Testhyperlink123: Difference between revisions

Revision as of 19:27, 7 April 2023

Lewis a

term (main_entry) : Lewis a 

glycan_dictionary_accession : GSD000119 

glytoucan_accession  : G00047MO 

term_in_sentence : Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). [PMID:29367698] 

publication : 29367698|27187324|30562693|27646625|26911286|30225822|28600306|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|11064310|23809433|30050155|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|1675497|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|27705835|7593252|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|17630273|9350993|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001] 

definition : A lewis blood group antigen with structure beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcpNAc consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an alpha-linkage and a galactosyl residue attached at the 3-position via a beta-linkage. It has a role as an epitope and an antigen. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:62265] 

term_xref : GTC:G00047MO|CID:22806751|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155 

synonyms : Le(a)|Lea-3|Lea|Le^a 

function :  

disease_associations : Gastroenteritis[SugarBind_Ligand:155] 

wikipedia : https://www.wikidata.org/wiki/Q50687009 

essentials_of_glycobiology :

Lewis b

term (main_entry) : Lewis b 

glycan_dictionary_accession : GSD000120 

glytoucan_accession  : G39211DH 

term_in_sentence : Human mannose-binding lectin preferentially binds to human colon adenocarcinoma cell lines expressing high amount of Lewis A and Lewis B antigens.[PMID:10328552] 

publication : 10328552|23408949|31927399|26601230|28279343|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|30831115|27318698|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|23828675|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|25516619|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|8509439|19832116|15270746|3166398|30909206|7718581|18400963|29751628|8982241|30284922|24576035|30974776|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001]|31768613|1651804|25428879|15946883|30298790|30544260|29197783|8632739|7679772|18666312|20231766|29922666|95124|2247887|21519121|25153235|28751211 

definition :  

term_xref : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:45480568|CHEBI:59440 

synonyms : Le(b)|Lewis(b)|Le^b 

function : possible receptor for Helicobacter pylori[https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/blood-group-lewis-system] 

disease_associations : Gastroenteritis[SugarBind_Ligand:146] 

wikipedia :  

essentials_of_glycobiology :

