
'''function''' :  <br>
'''disease_associations''' : Pyelonephritis[SugarBind_Ligand:27]|Acute cystitis[SugarBind_Ligand:27]|Shigellosis[SugarBind_Ligand:27]|Lyme disease[SugarBind_Ligand:27]|Cutaneous lesions[SugarBind_Ligand:27]|Diarrhea[SugarBind_Ligand:27] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>




===GSD000090===
===GSD000145===
  '''term (main_entry)''' : Glucosylceramide <br>
  '''term (main_entry)''' : Sd(A)/Cad <br>
  '''glycan_dictionary_accession''' : GSD000090 <br>
  '''glycan_dictionary_accession''' : GSD000145 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G71142DF G71142DF] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G41052GC G41052GC] <br>
  '''term_in_sentence''' : Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), is required for embryonic survival, but its role in the lung is unknown.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31265321 31265321]] <br>
  '''term_in_sentence''' : The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2.[PMID:[https://pubmed.ncbi.nlm.nih.gov/24112972 24112972]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/31265321 31265321]|[https://pubmed.ncbi.nlm.nih.gov/29290548 29290548]|[https://pubmed.ncbi.nlm.nih.gov/29627573 29627573]|[https://pubmed.ncbi.nlm.nih.gov/20919653 20919653]|[https://pubmed.ncbi.nlm.nih.gov/28427052 28427052]|[https://pubmed.ncbi.nlm.nih.gov/30550553 30550553]|[https://pubmed.ncbi.nlm.nih.gov/24415933 24415933]|[https://pubmed.ncbi.nlm.nih.gov/31914593 31914593]|[https://pubmed.ncbi.nlm.nih.gov/31051284 31051284]|[https://pubmed.ncbi.nlm.nih.gov/23073611 23073611]|[https://pubmed.ncbi.nlm.nih.gov/30146946 30146946]|[https://pubmed.ncbi.nlm.nih.gov/31619618 31619618]|[https://pubmed.ncbi.nlm.nih.gov/26840726 26840726]|[https://pubmed.ncbi.nlm.nih.gov/29750412 29750412]|[https://pubmed.ncbi.nlm.nih.gov/8065509 8065509]|[https://pubmed.ncbi.nlm.nih.gov/27412675 27412675]|[https://pubmed.ncbi.nlm.nih.gov/27840079 27840079]|[https://pubmed.ncbi.nlm.nih.gov/30611744 30611744]|[https://pubmed.ncbi.nlm.nih.gov/31353719 31353719]|[https://pubmed.ncbi.nlm.nih.gov/25661072 25661072]|[https://pubmed.ncbi.nlm.nih.gov/28686011 28686011]|[https://pubmed.ncbi.nlm.nih.gov/25803043 25803043]|[https://pubmed.ncbi.nlm.nih.gov/28865794 28865794]|[https://pubmed.ncbi.nlm.nih.gov/28154347 28154347]|[https://pubmed.ncbi.nlm.nih.gov/31466334 31466334]|[https://pubmed.ncbi.nlm.nih.gov/30242129 30242129]|[https://pubmed.ncbi.nlm.nih.gov/12531551 12531551]|[https://pubmed.ncbi.nlm.nih.gov/30639288 30639288]|[https://pubmed.ncbi.nlm.nih.gov/30864417 30864417]|[https://pubmed.ncbi.nlm.nih.gov/27711049 27711049]|[https://pubmed.ncbi.nlm.nih.gov/22764777 22764777]|[https://pubmed.ncbi.nlm.nih.gov/27905603 27905603]|[https://pubmed.ncbi.nlm.nih.gov/29077010 29077010]|[https://pubmed.ncbi.nlm.nih.gov/28744000 28744000]|[https://pubmed.ncbi.nlm.nih.gov/23555901 23555901]|[https://pubmed.ncbi.nlm.nih.gov/24115322 24115322]|[https://pubmed.ncbi.nlm.nih.gov/12803919 12803919]|[https://pubmed.ncbi.nlm.nih.gov/29204666 29204666]|[https://pubmed.ncbi.nlm.nih.gov/23628459 23628459]|[https://pubmed.ncbi.nlm.nih.gov/28851512 28851512]|[https://pubmed.ncbi.nlm.nih.gov/26136173 26136173]|[https://pubmed.ncbi.nlm.nih.gov/23563543 23563543]|[https://pubmed.ncbi.nlm.nih.gov/30110701 30110701]|[https://pubmed.ncbi.nlm.nih.gov/26572681 26572681]|[https://pubmed.ncbi.nlm.nih.gov/2193825 2193825]|[https://pubmed.ncbi.nlm.nih.gov/29926415 29926415]|[https://pubmed.ncbi.nlm.nih.gov/31727994 31727994]|[https://pubmed.ncbi.nlm.nih.gov/27479571 27479571] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/24112972 24112972]|[https://pubmed.ncbi.nlm.nih.gov/11577689 11577689]|[https://pubmed.ncbi.nlm.nih.gov/30067891 30067891]|[https://pubmed.ncbi.nlm.nih.gov/15361072 15361072] <br>
'''definition''' : Cerebrosides which contain as their polar head group a glucose moiety bound in glycosidic linkage to the hydroxyl group of ceramides. Their accumulation in tissue, due to a defect in beta-glucosidase, is the cause of Gaucher's disease.[MeSH:D005963] <br>
  '''definition''' : A branched amino tetrasaccharide comprised of a trisaccharide chain of N-acetyl-α-neuraminic acid, β-D-galactose and N-acetyl-β-D-glucosamine residues linked sequentially (2→3) and (1→4), to the galactose residue of which is also linked (1→4) an N-acetyl-β-L-galactosamine residue.
'''term_xref''' : MeSH:D005963|GlycoMotif:GGM.000060|CHEBI:83264|GTC:G71142DF<br>
[CHEBI:71561] <br>
'''synonyms''' : GlcCer|Glucocerebroside|Ceramide monohexoside|CMH <br>
  '''term_xref''' : GlycoMotif:GGM.000051|GTC:G41052GC|CID:[https://pubmed.ncbi.nlm.nih.gov/70698375 70698375]|CHEBI:71561 <br>
'''function''' : The structural characterization of mixed membranes made of cationic lipids and glucosylceramides may be important for developing novel immunotherapeutic tools such as vaccine adjuvants.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30611744 30611744]]|Glucosylceramide (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), is required for embryonic survival, but its role in the lung is unknown.[PMID:[https://pubmed.ncbi.nlm.nih.gov/31265321 31265321]] <br>
  '''synonyms''' : Sd^a /Cad <br>
'''disease_associations''' : Gaucher's Disease|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453065/ Chapter 31]<br>
 
 
===GSD000091===
[[File:G48558GR.png|thumb|G48558GR]]
'''term (main_entry)''' : GM1 <br>
'''glycan_dictionary_accession''' : GSD000091 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G48558GR G48558GR] <br>
'''term_in_sentence''' : GM1-induced fluidization of the phospholipid membranes and probable physical contact between bulky sugar head group of GM1 and spectrin, may explain the modulatory role of GM1 on aminophospholipid interactions with nonerythroid brain spectrin.[PMID: 29920238] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/18524657 18524657]|[https://pubmed.ncbi.nlm.nih.gov/31761138 31761138]|[https://pubmed.ncbi.nlm.nih.gov/36180805 36180805]|[https://pubmed.ncbi.nlm.nih.gov/29920238 29920238]|[https://pubmed.ncbi.nlm.nih.gov/33859490 33859490]|[https://pubmed.ncbi.nlm.nih.gov/31937438 31937438]|[https://pubmed.ncbi.nlm.nih.gov/25762012 25762012]|[https://pubmed.ncbi.nlm.nih.gov/25931034 25931034]|[https://pubmed.ncbi.nlm.nih.gov/31776384 31776384]|[https://pubmed.ncbi.nlm.nih.gov/32013258 32013258]|[https://pubmed.ncbi.nlm.nih.gov/30776097 30776097]|[https://pubmed.ncbi.nlm.nih.gov/31048748 31048748]|[https://pubmed.ncbi.nlm.nih.gov/31447771 31447771]|[https://pubmed.ncbi.nlm.nih.gov/30292198 30292198]|[https://pubmed.ncbi.nlm.nih.gov/28796418 28796418]|[https://pubmed.ncbi.nlm.nih.gov/27806275 27806275]|[https://pubmed.ncbi.nlm.nih.gov/21076871 21076871]|[https://pubmed.ncbi.nlm.nih.gov/27552916 27552916]|[https://pubmed.ncbi.nlm.nih.gov/17986147 17986147]|[https://pubmed.ncbi.nlm.nih.gov/26960162 26960162]|[https://pubmed.ncbi.nlm.nih.gov/27815022 27815022]|[https://pubmed.ncbi.nlm.nih.gov/25851126 25851126]|[https://pubmed.ncbi.nlm.nih.gov/32916822 32916822]|[https://pubmed.ncbi.nlm.nih.gov/11462671 11462671]|[https://pubmed.ncbi.nlm.nih.gov/28236574 28236574]|[https://pubmed.ncbi.nlm.nih.gov/15911874 15911874]|[https://pubmed.ncbi.nlm.nih.gov/28577204 28577204]|[https://pubmed.ncbi.nlm.nih.gov/28497346 28497346]|[https://pubmed.ncbi.nlm.nih.gov/1794005 1794005]|[https://pubmed.ncbi.nlm.nih.gov/31934908 31934908]|[https://pubmed.ncbi.nlm.nih.gov/30267299 30267299]|[https://pubmed.ncbi.nlm.nih.gov/16902585 16902585]|[https://pubmed.ncbi.nlm.nih.gov/29439846 29439846]|[https://pubmed.ncbi.nlm.nih.gov/32325905 32325905]|[https://pubmed.ncbi.nlm.nih.gov/29747823 29747823]|[https://pubmed.ncbi.nlm.nih.gov/27576485 27576485]|[https://pubmed.ncbi.nlm.nih.gov/26338710 26338710]|[https://pubmed.ncbi.nlm.nih.gov/27858734 27858734]|[https://pubmed.ncbi.nlm.nih.gov/24501414 24501414]|[https://pubmed.ncbi.nlm.nih.gov/26818965 26818965]|[https://pubmed.ncbi.nlm.nih.gov/26629687 26629687]|[https://pubmed.ncbi.nlm.nih.gov/26958633 26958633]|[https://pubmed.ncbi.nlm.nih.gov/1854596 1854596]|[https://pubmed.ncbi.nlm.nih.gov/32134593 32134593]|[https://pubmed.ncbi.nlm.nih.gov/32198666 32198666]|[https://pubmed.ncbi.nlm.nih.gov/6619101 6619101] <br>
  '''definition''' : A branched amino pentasaccharide consisting of the linear sequence β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the inner galactose via an α-(2→3) linkage. The oligosaccharide of ganglioside GM1a.[CHEBI:59208] <br>
  '''term_xref''' : GlycoMotif:GGM.000098|GTC:G48558GR|CID:196569|CHEBI:59208|GlycoEpitope:EP0050|SugarBind_Ligand:13|KEGG:G00110 <br>
'''synonyms''' :  GM1 ganglioside|GM1-ganglioside<br>
'''function''' :  The branched pentasaccharide chain of ganglioside GM1 is a prominent cell surface ligand, for example, for cholera toxin or tumor growth-regulatory homodimeric galectins.[PMID:[https://pubmed.ncbi.nlm.nih.gov/16267866/ 16267866]]<br>
'''disease_associations''' : GM1 gangliosidosis (GM1) [PMID: [https://pubmed.ncbi.nlm.nih.gov/33859490/ 33859490]]|Gastroenteritis[SugarBind_Ligand:13]|Actinomycosis[SugarBind_Ligand:13]|Lazy leukocyte syndrome[SugarBind_Ligand:13]|Toxoplasmosis[SugarBind_Ligand:13]|Cholera[SugarBind_Ligand:13]|Botulism[SugarBind_Ligand:13] <br>
'''wikipedia''' : https://en.wikipedia.org/wiki/GM1 <br>
'''essentials_of_glycobiology''' :  [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]| [https://www.ncbi.nlm.nih.gov/books/NBK579929/ Chapter 14] <br>
 
