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'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/32266657 32266657]|[https://pubmed.ncbi.nlm.nih.gov/29554552 29554552]|[https://pubmed.ncbi.nlm.nih.gov/29032302 29032302]|[https://pubmed.ncbi.nlm.nih.gov/30003471 30003471]|[https://pubmed.ncbi.nlm.nih.gov/25197032 25197032]|[https://pubmed.ncbi.nlm.nih.gov/28538085 28538085]|[https://pubmed.ncbi.nlm.nih.gov/26236728 26236728]|[https://pubmed.ncbi.nlm.nih.gov/16917509 16917509]|[https://pubmed.ncbi.nlm.nih.gov/22899865 22899865]|[https://pubmed.ncbi.nlm.nih.gov/17080204 17080204]|[https://pubmed.ncbi.nlm.nih.gov/23042481 23042481]|[https://pubmed.ncbi.nlm.nih.gov/28982096 28982096]|[https://pubmed.ncbi.nlm.nih.gov/24146040 24146040]|[https://pubmed.ncbi.nlm.nih.gov/25081076 25081076]|[https://pubmed.ncbi.nlm.nih.gov/15719168 15719168]|[https://pubmed.ncbi.nlm.nih.gov/17453622 17453622]|[https://pubmed.ncbi.nlm.nih.gov/25325954 25325954]|[https://pubmed.ncbi.nlm.nih.gov/21110089 21110089]|[https://pubmed.ncbi.nlm.nih.gov/29797526 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8370471]|[https://pubmed.ncbi.nlm.nih.gov/26571620 26571620]|[https://pubmed.ncbi.nlm.nih.gov/29920400 29920400]|[https://pubmed.ncbi.nlm.nih.gov/31731076 31731076]|[https://pubmed.ncbi.nlm.nih.gov/20816205 20816205]|[https://pubmed.ncbi.nlm.nih.gov/16880267 16880267]|[https://pubmed.ncbi.nlm.nih.gov/31547957 31547957]|[https://pubmed.ncbi.nlm.nih.gov/11457867 11457867]|[https://pubmed.ncbi.nlm.nih.gov/27241222 27241222]|[https://pubmed.ncbi.nlm.nih.gov/28718936 28718936]|[https://pubmed.ncbi.nlm.nih.gov/21204109 21204109]|[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]|[https://pubmed.ncbi.nlm.nih.gov/11166215 11166215]|[https://pubmed.ncbi.nlm.nih.gov/11457866 11457866] <br> | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/32266657 32266657]|[https://pubmed.ncbi.nlm.nih.gov/29554552 29554552]|[https://pubmed.ncbi.nlm.nih.gov/29032302 29032302]|[https://pubmed.ncbi.nlm.nih.gov/30003471 30003471]|[https://pubmed.ncbi.nlm.nih.gov/25197032 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16880267]|[https://pubmed.ncbi.nlm.nih.gov/31547957 31547957]|[https://pubmed.ncbi.nlm.nih.gov/11457867 11457867]|[https://pubmed.ncbi.nlm.nih.gov/27241222 27241222]|[https://pubmed.ncbi.nlm.nih.gov/28718936 28718936]|[https://pubmed.ncbi.nlm.nih.gov/21204109 21204109]|[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]|[https://pubmed.ncbi.nlm.nih.gov/11166215 11166215]|[https://pubmed.ncbi.nlm.nih.gov/11457866 11457866] <br> | ||
'''definition''' : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815] <br> | '''definition''' : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815] <br> | ||
'''term_xref''' : CHEBI:28815|CID: | '''term_xref''' : CHEBI:28815|CID: 53477715|GlycoEpitope: EP0086 <br> | ||
'''synonyms''' : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate <br> | '''synonyms''' : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate <br> | ||