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-===Heparan sulfate===
- '''term (main_entry)''' : Heparan sulfate <br>
- '''glycan_dictionary_accession''' : GSD000106 <br>
- '''glytoucan_accession ''' :  <br>
- '''term_in_sentence''' : In Niemann-Pick C-1 fibroblasts, where deaminative degradation of heparan sulfate is defective, carbonylated proteins were abundant.[PMID: 17540770] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/32266657 32266657]|[https://pubmed.ncbi.nlm.nih.gov/29554552 29554552]|[https://pubmed.ncbi.nlm.nih.gov/29032302 29032302]|[https://pubmed.ncbi.nlm.nih.gov/30003471 30003471]|[https://pubmed.ncbi.nlm.nih.gov/25197032 25197032]|[https://pubmed.ncbi.nlm.nih.gov/28538085 28538085]|[https://pubmed.ncbi.nlm.nih.gov/26236728 26236728]|[https://pubmed.ncbi.nlm.nih.gov/16917509 16917509]|[https://pubmed.ncbi.nlm.nih.gov/22899865 22899865]|[https://pubmed.ncbi.nlm.nih.gov/17080204 17080204]|[https://pubmed.ncbi.nlm.nih.gov/23042481 23042481]|[https://pubmed.ncbi.nlm.nih.gov/28982096 28982096]|[https://pubmed.ncbi.nlm.nih.gov/24146040 24146040]|[https://pubmed.ncbi.nlm.nih.gov/25081076 25081076]|[https://pubmed.ncbi.nlm.nih.gov/15719168 15719168]|[https://pubmed.ncbi.nlm.nih.gov/17453622 17453622]|[https://pubmed.ncbi.nlm.nih.gov/25325954 25325954]|[https://pubmed.ncbi.nlm.nih.gov/21110089 21110089]|[https://pubmed.ncbi.nlm.nih.gov/29797526 29797526]|[https://pubmed.ncbi.nlm.nih.gov/21967329 21967329]|[https://pubmed.ncbi.nlm.nih.gov/23313092 23313092]|[https://pubmed.ncbi.nlm.nih.gov/11212344 11212344]|[https://pubmed.ncbi.nlm.nih.gov/28465034 28465034]|[https://pubmed.ncbi.nlm.nih.gov/11746174 11746174]|[https://pubmed.ncbi.nlm.nih.gov/12512855 12512855]|[https://pubmed.ncbi.nlm.nih.gov/8836040 8836040]|[https://pubmed.ncbi.nlm.nih.gov/28394734 28394734]|[https://pubmed.ncbi.nlm.nih.gov/24182748 24182748]|[https://pubmed.ncbi.nlm.nih.gov/28264929 28264929]|[https://pubmed.ncbi.nlm.nih.gov/28745308 28745308]|[https://pubmed.ncbi.nlm.nih.gov/26555370 26555370]|[https://pubmed.ncbi.nlm.nih.gov/14718374 14718374]|[https://pubmed.ncbi.nlm.nih.gov/16767693 16767693]|[https://pubmed.ncbi.nlm.nih.gov/25246018 25246018]|[https://pubmed.ncbi.nlm.nih.gov/19584012 19584012]|[https://pubmed.ncbi.nlm.nih.gov/8274190 8274190]|[https://pubmed.ncbi.nlm.nih.gov/25034023 25034023]|[https://pubmed.ncbi.nlm.nih.gov/8370471 8370471]|[https://pubmed.ncbi.nlm.nih.gov/26571620 26571620]|[https://pubmed.ncbi.nlm.nih.gov/29920400 29920400]|[https://pubmed.ncbi.nlm.nih.gov/31731076 31731076]|[https://pubmed.ncbi.nlm.nih.gov/20816205 20816205]|[https://pubmed.ncbi.nlm.nih.gov/16880267 16880267]|[https://pubmed.ncbi.nlm.nih.gov/31547957 31547957]|[https://pubmed.ncbi.nlm.nih.gov/11457867 11457867]|[https://pubmed.ncbi.nlm.nih.gov/27241222 27241222]|[https://pubmed.ncbi.nlm.nih.gov/28718936 28718936]|[https://pubmed.ncbi.nlm.nih.gov/21204109 21204109]|[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]|[https://pubmed.ncbi.nlm.nih.gov/11166215 11166215]|[https://pubmed.ncbi.nlm.nih.gov/11457866 11457866] <br>
- '''definition''' : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815] <br>
- '''term_xref''' : CHEBI:28815|CID: 53477715|GlycoEpitope: EP0086 <br>
- '''synonyms''' : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate <br>
- '''function''' : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[GlycoEpitope: EP0086] <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>
-===Heparin===
- '''term (main_entry)''' : Heparin <br>
- '''glycan_dictionary_accession''' : GSD000107 <br>
- '''glytoucan_accession ''' :  <br>
- '''term_in_sentence''' : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:[https://pubmed.ncbi.nlm.nih.gov/6416324 6416324]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27100512 27100512]|[https://pubmed.ncbi.nlm.nih.gov/22566218 22566218]|[https://pubmed.ncbi.nlm.nih.gov/27264866 27264866]|[https://pubmed.ncbi.nlm.nih.gov/30094590 30094590]|[https://pubmed.ncbi.nlm.nih.gov/31077659 31077659]|[https://pubmed.ncbi.nlm.nih.gov/26975675 26975675]|[https://pubmed.ncbi.nlm.nih.gov/2083874 2083874]|[https://pubmed.ncbi.nlm.nih.gov/25088334 25088334]|[https://pubmed.ncbi.nlm.nih.gov/3333067 3333067]|[https://pubmed.ncbi.nlm.nih.gov/2191809 2191809]|[https://pubmed.ncbi.nlm.nih.gov/28118750 28118750]|[https://pubmed.ncbi.nlm.nih.gov/28224913 28224913]|[https://pubmed.ncbi.nlm.nih.gov/22495506 22495506]|[https://pubmed.ncbi.nlm.nih.gov/29385025 29385025]|[https://pubmed.ncbi.nlm.nih.gov/10332503 10332503]|[https://pubmed.ncbi.nlm.nih.gov/22393937 22393937]|[https://pubmed.ncbi.nlm.nih.gov/19947315 19947315]|[https://pubmed.ncbi.nlm.nih.gov/27655335 27655335]|[https://pubmed.ncbi.nlm.nih.gov/14529394 14529394]|[https://pubmed.ncbi.nlm.nih.gov/2419035 2419035]|[https://pubmed.ncbi.nlm.nih.gov/22048616 22048616]|[https://pubmed.ncbi.nlm.nih.gov/23849978 23849978]|[https://pubmed.ncbi.nlm.nih.gov/10204652 10204652]|[https://pubmed.ncbi.nlm.nih.gov/28958760 28958760]|[https://pubmed.ncbi.nlm.nih.gov/12627673 12627673]|[https://pubmed.ncbi.nlm.nih.gov/9042555 9042555]|[https://pubmed.ncbi.nlm.nih.gov/15639107 15639107]|[https://pubmed.ncbi.nlm.nih.gov/28880550 28880550]|[https://pubmed.ncbi.nlm.nih.gov/27238483 27238483]|[https://pubmed.ncbi.nlm.nih.gov/1964668 1964668]|[https://pubmed.ncbi.nlm.nih.gov/16716101 16716101]|[https://pubmed.ncbi.nlm.nih.gov/10796377 10796377]|[https://pubmed.ncbi.nlm.nih.gov/25981976 25981976]|[https://pubmed.ncbi.nlm.nih.gov/24680753 24680753]|[https://pubmed.ncbi.nlm.nih.gov/2191118 2191118]|[https://pubmed.ncbi.nlm.nih.gov/21166465 21166465]|[https://pubmed.ncbi.nlm.nih.gov/30582884 30582884]|[https://pubmed.ncbi.nlm.nih.gov/1322434 1322434]|[https://pubmed.ncbi.nlm.nih.gov/15330727 15330727]|[https://pubmed.ncbi.nlm.nih.gov/9752370 9752370]|[https://pubmed.ncbi.nlm.nih.gov/6416324 6416324]|[https://pubmed.ncbi.nlm.nih.gov/14996629 14996629]|[https://pubmed.ncbi.nlm.nih.gov/20452241 20452241]|[https://pubmed.ncbi.nlm.nih.gov/1340407 1340407]|[https://pubmed.ncbi.nlm.nih.gov/29050610 29050610]|[https://pubmed.ncbi.nlm.nih.gov/345399 345399]|[https://pubmed.ncbi.nlm.nih.gov/6916469 6916469]|[https://pubmed.ncbi.nlm.nih.gov/6565376 6565376]|[https://pubmed.ncbi.nlm.nih.gov/26714061 26714061] <br>
- '''definition''' : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304] <br>
- '''term_xref''' : CID:772|CHEBI:28304 <br>
- '''synonyms''' : bemiparin|bemiparin|certoparin|Cy 222|enoxaparin|fluxum|Heparin|Heparinic acid|parnaparin|reviparin|sandoparin <br>
- '''function''' :  <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' :  <br>
-===Heparan sulfate/heparin===
- '''term (main_entry)''' : Heparan sulfate/heparin<br>
- '''glycan_dictionary_accession''' : GSD000185<br>
- '''glytoucan_accession ''' : <br>
- '''term_in_sentence''' : Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. [PMID:[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]]<br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/23313092 23313092]|[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]|[https://pubmed.ncbi.nlm.nih.gov/23152789 23152789]<br>
- '''definition''' : <br>
- '''term_xref''' : <br>
- '''synonyms''' :  HS/heparin|heparan sufate (HS)/heparin|H/HS<br>
- '''function''' : <br>
- '''disease_associations''' : <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' :  <br>
-===High mannose===
-[[File:G55220VL.png|thumb|G55220VL]]
- '''term (main_entry)''' : High mannose <br>