 
===GSD000092===
'''term (main_entry)''' : GM2 <br>
'''glycan_dictionary_accession''' : GSD000092 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G79389NT G79389NT] <br>
'''term_in_sentence''' : GM1 gangliosidosis has both central nervous system and systemic findings; while, GM2 gangliosidosis is restricted primarily to the central nervous system.[PMID: [https://pubmed.ncbi.nlm.nih.gov/27491214 27491214]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29618308 29618308]|[https://pubmed.ncbi.nlm.nih.gov/27491214 27491214]|[https://pubmed.ncbi.nlm.nih.gov/32867370 32867370]|[https://pubmed.ncbi.nlm.nih.gov/30030044 30030044]|[https://pubmed.ncbi.nlm.nih.gov/27499644 27499644]|[https://pubmed.ncbi.nlm.nih.gov/31097363 31097363]|[https://pubmed.ncbi.nlm.nih.gov/29100724 29100724]|[https://pubmed.ncbi.nlm.nih.gov/27402091 27402091]|[https://pubmed.ncbi.nlm.nih.gov/31852956 31852956]|[https://pubmed.ncbi.nlm.nih.gov/30389374 30389374]|[https://pubmed.ncbi.nlm.nih.gov/30988135 30988135]|[https://pubmed.ncbi.nlm.nih.gov/8786814 8786814]|[https://pubmed.ncbi.nlm.nih.gov/14533808 14533808]|[https://pubmed.ncbi.nlm.nih.gov/23370522 23370522]|[https://pubmed.ncbi.nlm.nih.gov/28192816 28192816]|[https://pubmed.ncbi.nlm.nih.gov/32692591 32692591]|[https://pubmed.ncbi.nlm.nih.gov/29106755 29106755]|[https://pubmed.ncbi.nlm.nih.gov/28833537 28833537]|[https://pubmed.ncbi.nlm.nih.gov/11339652 11339652]|[https://pubmed.ncbi.nlm.nih.gov/9728335 9728335]|[https://pubmed.ncbi.nlm.nih.gov/27270764 27270764]|[https://pubmed.ncbi.nlm.nih.gov/9714704 9714704]|[https://pubmed.ncbi.nlm.nih.gov/26175473 26175473]|[https://pubmed.ncbi.nlm.nih.gov/27018595 27018595]|[https://pubmed.ncbi.nlm.nih.gov/28615102 28615102]|[https://pubmed.ncbi.nlm.nih.gov/28974375 28974375]|[https://pubmed.ncbi.nlm.nih.gov/32951593 32951593]|[https://pubmed.ncbi.nlm.nih.gov/11462672 11462672]|[https://pubmed.ncbi.nlm.nih.gov/28955902 28955902]|[https://pubmed.ncbi.nlm.nih.gov/17192692 17192692]|[https://pubmed.ncbi.nlm.nih.gov/26538065 26538065]|[https://pubmed.ncbi.nlm.nih.gov/25421609 25421609]|[https://pubmed.ncbi.nlm.nih.gov/9572057 9572057]|[https://pubmed.ncbi.nlm.nih.gov/11596983 11596983]|[https://pubmed.ncbi.nlm.nih.gov/15264019 15264019]|[https://pubmed.ncbi.nlm.nih.gov/23236285 23236285]|[https://pubmed.ncbi.nlm.nih.gov/11596984 11596984]|[https://pubmed.ncbi.nlm.nih.gov/31261761 31261761]|[https://pubmed.ncbi.nlm.nih.gov/30113798 30113798]|[https://pubmed.ncbi.nlm.nih.gov/24391178 24391178]|[https://pubmed.ncbi.nlm.nih.gov/24309906 24309906]|[https://pubmed.ncbi.nlm.nih.gov/22224667 22224667]|[https://pubmed.ncbi.nlm.nih.gov/7980537 7980537]|[https://pubmed.ncbi.nlm.nih.gov/18272501 18272501]|[https://pubmed.ncbi.nlm.nih.gov/9006924 9006924]| <br>
'''definition''' : A branched amino tetrasaccharide consisting of the linear sequence β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the galactose via an α-(2→3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2.[CHEBI:59220] <br>
'''term_xref''' : GlycoMotif:GGM.000095|GTC:G79389NT|CID: 45266845|CHEBI:59220|GlycoEpitope:EP0051|SugarBind_Ligand:39|KEGG:G00109|KEGG:G10351 <br>
  '''synonyms''' : <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051]|Gastroenteritis[SugarBind_Ligand:39]|Cholera[SugarBind_Ligand:39]|Clostridial myonecrosis[SugarBind_Ligand:39]|Tetanus[SugarBind_Ligand:39] <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' : https://en.wikipedia.org/wiki/GM1_gangliosidoses <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>
 
 
===GSD000093===
'''term (main_entry)''' : GM3 <br>
'''glycan_dictionary_accession''' : GSD000093 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G91237TK G91237TK] <br>
'''term_in_sentence''' : We also demonstrated an essential role of GM3 in murine and human auditory systems; a common pathological feature of GM3S deficiency is deafness. [PMID: [https://pubmed.ncbi.nlm.nih.gov/29747813 29747813]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29376491 29376491]|[https://pubmed.ncbi.nlm.nih.gov/29747813 29747813]|[https://pubmed.ncbi.nlm.nih.gov/25613425 25613425]|[https://pubmed.ncbi.nlm.nih.gov/30318083 30318083]|[https://pubmed.ncbi.nlm.nih.gov/31526872 31526872]|[https://pubmed.ncbi.nlm.nih.gov/31004109 31004109]|[https://pubmed.ncbi.nlm.nih.gov/28019668 28019668]|[https://pubmed.ncbi.nlm.nih.gov/26434718 26434718]|[https://pubmed.ncbi.nlm.nih.gov/27313500 27313500]|[https://pubmed.ncbi.nlm.nih.gov/27539856 27539856]|[https://pubmed.ncbi.nlm.nih.gov/30111401 30111401]|[https://pubmed.ncbi.nlm.nih.gov/28544772 28544772]|[https://pubmed.ncbi.nlm.nih.gov/29407985 29407985]|[https://pubmed.ncbi.nlm.nih.gov/19364317 19364317]|[https://pubmed.ncbi.nlm.nih.gov/30190430 30190430]|[https://pubmed.ncbi.nlm.nih.gov/31297734 31297734]|[https://pubmed.ncbi.nlm.nih.gov/30091781 30091781]|[https://pubmed.ncbi.nlm.nih.gov/26043887 26043887]|[https://pubmed.ncbi.nlm.nih.gov/32183071 32183071]|[https://pubmed.ncbi.nlm.nih.gov/30665141 30665141]|[https://pubmed.ncbi.nlm.nih.gov/27873002 27873002]|[https://pubmed.ncbi.nlm.nih.gov/25801320 25801320]|[https://pubmed.ncbi.nlm.nih.gov/30209782 30209782]|[https://pubmed.ncbi.nlm.nih.gov/32378734 32378734]|[https://pubmed.ncbi.nlm.nih.gov/23050851 23050851]|[https://pubmed.ncbi.nlm.nih.gov/22768242 22768242]|[https://pubmed.ncbi.nlm.nih.gov/14993837 14993837]|[https://pubmed.ncbi.nlm.nih.gov/24934090 24934090]|[https://pubmed.ncbi.nlm.nih.gov/17638075 17638075]|[https://pubmed.ncbi.nlm.nih.gov/21518140 21518140]|[https://pubmed.ncbi.nlm.nih.gov/26102277 26102277]|[https://pubmed.ncbi.nlm.nih.gov/19759399 19759399]|[https://pubmed.ncbi.nlm.nih.gov/24502144 24502144]|[https://pubmed.ncbi.nlm.nih.gov/25303960 25303960]|[https://pubmed.ncbi.nlm.nih.gov/23564406 23564406]|[https://pubmed.ncbi.nlm.nih.gov/16636105 16636105]|[https://pubmed.ncbi.nlm.nih.gov/16491123 16491123]|[https://pubmed.ncbi.nlm.nih.gov/11259118 11259118]|[https://pubmed.ncbi.nlm.nih.gov/15102521 15102521]|[https://pubmed.ncbi.nlm.nih.gov/12724312 12724312]|[https://pubmed.ncbi.nlm.nih.gov/24985965 24985965]|[https://pubmed.ncbi.nlm.nih.gov/8496625 8496625]|[https://pubmed.ncbi.nlm.nih.gov/25403557 25403557]|[https://pubmed.ncbi.nlm.nih.gov/15690123 15690123]|[https://pubmed.ncbi.nlm.nih.gov/15939439 15939439]|[https://pubmed.ncbi.nlm.nih.gov/25893133 25893133]|[https://pubmed.ncbi.nlm.nih.gov/23591593 23591593]|[https://pubmed.ncbi.nlm.nih.gov/20634908 20634908]|[https://pubmed.ncbi.nlm.nih.gov/2004380 2004380]|739008| <br>
'''definition''' : Ganglioside GM3 (d18:1/16:0) is a glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GM3 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissuesGangliosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Gangliosides are very similar to globosides except that they also contain N-acetyl neuraminic acid (NANA) in varying amounts. The specific names for the gangliosides provide information about their structure. The letter G refers to ganglioside, and the subscripts M, D, T and Q indicate that the molecule contains mono-, di-, tri and quatra-sialic acid. The numbered subscripts 1, 2 and 3 refer to the carbohydrate sequence that is attached to the ceramide. In particular, 1 stands for GalGalNAcGalGlc-ceramide, 2 stands for GalNAcGalGlc-ceramide and 3 stands for GalGlc-ceramide. Deficiencies in lysosomal enzymes that degrade the carbohydrate portions of various gangliosides are responsible for a number of lysosomal storage diseases such as Tay-Sachs disease, Sandhoff disease, and GM1 gangliosidosis. The carbohydrate portion of the ganglioside GM1 is the site of attachment of cholera toxin, the protein secreted by Vibrio cholerae.[HMDB0004844] <br>
'''term_xref''' : GlycoMotif:GGM.000090|GTC:G91237TK|CID: 5288424|CHEBI:59226|GlycoEpitope:EP0053|SugarBind_Ligand:35 <br>
'''synonyms''' :  <br>
'''function''' : Membrane stabilizer|Energy source|Energy storage|Molecular messenger:|Signaling molecule[HMDB0004844] <br>
'''disease_associations''' : Gastroenteritis[SugarBind_Ligand:35]|Chronic gastritis[SugarBind_Ligand:35]|Toxoplasmosis[SugarBind_Ligand:35]|Peptic ulcerSugarBind_Ligand:35|Gastric cancer[SugarBind_Ligand:35]|Influenza[SugarBind_Ligand:35]|Diarrhea[SugarBind_Ligand:35]|Botulism[SugarBind_Ligand:35] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453032/ Chapter 37]<br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9] <br>