- '''glycan_dictionary_accession''' : GSD000108 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G55220VL G55220VL] <br>
- '''term_in_sentence''' : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:[https://pubmed.ncbi.nlm.nih.gov/11258925 11258925]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/11258925 11258925]|[https://pubmed.ncbi.nlm.nih.gov/17956937 17956937]|[https://pubmed.ncbi.nlm.nih.gov/2059624 2059624]|[https://pubmed.ncbi.nlm.nih.gov/2065054 2065054]|[https://pubmed.ncbi.nlm.nih.gov/26791533 26791533]|[https://pubmed.ncbi.nlm.nih.gov/4077844 4077844]|[https://pubmed.ncbi.nlm.nih.gov/7780197 7780197]|[https://pubmed.ncbi.nlm.nih.gov/9136890 9136890]|[https://pubmed.ncbi.nlm.nih.gov/30659065 30659065]|[https://pubmed.ncbi.nlm.nih.gov/30075362 30075362]|[https://pubmed.ncbi.nlm.nih.gov/21421994 21421994]|[https://pubmed.ncbi.nlm.nih.gov/31076349 31076349]|[https://pubmed.ncbi.nlm.nih.gov/29738673 29738673]|[https://pubmed.ncbi.nlm.nih.gov/29508223 29508223]|[https://pubmed.ncbi.nlm.nih.gov/26747427 26747427]|[https://pubmed.ncbi.nlm.nih.gov/30634645 30634645]|[https://pubmed.ncbi.nlm.nih.gov/23007868 23007868]|[https://pubmed.ncbi.nlm.nih.gov/29051951 29051951]|[https://pubmed.ncbi.nlm.nih.gov/24549150 24549150]|[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]|[https://pubmed.ncbi.nlm.nih.gov/26724786 26724786]|[https://pubmed.ncbi.nlm.nih.gov/26956389 26956389]|[https://pubmed.ncbi.nlm.nih.gov/26493153 26493153]|[https://pubmed.ncbi.nlm.nih.gov/31102532 31102532]|[https://pubmed.ncbi.nlm.nih.gov/29673624 29673624]|[https://pubmed.ncbi.nlm.nih.gov/8348230 8348230]|[https://pubmed.ncbi.nlm.nih.gov/25586968 25586968]|[https://pubmed.ncbi.nlm.nih.gov/24975601 24975601]|[https://pubmed.ncbi.nlm.nih.gov/29803109 29803109]|[https://pubmed.ncbi.nlm.nih.gov/28465212 28465212]|[https://pubmed.ncbi.nlm.nih.gov/25776945 25776945]|[https://pubmed.ncbi.nlm.nih.gov/30151520 30151520]|[https://pubmed.ncbi.nlm.nih.gov/21097542 21097542]|[https://pubmed.ncbi.nlm.nih.gov/24326091 24326091]|[https://pubmed.ncbi.nlm.nih.gov/27995699 27995699]|[https://pubmed.ncbi.nlm.nih.gov/26003537 26003537]|[https://pubmed.ncbi.nlm.nih.gov/6722291 6722291]|[https://pubmed.ncbi.nlm.nih.gov/2925680 2925680]|[https://pubmed.ncbi.nlm.nih.gov/25565276 25565276]|[https://pubmed.ncbi.nlm.nih.gov/21460211 21460211]|[https://pubmed.ncbi.nlm.nih.gov/25196214 25196214]|[https://pubmed.ncbi.nlm.nih.gov/27387600 27387600]|[https://pubmed.ncbi.nlm.nih.gov/22373601 22373601]|[https://pubmed.ncbi.nlm.nih.gov/3729933 3729933]|[https://pubmed.ncbi.nlm.nih.gov/16423983 16423983]|[https://pubmed.ncbi.nlm.nih.gov/24174266 24174266]|[https://pubmed.ncbi.nlm.nih.gov/30605318 30605318]|[https://pubmed.ncbi.nlm.nih.gov/32371950 32371950]<br>
- '''definition''' : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man . <br>
- '''term_xref''' : GTC:G55220VL|CID:70698382|CHEBI:71514<br>
- '''synonyms''' : oligomannose, high-mannose, oligomannose-type <br>
- '''function''' : Involved in promotion of protein folding in ER. [PMID:[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205] <br>
- '''disease_associations''' : Relative abundance changes in multiple CDGs [PMID: 30770376][PMID: 28484880] <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17] <br>
-===HNK-1===
-[[File:G54406UD.png|thumb|G54406UD]]
- '''term (main_entry)''' : HNK-1 <br>
- '''glycan_dictionary_accession''' : GSD000109 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G54406UD G54406UD] <br>
- '''term_in_sentence''' : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:[https://pubmed.ncbi.nlm.nih.gov/28709864 28709864]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28709864 28709864]|[https://pubmed.ncbi.nlm.nih.gov/31738061 31738061]|[https://pubmed.ncbi.nlm.nih.gov/26738850 26738850]|[https://pubmed.ncbi.nlm.nih.gov/30306736 30306736]|[https://pubmed.ncbi.nlm.nih.gov/11070366 11070366]|[https://pubmed.ncbi.nlm.nih.gov/20855890 20855890]|[https://pubmed.ncbi.nlm.nih.gov/18024472 18024472]|[https://pubmed.ncbi.nlm.nih.gov/22669261 22669261]|[https://pubmed.ncbi.nlm.nih.gov/19729452 19729452]|[https://pubmed.ncbi.nlm.nih.gov/19796667 19796667]|[https://pubmed.ncbi.nlm.nih.gov/26850637 26850637]|[https://pubmed.ncbi.nlm.nih.gov/11769463 11769463]|[https://pubmed.ncbi.nlm.nih.gov/18263654 18263654]|[https://pubmed.ncbi.nlm.nih.gov/15843379 15843379]|[https://pubmed.ncbi.nlm.nih.gov/26659409 26659409]|[https://pubmed.ncbi.nlm.nih.gov/9003039 9003039]|[https://pubmed.ncbi.nlm.nih.gov/22087768 22087768]|[https://pubmed.ncbi.nlm.nih.gov/21771787 21771787]|[https://pubmed.ncbi.nlm.nih.gov/15173636 15173636]|[https://pubmed.ncbi.nlm.nih.gov/9210489 9210489]|[https://pubmed.ncbi.nlm.nih.gov/15258996 15258996]|[https://pubmed.ncbi.nlm.nih.gov/17924534 17924534]|[https://pubmed.ncbi.nlm.nih.gov/26382082 26382082]|[https://pubmed.ncbi.nlm.nih.gov/16171882 16171882]|[https://pubmed.ncbi.nlm.nih.gov/18802400 18802400]|[https://pubmed.ncbi.nlm.nih.gov/9800516 9800516]|[https://pubmed.ncbi.nlm.nih.gov/7504418 7504418]|[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229]|[https://pubmed.ncbi.nlm.nih.gov/15232286 15232286]|[https://pubmed.ncbi.nlm.nih.gov/9013478 9013478]|[https://pubmed.ncbi.nlm.nih.gov/21621858 21621858]|[https://pubmed.ncbi.nlm.nih.gov/11677051 11677051]|[https://pubmed.ncbi.nlm.nih.gov/18668221 18668221]|[https://pubmed.ncbi.nlm.nih.gov/11414798 11414798]|[https://pubmed.ncbi.nlm.nih.gov/19265195 19265195]|[https://pubmed.ncbi.nlm.nih.gov/8982638 8982638]|[https://pubmed.ncbi.nlm.nih.gov/8798480 8798480]|[https://pubmed.ncbi.nlm.nih.gov/28403522 28403522]|[https://pubmed.ncbi.nlm.nih.gov/17935701 17935701]|[https://pubmed.ncbi.nlm.nih.gov/1691305 1691305]|[https://pubmed.ncbi.nlm.nih.gov/10998116 10998116]|[https://pubmed.ncbi.nlm.nih.gov/9364602 9364602]|[https://pubmed.ncbi.nlm.nih.gov/7528651 7528651]|[https://pubmed.ncbi.nlm.nih.gov/12472892 12472892]|[https://pubmed.ncbi.nlm.nih.gov/21176892 21176892]|[https://pubmed.ncbi.nlm.nih.gov/28416698 28416698]|[https://pubmed.ncbi.nlm.nih.gov/19389918 19389918]|[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937]|[https://pubmed.ncbi.nlm.nih.gov/25450311 25450311] <br>
- '''definition''' : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322] <br>
- '''term_xref''' : GTC:G54406UD|GlycoEpitope:EP0001|CID:46906103|CHEBI:60322|GlycoMotif:GGM.000058 <br>
- '''synonyms''' : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen <br>
- '''function''' : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001] <br>
- '''disease_associations''' : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001] <br>
- '''wikipedia''' : https://en.wikipedia.org/wiki/N-linked_glycosylation <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17]<br>
-===Hybrid===
-[[File:G16828VN.png|thumb|G16828VN]]
- '''term (main_entry)''' : Hybrid <br>
- '''glycan_dictionary_accession''' : GSD000110 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G16828VN G16828VN] <br>
- '''term_in_sentence''' : A hybrid-type N-glycan was accessed by total synthesis, converted to an oxazoline, and used as a donor substrate with both wild type Endo M and an N175Q glycosynthase Endo M mutant allowing the convergent synthesis of a glycosylated amino acid bearing a hybrid N-glycan structure. [PMID:[https://pubmed.ncbi.nlm.nih.gov/27058295 27058295]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27058295 27058295]|[https://pubmed.ncbi.nlm.nih.gov/15044398 15044398]|[https://pubmed.ncbi.nlm.nih.gov/28714086 28714086]|[https://pubmed.ncbi.nlm.nih.gov/29578688 29578688]|[https://pubmed.ncbi.nlm.nih.gov/26999365 26999365] <br>