===GSD000094===
===GSD000146===
[[File:G30207PZ.png|thumb|G30207PZ]]
  '''term (main_entry)''' : SDlex <br>
  '''term (main_entry)''' : GM4 <br>
  '''glycan_dictionary_accession''' : GSD000146 <br>
  '''glycan_dictionary_accession''' : GSD000094 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G19619KS G19619KS] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G30207PZ G30207PZ] <br>
  '''term_in_sentence''' : Hepatic expression of sialylated difucosyl Lex antigen (SDLex, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-) was studied with monoclonal antibody FH6, which defines this structure.[PMID: [https://pubmed.ncbi.nlm.nih.gov/3341453 3341453]] <br>
  '''term_in_sentence''' : GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).[PMID:[https://pubmed.ncbi.nlm.nih.gov/23999868 23999868]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/30226570 30226570]|[https://pubmed.ncbi.nlm.nih.gov/3341453 3341453]|[https://pubmed.ncbi.nlm.nih.gov/12725333 12725333] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/23999868 23999868]|[https://pubmed.ncbi.nlm.nih.gov/2332419 2332419]|[https://pubmed.ncbi.nlm.nih.gov/12091485 12091485]|[https://pubmed.ncbi.nlm.nih.gov/19542236 19542236]|[https://pubmed.ncbi.nlm.nih.gov/8407875 8407875]|[https://pubmed.ncbi.nlm.nih.gov/23320941 23320941]|[https://pubmed.ncbi.nlm.nih.gov/28808804 28808804]|[https://pubmed.ncbi.nlm.nih.gov/3621237 3621237]|[https://pubmed.ncbi.nlm.nih.gov/23203271 23203271]|[https://pubmed.ncbi.nlm.nih.gov/7057115 7057115]|[https://pubmed.ncbi.nlm.nih.gov/26362868 26362868]|[https://pubmed.ncbi.nlm.nih.gov/6170387 6170387]|[https://pubmed.ncbi.nlm.nih.gov/18034482 18034482]|[https://pubmed.ncbi.nlm.nih.gov/7076644 7076644]|[https://pubmed.ncbi.nlm.nih.gov/2391348 2391348]|[https://pubmed.ncbi.nlm.nih.gov/25464080 25464080]|[https://pubmed.ncbi.nlm.nih.gov/3701369 3701369]|[https://pubmed.ncbi.nlm.nih.gov/11217952 11217952]|[https://pubmed.ncbi.nlm.nih.gov/6201236 6201236]|[https://pubmed.ncbi.nlm.nih.gov/30744426 30744426]|[https://pubmed.ncbi.nlm.nih.gov/9388026 9388026]|[https://pubmed.ncbi.nlm.nih.gov/27177620 27177620]|[https://pubmed.ncbi.nlm.nih.gov/30246056 30246056]|[https://pubmed.ncbi.nlm.nih.gov/15979459 15979459]|[https://pubmed.ncbi.nlm.nih.gov/7586078 7586078]|[https://pubmed.ncbi.nlm.nih.gov/6779816 6779816]|[https://pubmed.ncbi.nlm.nih.gov/29402905 29402905]|[https://pubmed.ncbi.nlm.nih.gov/7335153 7335153]|[https://pubmed.ncbi.nlm.nih.gov/3306476 3306476]|[https://pubmed.ncbi.nlm.nih.gov/17499534 17499534]|[https://pubmed.ncbi.nlm.nih.gov/7074082 7074082]|[https://pubmed.ncbi.nlm.nih.gov/9668345 9668345]|[https://pubmed.ncbi.nlm.nih.gov/3701884 3701884]|[https://pubmed.ncbi.nlm.nih.gov/26862430 26862430]|[https://pubmed.ncbi.nlm.nih.gov/6831238 6831238]|[https://pubmed.ncbi.nlm.nih.gov/27311552 27311552]|[https://pubmed.ncbi.nlm.nih.gov/26831445 26831445]|[https://pubmed.ncbi.nlm.nih.gov/24417799 24417799]|[https://pubmed.ncbi.nlm.nih.gov/7097284 7097284]|[https://pubmed.ncbi.nlm.nih.gov/4169231 4169231]|[https://pubmed.ncbi.nlm.nih.gov/16854400 16854400]|[https://pubmed.ncbi.nlm.nih.gov/26483798 26483798] <br>
'''definition''' : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-5-acetamido-6-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CHEBI:148203] <br>
'''definition''' : An amino disaccharide consisting of β-D-galactose having an α-N-acetylneuraminyl residue attached at the 3-position
  '''term_xref''' : GlycoMotif:GGM.000032|GTC:G19619KS|CID:[https://pubmed.ncbi.nlm.nih.gov/91856705 91856705]|CHEBI:148203  <br>
[CHEBI:63155] <br>
  '''synonyms''' : Sdlex|SDLe^x|SDLex <br>
  '''term_xref''' : GlycoMotif:GGM.000089|GTC:G30207PZ|CID:5289366|CHEBI:63155|KEGG:G00317|SugarBind_Ligand:110 <br>
  '''synonyms''' : Sialylated GalCer<br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' : Chronic gastritis[SugarBind_Ligand:110]|Peptic ulcers[SugarBind_Ligand:110]|Gastric cancer[SugarBind_Ligand:110] <br>
  '''disease_associations''' : <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]|[https://www.ncbi.nlm.nih.gov/books/NBK453082/ Chapter 15]|[https://www.ncbi.nlm.nih.gov/books/NBK453095/ Chapter 44]|[https://www.ncbi.nlm.nih.gov/books/NBK453018/ Appendix 45A] <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000095===
===GSD000147===
  '''term (main_entry)''' : GP1c <br>
  '''term (main_entry)''' : Seminolipid <br>
  '''glycan_dictionary_accession''' : GSD000095 <br>
  '''glycan_dictionary_accession''' : GSD000147 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G93805MV G93805MV] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G72548RZ G72548RZ] <br>
  '''term_in_sentence''' : n this report, we describe an efficient convergent synthesis of the GP1c glycolipid epitope, which is one of the most complex c-series gangliosides. [PMID:[https://pubmed.ncbi.nlm.nih.gov/19053458 19053458]] <br>
  '''term_in_sentence''' : A concise total synthesis of seminolipid, a sulfoglycolipid, has been achieved; key features include regioselective, tin-free sulfation of allyl β-d-galactopyranoside using 2,6-bis(trifluoromethyl)phenylboronic acid as protective reagent, stereoselective epoxidation, and site-selective acylation. [PMID: [https://pubmed.ncbi.nlm.nih.gov/31353379 31353379]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358]|[https://pubmed.ncbi.nlm.nih.gov/19053458 19053458]|[https://pubmed.ncbi.nlm.nih.gov/1695858 1695858]|[https://pubmed.ncbi.nlm.nih.gov/4091974 4091974]|[https://pubmed.ncbi.nlm.nih.gov/10775425 10775425]|[https://pubmed.ncbi.nlm.nih.gov/2468656 2468656]|[https://pubmed.ncbi.nlm.nih.gov/2299350 2299350]|[https://pubmed.ncbi.nlm.nih.gov/3064875 3064875]|[https://pubmed.ncbi.nlm.nih.gov/11432974 11432974]| [https://pubmed.ncbi.nlm.nih.gov/9613831 9613831]|[https://pubmed.ncbi.nlm.nih.gov/11831845 11831845]|[https://pubmed.ncbi.nlm.nih.gov/1879553 1879553]| [https://pubmed.ncbi.nlm.nih.gov/10699494 10699494]|[https://pubmed.ncbi.nlm.nih.gov/8969459 8969459]|[https://pubmed.ncbi.nlm.nih.gov/8474578 8474578]|[https://pubmed.ncbi.nlm.nih.gov/12031286 12031286]|[https://pubmed.ncbi.nlm.nih.gov/1304332 1304332]|[https://pubmed.ncbi.nlm.nih.gov/9153001 9153001]|[https://pubmed.ncbi.nlm.nih.gov/10564776 10564776] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/31353379 31353379]|[https://pubmed.ncbi.nlm.nih.gov/31736776 31736776]|[https://pubmed.ncbi.nlm.nih.gov/12810822 12810822]|[https://pubmed.ncbi.nlm.nih.gov/19582571 19582571]|[https://pubmed.ncbi.nlm.nih.gov/19542524 19542524]|[https://pubmed.ncbi.nlm.nih.gov/20670037 20670037]|[https://pubmed.ncbi.nlm.nih.gov/15659616 15659616]|[https://pubmed.ncbi.nlm.nih.gov/20817833 20817833]|870059|[https://pubmed.ncbi.nlm.nih.gov/10801776 10801776]|[https://pubmed.ncbi.nlm.nih.gov/21965315 21965315]|[https://pubmed.ncbi.nlm.nih.gov/8095813 8095813]|[https://pubmed.ncbi.nlm.nih.gov/1280685 1280685]|[https://pubmed.ncbi.nlm.nih.gov/4690236 4690236]|[https://pubmed.ncbi.nlm.nih.gov/34199863 34199863]|[https://pubmed.ncbi.nlm.nih.gov/4207869 4207869]|[https://pubmed.ncbi.nlm.nih.gov/2373957 2373957]|845131 <br>
  '''definition''' :  <br>
  '''definition''' :  <br>
  '''term_xref''' : GlycoMotif:GGM.000118|GTC:G93805MV<br>
  '''term_xref''' : GlycoMotif:GGM.000062|GTC:G72548RZ  <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]|[https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]|[https://www.ncbi.nlm.nih.gov/books/NBK453076/ Chapter 27]|[https://www.ncbi.nlm.nih.gov/books/NBK453073/ Chapter 35]|[https://www.ncbi.nlm.nih.gov/books/NBK453041/ Chapter 45] |[https://www.ncbi.nlm.nih.gov/books/NBK453023/ Chapter 47]|[https://www.ncbi.nlm.nih.gov/books/NBK453088/ Chapter 49] <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>




===GSD000096===
===GSD000148===
  '''term (main_entry)''' : GQ1b <br>
  '''term (main_entry)''' : Sialopentaosylceramide <br>
  '''glycan_dictionary_accession''' : GSD000096 <br>
  '''glycan_dictionary_accession''' : GSD000148 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G18625KA G18625KA] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G13224CR G13224CR] <br>
  '''term_in_sentence''' : Bilateral infusion of GQ1b into the hippocampus ameliorates cognitive deficits in the triple-transgenic AD mouse model (3xTg-AD).[PMID:[https://pubmed.ncbi.nlm.nih.gov/31186474 31186474]] <br>
  '''term_in_sentence''' : Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosap[PMID: [https://pubmed.ncbi.nlm.nih.gov/2139874 2139874]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/30798387 30798387]|[https://pubmed.ncbi.nlm.nih.gov/31186474 31186474]|[https://pubmed.ncbi.nlm.nih.gov/26704905 26704905]|[https://pubmed.ncbi.nlm.nih.gov/23677659 23677659]|[https://pubmed.ncbi.nlm.nih.gov/26984947 26984947]|[https://pubmed.ncbi.nlm.nih.gov/24184316 24184316]|[https://pubmed.ncbi.nlm.nih.gov/23804237 23804237]|[https://pubmed.ncbi.nlm.nih.gov/9819299 9819299]|[https://pubmed.ncbi.nlm.nih.gov/18514410 18514410]|[https://pubmed.ncbi.nlm.nih.gov/22189683 22189683]|[https://pubmed.ncbi.nlm.nih.gov/24859332 24859332] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2139874 2139874] <br>
  '''definition''' : An amino oligosaccharide that is a branched octasaccharide derivative consisting of four sialyl residues, two galactose residues, one N-acetylglucosamine and a glucose residue at the reducing end.[CHEBI:59212] <br>
  '''definition''' : A ganglioside in which the oligosaccharide portion is composed of a pentasaccharide containing one or more sialic acid residues.[CHEBI:36542] <br>
  '''term_xref''' : GlycoMotif:GGM.000115|GTC:G18625KA|GlycoEpitope:EP0069|CID:45266843|KEGG:G00117|CHEBI:59212  <br>
  '''term_xref''' : GlycoMotif:GGM.000097|GTC:G13224CR|CID:[https://pubmed.ncbi.nlm.nih.gov/91859576 91859576]|CHEBI:148045|KEGG:G00883|CHEBI:36542 <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
'''function''' :  <br>
'''disease_associations''' :  <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453016/ Chapter 11]<br>
===GSD000097===
'''term (main_entry)''' : GQ1ba <br>
'''glycan_dictionary_accession''' : GSD000097 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G54733XO G54733XO] <br>
'''term_in_sentence''' : A few studies have reported the association of autoantibodies to GM1 or GQ1bα with Alzheimer's disease (AD) or vascular dementia.[PMID:[https://pubmed.ncbi.nlm.nih.gov/25024341 25024341]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/25024341 25024341]|[https://pubmed.ncbi.nlm.nih.gov/23717411 23717411]|[https://pubmed.ncbi.nlm.nih.gov/17870542 17870542]|[https://pubmed.ncbi.nlm.nih.gov/10702226 10702226]|[https://pubmed.ncbi.nlm.nih.gov/21137678 21137678]|[https://pubmed.ncbi.nlm.nih.gov/26748510 26748510]|[https://pubmed.ncbi.nlm.nih.gov/8662799 8662799]|[https://pubmed.ncbi.nlm.nih.gov/21274438 21274438]|[https://pubmed.ncbi.nlm.nih.gov/24649890 24649890]|[https://pubmed.ncbi.nlm.nih.gov/16580208 16580208]|[https://pubmed.ncbi.nlm.nih.gov/28124591 28124591]|[https://pubmed.ncbi.nlm.nih.gov/20095613 20095613]|[https://pubmed.ncbi.nlm.nih.gov/17507233 17507233]|[https://pubmed.ncbi.nlm.nih.gov/23565921 23565921]|[https://pubmed.ncbi.nlm.nih.gov/14505645 14505645]|[https://pubmed.ncbi.nlm.nih.gov/20930939 20930939]|[https://pubmed.ncbi.nlm.nih.gov/9201997 9201997] <br>
'''definition''' :  <br>
'''term_xref''' : GlycoMotif:GGM.000116|GTC:G54733XO  <br>
'''synonyms''' : GQ1balpha <br>
  '''function''' :  <br>
  '''function''' :  <br>
  '''disease_associations''' :  <br>
  '''disease_associations''' :  <br>
Line 1,002: Line 726:




===GSD000098===
===GSD000149===
  '''term (main_entry)''' : GQ1c <br>
  '''term (main_entry)''' : Sialosyl paragloboside <br>
  '''glycan_dictionary_accession''' : GSD000098 <br>
  '''glycan_dictionary_accession''' : GSD000149 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G99524KA G99524KA] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G50123ZO G50123ZO] <br>
  '''term_in_sentence''' : The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with Gq1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1.[PMID: [https://pubmed.ncbi.nlm.nih.gov/6640289 6640289]] <br>
  '''term_in_sentence''' : Unlike CNS myelin, human peripheral nerve myelin has the acidic glycosphingolipids sialosyl paragloboside (SPG), sialosyl lactosaminyl paragloboside (SLPG), and sulfated glucuronyl paragloboside (SGPG).[PMID:[https://pubmed.ncbi.nlm.nih.gov/8862128 8862128]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/6640289 6640289]| [https://pubmed.ncbi.nlm.nih.gov/1695858 1695858]|[https://pubmed.ncbi.nlm.nih.gov/7798936 7798936]|[https://pubmed.ncbi.nlm.nih.gov/1729139 1729139]|[https://pubmed.ncbi.nlm.nih.gov/2468656 2468656]|[https://pubmed.ncbi.nlm.nih.gov/20368669 20368669]|[https://pubmed.ncbi.nlm.nih.gov/2723647 2723647]|[https://pubmed.ncbi.nlm.nih.gov/1814411 1814411]| [https://pubmed.ncbi.nlm.nih.gov/3064875 3064875]|[https://pubmed.ncbi.nlm.nih.gov/6085330 6085330]|[https://pubmed.ncbi.nlm.nih.gov/1613492 1613492]|[https://pubmed.ncbi.nlm.nih.gov/17883393 17883393]|[https://pubmed.ncbi.nlm.nih.gov/11831845 11831845]| [https://pubmed.ncbi.nlm.nih.gov/10775425 10775425]|[https://pubmed.ncbi.nlm.nih.gov/8219015 8219015]|[https://pubmed.ncbi.nlm.nih.gov/8804704 8804704]|[https://pubmed.ncbi.nlm.nih.gov/1384262 1384262]|[https://pubmed.ncbi.nlm.nih.gov/7066685 7066685]|[https://pubmed.ncbi.nlm.nih.gov/2299192 2299192]|[https://pubmed.ncbi.nlm.nih.gov/9613831 9613831]|[https://pubmed.ncbi.nlm.nih.gov/10350354 10350354]|[https://pubmed.ncbi.nlm.nih.gov/1304337 1304337]|[https://pubmed.ncbi.nlm.nih.gov/9153001 9153001]|[https://pubmed.ncbi.nlm.nih.gov/11959025 11959025]|[https://pubmed.ncbi.nlm.nih.gov/8474578 8474578]|[https://pubmed.ncbi.nlm.nih.gov/2299350 2299350]| [https://pubmed.ncbi.nlm.nih.gov/10564776 10564776]|[https://pubmed.ncbi.nlm.nih.gov/10699494 10699494]|[https://pubmed.ncbi.nlm.nih.gov/3942818 3942818]|[https://pubmed.ncbi.nlm.nih.gov/12031286 12031286]|[https://pubmed.ncbi.nlm.nih.gov/7361620 7361620] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/8862128 8862128]|[https://pubmed.ncbi.nlm.nih.gov/7236652 7236652]|[https://pubmed.ncbi.nlm.nih.gov/2370108 2370108]|[https://pubmed.ncbi.nlm.nih.gov/3133978 3133978]|[https://pubmed.ncbi.nlm.nih.gov/2905604 2905604]|[https://pubmed.ncbi.nlm.nih.gov/1749114 1749114]|[https://pubmed.ncbi.nlm.nih.gov/1573418 1573418] <br>
  '''definition''' : Alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-[alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)]-beta-D-Galp-(1->4)-beta-D-Glcp is a member of neuraminic acids and an amino octasaccharide.[CID: 91860352] <br>
  '''definition''' : α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-D-GlcpNAc with β configuration at the anomeric position of the reducing-end N-acetyl-D-glucosamine residue.[CHEBI:71612] <br>
  '''term_xref''' : GlycoMotif:GGM.000117|GTC:G99524KA|CID: 91860352|CHEBI:145645|KEGG:G00121 <br>
  '''term_xref''' : GlycoMotif:GGM.000081|GTC:G50123ZO|CID:[https://pubmed.ncbi.nlm.nih.gov/91845504 91845504]|KEGG:G01429|CHEBI:151914 <br>
'''synonyms''' :  <br>
'''function''' :  <br>
'''disease_associations''' :  <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453044/ Chapter 46]<br>
 
 
===GSD000099===
'''term (main_entry)''' : GT1a <br>
'''glycan_dictionary_accession''' : GSD000099 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G68110IF G68110IF] <br>
'''term_in_sentence''' : GT1a mimicry was found in the lipo-oligosaccharides of strain ICDCCJ07002 and ICDCCJ07004; but a combination of GM3/GD3 mimics was observed in ICDCCJ07001, although this patient had anti-GT1a IgG antibodies.[PMID:[https://pubmed.ncbi.nlm.nih.gov/26197476 26197476]] <br>
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/12023422 12023422]|[https://pubmed.ncbi.nlm.nih.gov/32623212 32623212]|[https://pubmed.ncbi.nlm.nih.gov/26197476 26197476]|[https://pubmed.ncbi.nlm.nih.gov/9585812 9585812]|[https://pubmed.ncbi.nlm.nih.gov/29747820 29747820]|[https://pubmed.ncbi.nlm.nih.gov/23804237 23804237]|[https://pubmed.ncbi.nlm.nih.gov/11993188 11993188]|[https://pubmed.ncbi.nlm.nih.gov/31683059 31683059]|[https://pubmed.ncbi.nlm.nih.gov/19631994 19631994]|[https://pubmed.ncbi.nlm.nih.gov/9742882 9742882]|[https://pubmed.ncbi.nlm.nih.gov/29709941 29709941]|[https://pubmed.ncbi.nlm.nih.gov/8971119 8971119]|[https://pubmed.ncbi.nlm.nih.gov/8706663 8706663]|893404|[https://pubmed.ncbi.nlm.nih.gov/31829433 31829433]|[https://pubmed.ncbi.nlm.nih.gov/8910600 8910600]|[https://pubmed.ncbi.nlm.nih.gov/30600291 30600291]|[https://pubmed.ncbi.nlm.nih.gov/29319803 29319803]|[https://pubmed.ncbi.nlm.nih.gov/26176883 26176883]|[https://pubmed.ncbi.nlm.nih.gov/29063860 29063860]|[https://pubmed.ncbi.nlm.nih.gov/6766128 6766128]|[https://pubmed.ncbi.nlm.nih.gov/31602715 31602715]|[https://pubmed.ncbi.nlm.nih.gov/29808463 29808463]|[https://pubmed.ncbi.nlm.nih.gov/30711390 30711390]|[https://pubmed.ncbi.nlm.nih.gov/29847988 29847988]|[https://pubmed.ncbi.nlm.nih.gov/30116054 30116054]|[https://pubmed.ncbi.nlm.nih.gov/28187751 28187751] <br>
'''definition''' : A branched heptasaccharide derivative consisting of three sialyl residues, two galactose residues, one N-acetylglucosamine and a glucose residue at the reducing end.[CHEBI:59215] <br>
'''term_xref''' : CID:45266863|GlycoMotif:GGM.000110|GTC:G68110IF|GlycoEpitope:EP0066|KEGG:G00112|CHEBI:59215 <br>
  '''synonyms''' :  <br>
  '''synonyms''' :  <br>
  '''function''' :  <br>
  '''function''' :  <br>
Line 1,032: Line 741:




===GSD000100===
===GSD000150===
  '''term (main_entry)''' : GT1a alpha <br>
  '''term (main_entry)''' : Sialyl Lewis a <br>
  '''glycan_dictionary_accession''' : GSD000100 <br>
  '''glycan_dictionary_accession''' : GSD000150 <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G02149VR G02149VR] <br>
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00053MO G00053MO] <br>
  '''term_in_sentence''' : A new class of gangliosides, GT1a alpha and GQ1b alpha, were initially identified as cholinergic neuron-specific antigens in bovine brain. [PMID:[https://pubmed.ncbi.nlm.nih.gov/8082783 8082783]] <br>
  '''term_in_sentence''' : By comparing the serum O-glycan profiles from healthy controls with those of cancer patients, we identified a marker candidate, core 1 sialyl Lewis A (NeuAcα2-3Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal) (abbreviated C1SLA), whose concentration appeared to be weakly correlated with CA19-9 values.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888] [https://pubmed.ncbi.nlm.nih.gov/26641888 26641888]]] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/7710562 7710562]|[https://pubmed.ncbi.nlm.nih.gov/8082783 8082783]|[https://pubmed.ncbi.nlm.nih.gov/10972137 10972137]|[https://pubmed.ncbi.nlm.nih.gov/9468624 9468624]|[https://pubmed.ncbi.nlm.nih.gov/9143254 9143254]|[https://pubmed.ncbi.nlm.nih.gov/8221098 8221098]|[https://pubmed.ncbi.nlm.nih.gov/9679279 9679279]|[https://pubmed.ncbi.nlm.nih.gov/11368158 11368158]|[https://pubmed.ncbi.nlm.nih.gov/11878808 11878808] <br>
  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888] [https://pubmed.ncbi.nlm.nih.gov/26641888 26641888]]|[https://pubmed.ncbi.nlm.nih.gov/31424423 31424423]|[https://pubmed.ncbi.nlm.nih.gov/26530370 26530370]|[https://pubmed.ncbi.nlm.nih.gov/17760270 17760270]|[https://pubmed.ncbi.nlm.nih.gov/18343410 18343410]|[https://pubmed.ncbi.nlm.nih.gov/16033091 16033091]|[https://pubmed.ncbi.nlm.nih.gov/8829184 8829184]|[https://pubmed.ncbi.nlm.nih.gov/11907351 11907351]|[https://pubmed.ncbi.nlm.nih.gov/20592391 20592391]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888] [https://pubmed.ncbi.nlm.nih.gov/26641888 26641888]]|[https://pubmed.ncbi.nlm.nih.gov/24128856 24128856]|[https://pubmed.ncbi.nlm.nih.gov/30249386 30249386]|[https://pubmed.ncbi.nlm.nih.gov/10773785 10773785]|[https://pubmed.ncbi.nlm.nih.gov/16149606 16149606]|[https://pubmed.ncbi.nlm.nih.gov/10996727 10996727]|[https://pubmed.ncbi.nlm.nih.gov/10436809 10436809]|[https://pubmed.ncbi.nlm.nih.gov/10667238 10667238]|[https://pubmed.ncbi.nlm.nih.gov/7720892 7720892]|[https://pubmed.ncbi.nlm.nih.gov/7630017 7630017]|[https://pubmed.ncbi.nlm.nih.gov/10612415 10612415]|[https://pubmed.ncbi.nlm.nih.gov/9836451 9836451]|[https://pubmed.ncbi.nlm.nih.gov/12511721 12511721]|[https://pubmed.ncbi.nlm.nih.gov/22623153 22623153] <br>
  '''definition''' : <br>
  '''definition''' : A sialyated version of Lewis A with a branched structure of amino tetrasaccharide consisting of a sialyl residue, linked (2→3) to a galactosyl residue that in turn is linked (1→3) to a glucosaminyl residue at the reducing end, which is also carrying a fucosyl residue at the 4-position.[CHEBI:62681] <br>
  '''term_xref''' : GlycoMotif:GGM.000111|GTC:G02149VR|GlycoEpitope:EP0111|CID: 91851751|CHEBI:156678|KEGG:G00128  <br>
  '''term_xref''' : GTC:G00053MO|GlycoEpitope:EP0008|CID:[https://pubmed.ncbi.nlm.nih.gov/53356732 53356732]|CHEBI:62681|GlycoMotif:GGM.000024 <br>
  '''synonyms''' : GT1aa <br>
  '''synonyms''' : SLea|CA19-9|CA19-9 antigen|SLe^a|Slea <br>
  '''function''' : GT1a alpha was a cholinerginic-specific antigen.[GlycoEpitope:EP0111] <br>
  '''function''' : The carbohydrate determinants,Sialyl Lea and Sialyl Lex,which are frequently expressed on human cancer cells,serve as ligands for a cell adhesion molecule of the selectin family,E-selectin,which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0008] <br>
  '''disease_associations''' : <br>
  '''disease_associations''' : pancreatic adenocarcinoma[GlycoEpitope:EP0008]|hepatocellular cancer[GlycoEpitope:EP0008]|cholangiocellular cancer[GlycoEpitope:EP0008]|gastric cancer|[GlycoEpitope:EP0008]colorectal cancer[GlycoEpitope:EP0008]|ovarian cancer[GlycoEpitope:EP0008]|lung cancer[GlycoEpitope:EP0008]|breast cancer[GlycoEpitope:EP0008]|uterine cancer[GlycoEpitope:EP0008] <br>
  '''wikipedia''' :  <br>
  '''wikipedia''' :  <br>
  '''essentials_of_glycobiology''' :  <br>
  '''essentials_of_glycobiology''' :  <br>

Revision as of 14:06, 11 April 2023

GSD000101

term (main_entry) : GT1b 

glycan_dictionary_accession : GSD000101 

glytoucan_accession  : G40183QN 

term_in_sentence : GT1b ganglioside is axonally transported to the spinal cord dorsal horn and contributes to characteristics of neuropathic pain such as mechanical and thermal hypersensitivity.[PMID: 32030804] 

publication : 32030804|26370787|32046393|9712688|7636307|9931455|25520869|19605473|17188834|10233751|22735313|20540782|22746533|1861141|19490186|9521848|11921200|10731661|31431523|15274627|32726962|12573517|18277613|11370834|11234774|11123278|18704164|16291967|11411041|27549393|25253868|22720883|10686582|11511306|29904724|31472390|19156870 

definition : A branched amino heptasaccharide comprising a β-D-galactosyl-(1→4)-β-D-glucose disaccharide, the galactosyl residue of which carries an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl trisaccharide unit and an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl disaccharide unit through (2→4) and (2→3) linkages respectively. It corresponds to the carbohydrate portion of ganglioside GT1b.[CHEBI:59225] 

term_xref : GlycoMotif:GGM.000112|GTC:G40183QN|GlycoEpitopeEP0067|CID:45266781|CHEBI:59225| GlycoGlycoEpitope:130680|SugarBind_Ligand:26|KEGG:G00116  

synonyms :  

function :  

disease_associations : Toxoplasmosis[SugarBind_Ligand:26]|Lyme disease[SugarBind_Ligand:26]|Cholera[SugarBind_Ligand:26]|Botulism[SugarBind_Ligand:26]|Tetanus[SugarBind_Ligand:26]|Influenza[SugarBind_Ligand:26] 

wikipedia :  

essentials_of_glycobiology :