- '''definition''' : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1–Asn-X-Ser/Thr is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the α-linked Man residue.[Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]] <br>
- '''term_xref''' : GTC:G16828VN|CID:91847108|CHEBI:147471 <br>
- '''synonyms''' :  <br>
- '''function''' :  <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]<br>
-===Hyaluronan===
-[[File:G29086KO.png|thumb|G29086KO]]
- '''term (main_entry)''' : Hyaluronan<br>
- '''glycan_dictionary_accession''' : GSD000183<br>
- '''glytoucan_accession ''' : [https://glygen.org/glycan/G29086KO G29086KO]<br>
- '''term_in_sentence''' : Hyaluronan (HA) comprises a major component of the extracellular matrix (ECM) in vertebrate connective tissues and is abundant in the cartilage, skin, brain, vitreous body, umbilical cord, and synovial fluid. [PMID:33171800]<br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/33171800 33171800]|[https://pubmed.ncbi.nlm.nih.gov/34209222 34209222]<br>
- '''definition''' : <br>
- '''term_xref''' : GTC:[https://glygen.org/glycan/G29086KO G29086KO]<br>
- '''synonyms''' :  HA<br>
- '''function''' : <br>
- '''disease_associations''' : <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' :
-===i antigen===
-[[File:G00058MO.png|thumb|G00058MO]]
-[[File:G46055MA.png|thumb|G46055MA]]
- '''term (main_entry)''' : i antigen <br>
- '''glycan_dictionary_accession''' : GSD000111 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00058MO G00058MO]|[https://www.glygen.org/glycan/G46055MA G46055MA] <br>
- '''term_in_sentence''' : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]|[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]| [https://pubmed.ncbi.nlm.nih.gov/21912254 21912254]|[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428]|[https://pubmed.ncbi.nlm.nih.gov/28508465 28508465]|[https://pubmed.ncbi.nlm.nih.gov/6203982 6203982]|[https://pubmed.ncbi.nlm.nih.gov/30728302 30728302]|[https://pubmed.ncbi.nlm.nih.gov/8449405 8449405]|[https://pubmed.ncbi.nlm.nih.gov/9122902 9122902]|[https://pubmed.ncbi.nlm.nih.gov/10360315 10360315]|[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787]|[https://pubmed.ncbi.nlm.nih.gov/6183759 6183759]|[https://pubmed.ncbi.nlm.nih.gov/518539 518539]|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951]|[https://pubmed.ncbi.nlm.nih.gov/21933024 21933024] <br>
- '''definition''' :  <br>
- '''term_xref''' : GlycoMotif:GGM.000004|GlycoMotif:GGM.000002|GTC:G46055MA|GTC:G00058MO <br>
- '''synonyms''' : Type 2 LN2 <br>
- '''function''' :  <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' :  <br>
-===I antigen===
-[[File:G56045WU.png|thumb|G56045WU]]
- '''term (main_entry)''' : I antigen <br>
- '''glycan_dictionary_accession''' : GSD000112 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G56045WU G56045WU] <br>
- '''term_in_sentence''' : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID:[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]|[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254]|[https://pubmed.ncbi.nlm.nih.gov/30705292 30705292]|[https://pubmed.ncbi.nlm.nih.gov/33403394 33403394]|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951]| [https://pubmed.ncbi.nlm.nih.gov/12468428 12468428]|[https://pubmed.ncbi.nlm.nih.gov/6088627 6088627]| [https://pubmed.ncbi.nlm.nih.gov/6159787 6159787] <br>
- '''definition''' : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390] <br>
- '''term_xref''' : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:91852915|CHEBI:151390<br>
- '''synonyms''' :  <br>
- '''function''' :  <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]<br>
-===Isoglobotetraosylceramide===
- '''term (main_entry)''' : Isoglobotetraosylceramide <br>
- '''glycan_dictionary_accession''' : GSD000113 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G57710SU G57710SU] <br>
- '''term_in_sentence''' : Furthermore, isoglobotetraosylceramide seems to play a direct role in the metastatic process since the blocking of exposed antigen with monoclonal antibodies, or their Fab fragments, results in a highly significant decrease in lung colony formation.[PMID:[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/1396705 1396705]|[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]|[https://pubmed.ncbi.nlm.nih.gov/2713378 2713378]|[https://pubmed.ncbi.nlm.nih.gov/3489485 3489485]|[https://pubmed.ncbi.nlm.nih.gov/18997175 18997175]|[https://pubmed.ncbi.nlm.nih.gov/7053385 7053385]|[https://pubmed.ncbi.nlm.nih.gov/3379797 3379797]|[https://pubmed.ncbi.nlm.nih.gov/2465279 2465279]|[https://pubmed.ncbi.nlm.nih.gov/3743633 3743633]|[https://pubmed.ncbi.nlm.nih.gov/11479210 11479210] <br>
- '''definition''' :  <br>
- '''term_xref''' : GlycoMotif:GGM.000071|GTC:G57710SU|CID: 91849719|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17 <br>
- '''synonyms''' :  <br>
- '''function''' : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]] <br>
- '''disease_associations''' : Actinomycosis[SugarBind_Ligand:17] <br>
- '''wikipedia''' : https://en.wikipedia.org/wiki/Ii_antigen_system <br>
- '''essentials_of_glycobiology''' :  <br>
-===Keratan sulfate===
-[[File:G82109MW.png|thumb|G82109MW]]
- '''term (main_entry)''' : Keratan sulfate <br>
- '''glycan_dictionary_accession''' : GSD000114 <br>
- '''glytoucan_accession ''' :  [https://www.glygen.org/glycan/G82109MW G82109MW] <br>
- '''term_in_sentence''' : Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties.[PMID: [https://pubmed.ncbi.nlm.nih.gov/30578672 30578672]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29340594 29340594]|[https://pubmed.ncbi.nlm.nih.gov/30578672 30578672]|[https://pubmed.ncbi.nlm.nih.gov/12512857 12512857]|[https://pubmed.ncbi.nlm.nih.gov/29625490 29625490]|[https://pubmed.ncbi.nlm.nih.gov/25325967 25325967]|[https://pubmed.ncbi.nlm.nih.gov/30025865 30025865]|[https://pubmed.ncbi.nlm.nih.gov/29924315 29924315]|[https://pubmed.ncbi.nlm.nih.gov/9549787 9549787]|[https://pubmed.ncbi.nlm.nih.gov/11030741 11030741]|[https://pubmed.ncbi.nlm.nih.gov/28078490 28078490]|[https://pubmed.ncbi.nlm.nih.gov/8298243 8298243]|[https://pubmed.ncbi.nlm.nih.gov/29096187 29096187]|[https://pubmed.ncbi.nlm.nih.gov/30059256 30059256]|[https://pubmed.ncbi.nlm.nih.gov/26958998 26958998]|[https://pubmed.ncbi.nlm.nih.gov/26773479 26773479]|[https://pubmed.ncbi.nlm.nih.gov/22840010 22840010]|[https://pubmed.ncbi.nlm.nih.gov/15597951 15597951]|[https://pubmed.ncbi.nlm.nih.gov/28110685 28110685]|[https://pubmed.ncbi.nlm.nih.gov/28535934 28535934]|[https://pubmed.ncbi.nlm.nih.gov/2942429 2942429]|[https://pubmed.ncbi.nlm.nih.gov/18234072 18234072]|[https://pubmed.ncbi.nlm.nih.gov/8641829 8641829]|[https://pubmed.ncbi.nlm.nih.gov/8940154 8940154]|[https://pubmed.ncbi.nlm.nih.gov/2027120 2027120]|[https://pubmed.ncbi.nlm.nih.gov/30849116 30849116]|41589|[https://pubmed.ncbi.nlm.nih.gov/6238957 6238957]|[https://pubmed.ncbi.nlm.nih.gov/1907283 1907283]|[https://pubmed.ncbi.nlm.nih.gov/7722002 7722002]|[https://pubmed.ncbi.nlm.nih.gov/29275050 29275050]|[https://pubmed.ncbi.nlm.nih.gov/24274541 24274541]|[https://pubmed.ncbi.nlm.nih.gov/2527236 2527236]|[https://pubmed.ncbi.nlm.nih.gov/1731862 1731862]|[https://pubmed.ncbi.nlm.nih.gov/8991509 8991509]|[https://pubmed.ncbi.nlm.nih.gov/24291704 24291704]|[https://pubmed.ncbi.nlm.nih.gov/10517185 10517185]|[https://pubmed.ncbi.nlm.nih.gov/6451953 6451953]|[https://pubmed.ncbi.nlm.nih.gov/7688312 7688312]|[https://pubmed.ncbi.nlm.nih.gov/8663590 8663590]|139406|[https://pubmed.ncbi.nlm.nih.gov/25770829 25770829]|[https://pubmed.ncbi.nlm.nih.gov/25036480 25036480]|[https://pubmed.ncbi.nlm.nih.gov/9275006 9275006]|[https://pubmed.ncbi.nlm.nih.gov/25179279 25179279]|[https://pubmed.ncbi.nlm.nih.gov/32627425 32627425]|[https://pubmed.ncbi.nlm.nih.gov/26903438 26903438]|[https://pubmed.ncbi.nlm.nih.gov/27941632 27941632]|[https://pubmed.ncbi.nlm.nih.gov/12807022 12807022]|[https://pubmed.ncbi.nlm.nih.gov/32266652 32266652]|[https://pubmed.ncbi.nlm.nih.gov/21624346 21624346] <br>
- '''definition''' : A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions.[CHEBI:60924] <br>
- '''term_xref''' : CHEBI:60924|CID:446715|GlycoEpitope: EP0085|GTC: G82109MW <br>
- '''synonyms''' : keratan| Kerato sulphate|Kerato sulfate|Keratan sulphate|kerato 6'-sulfate|keratan 6'-sulfate|Kerato 6'-sulphate|Keratan 6'-sulphate <br>
- '''function''' : Tissue hydration.[PMID: [https://pubmed.ncbi.nlm.nih.gov/11030741 11030741]] <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' :  <br>
-===LacdiNac===
-[[File:G31736BK.png|thumb|G31736BK]]
- '''term (main_entry)''' : LacdiNac <br>
- '''glycan_dictionary_accession''' : GSD000115 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G31736BK G31736BK] <br>
- '''term_in_sentence''' : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:[https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]|[https://pubmed.ncbi.nlm.nih.gov/31711843 31711843]|[https://pubmed.ncbi.nlm.nih.gov/31145522 31145522]|[https://pubmed.ncbi.nlm.nih.gov/27601469 27601469]|[https://pubmed.ncbi.nlm.nih.gov/30669833 30669833]|[https://pubmed.ncbi.nlm.nih.gov/25210040 25210040]|[https://pubmed.ncbi.nlm.nih.gov/24633693 24633693]|[https://pubmed.ncbi.nlm.nih.gov/24755437 24755437]|[https://pubmed.ncbi.nlm.nih.gov/22653491 22653491]|[https://pubmed.ncbi.nlm.nih.gov/30898876 30898876]|[https://pubmed.ncbi.nlm.nih.gov/7758724 7758724]|[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328]|[https://pubmed.ncbi.nlm.nih.gov/21305673 21305673]|[https://pubmed.ncbi.nlm.nih.gov/31558607 31558607]|[https://pubmed.ncbi.nlm.nih.gov/31271862 31271862]|[https://pubmed.ncbi.nlm.nih.gov/28549117 28549117]|[https://pubmed.ncbi.nlm.nih.gov/26213980 26213980]|[https://pubmed.ncbi.nlm.nih.gov/9134425 9134425]|[https://pubmed.ncbi.nlm.nih.gov/25561735 25561735]|[https://pubmed.ncbi.nlm.nih.gov/31756927 31756927]|[https://pubmed.ncbi.nlm.nih.gov/31170332 31170332]|[https://pubmed.ncbi.nlm.nih.gov/16282603 16282603]|[https://pubmed.ncbi.nlm.nih.gov/15265923 15265923]|[https://pubmed.ncbi.nlm.nih.gov/32267274 32267274]|[https://pubmed.ncbi.nlm.nih.gov/23015818 23015818]|[https://pubmed.ncbi.nlm.nih.gov/32676595 32676595]|[https://pubmed.ncbi.nlm.nih.gov/16728562 16728562]|[https://pubmed.ncbi.nlm.nih.gov/10814702 10814702]|[https://pubmed.ncbi.nlm.nih.gov/9591048 9591048]|[https://pubmed.ncbi.nlm.nih.gov/22245701 22245701]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628] [https://pubmed.ncbi.nlm.nih.gov/29751628 29751628]]|[https://pubmed.ncbi.nlm.nih.gov/22997242 22997242]|[https://pubmed.ncbi.nlm.nih.gov/15535969 15535969]|[https://pubmed.ncbi.nlm.nih.gov/31911241 31911241]|[https://pubmed.ncbi.nlm.nih.gov/30622255 30622255]|[https://pubmed.ncbi.nlm.nih.gov/29888905 29888905]|[https://pubmed.ncbi.nlm.nih.gov/30236114 30236114]| [https://pubmed.ncbi.nlm.nih.gov/30298790 30298790]|[https://pubmed.ncbi.nlm.nih.gov/29373511 29373511]|[https://pubmed.ncbi.nlm.nih.gov/22298779 22298779]|[https://pubmed.ncbi.nlm.nih.gov/19179461 19179461]|[https://pubmed.ncbi.nlm.nih.gov/31606752 31606752]|[https://pubmed.ncbi.nlm.nih.gov/15653684 15653684]|[https://pubmed.ncbi.nlm.nih.gov/16403022 16403022]|[https://pubmed.ncbi.nlm.nih.gov/11162373 11162373]|[https://pubmed.ncbi.nlm.nih.gov/32005658 32005658]|[https://pubmed.ncbi.nlm.nih.gov/30529570 30529570] <br>
- '''definition''' : An amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a β-linkage.[CHEBI:61190] <br>
- '''term_xref''' : GTC:G31736BK|GlycoEpitope:P0150|CID:25257164 25257164|CHEBI:61190|GlycoMotif:GGM.000016  <br>
- '''synonyms''' : LDN <br>
- '''function''' : Has a role of epitope.[CHEBI:61190] <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' :  <br>
-===Lactosylceramide===
-[[File:G84224TW.png|thumb|G84224TW]]
- '''term (main_entry)''' : Lactosylceramide <br>
- '''glycan_dictionary_accession''' : GSD000116 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G84224TW G84224TW] <br>
- '''term_in_sentence''' : In the 1970s, a neutral glycosphingolipid lactosylceramide (LacCer) was found to bind specifically to several kinds of microorganisms.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30175814 30175814]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/30175814 30175814]|[https://pubmed.ncbi.nlm.nih.gov/26900161 26900161]|[https://pubmed.ncbi.nlm.nih.gov/30502090 30502090]|[https://pubmed.ncbi.nlm.nih.gov/29624959 29624959]|[https://pubmed.ncbi.nlm.nih.gov/28444900 28444900]|[https://pubmed.ncbi.nlm.nih.gov/25408340 25408340]|[https://pubmed.ncbi.nlm.nih.gov/31801289 31801289]|[https://pubmed.ncbi.nlm.nih.gov/29099167 29099167]|[https://pubmed.ncbi.nlm.nih.gov/25595946 25595946]|[https://pubmed.ncbi.nlm.nih.gov/32592089 32592089]|[https://pubmed.ncbi.nlm.nih.gov/27729551 27729551]|[https://pubmed.ncbi.nlm.nih.gov/24658420 24658420]|[https://pubmed.ncbi.nlm.nih.gov/25216636 25216636]|[https://pubmed.ncbi.nlm.nih.gov/25638276 25638276]|[https://pubmed.ncbi.nlm.nih.gov/9499377 9499377]|[https://pubmed.ncbi.nlm.nih.gov/17986153 17986153]|[https://pubmed.ncbi.nlm.nih.gov/8143857 8143857]|[https://pubmed.ncbi.nlm.nih.gov/23801329 23801329]|[https://pubmed.ncbi.nlm.nih.gov/18077097 18077097]|[https://pubmed.ncbi.nlm.nih.gov/32708181 32708181]|[https://pubmed.ncbi.nlm.nih.gov/15346887 15346887]|[https://pubmed.ncbi.nlm.nih.gov/19015977 19015977]|[https://pubmed.ncbi.nlm.nih.gov/18393821 18393821]|[https://pubmed.ncbi.nlm.nih.gov/25279740 25279740]|[https://pubmed.ncbi.nlm.nih.gov/21057870 21057870]|[https://pubmed.ncbi.nlm.nih.gov/11915327 11915327]|[https://pubmed.ncbi.nlm.nih.gov/25212460 25212460]|[https://pubmed.ncbi.nlm.nih.gov/23882130 23882130]|[https://pubmed.ncbi.nlm.nih.gov/11915329 11915329]|[https://pubmed.ncbi.nlm.nih.gov/8195125 8195125]|[https://pubmed.ncbi.nlm.nih.gov/8808768 8808768]|[https://pubmed.ncbi.nlm.nih.gov/3396945 3396945]|[https://pubmed.ncbi.nlm.nih.gov/22128256 22128256]|[https://pubmed.ncbi.nlm.nih.gov/6733104 6733104]|[https://pubmed.ncbi.nlm.nih.gov/24968752 24968752]|[https://pubmed.ncbi.nlm.nih.gov/32518749 32518749]|[https://pubmed.ncbi.nlm.nih.gov/30688114 30688114]|[https://pubmed.ncbi.nlm.nih.gov/7666005 7666005]|[https://pubmed.ncbi.nlm.nih.gov/8200356 8200356]|[https://pubmed.ncbi.nlm.nih.gov/24718572 24718572]|[https://pubmed.ncbi.nlm.nih.gov/6193809 6193809]|[https://pubmed.ncbi.nlm.nih.gov/25781947 25781947]|[https://pubmed.ncbi.nlm.nih.gov/12383912 12383912]|[https://pubmed.ncbi.nlm.nih.gov/26086247 26086247]|[https://pubmed.ncbi.nlm.nih.gov/30606995 30606995]|[https://pubmed.ncbi.nlm.nih.gov/12419803 12419803] <br>
- '''definition''' : Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.[MeSH:D007790] <br>
- '''term_xref''' : GTC:G84224TW|MeSH:D007790|GlycoMotif:GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3 <br>
- '''synonyms''' : LacCer|Lc2|CDH <br>