GSD000102

G78818SP
term (main_entry) : GT1c 

glycan_dictionary_accession : GSD000102 

glytoucan_accession  : G78818SP 

term_in_sentence : We show here that VVH associates with ganglioside GM1a, Fucosyl-GM1, GD1a, GT1c, and GD1b by glycan array.[PMID: 32228455] 

publication : 28088450|30085356|32228455|2468656|19841910|23877172|1695858|10564776|1613492|8474578|7798936|11180643|2723647|7066685|9613831|7361620|10699494 

definition : A branched amino heptasaccharide consisting of a linear tetrasaccharide of β-D-galactose, N-acetyl-β-D-galactosamine, β-D-galactose and β-D-glucose residues linked sequentially (1→3), (1→4) and (1→4), to the galactose residue proximal to the reducing end is also linked (2→3) an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl trisaccharide side-chain. The carbohydrate moiety of ganglioside GT1c.[CHEBI:90509] 

term_xref : GlycoMotif:GGM.000113|GTC:G78818SP|CID:91846734|CHEBI:90509|GlycoEpitope:EP0033|KEGG:G00120 

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000103

term (main_entry) : GT2 

glycan_dictionary_accession : GSD000103 

glytoucan_accession  : G36476BA 

term_in_sentence : Biosynthesis of the c-series gangliosides GT3, GT2 and GP1c was studied in Golgi derived from rat liver.[PMID:[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]|15498585|16005859|27540730|31533196|31201844 

definition : A branched amino hexasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4), to the galactosyl residue of which is also linked (1→4) an N-acetyl-β-D-galactosaminyl residue. The carbohydrate moiety of ganglioside GT2.[CHEBI:72446] 

term_xref : GlycoMotif:GGM.000109|GTC:G36476BA|CID:70788971|CHEBI:72446|KEGG:G00119  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 11


GSD000104

term (main_entry) : GT3 

glycan_dictionary_accession : GSD000104 

glytoucan_accession  : G93899SO 

term_in_sentence : The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound.[PMID: 28029115] 

publication : 28029115|31355968|30987413|27869747|27216753|8631981|29672891|10385047|29642403|10412028|27193023|30068561|23415908|8858920|2303428|27153057|27128741|2654294|26930378|7561885|25860286|30845647|24712339|30070965|8910600|[https://pubmed.ncbi.nlm.nih.gov/1606358 1606358 1606358]|27356050|8514740|18509108|23000517|29769046|29566611 

definition : A linear amino pentasaccharide consisting of a chain of three α-sialyl residues, a β-D-galactosyl residue and a β-D-glucose residue linked sequentially (2→8), (2→8), (2→3) and (1→4).[CHEBI:72444] 

term_xref : GlycoEpitope:EP0070|KEGG:G00118|CID:70788970|GlycoMotif:GGM.000092|GTC:G93899SO|CHEBI:72444  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 11


GSD000105

G94435QH
term (main_entry) : Blood group H (Type 3) 

glycan_dictionary_accession : GSD000105 

glytoucan_accession  :  G94435QH

term_in_sentence : One particular lambody, VLRB.aGPA.23, was shown by glycan array analysis to be selective for the blood group H type 3 trisaccharide (BG-H3, Fucα1-2Galβ1-3GalNAcα), aGPA, and TFα (Galβ1-3GalNAcα), with affinity constants of 0.2, 1, and 8 nM, respectively.[PMID:23030719] 

publication : 23030719|20466654|1563908|3944092|11218748|11101633|18842005|27550195|2469783|2433836|23118206|8445257|2664192|3063304 

definition :  

term_xref :  GlycoMotif:GGM.000010|GTC:G94435QH

synonyms : H type 3|H antigen (type 3)|Type 3 chain H 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 11


GSD000106

term (main_entry) : Heparan sulfate 

glycan_dictionary_accession : GSD000106 

glytoucan_accession  :  

term_in_sentence : In Niemann-Pick C-1 fibroblasts, where deaminative degradation of heparan sulfate is defective, carbonylated proteins were abundant.[PMID: 17540770] 

publication : 32266657|29554552|29032302|30003471|25197032|28538085|26236728|16917509|22899865|17080204|23042481|28982096|24146040|25081076|15719168|17453622|25325954|21110089|29797526|21967329|23313092|11212344|28465034|11746174|12512855|8836040|28394734|24182748|28264929|28745308|26555370|14718374|16767693|25246018|19584012|8274190|25034023|8370471|26571620|29920400|31731076|20816205|16880267|31547957|11457867|27241222|28718936|21204109|31016560|11166215|11457866 

definition : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815] 

term_xref : CHEBI:28815|CID: 53477715|GlycoEpitope: EP0086 

synonyms : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate 

function : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[GlycoEpitope: EP0086] 

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000107

term (main_entry) : Heparin 

glycan_dictionary_accession : GSD000107 

glytoucan_accession  :  

term_in_sentence : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:6416324] 

publication : 27100512|22566218|27264866|30094590|31077659|26975675|2083874|25088334|3333067|2191809|28118750|28224913|22495506|29385025|10332503|22393937|19947315|27655335|14529394|2419035|22048616|23849978|10204652|28958760|12627673|9042555|15639107|28880550|27238483|1964668|16716101|10796377|25981976|24680753|2191118|21166465|30582884|1322434|15330727|9752370|6416324|14996629|20452241|1340407|29050610|345399|6916469|6565376|26714061 

definition : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304] 

term_xref : CID:772|CHEBI:28304  

synonyms : bemiparin|bemiparin|certoparin|Cy 222|enoxaparin|fluxum|Heparin|Heparinic acid|parnaparin|reviparin|sandoparin 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000108

term (main_entry) : High mannose 

glycan_dictionary_accession : GSD000108 

glytoucan_accession  : G55220VL 

term_in_sentence : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:11258925] 

publication : 11258925|17956937|2059624|2065054|26791533|4077844|7780197|9136890|30659065|30075362|21421994|31076349|29738673|29508223|[https://pubmed.ncbi.nlm.nih.gov/26747427 26747427 26747427]|30634645|23007868|29051951|24549150|12417032|26724786|26956389|26493153|31102532|29673624|8348230|25586968|24975601|[https://pubmed.ncbi.nlm.nih.gov/29803109 29803109 29803109]|28465212|25776945|30151520|21097542|24326091|27995699|26003537|6722291|2925680|25565276|21460211|25196214|27387600|22373601|3729933|16423983|24174266|30605318 

definition : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man . 

term_xref : GTC:G55220VL|CID:70698382|CHEBI:71514  

synonyms : oligomannose 

function : Involved in promotion of protein folding in ER. [PMID:12417032].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205] 

disease_associations : Relative abundance changes in multiple CDGs [PMID: 30770376][PMID: 28484880] 

wikipedia :  

essentials_of_glycobiology : Chapter 17


GSD000109

term (main_entry) : HNK-1 

glycan_dictionary_accession : GSD000109 

glytoucan_accession  : G54406UD 

term_in_sentence : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:28709864] 

publication : 28709864|31738061|26738850|30306736|11070366|20855890|18024472|22669261|19729452|19796667|26850637|11769463|18263654|15843379|26659409|9003039|22087768|21771787|15173636|9210489|15258996|17924534|26382082|16171882|18802400|9800516|7504418|[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229 11891229]|15232286|9013478|21621858|11677051|18668221|11414798|19265195|8982638|8798480|28403522|17935701|1691305|10998116|9364602|7528651|12472892|21176892|28416698|19389918|[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937 28427937]|25450311 

definition : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322] 

term_xref : GTC:G54406UD|GlycoEpitope:EP0001|CID:46906103|CHEBI:60322|GlycoMotif:GGM.000058 

synonyms : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen 

function : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001] 

disease_associations : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001] 

wikipedia : https://en.wikipedia.org/wiki/N-linked_glycosylation 

essentials_of_glycobiology : Chapter 17


GSD000110

term (main_entry) : Hybrid 

glycan_dictionary_accession : GSD000110 

glytoucan_accession  : G16828VN 

term_in_sentence : A hybrid-type N-glycan was accessed by total synthesis, converted to an oxazoline, and used as a donor substrate with both wild type Endo M and an N175Q glycosynthase Endo M mutant allowing the convergent synthesis of a glycosylated amino acid bearing a hybrid N-glycan structure. [PMID:27058295] 

publication : 27058295|15044398|28714086|29578688|26999365 

definition : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1–Asn-X-Ser/Thr is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the α-linked Man residue.[Essentials of Glycobiology:Chapter 9] 

term_xref : GTC:G16828VN|CID:91847108|CHEBI:147471 

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 9


GSD000111

term (main_entry) : i antigen 

glycan_dictionary_accession : GSD000111 

glytoucan_accession  : G00058MO|G46055MA 

term_in_sentence : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:2422274] 

publication : 2422274|[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458 15679458]|[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254 21912254]|[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428 12468428]|28508465|6203982|30728302|8449405|9122902|10360315|[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787 6159787]|6183759|518539|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951 6715951]|21933024 

definition :  

term_xref : GlycoMotif:GGM.000004|GlycoMotif:GGM.000002|GTC:G46055MA|GTC:G00058MO 

synonyms : Type 2 LN2 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000112

term (main_entry) : I antigen 

glycan_dictionary_accession : GSD000112 

glytoucan_accession  : G56045WU 

term_in_sentence : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID:[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458 15679458]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/15679458 15679458 15679458]|[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254 21912254]|30705292|33403394|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951 6715951]|[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428 12468428]|6088627|[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787 6159787] 

definition : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390] 

term_xref : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:91852915|CHEBI:151390 

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 9


GSD000113

term (main_entry) : Isoglobotetraosylceramide 

glycan_dictionary_accession : GSD000113 

glytoucan_accession  : G57710SU 

term_in_sentence : Furthermore, isoglobotetraosylceramide seems to play a direct role in the metastatic process since the blocking of exposed antigen with monoclonal antibodies, or their Fab fragments, results in a highly significant decrease in lung colony formation.[PMID:8504431] 

publication : 1396705|8504431|2713378|3489485|18997175|7053385|3379797|2465279|3743633|11479210 

definition :  

term_xref : GlycoMotif:GGM.000071|GTC:G57710SU|CID:91849719|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17  

synonyms :  

function : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:8504431] 

disease_associations : Actinomycosis[SugarBind_Ligand:17] 

wikipedia : https://en.wikipedia.org/wiki/Ii_antigen_system 

essentials_of_glycobiology :


GSD000114

term (main_entry) : Keratan sulfate 

glycan_dictionary_accession : GSD000114 

glytoucan_accession  :  G82109MW 

term_in_sentence : Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties.[PMID: 30578672] 

publication : 29340594|30578672|12512857|29625490|25325967|30025865|29924315|9549787|11030741|28078490|8298243|29096187|30059256|26958998|26773479|22840010|15597951|28110685|28535934|2942429|18234072|8641829|8940154|2027120|30849116|41589|6238957|1907283|7722002|29275050|24274541|2527236|1731862|8991509|24291704|10517185|6451953|7688312|8663590|139406|25770829|25036480|9275006|25179279|32627425|26903438|27941632|12807022|32266652|21624346 

definition : A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions.[CHEBI:60924] 

term_xref : CHEBI:60924|CID:446715|GlycoEpitope: EP0085|GTC: G82109MW  

synonyms : keratan| Kerato sulphate|Kerato sulfate|Keratan sulphate|kerato 6'-sulfate|keratan 6'-sulfate|Kerato 6'-sulphate|Keratan 6'-sulphate 

function : Tissue hydration.[PMID: 11030741] 

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000115

term (main_entry) : LacdiNac 

glycan_dictionary_accession : GSD000115 

glytoucan_accession  : G31736BK 

term_in_sentence : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:25003135] 

publication : 25003135|31711843|31145522|27601469|30669833|25210040|24633693|24755437|22653491|30898876|7758724|[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328 22474328]|21305673|31558607|31271862|28549117|26213980|9134425|25561735|31756927|31170332|16282603|15265923|32267274|23015818|32676595|16728562|10814702|9591048|22245701|[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628 29751628]|22997242|15535969|31911241|30622255|29888905|30236114|[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790 30298790]|29373511|22298779|19179461|31606752|15653684|16403022|11162373|32005658|30529570 

definition : An amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a β-linkage.[CHEBI:61190] 

term_xref : GTC:G31736BK|GlycoEpitope:P0150|CID:25257164|CHEBI:61190|GlycoMotif:GGM.000016 

synonyms : LDN 

function : Has a role of epitope.[CHEBI:61190] 