- '''function''' : mammalian cell receptors for Neisseria gonorrhoeae recognized by Helicobacter pylori[GlycoEpitope:EP0078] <br>
- '''disease_associations''' : chronic gastritis[GlycoEpitope:EP0078,SugarBind_Ligand:3]|duodenal ulcers[GlycoEpitope:EP0078]|gastric adenocarcinoma[GlycoEpitope:EP0078,SugarBind_Ligand:3]|gastric ulcers[GlycoEpitope:EP0078]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Actinomycosis[SugarBind_Ligand:3]|Pertussis[SugarBind_Ligand:3]|Candidiasis[SugarBind_Ligand:3]|Cryptococcosis[SugarBind_Ligand:3]|Hemorrhagic colitis[SugarBind_Ligand:3]|Peptic ulcers[SugarBind_Ligand:3]|Histoplasmosis[SugarBind_Ligand:3]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Gonorrhea[SugarBind_Ligand:3]|Sporotrichosis[SugarBind_Ligand:3]|Plague[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3] <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17] <br>
-===Lactotriaosylceramide===
-[[File:G06239NA.png|thumb|G06239NA]]
- '''term (main_entry)''' : Lactotriaosylceramide <br>
- '''glycan_dictionary_accession''' : GSD000117 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G06239NA G06239NA] <br>
- '''term_in_sentence''' : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]|[https://pubmed.ncbi.nlm.nih.gov/20693232 20693232]|[https://pubmed.ncbi.nlm.nih.gov/26104834 26104834]|[https://pubmed.ncbi.nlm.nih.gov/27435676 27435676]|[https://pubmed.ncbi.nlm.nih.gov/26405105 26405105]|[https://pubmed.ncbi.nlm.nih.gov/32340400 32340400]|[https://pubmed.ncbi.nlm.nih.gov/25241919 25241919]|[https://pubmed.ncbi.nlm.nih.gov/23404501 23404501]|[https://pubmed.ncbi.nlm.nih.gov/32452379 32452379]|[https://pubmed.ncbi.nlm.nih.gov/2960671 2960671]|272643|[https://pubmed.ncbi.nlm.nih.gov/27711049 27711049]|[https://pubmed.ncbi.nlm.nih.gov/33202844 33202844]|[https://pubmed.ncbi.nlm.nih.gov/4060695 4060695]|[https://pubmed.ncbi.nlm.nih.gov/27638607 27638607]|[https://pubmed.ncbi.nlm.nih.gov/20547865 20547865]|[https://pubmed.ncbi.nlm.nih.gov/2277039 2277039]|[https://pubmed.ncbi.nlm.nih.gov/6238026 6238026]|[https://pubmed.ncbi.nlm.nih.gov/8448388 8448388]|[https://pubmed.ncbi.nlm.nih.gov/8489255 8489255]|[https://pubmed.ncbi.nlm.nih.gov/9363437 9363437]|[https://pubmed.ncbi.nlm.nih.gov/11836161 11836161]|[https://pubmed.ncbi.nlm.nih.gov/6892925 6892925]|[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117]|[https://pubmed.ncbi.nlm.nih.gov/6811267 6811267]|[https://pubmed.ncbi.nlm.nih.gov/8059935 8059935]|[https://pubmed.ncbi.nlm.nih.gov/7861954 7861954]|[https://pubmed.ncbi.nlm.nih.gov/11283017 11283017]|[https://pubmed.ncbi.nlm.nih.gov/8514762 8514762]|[https://pubmed.ncbi.nlm.nih.gov/1291049 1291049]|[https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]|[https://pubmed.ncbi.nlm.nih.gov/10816509 10816509]|[https://pubmed.ncbi.nlm.nih.gov/12393713 12393713]|[https://pubmed.ncbi.nlm.nih.gov/6417117 6417117]|[https://pubmed.ncbi.nlm.nih.gov/11054095 11054095]|[https://pubmed.ncbi.nlm.nih.gov/8781973 8781973]|[https://pubmed.ncbi.nlm.nih.gov/1692829 1692829] <br>
- '''definition''' : A linear amino trisaccharide consisting of β-D-glucose at the reducing end having an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl group attached at the 4-position.[CHEBI:61758] <br>
- '''term_xref''' : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:10230777|CHEBI:61758|SugarBind_Ligand:20 <br>
- '''synonyms''' : Lc3|Lc(3)Cer|Lc_3 <br>
- '''function''' : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br>
- '''disease_associations''' : Pharyngitis[SugarBind_Ligand:20]|Tracheobronchitis[SugarBind_Ligand:20]|Gonorrhea[SugarBind_Ligand:20]|Actinomycosis[SugarBind_Ligand:20]|Diarrhea[SugarBind_Ligand:20] <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>
-===LcGg4===
-[[File:G62554JH.png|thumb|G62554JH]]
- '''term (main_entry)''' : LcGg4 <br>
- '''glycan_dictionary_accession''' : GSD000118 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G62554JH G62554JH] <br>
- '''term_in_sentence''' : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]|[https://pubmed.ncbi.nlm.nih.gov/33395290 33395290] <br>
- '''definition''' : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521] <br>
- '''term_xref''' : GlycoMotif:GGM.000075|GTC:G62554JH|CID:91850076|CHEBI:152521|GlycoEpitope:EP0035 <br>
- '''synonyms''' :  <br>
- '''function''' :  <br>
- '''disease_associations''' :  <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>
 ===Lewis a===
@@ Line 243: / Line 6: @@
   '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00047MO G00047MO] <br>
   '''term_in_sentence''' : Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). [PMID:[https://pubmed.ncbi.nlm.nih.gov/29367698 29367698]] <br>
-  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29367698 29367698]|[https://pubmed.ncbi.nlm.nih.gov/27187324 27187324]|[https://pubmed.ncbi.nlm.nih.gov/30562693 30562693]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625] [https://pubmed.ncbi.nlm.nih.gov/27646625 27646625]]|[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286]|[https://pubmed.ncbi.nlm.nih.gov/30225822 30225822]|[https://pubmed.ncbi.nlm.nih.gov/28600306 28600306]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016] [https://pubmed.ncbi.nlm.nih.gov/32527016 32527016]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097] [https://pubmed.ncbi.nlm.nih.gov/2385097 2385097]]|[https://pubmed.ncbi.nlm.nih.gov/11064310 11064310]|[https://pubmed.ncbi.nlm.nih.gov/23809433 23809433]|[https://pubmed.ncbi.nlm.nih.gov/30050155 30050155]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929] [https://pubmed.ncbi.nlm.nih.gov/1615929 1615929]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514] [https://pubmed.ncbi.nlm.nih.gov/29527514 29527514]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264] [https://pubmed.ncbi.nlm.nih.gov/9207264 9207264]]|[https://pubmed.ncbi.nlm.nih.gov/1675497 1675497]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023] [https://pubmed.ncbi.nlm.nih.gov/3677023 3677023]]|[https://pubmed.ncbi.nlm.nih.gov/27705835 27705835]|[https://pubmed.ncbi.nlm.nih.gov/7593252 7593252]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997] [https://pubmed.ncbi.nlm.nih.gov/2579997 2579997]]|[https://pubmed.ncbi.nlm.nih.gov/17630273 17630273]|[https://pubmed.ncbi.nlm.nih.gov/9350993 9350993]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001] [https://pubmed.ncbi.nlm.nih.gov/9098001 9098001]] <br>
+  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/29367698 29367698]|[https://pubmed.ncbi.nlm.nih.gov/27187324 27187324]|[https://pubmed.ncbi.nlm.nih.gov/30562693 30562693]|[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625]|[https://pubmed.ncbi.nlm.nih.gov/26911286 26911286]|[https://pubmed.ncbi.nlm.nih.gov/30225822 30225822]|[https://pubmed.ncbi.nlm.nih.gov/28600306 28600306]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016] [https://pubmed.ncbi.nlm.nih.gov/32527016 32527016]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097] [https://pubmed.ncbi.nlm.nih.gov/2385097 2385097]]|[https://pubmed.ncbi.nlm.nih.gov/11064310 11064310]|[https://pubmed.ncbi.nlm.nih.gov/23809433 23809433]|[https://pubmed.ncbi.nlm.nih.gov/30050155 30050155]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929] [https://pubmed.ncbi.nlm.nih.gov/1615929 1615929]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514] [https://pubmed.ncbi.nlm.nih.gov/29527514 29527514]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264] [https://pubmed.ncbi.nlm.nih.gov/9207264 9207264]]|[https://pubmed.ncbi.nlm.nih.gov/1675497 1675497]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023] [https://pubmed.ncbi.nlm.nih.gov/3677023 3677023]]|[https://pubmed.ncbi.nlm.nih.gov/27705835 27705835]|[https://pubmed.ncbi.nlm.nih.gov/7593252 7593252]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997] [https://pubmed.ncbi.nlm.nih.gov/2579997 2579997]]|[https://pubmed.ncbi.nlm.nih.gov/17630273 17630273]|[https://pubmed.ncbi.nlm.nih.gov/9350993 9350993]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001] [https://pubmed.ncbi.nlm.nih.gov/9098001 9098001]] <br>