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000116

term (main_entry) : Lactosylceramide 

glycan_dictionary_accession : GSD000116 

glytoucan_accession  : G84224TW 

term_in_sentence : In the 1970s, a neutral glycosphingolipid lactosylceramide (LacCer) was found to bind specifically to several kinds of microorganisms.[PMID:30175814] 

publication : 30175814|26900161|30502090|29624959|28444900|25408340|31801289|29099167|25595946|32592089|27729551|24658420|25216636|25638276|9499377|17986153|8143857|23801329|18077097|32708181|15346887|19015977|18393821|25279740|21057870|11915327|25212460|23882130|11915329|8195125|8808768|3396945|22128256|6733104|24968752|32518749|30688114|7666005|8200356|24718572|6193809|25781947|12383912|26086247|30606995|12419803 

definition : Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.[MeSH:D007790] 

term_xref : GTC:G84224TW|MeSH:D007790|GlycoMotif:GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3 

synonyms : LacCer|Lc2|CDH 

function : mammalian cell receptors for Neisseria gonorrhoeae recognized by Helicobacter pylori[GlycoEpitope:EP0078] 

disease_associations : chronic gastritis[GlycoEpitope:EP0078,SugarBind_Ligand:3]|duodenal ulcers[GlycoEpitope:EP0078]|gastric adenocarcinoma[GlycoEpitope:EP0078,SugarBind_Ligand:3]|gastric ulcers[GlycoEpitope:EP0078]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Actinomycosis[SugarBind_Ligand:3]|Pertussis[SugarBind_Ligand:3]|Candidiasis[SugarBind_Ligand:3]|Cryptococcosis[SugarBind_Ligand:3]|Hemorrhagic colitis[SugarBind_Ligand:3]|Peptic ulcers[SugarBind_Ligand:3]|Histoplasmosis[SugarBind_Ligand:3]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Gonorrhea[SugarBind_Ligand:3]|Sporotrichosis[SugarBind_Ligand:3]|Plague[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3] 

wikipedia :  

essentials_of_glycobiology : Chapter 17


GSD000117

term (main_entry) : Lactotriaosylceramide 

glycan_dictionary_accession : GSD000117 

glytoucan_accession  : G06239NA 

term_in_sentence : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:22411838] 

publication : 22411838|20693232|26104834|27435676|26405105|32340400|25241919|23404501|32452379|2960671|272643|27711049|33202844|4060695|27638607|20547865|2277039|6238026|8448388|8489255|9363437|11836161|6892925|[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117 1551117]|6811267|8059935|7861954|11283017|8514762|1291049|[https://pubmed.ncbi.nlm.nih.gov/3805024 3805024 3805024]|10816509|12393713|6417117|11054095|8781973|1692829 

definition : A linear amino trisaccharide consisting of β-D-glucose at the reducing end having an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl group attached at the 4-position.[CHEBI:61758] 

term_xref : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:10230777|CHEBI:61758|SugarBind_Ligand:20

synonyms : Lc3|Lc(3)Cer|Lc_3 

function : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:22411838] 

disease_associations : Pharyngitis[SugarBind_Ligand:20]|Tracheobronchitis[SugarBind_Ligand:20]|Gonorrhea[SugarBind_Ligand:20]|Actinomycosis[SugarBind_Ligand:20]|Diarrhea[SugarBind_Ligand:20] 

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000118

term (main_entry) : LcGg4 

glycan_dictionary_accession : GSD000118 

glytoucan_accession  : G62554JH 

term_in_sentence : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024 3805024]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024 3805024]|33395290 

definition : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521] 

term_xref : GlycoMotif:GGM.000075|GTC:G62554JH|CID:91850076|CHEBI:152521|GlycoEpitope:EP0035  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000119

term (main_entry) : Lewis a 

glycan_dictionary_accession : GSD000119 

glytoucan_accession  : G00047MO 

term_in_sentence : Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). [PMID:29367698] 

publication : 29367698|27187324|30562693|[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625 27646625]|[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286 26911286]|30225822|28600306|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|11064310|23809433|30050155|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|1675497|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|27705835|7593252|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|17630273|9350993|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001] 

definition : A lewis blood group antigen with structure beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcpNAc consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an alpha-linkage and a galactosyl residue attached at the 3-position via a beta-linkage. It has a role as an epitope and an antigen. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:62265] 

term_xref : GTC:G00047MO|CID:22806751|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155  

synonyms : Le(a)|Lea-3|Lea|Le^a 

function :  

disease_associations : Gastroenteritis[SugarBind_Ligand:155] 

wikipedia : https://www.wikidata.org/wiki/Q50687009 

essentials_of_glycobiology :


GSD000120

G39211DH
term (main_entry) : Lewis b 

glycan_dictionary_accession : GSD000120 

glytoucan_accession  : G39211DH 

term_in_sentence : Human mannose-binding lectin preferentially binds to human colon adenocarcinoma cell lines expressing high amount of Lewis A and Lewis B antigens.[PMID:10328552] 

publication : 10328552|23408949|31927399|26601230|28279343|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|30831115|27318698|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|23828675|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|25516619|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|8509439|19832116|15270746|3166398|30909206|7718581|18400963|[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628 29751628]|8982241|30284922|24576035|30974776|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001]|31768613|1651804|25428879|15946883|[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790 30298790]|30544260|29197783|8632739|7679772|18666312|20231766|29922666|95124|2247887|21519121|25153235|28751211 

definition :  

term_xref : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:45480568|CHEBI:59440 

synonyms : Le(b)|Lewis(b)|Le^b 

function : possible receptor for Helicobacter pylori[https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/blood-group-lewis-system] 

disease_associations : Gastroenteritis[SugarBind_Ligand:146] 

wikipedia :  

essentials_of_glycobiology :


GSD000121

term (main_entry) : Lewis x 

glycan_dictionary_accession : GSD000121 

glytoucan_accession  : G00051MO 

term_in_sentence : In particular, the observation of oxonium ions at m/z 512.2 and 803.2 is useful for probing outer non-reducing terminal fucosylation, which represented carbohydrate structures consisting of Hex Hex , dHex Hex , and HexNAc , and NeuNAc , Hex Hex , dHex Hex , and HexNAc , respectively, from which the Lewis X structure (Galbeta1-4(Fucalpha1-3)GlcNAc) was readily deduced.[PMID:15536627] 

publication : 15536627|31666308|29019053|28296340|29593094|17607374|16581086|20858014|19962782|7912739|25121780|24059473|29210428|31276881|9015359|7628844|7499837|16850248|28425129|28869691|19576189|[https://pubmed.ncbi.nlm.nih.gov/10223649 10223649 10223649]|22593503|15632313|27198630|26582608|11500392|31256373|23399157|21984435|26244810|26162743|17335083|15388363|9556613|10760152|11267844|20876654|12131290 

definition : A Lewis blood group antigen with structure α-L-Fucp-(1→3)-[β-D-Galp-(1→4)]-D-GlcpNAc where the glucosamine at the reducing end has β-configuration at its anomeric centre. Commonly known as Lewis x trisaccharide or Lex.[CHEBI:59294] 

term_xref : GTC:G00051MO |GlycoEpitope:EP0011|CID:44611539|CHEBI:59294|GlycoMotif:GGM.000018 

synonyms : Lex|Galbeta1-4(Fucalpha1-3)GlcNAc|Lewis x trisaccharide|Le(X)|Le^x|SSEA-1 

function : Involved in carbohydrate-carbohydrate interaction[Glycoepitope:EP0011].|Also implicated in apoptosis.[Glycoepitope:EP0011]|influence antigenic presentation and interfere with pathogen transfer in breastfed infants.[Glycoepitope:EP0011] 

disease_associations : acute leukemia[GlycoEpitope:EP0011]|lymphoma[GlycoEpitope:EP0011] 

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000122

G00052MO
term (main_entry) : Lewis y 

glycan_dictionary_accession : GSD000122 

glytoucan_accession  : G00052MO 

term_in_sentence : In conclusion, Lewis y antigen and CD147 were significantly upregulated in ovarian tumors, and the altered expression of Lewis y may cause changes in CD147.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]|[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467 20003467]|[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145 24692145]|[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328 24998328]|[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913 25726913]|29299130|[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]|[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467 20003467]|[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145 24692145]|[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328 24998328]|20127027|22138668|23894390|[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913 25726913]|25416440|[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625 27646625]|23725446|21294926|22312289|25973320|23242548|30328452|21119363|29130097|23443083|23708102|28671040|19715603|23468946|27723168|21747684|19771739 

definition : A Lewis blood group antigen which is a branched amino tetrasaccharide with structure alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, consisting of consisting of N-acetyl-beta-D-glucosamine at the reducing end having an alpha-L-fucosyl residue attached at the 3-position and an alpha-L-fucosyl-(1→2)-beta-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure. It has a role as an antigen and an epitope. [CHEBI:59045]] 

term_xref : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045|GlycoMotif:GGM.000019  

synonyms : LeY|Le(y)|Ley|Le^y 

function : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018] 

disease_associations : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018] 

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000123

term (main_entry) : Monosialylated 

glycan_dictionary_accession : GSD000123 

glytoucan_accession  :  

term_in_sentence : The structures of the asparagine-linked sugar chains of U- CD59 were biantennary complex type , only 4.2% of which are monosialylated.[PMID:7514386] 

publication : 7514386|8477709|8942648|29752599|31669586|29747818|16425369|12089170|31390883|1632647|29733234|31110965|31566965|30555678|28263871|29652662|25915761|16381065|29247593|28370937|23896595|26633899|32155999|25261856|2737211|26945091|27065039|26784838|26582205 

definition : A glycan that have the addition of one sialic acid residues. 

term_xref :  

synonyms :  

function : appears in bovine brain gangliosides.[PMID: 29752599] 

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000124

term (main_entry) : Monosialyl-biantennary 

glycan_dictionary_accession : GSD000124 

glytoucan_accession  :  

term_in_sentence : In contrast, the sugar chain structure of HCC highly specific AFP isoform was found to comprise a monosialyl-biantennary sugar chain with additional fucosylation of the proximal N-acetylglucosamine.[PMID:7686446] 

publication : 7686446|1374031|9648261|10460833|19524219|10207016|15797573|15218190 

definition : A biantennary glycan with two GlcNAc branches linked to the core and the addition of one sialic acid residues. 

term_xref :  

synonyms : monosialyl biantennary|sialylated diantennary|sialylated biantennary 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000125

term (main_entry) : Monosialyl-Gb5 

glycan_dictionary_accession : GSD000125 

glytoucan_accession  : G32254QI 

term_in_sentence : Thus, malignancy of MCF-7 is highly dependent on monosialyl-Gb5, and its activation of cSrc and FAK in GEM.[PMID:12401210] 

publication : 12401210|16995838|27318475 

definition : alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp is a linear amino hexasaccharide comprising β-D-glucose at the reducing end with at the 4-position a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-α-D-galactosyl-(1→4)-β-D-galactosyl moiety, α(2→3)-sialylated at the terminal galactosyl residue.[CHEBI:62313] 

term_xref : GTC:G32254QI|GlycoEpitope:EP0099|GlycoMotif:GGM.000080|CID:73427363|CHEBI:62313  

synonyms : GL-7 globoseries ganglioside (SSEA-4)|Monosialyl Gb5|Sialosyl galactosyl globoside|GL-7 globoseries ganglioside|SSEA-4 

function :  

disease_associations : renal cell carcinoma/RCC[GlycoEpitope:EP0099] 

wikipedia :  

essentials_of_glycobiology :


GSD000126

G80193TN
term (main_entry) : Mono-sulfated globopentaosylceramide 

glycan_dictionary_accession : GSD000126 

glytoucan_accession  : G80193TN 

term_in_sentence : Mono-sulfated globopentaosylceramide from human kidney.[PMID:2777788] 

publication : 2777788 

definition :  

term_xref : GlycoMotif:GGM.000072|GTC:G80193TN 

synonyms : Monosulfated globopentaosylceramide 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000127

term (main_entry) : Mono-sulfated globotetraosylceramide 

glycan_dictionary_accession : GSD000127 

glytoucan_accession  : G05297EK 

term_in_sentence : Mono-sulfated globotetraosylceramide from human kidney.[PMID:2559078] 

publication : 2559078 

definition :  

term_xref : GlycoMotif:GGM.000073|GTC:G05297EK

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000128

term (main_entry) : N-acetyl GM2 

glycan_dictionary_accession : GSD000128 

glytoucan_accession  : G79389NT 

term_in_sentence : The appearance of the N-acetyl GM2 antigen correlated well with the degree of differentiation of the cancer cells in patients with squamous cell carcinoma and adenocarcinoma of the lung.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]|2153431|[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107 25673107] 

definition : beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp is a branched amino tetrasaccharide consisting of the linear sequence β-D-GalNAc-(1→4)-β-D-Gal-(1→4)-β-D-Glc having a Neu5Ac residue attached to the galactose via an α-(2→3) linkage. Corresponds to the carbohydrate portion of ganglioside GM2.[CHEBI:59220] 

term_xref : GTC:G79389NT|GlycoEpitope:EP0051|CID:45266845|CHEBI:59220 

synonyms :  

function : The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.[CHEBI:59220] 

disease_associations : lung adenocarcinoma[GlycoEpitope:EP0051]|embryonal carcinoma[GlycoEpitope:EP0051]|germ cell tumor[GlycoEpitope:EP0051]|teratocarcinoma[GlycoEpitope:EP0051]|squamous cell carcinoma[GlycoEpitope:EP0051] 

wikipedia :  

essentials_of_glycobiology :


GSD000129

term (main_entry) : N-acetyllactosamine (Type 2)

glycan_dictionary_accession : GSD000129 

glytoucan_accession  : G00055MO 

term_in_sentence : Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial beta1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form N-acetyllactosamine in the presence of UDP.[PMID:31165848] 

publication : 31165848|31126011|28796164|6236210|9751793|29740087|9151975|10567443|21472942|26477523|6548353|28167527|20056550|7737204|22052010|[https://pubmed.ncbi.nlm.nih.gov/10223649 10223649 10223649]|11323440|10420596|7766648|25257940|17977857|15556936|26541999|23650594|9692202|29429899|21062783|25034434|8985145|28503789|8720464/ 

definition : N-acetyllactosamine is a beta-D-galactopyranosyl-(1→4)-N-acetyl-D-glucosamine having beta-configuration at the reducing end anomeric centre. It is also known as galb1-4glcnacb or lacnac, belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group. N-Acetyllactosamine is an extremely weak basic (essentially neutral) compound (based on its pKa). N-Acetyllactosamine exists in all living organisms, ranging from bacteria to humans.[CHEBI:16153,HMDB0001542] 

term_xref : GTC:G00055MO|CID:439271|CHEBI:16153|MeSH:C000458|GlycoMotif:GGM.000001  

synonyms : LacNAc|Type 2 LN 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000130

term (main_entry) : N-Glycolyl-GM2 

glycan_dictionary_accession : GSD000130 

glytoucan_accession  : G56478LD 

term_in_sentence : The monoclonal antibodies MK2-34 and MK1-16 (both IgM), which specifically detect N-glycolyl GM2 and N-acetyl GM2, respectively, were generated by immunizing mice with liposomes containing monophosphoryl lipid A, trehalose dimycolate, and the antigenic ganglioside.[PMID:[https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/3167861 3167861 3167861]|11861662|17980710|3731079|[https://pubmed.ncbi.nlm.nih.gov/25673107 25673107 25673107] 

definition : (2S,4S,5R,6R)-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-5-[(2-hydroxyacetyl)amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of carbohydrates and carbohydrate derivatives.[CHEBI:151464] 

term_xref : GTC:G56478LD |GlycoEpitope:EP0052|CID:91845742|CHEBI:151464|GlycoEpitope:GGM.000096  

synonyms :  

function :  

disease_associations : choriocarcinoma[GlycoEpitope:EP0052]|teratocarcinoma|[GlycoEpitope:EP0052]yolk sac tumor[GlycoEpitope:EP0052] 

wikipedia :  

essentials_of_glycobiology :


GSD000131

term (main_entry) : N-linked glycans 

glycan_dictionary_accession : GSD000131 

glytoucan_accession  : G78059CC 

term_in_sentence : Our study identifies extracellular N-linked glycans-and the glycoprotein neurexin 1β specifically-as key modulators of neuronal uptake of αSacetyl, drawing attention to the potential therapeutic value of αSacetyl-glycan interactions.[PMID:31211781] 

publication : 31211781|28384382|30305477|31364612|26899268|29945790|29652253|29723274|30962676|29778448|25325701|31100702|28898525|22944671|19277537|24473128|17957771|27554083|15189166|11269317|[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919 19577919]|24303005|12042249|22191536|28324664|25965797|25434632|30484244|28110657|[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]|20129637|27346875|30280442|[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286 26911286]|22491358|26582281|26398792|31548313|31066275|28331984|25482090|[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173 28518173]|30733536|22326428|30063825|30315103|21558494|[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555 31676555]|31256374 

definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the nitrogen of an asparagine side-chain.[CHEBI:59520] 

term_xref : GTC:G78059CC|CID:70679232|CHEBI:70967 

synonyms :  

function : N-glycans modulate the function of several cell surface proteins which involved in migration, adhesion and which are responsible for regulating myelination.[PMID: 25151374]|Affect transportation of the glycosylated proteins in the Golgi.[PMID: 25151374]|Affects cell-cell interaction, adhesion, expression, proper folding.[PMID: 25151374]|extracellular N-glycans act as key modulators of neuronal uptake of αacetyl [PMID: 31211781]. 

disease_associations : Rheumatoid arthritis[PMID:17392038]|Type 1 Diabetes[PMID:29146600]|Lung Cancer[PMID: 23766031] 

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000132

term (main_entry) : Nonfucosylated 

glycan_dictionary_accession : GSD000132 

glytoucan_accession  :  

term_in_sentence : In the carbohydrate moiety , alpha-subunit from normal pregnancy hCG contained nonfucosylated , mono- and biantennary N-linked structures (49.3 and 36.7%, means); fucosylated biantennary and triantennary oligosaccharides were also identified (7.3 and 6.9%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]|30258536|23554380|16675584|[https://pubmed.ncbi.nlm.nih.gov/26747427 26747427 26747427]|22457527|24362443|19657637|8811881|19218011|20022111|17363544|17368483|20564614|27054024|28397880|[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688 31490688]|31860772|17012310|29633346|9442021|30350565|30296068|31800250|30021910|31133022|[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385 29224385]|[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087 28630087]|26444434|31697975|30991260 

definition : glycans without a fucose component/monosaccharide residue. 

term_xref :  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000133

term (main_entry) : Nonfucosylated biantennary 

glycan_dictionary_accession : GSD000133 

glytoucan_accession  :  

term_in_sentence : Structural analysis combining methylation-mass spectrometry and 400 MHz 1H-n.m.r. spectrometry of oligosaccharide alditols released from human leucocyte lactotransferrin shows the presence of two disialylated and non-fucosylated biantennary glycans of the N-acetyl-lactosaminic type.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]|1375510|9101715|[https://pubmed.ncbi.nlm.nih.gov/2390069 2390069 2390069]|2332109 

definition : A biantennary glycan with two GlcNAc branches linked to the core and no fucose appears. 

term_xref :  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 9


GSD000134

term (main_entry) : Nonfucosylated biantennary N-Linked structures 

glycan_dictionary_accession : GSD000134 

glytoucan_accession  :  

term_in_sentence : The beta-subunit from normal pregnancy hCG contained fucosylated and nonfucosylated biantennary N-linked structures; however, mono- and triantennary oligosaccharides were also identified (4.6 and 13.7%).[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027] [https://pubmed.ncbi.nlm.nih.gov/9449027 9449027 9449027]] 

definition : A biantennary N-linked glycan with two GlcNAc branches linked to the core and no fucose appears. 

term_xref :  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000135

term (main_entry) : Nonfucosylated triantennary 

glycan_dictionary_accession : GSD000135 

glytoucan_accession  :  

term_in_sentence : Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.[PMID:7679920] 

publication : 7679920|23274891 

definition : A triantennary N-linked glycan with three GlcNAc branches linked to the core and no fucose appears. 

term_xref :  

synonyms :  

function : Appears in human alpha-fetoprotein (AFP).[PMID:7679920] 

disease_associations : hepatocellular carcinoma[PMID:7679920]. 

wikipedia :  

essentials_of_glycobiology :


GSD000136

term (main_entry) : Nonsialylated 

glycan_dictionary_accession : GSD000136 

glytoucan_accession  :  

term_in_sentence : The pattern of nonsialylated oligosaccharides was used for interpretation of the fully sialylated species using bioinformatics tools. From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively. Glycan structures carry dominantly between 15 and 16 sialic acids indicating an almost complete termination of all antenae with sialic acid.[PMID:30295034] 

publication : 14533820|1377689|9705949|30788437|28090561|12498371|26839900|[https://pubmed.ncbi.nlm.nih.gov/31490688 31490688 31490688]|2656426|30295034|31545048|12381155|25730103|26787879|25646460|[https://pubmed.ncbi.nlm.nih.gov/29224385 29224385 29224385]|26063435|26954852|32889432|2825412|27504786|22431161 

definition : A glycan which is not sialylated. 

term_xref :  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000137

term (main_entry) : O-fucose glycans 

glycan_dictionary_accession : GSD000137 

glytoucan_accession  : G39294YF 

term_in_sentence : Recently, a number of laboratories have shown that O-fucose glycans on the epidermal growth factor (EGF)-like repeats of the Notch extracellular domain modulate Notch signaling.[PMID:12417415] 

publication : 19594638|30690220|[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191 18952191]|22415200|12417415|16400812|18948267|21464368|20816394|30207383|20301232|27129198|17132502|22492969|30030822|30214079|26175457|25378397|18272537|28729422|11524432|31722217|23045360|24803430|28876865|25700513|32518939|30523691|18227520|20816217|24909690|17964136|12036964|27268051|15653671|19948734|31590629|32201074|15189151|17263732|32913123|12909620|[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176 28785176]|17132500|22949680|25053492|28939751 

definition : Form of glycosylation where the protein is modified by a fucose residue and can be extended futher to form a tetrasaccharide in certain cases. alpha-linked o-fucose have a consensus motif of C2X4(s/T)C3 where C2 and C3 are conserved cysteines number 2 and 3 respectively of the EGFR like repeats. [Essentials of Glycobiology:Chapter13]

term_xref : GTC:G39294YF|GlycoEpitope:EP0005  

synonyms :  

function : modification of Notch signaling.[GlycoEpitope:EP0005] 

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000138

term (main_entry) : O-GlcNAc 

glycan_dictionary_accession : GSD000138 

glytoucan_accession  : G49108TO 

term_in_sentence : A better understanding of the mechanisms of OGT/OGA action would enable us to derive therapeutic benefits of resetting cellular O-GlcNAc levels within an optimal range.[PMID:30464755] 

publication : 30464755|29049853|29594839|31654859|29404877|30105004|30669087|29790000|28408483|26862193|30523150|30037904|28408480|29352075|29456783|29577901|29223644|28638491|30221662|29904918|32155042|30298013|31630803|31847126|29784830|30181664|28768194|30134155|25336654|30356792|30199580|32329777|28408494|29774032|29044951|23836420|20301273|29772801|28922739|30100348|30793403|30657688|31237748|29756380|29954943|30018219|32207184|25566193|30626734|24759912| 

definition : Form of glycosylation which exclusively occurs in the mitochondrial, cytoplasmic or nuclear compartments of the cell where the protein is modified by a GlcNAc monosaccharide on the serine or threonine residues and is generally not modified or elongated further to form more complex structures. [Essentials of Glycobiology:Chapter19] 

term_xref : GTC:G49108TO|GlycoEpitope:EP0004|CID:24139|HMDB:HMDB0000803  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000139

term (main_entry) : O-linked glycans 

glycan_dictionary_accession : GSD000139 

glytoucan_accession  :  

term_in_sentence : Among these, six fucosylated N-linked glycansand four O-linked glycans exhibited significantly increased expression levels in GC, while five fucosylated N-linked glycans and ten fucosylated O-linked glycans exhibited significantly decreased expression levels in GC.[PMID:[https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/29865036 29865036 29865036]|30952424|31611643|[https://pubmed.ncbi.nlm.nih.gov/19577919 19577919 19577919]|32019882|19139197|26184710|11159917|21536259|25186198|19277556|22261557|24115046|18725413|[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855 15966855]|24256304|25477510|10359703|24406064|22259135|29279989|[https://pubmed.ncbi.nlm.nih.gov/15966855 15966855 15966855]|30619255|9673446|[https://pubmed.ncbi.nlm.nih.gov/31676555 31676555 31676555]|28745859|28196325|27975143|30591584|[https://pubmed.ncbi.nlm.nih.gov/28518173 28518173 28518173]|17522109|[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495 26328495]|32178593|27529638|24663386|[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328 22474328]|28096352|27496768|[https://pubmed.ncbi.nlm.nih.gov/18952191 18952191 18952191]|11135308|24917611|11532966|22786570|[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229 11891229]|18332077|26867212|26925665|16769205|23475718|16005634|[https://pubmed.ncbi.nlm.nih.gov/28785176 28785176 28785176] 

definition : The carbohydrate portion of a glycoprotein that has a glycan linked through the hydroxyl oxygen of serine, threonine, hydroxylysine or hydroxyproline side-chains.[CHEBI:59521] 

term_xref : CHEBI:59521 

synonyms :  

function : Affects several important activities like protein stability, modulation of signaling molecules and enzyme activity.[PMID:9673446] 

disease_associations : 

wikipedia :  

essentials_of_glycobiology :