   '''definition''' : A lewis blood group antigen with structure beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcpNAc consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an alpha-linkage and a galactosyl residue attached at the 3-position via a beta-linkage. It has a role as an epitope and an antigen. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:62265] <br>
   '''term_xref''' : GTC:G00047MO|CID:[https://pubmed.ncbi.nlm.nih.gov/22806751 22806751]|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155 <br>
@@ Line 259: / Line 22: @@
   '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G39211DH G39211DH] <br>
   '''term_in_sentence''' : Human mannose-binding lectin preferentially binds to human colon adenocarcinoma cell lines expressing high amount of Lewis A and Lewis B antigens.[PMID:[https://pubmed.ncbi.nlm.nih.gov/10328552 10328552]] <br>
-  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/10328552 10328552]|[https://pubmed.ncbi.nlm.nih.gov/23408949 23408949]|[https://pubmed.ncbi.nlm.nih.gov/31927399 31927399]|[https://pubmed.ncbi.nlm.nih.gov/26601230 26601230]|[https://pubmed.ncbi.nlm.nih.gov/28279343 28279343]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016] [https://pubmed.ncbi.nlm.nih.gov/32527016 32527016]]|[https://pubmed.ncbi.nlm.nih.gov/30831115 30831115]|[https://pubmed.ncbi.nlm.nih.gov/27318698 27318698]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264] [https://pubmed.ncbi.nlm.nih.gov/9207264 9207264]]|[https://pubmed.ncbi.nlm.nih.gov/23828675 23828675]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514] [https://pubmed.ncbi.nlm.nih.gov/29527514 29527514]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929] [https://pubmed.ncbi.nlm.nih.gov/1615929 1615929]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097] [https://pubmed.ncbi.nlm.nih.gov/2385097 2385097]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997] [https://pubmed.ncbi.nlm.nih.gov/2579997 2579997]]|[https://pubmed.ncbi.nlm.nih.gov/25516619 25516619]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023] [https://pubmed.ncbi.nlm.nih.gov/3677023 3677023]]|[https://pubmed.ncbi.nlm.nih.gov/8509439 8509439]|[https://pubmed.ncbi.nlm.nih.gov/19832116 19832116]|[https://pubmed.ncbi.nlm.nih.gov/15270746 15270746]|[https://pubmed.ncbi.nlm.nih.gov/3166398 3166398]|[https://pubmed.ncbi.nlm.nih.gov/30909206 30909206]|[https://pubmed.ncbi.nlm.nih.gov/7718581 7718581]|[https://pubmed.ncbi.nlm.nih.gov/18400963 18400963]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628] [https://pubmed.ncbi.nlm.nih.gov/29751628 29751628]]|[https://pubmed.ncbi.nlm.nih.gov/8982241 8982241]|[https://pubmed.ncbi.nlm.nih.gov/30284922 30284922]|[https://pubmed.ncbi.nlm.nih.gov/24576035 24576035]|[https://pubmed.ncbi.nlm.nih.gov/30974776 30974776]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001] [https://pubmed.ncbi.nlm.nih.gov/9098001 9098001]]|[https://pubmed.ncbi.nlm.nih.gov/31768613 31768613]|[https://pubmed.ncbi.nlm.nih.gov/1651804 1651804]|[https://pubmed.ncbi.nlm.nih.gov/25428879 25428879]|[https://pubmed.ncbi.nlm.nih.gov/15946883 15946883]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790] [https://pubmed.ncbi.nlm.nih.gov/30298790 30298790]]|[https://pubmed.ncbi.nlm.nih.gov/30544260 30544260]|[https://pubmed.ncbi.nlm.nih.gov/29197783 29197783]|[https://pubmed.ncbi.nlm.nih.gov/8632739 8632739]|[https://pubmed.ncbi.nlm.nih.gov/7679772 7679772]|[https://pubmed.ncbi.nlm.nih.gov/18666312 18666312]|[https://pubmed.ncbi.nlm.nih.gov/20231766 20231766]|[https://pubmed.ncbi.nlm.nih.gov/29922666 29922666]|95124|[https://pubmed.ncbi.nlm.nih.gov/2247887 2247887]|[https://pubmed.ncbi.nlm.nih.gov/21519121 21519121]|[https://pubmed.ncbi.nlm.nih.gov/25153235 25153235]|[https://pubmed.ncbi.nlm.nih.gov/28751211 28751211] <br>
+  '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/10328552 10328552]|[https://pubmed.ncbi.nlm.nih.gov/23408949 23408949]|[https://pubmed.ncbi.nlm.nih.gov/31927399 31927399]|[https://pubmed.ncbi.nlm.nih.gov/26601230 26601230]|[https://pubmed.ncbi.nlm.nih.gov/28279343 28279343]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016] [https://pubmed.ncbi.nlm.nih.gov/32527016 32527016]]|[https://pubmed.ncbi.nlm.nih.gov/30831115 30831115]|[https://pubmed.ncbi.nlm.nih.gov/27318698 27318698]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264] [https://pubmed.ncbi.nlm.nih.gov/9207264 9207264]]|[https://pubmed.ncbi.nlm.nih.gov/23828675 23828675]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514] [https://pubmed.ncbi.nlm.nih.gov/29527514 29527514]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929] [https://pubmed.ncbi.nlm.nih.gov/1615929 1615929]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097] [https://pubmed.ncbi.nlm.nih.gov/2385097 2385097]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997] [https://pubmed.ncbi.nlm.nih.gov/2579997 2579997]]|[https://pubmed.ncbi.nlm.nih.gov/25516619 25516619]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023] [https://pubmed.ncbi.nlm.nih.gov/3677023 3677023]]|[https://pubmed.ncbi.nlm.nih.gov/8509439 8509439]|[https://pubmed.ncbi.nlm.nih.gov/19832116 19832116]|[https://pubmed.ncbi.nlm.nih.gov/15270746 15270746]|[https://pubmed.ncbi.nlm.nih.gov/3166398 3166398]|[https://pubmed.ncbi.nlm.nih.gov/30909206 30909206]|[https://pubmed.ncbi.nlm.nih.gov/7718581 7718581]|[https://pubmed.ncbi.nlm.nih.gov/18400963 18400963]|[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628]|[https://pubmed.ncbi.nlm.nih.gov/8982241 8982241]|[https://pubmed.ncbi.nlm.nih.gov/30284922 30284922]|[https://pubmed.ncbi.nlm.nih.gov/24576035 24576035]|[https://pubmed.ncbi.nlm.nih.gov/30974776 30974776]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001] [https://pubmed.ncbi.nlm.nih.gov/9098001 9098001]]|[https://pubmed.ncbi.nlm.nih.gov/31768613 31768613]|[https://pubmed.ncbi.nlm.nih.gov/1651804 1651804]|[https://pubmed.ncbi.nlm.nih.gov/25428879 25428879]|[https://pubmed.ncbi.nlm.nih.gov/15946883 15946883]|[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790]|[https://pubmed.ncbi.nlm.nih.gov/30544260 30544260]|[https://pubmed.ncbi.nlm.nih.gov/29197783 29197783]|[https://pubmed.ncbi.nlm.nih.gov/8632739 8632739]|[https://pubmed.ncbi.nlm.nih.gov/7679772 7679772]|[https://pubmed.ncbi.nlm.nih.gov/18666312 18666312]|[https://pubmed.ncbi.nlm.nih.gov/20231766 20231766]|[https://pubmed.ncbi.nlm.nih.gov/29922666 29922666]|95124|[https://pubmed.ncbi.nlm.nih.gov/2247887 2247887]|[https://pubmed.ncbi.nlm.nih.gov/21519121 21519121]|[https://pubmed.ncbi.nlm.nih.gov/25153235 25153235]|[https://pubmed.ncbi.nlm.nih.gov/28751211 28751211] <br>
   '''definition''' :  <br>
   '''term_xref''' : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:[https://pubmed.ncbi.nlm.nih.gov/45480568 45480568]|CHEBI:59440 <br>
@@ Line 267: / Line 30: @@
   '''wikipedia''' :  <br>
   '''essentials_of_glycobiology''' :  <br>
-===Lewis x===
-[[File:G00051MO.png|thumb|G00051MO]]
- '''term (main_entry)''' : Lewis x <br>
- '''glycan_dictionary_accession''' : GSD000121 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00051MO G00051MO] <br>
- '''term_in_sentence''' : In particular, the observation of oxonium ions at m/z 512.2 and 803.2 is useful for probing outer non-reducing terminal fucosylation, which represented carbohydrate structures consisting of Hex Hex , dHex Hex , and HexNAc , and NeuNAc , Hex Hex , dHex Hex , and HexNAc , respectively, from which the Lewis X structure (Galbeta1-4(Fucalpha1-3)GlcNAc) was readily deduced.[PMID:[https://pubmed.ncbi.nlm.nih.gov/15536627 15536627]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/15536627 15536627]|[https://pubmed.ncbi.nlm.nih.gov/31666308 31666308]|[https://pubmed.ncbi.nlm.nih.gov/29019053 29019053]|[https://pubmed.ncbi.nlm.nih.gov/28296340 28296340]|[https://pubmed.ncbi.nlm.nih.gov/29593094 29593094]|[https://pubmed.ncbi.nlm.nih.gov/17607374 17607374]|[https://pubmed.ncbi.nlm.nih.gov/16581086 16581086]|[https://pubmed.ncbi.nlm.nih.gov/20858014 20858014]|[https://pubmed.ncbi.nlm.nih.gov/19962782 19962782]|[https://pubmed.ncbi.nlm.nih.gov/7912739 7912739]|[https://pubmed.ncbi.nlm.nih.gov/25121780 25121780]|[https://pubmed.ncbi.nlm.nih.gov/24059473 24059473]|[https://pubmed.ncbi.nlm.nih.gov/29210428 29210428]|[https://pubmed.ncbi.nlm.nih.gov/31276881 31276881]|[https://pubmed.ncbi.nlm.nih.gov/9015359 9015359]|[https://pubmed.ncbi.nlm.nih.gov/7628844 7628844]|[https://pubmed.ncbi.nlm.nih.gov/7499837 7499837]|[https://pubmed.ncbi.nlm.nih.gov/16850248 16850248]|[https://pubmed.ncbi.nlm.nih.gov/28425129 28425129]|[https://pubmed.ncbi.nlm.nih.gov/28869691 28869691]|[https://pubmed.ncbi.nlm.nih.gov/19576189 19576189]|[https://pubmed.ncbi.nlm.nih.gov/10223649 10223649]|[https://pubmed.ncbi.nlm.nih.gov/22593503 22593503]|[https://pubmed.ncbi.nlm.nih.gov/15632313 15632313]|[https://pubmed.ncbi.nlm.nih.gov/27198630 27198630]|[https://pubmed.ncbi.nlm.nih.gov/26582608 26582608]|[https://pubmed.ncbi.nlm.nih.gov/11500392 11500392]|[https://pubmed.ncbi.nlm.nih.gov/31256373 31256373]|[https://pubmed.ncbi.nlm.nih.gov/23399157 23399157]|[https://pubmed.ncbi.nlm.nih.gov/21984435 21984435]|[https://pubmed.ncbi.nlm.nih.gov/26244810 26244810]|[https://pubmed.ncbi.nlm.nih.gov/26162743 26162743]|[https://pubmed.ncbi.nlm.nih.gov/17335083 17335083]|[https://pubmed.ncbi.nlm.nih.gov/15388363 15388363]|[https://pubmed.ncbi.nlm.nih.gov/9556613 9556613]|[https://pubmed.ncbi.nlm.nih.gov/10760152 10760152]|[https://pubmed.ncbi.nlm.nih.gov/11267844 11267844]|[https://pubmed.ncbi.nlm.nih.gov/20876654 20876654]|[https://pubmed.ncbi.nlm.nih.gov/12131290 12131290] <br>
- '''definition''' : A Lewis blood group antigen with structure α-L-Fucp-(1→3)-[β-D-Galp-(1→4)]-D-GlcpNAc where the glucosamine at the reducing end has β-configuration at its anomeric centre. Commonly known as Lewis x trisaccharide or Lex.[CHEBI:59294] <br>
- '''term_xref''' : GTC:G00051MO |GlycoEpitope:EP0011|CID:[https://pubmed.ncbi.nlm.nih.gov/44611539 44611539]|CHEBI:59294|GlycoMotif:GGM.000018  <br>
- '''synonyms''' : Lex|Galbeta1-4(Fucalpha1-3)GlcNAc|Lewis x trisaccharide|Le(X)|Le^x|SSEA-1 <br>
- '''function''' : Involved in carbohydrate-carbohydrate interaction[Glycoepitope:EP0011].|Also implicated in apoptosis.[Glycoepitope:EP0011]|influence antigenic presentation and interfere with pathogen transfer in breastfed infants.[Glycoepitope:EP0011] <br>
- '''disease_associations''' : acute leukemia[GlycoEpitope:EP0011]|lymphoma[GlycoEpitope:EP0011] <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>
-===Lewis y===
-[[File:G00052MO.png|alt=|thumb|G00052MO]]
- '''term (main_entry)''' : Lewis y <br>
- '''glycan_dictionary_accession''' : GSD000122 <br>
- '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00052MO G00052MO] <br>
- '''term_in_sentence''' : In conclusion, Lewis y antigen and CD147 were significantly upregulated in ovarian tumors, and the altered expression of Lewis y may cause changes in CD147.[PMID:[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446] [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446]]] <br>
- '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446] [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467] [https://pubmed.ncbi.nlm.nih.gov/20003467 20003467]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145] [https://pubmed.ncbi.nlm.nih.gov/24692145 24692145]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328] [https://pubmed.ncbi.nlm.nih.gov/24998328 24998328]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913] [https://pubmed.ncbi.nlm.nih.gov/25726913 25726913]]|[https://pubmed.ncbi.nlm.nih.gov/29299130 29299130]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446] [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467] [https://pubmed.ncbi.nlm.nih.gov/20003467 20003467]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145] [https://pubmed.ncbi.nlm.nih.gov/24692145 24692145]]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328] [https://pubmed.ncbi.nlm.nih.gov/24998328 24998328]]|[https://pubmed.ncbi.nlm.nih.gov/20127027 20127027]|[https://pubmed.ncbi.nlm.nih.gov/22138668 22138668]|[https://pubmed.ncbi.nlm.nih.gov/23894390 23894390]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913] [https://pubmed.ncbi.nlm.nih.gov/25726913 25726913]]|[https://pubmed.ncbi.nlm.nih.gov/25416440 25416440]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625] [https://pubmed.ncbi.nlm.nih.gov/27646625 27646625]]|[https://pubmed.ncbi.nlm.nih.gov/23725446 23725446]|[https://pubmed.ncbi.nlm.nih.gov/21294926 21294926]|[https://pubmed.ncbi.nlm.nih.gov/22312289 22312289]|[https://pubmed.ncbi.nlm.nih.gov/25973320 25973320]|[https://pubmed.ncbi.nlm.nih.gov/23242548 23242548]|[https://pubmed.ncbi.nlm.nih.gov/30328452 30328452]|[https://pubmed.ncbi.nlm.nih.gov/21119363 21119363]|[https://pubmed.ncbi.nlm.nih.gov/29130097 29130097]|[https://pubmed.ncbi.nlm.nih.gov/23443083 23443083]|[https://pubmed.ncbi.nlm.nih.gov/23708102 23708102]|[https://pubmed.ncbi.nlm.nih.gov/28671040 28671040]|[https://pubmed.ncbi.nlm.nih.gov/19715603 19715603]|[https://pubmed.ncbi.nlm.nih.gov/23468946 23468946]|[https://pubmed.ncbi.nlm.nih.gov/27723168 27723168]|[https://pubmed.ncbi.nlm.nih.gov/21747684 21747684]|[https://pubmed.ncbi.nlm.nih.gov/19771739 19771739] <br>
- '''definition''' : A Lewis blood group antigen which is a branched amino tetrasaccharide with structure alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, consisting of consisting of N-acetyl-beta-D-glucosamine at the reducing end having an alpha-L-fucosyl residue attached at the 3-position and an alpha-L-fucosyl-(1→2)-beta-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure. It has a role as an antigen and an epitope. [CHEBI:59045]] <br>
- '''term_xref''' : GTC:G00052MO|GlycoEpitope:EP0018|CID:[https://pubmed.ncbi.nlm.nih.gov/45266908 45266908]|CHEBI:59045|GlycoMotif:GGM.000019 <br>
- '''synonyms''' : LeY|Le(y)|Ley|Le^y <br>
- '''function''' : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018] <br>
- '''disease_associations''' : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018] <br>
- '''wikipedia''' :  <br>
- '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453042/ Chapter 14]<br>

Testhyperlink123: Difference between revisions

Revision as of 19:27, 7 April 2023

Lewis a

Lewis b

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