GSD000140

term (main_entry) : O-linked mannose 

glycan_dictionary_accession : GSD000140 

glytoucan_accession  : G59126YU 

term_in_sentence : Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the first step toward the functional matriglycan structure on alpha-dystroglycan that is responsible for binding extracellular matrix proteins and certain arenaviruses.[PMID: 27932460] 

publication : 27932460|24526361|25381909|26644575|23851827|28810660|19054127|23929950|21684258|22608994|28973932|24733390|31851597|29884773|28711406|14577328|21089343|14617637|9838223|17072003|[https://pubmed.ncbi.nlm.nih.gov/26328495 26328495 26328495]|11181560|31949166|31988979|20362685|27733679|27493216|20044576|30643095|29732660|10580142|14568618|28079948|15467391|27812179|23761899|25737452|32930586|25381372|23434682|16857188|21452199|19429925|25361541|24297939|30322079|23428289|[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937 28427937]|22746206|27533452|17502374|20816174|27496765 

definition : O-linked glycans that are initiated by the addtion of a Man residue to Ser or Thr. Subsequent extension of the Man defines the O-Man core type, either M1, M2, or M3. The M1 type is initated by addition of a GlcNAc in β-linkage to the 2 position of the Man residue. M2 is initiated by addition of another GlcNAc to the 6 position of the M1 core. M3 is initiated by the addition of a GlcNAc in β-linkage to the 4 position of the Man residue. M1 and M2 type core glycans can be extended and branched with Gal, Fuc, Sialic Acid, and GlcA. The M3 core is uniquely extended by a multienzyme system to generate the matriglycan polysaccharide, a protein-specific modification found only on alpha-dystroglycan. [CHEBI:87761] 

term_xref : GlycoMotif:GGM.000055|GTC:G59126YU|CHEBI:87761|GlycoEpitope:EP0002|CID:91859038 

synonyms : O-mannosyl glycan 

function :  

disease_associations : MEB/muscle-eye-brain disease[GlycoEpitope:EP0002]|WWS/walker-warburg syndrome |muscular dystrophy[GlycoEpitope:EP0002]|neuronal migration disorder[GlycoEpitope:EP0002]|Muscle-Eye-Brain disease (MEB) and Walker-Warburg Syndrome (WWS) have mutations in genes encoding glycosyltransferases needed for O -mannosyl oligosaccharide synthesis[GlycoEpitope:EP0002]|Muscular dystrophy and neuronal migration disorder are caused by mutations in a glycosyltransferase, POMGnT1.[GlycoEpitope:EP0002] 

wikipedia :  

essentials_of_glycobiology :


GSD000141

term (main_entry) : P1 antigen 

glycan_dictionary_accession : GSD000141 

glytoucan_accession  : G12460DL 

term_in_sentence : The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively.[PMID: 24046920] 

publication : 29622537|26773500|24046920|6207232|8550516|6609976|6375319|817855|2428855|3312011|15364312|1937801|7729906 

definition : An amino pentasaccharide consisting of α-D-galactose, β-D-galactose N-acetyl-α-D-glucosamine, β-D-galactose, and β-D-glucose residues joined in sequence with ((1→4)-, (1→4)-, (1→3)- and (1→4)-linkages, respectively.[CHEBI:68484] 

term_xref : GlycoMotif:GGM.000069|GTC:G12460DL|CID:71296137|CHEBI:68484|SugarBind_Ligand:160  

synonyms :  

function :  

disease_associations : Shigellosis[SugarBind_Ligand:160] 

wikipedia :  

essentials_of_glycobiology : Chapter 23


GSD000142

G51699SI
term (main_entry) : Para-Forssman glycolipid 

glycan_dictionary_accession : GSD000142 

glytoucan_accession  : G51699SI 

term_in_sentence : A novel pentaglycosyl ceramide containing di-beta-N-acetylgalactos-aminyl residue (Para-Forssman glycolipid) isolated from human erythrocyte membrane. [PMID:6814203] 

publication : 6814203 

definition : GalNAcβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1→1Cer [https://doi.org/10.1016/S0040-4039(01)93814-6] 

term_xref : GlycoMotif:GGM.000085|GTC:G51699SI|CID:56836111|KEGG:G00096|SugarBind_Ligand:19|CHEBI:151565 

synonyms :  

function :  

disease_associations : Actinomycosis[SugarBind_Ligand:19] 

wikipedia : https://en.wikipedia.org/wiki/P1PK_blood_group_system 

essentials_of_glycobiology :


GSD000143

term (main_entry) : Paragloboside 

glycan_dictionary_accession : GSD000143 

glytoucan_accession  : G58896AZ 

term_in_sentence : Galactosyltransferase activities in sera of cancer patients were determined by assaying the formation of paragloboside from UDP-galactose and lactotriaosylceramide immobilized on microtiter plates by means of the enzyme-linked immunosorbent assay using a monoclonal antibody, H-11, directed to paragloboside. [PMID: [https://pubmed.ncbi.nlm.nih.gov/1551117 1551117 1551117]] 

publication : 3345524|850070|10569746|30624951|29438961|6816790|[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117 1551117]|6865961|25039255 

definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→3)-D-GalpNAc in which the configuration at the GalNAc anomeric carbon is α.[CHEBI:65257] 

term_xref : GlycoMotif:GGM.000077|GTC:G58896AZ|CID:21670519|CHEBI:65257|GlycoEpitope:EP0075|SugarBind_Ligand:15 

synonyms :  

function :  

disease_associations : Pharyngitis[SugarBind_Ligand:15]|Tracheobronchitis[SugarBind_Ligand:15]|Gonorrhea[SugarBind_Ligand:15]|Actinomycosis[SugarBind_Ligand:15]|Diarrhea[SugarBind_Ligand:15]|Hemorrhagic colitis[SugarBind_Ligand:15]|Chronic gastritis[SugarBind_Ligand:15]|Peptic ulcers[SugarBind_Ligand:15]|Gastric cancer[SugarBind_Ligand:15]|Influenza[SugarBind_Ligand:15] 

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000144

term (main_entry) : Paucimannose 

glycan_dictionary_accession : GSD000144 

glytoucan_accession  :  

term_in_sentence : The galactosylation of core fucose (GalFuc epitope) in paucimannose and complex-type N-glycans is characteristic of protostome organisms, including flatworms (planarians).[PMID:29475940] 

publication : 29475940|[https://pubmed.ncbi.nlm.nih.gov/29803109 29803109 29803109]|12603202|31817246|31719144|21057214|31932305|17132514|30382146|27731363|31325506|25746926|26513758|16522637|21169367|25190359|27928741|22496646|27384337|16897177|15228383|27379103|27189951|23475714|24907509|20558211|28060516|20441997|27720757|28817611|24550396|19494052|19515361|[https://pubmed.ncbi.nlm.nih.gov/28630087 28630087 28630087]|31320997|30651366|30253927|25922361|31655162|18056652|24467287|32367383 

definition : Any N-linked glycan derivative with composition Man1-4Fuc0-1 GlcNAc2, in which the chitobiose core (GlcNAc2) is intact. Found in relatively large amounts in invertebrates and plants, they are formed by removal of the non-reducing terminal GlcNAc (\added by GlcNAcT1) from GlcNAcMan3-5GlcNAc2 by a Golgi hexosaminidase and subsequent removal of Man residues by Golgi mannosidases. Pauscimannose glycans have also been detected in vertebrates.[CHEBI:144386] 

term_xref : CHEBI:144386 

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000145

term (main_entry) : Sd(A)/Cad 

glycan_dictionary_accession : GSD000145 

glytoucan_accession  : G41052GC 

term_in_sentence : The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2.[PMID:24112972] 

publication : 24112972|11577689|30067891|15361072 

definition : A branched amino tetrasaccharide comprised of a trisaccharide chain of N-acetyl-α-neuraminic acid, β-D-galactose and N-acetyl-β-D-glucosamine residues linked sequentially (2→3) and (1→4), to the galactose residue of which is also linked (1→4) an N-acetyl-β-L-galactosamine residue.
[CHEBI:71561] 

term_xref : GlycoMotif:GGM.000051|GTC:G41052GC|CID:70698375|CHEBI:71561  

synonyms : Sd^a /Cad 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 9


GSD000146

term (main_entry) : SDlex 

glycan_dictionary_accession : GSD000146 

glytoucan_accession  : G19619KS 

term_in_sentence : Hepatic expression of sialylated difucosyl Lex antigen (SDLex, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-) was studied with monoclonal antibody FH6, which defines this structure.[PMID: 3341453] 

publication : 30226570|3341453|12725333 

definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-5-acetamido-6-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.[CHEBI:148203] 

term_xref : GlycoMotif:GGM.000032|GTC:G19619KS|CID:91856705|CHEBI:148203  

synonyms : Sdlex|SDLe^x|SDLex 

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000147

term (main_entry) : Seminolipid 

glycan_dictionary_accession : GSD000147 

glytoucan_accession  : G72548RZ 

term_in_sentence : A concise total synthesis of seminolipid, a sulfoglycolipid, has been achieved; key features include regioselective, tin-free sulfation of allyl β-d-galactopyranoside using 2,6-bis(trifluoromethyl)phenylboronic acid as protective reagent, stereoselective epoxidation, and site-selective acylation. [PMID: 31353379] 

publication : 31353379|31736776|12810822|19582571|19542524|20670037|15659616|20817833|870059|10801776|21965315|8095813|1280685|4690236|34199863|4207869|2373957|845131 

definition :  

term_xref : GlycoMotif:GGM.000062|GTC:G72548RZ  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology : Chapter 14


GSD000148

term (main_entry) : Sialopentaosylceramide 

glycan_dictionary_accession : GSD000148 

glytoucan_accession  : G13224CR 

term_in_sentence : Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosap[PMID: 2139874] 

publication : 2139874 

definition : A ganglioside in which the oligosaccharide portion is composed of a pentasaccharide containing one or more sialic acid residues.[CHEBI:36542] 

term_xref : GlycoMotif:GGM.000097|GTC:G13224CR|CID:91859576|CHEBI:148045|KEGG:G00883|CHEBI:36542 

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000149

term (main_entry) : Sialosyl paragloboside 

glycan_dictionary_accession : GSD000149 

glytoucan_accession  : G50123ZO 

term_in_sentence : Unlike CNS myelin, human peripheral nerve myelin has the acidic glycosphingolipids sialosyl paragloboside (SPG), sialosyl lactosaminyl paragloboside (SLPG), and sulfated glucuronyl paragloboside (SGPG).[PMID:8862128] 

publication : 8862128|7236652|2370108|3133978|2905604|1749114|1573418 

definition : α-Neup5Ac-(2→3)-β-D-Galp-(1→4)-D-GlcpNAc with β configuration at the anomeric position of the reducing-end N-acetyl-D-glucosamine residue.[CHEBI:71612] 

term_xref : GlycoMotif:GGM.000081|GTC:G50123ZO|CID:91845504|KEGG:G01429|CHEBI:151914  

synonyms :  

function :  

disease_associations :  

wikipedia :  

essentials_of_glycobiology :


GSD000150

term (main_entry) : Sialyl Lewis a 

glycan_dictionary_accession : GSD000150 

glytoucan_accession  : G00053MO 

term_in_sentence : By comparing the serum O-glycan profiles from healthy controls with those of cancer patients, we identified a marker candidate, core 1 sialyl Lewis A (NeuAcα2-3Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal) (abbreviated C1SLA), whose concentration appeared to be weakly correlated with CA19-9 values.[PMID:[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]] 

publication : [https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]|31424423|26530370|17760270|18343410|16033091|8829184|11907351|20592391|[https://pubmed.ncbi.nlm.nih.gov/26641888 26641888 26641888]|24128856|30249386|10773785|16149606|10996727|10436809|10667238|7720892|7630017|10612415|9836451|12511721|22623153 

definition : A sialyated version of Lewis A with a branched structure of amino tetrasaccharide consisting of a sialyl residue, linked (2→3) to a galactosyl residue that in turn is linked (1→3) to a glucosaminyl residue at the reducing end, which is also carrying a fucosyl residue at the 4-position.[CHEBI:62681] 

term_xref : GTC:G00053MO|GlycoEpitope:EP0008|CID:53356732|CHEBI:62681|GlycoMotif:GGM.000024 

synonyms : SLea|CA19-9|CA19-9 antigen|SLe^a|Slea 

function : The carbohydrate determinants,Sialyl Lea and Sialyl Lex,which are frequently expressed on human cancer cells,serve as ligands for a cell adhesion molecule of the selectin family,E-selectin,which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0008] 

disease_associations : pancreatic adenocarcinoma[GlycoEpitope:EP0008]|hepatocellular cancer[GlycoEpitope:EP0008]|cholangiocellular cancer[GlycoEpitope:EP0008]|gastric cancer|[GlycoEpitope:EP0008]colorectal cancer[GlycoEpitope:EP0008]|ovarian cancer[GlycoEpitope:EP0008]|lung cancer[GlycoEpitope:EP0008]|breast cancer[GlycoEpitope:EP0008]|uterine cancer[GlycoEpitope:EP0008] 

wikipedia :  

essentials_of_glycobiology :
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