'''function''' : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[GlycoEpitope: EP0086] <br> | '''function''' : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[GlycoEpitope: EP0086] <br> | ||
| Line 20: | Line 20: | ||
'''glytoucan_accession ''' : <br> | '''glytoucan_accession ''' : <br> | ||
'''term_in_sentence''' : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:[https://pubmed.ncbi.nlm.nih.gov/6416324 6416324]] <br> | '''term_in_sentence''' : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:[https://pubmed.ncbi.nlm.nih.gov/6416324 6416324]] <br> | ||
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27100512 27100512]|[https://pubmed.ncbi.nlm.nih.gov/22566218 22566218]|[https://pubmed.ncbi.nlm.nih.gov/27264866 27264866]|[https://pubmed.ncbi.nlm.nih.gov/30094590 30094590]|[https://pubmed.ncbi.nlm.nih.gov/31077659 31077659]|[https://pubmed.ncbi.nlm.nih.gov/26975675 26975675]|[https://pubmed.ncbi.nlm.nih.gov/2083874 2083874]|[https://pubmed.ncbi.nlm.nih.gov/25088334 25088334]|[https://pubmed.ncbi.nlm.nih.gov/3333067 3333067]|[https://pubmed.ncbi.nlm.nih.gov/2191809 2191809]|[https://pubmed.ncbi.nlm.nih.gov/28118750 28118750]|[https://pubmed.ncbi.nlm.nih.gov/28224913 28224913]|[https://pubmed.ncbi.nlm.nih.gov/22495506 22495506]|[https://pubmed.ncbi.nlm.nih.gov/29385025 29385025]|[https://pubmed.ncbi.nlm.nih.gov/10332503 10332503]|[https://pubmed.ncbi.nlm.nih.gov/22393937 22393937]|[https://pubmed.ncbi.nlm.nih.gov/19947315 19947315]|[https://pubmed.ncbi.nlm.nih.gov/27655335 27655335]|[https://pubmed.ncbi.nlm.nih.gov/14529394 14529394]|[https://pubmed.ncbi.nlm.nih.gov/2419035 2419035]|[https://pubmed.ncbi.nlm.nih.gov/22048616 22048616]|[https://pubmed.ncbi.nlm.nih.gov/23849978 23849978]|[https://pubmed.ncbi.nlm.nih.gov/10204652 10204652]|[https://pubmed.ncbi.nlm.nih.gov/28958760 28958760]|[https://pubmed.ncbi.nlm.nih.gov/12627673 12627673]|[https://pubmed.ncbi.nlm.nih.gov/9042555 9042555]|[https://pubmed.ncbi.nlm.nih.gov/15639107 15639107]|[https://pubmed.ncbi.nlm.nih.gov/28880550 28880550]|[https://pubmed.ncbi.nlm.nih.gov/27238483 27238483]|[https://pubmed.ncbi.nlm.nih.gov/1964668 1964668]|[https://pubmed.ncbi.nlm.nih.gov/16716101 16716101]|[https://pubmed.ncbi.nlm.nih.gov/10796377 10796377]|[https://pubmed.ncbi.nlm.nih.gov/25981976 25981976]|[https://pubmed.ncbi.nlm.nih.gov/24680753 24680753]|[https://pubmed.ncbi.nlm.nih.gov/2191118 2191118]|[https://pubmed.ncbi.nlm.nih.gov/21166465 21166465]|[https://pubmed.ncbi.nlm.nih.gov/30582884 30582884]|[https://pubmed.ncbi.nlm.nih.gov/1322434 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25088334]|[https://pubmed.ncbi.nlm.nih.gov/3333067 3333067]|[https://pubmed.ncbi.nlm.nih.gov/2191809 2191809]|[https://pubmed.ncbi.nlm.nih.gov/28118750 28118750]|[https://pubmed.ncbi.nlm.nih.gov/28224913 28224913]|[https://pubmed.ncbi.nlm.nih.gov/22495506 22495506]|[https://pubmed.ncbi.nlm.nih.gov/29385025 29385025]|[https://pubmed.ncbi.nlm.nih.gov/10332503 10332503]|[https://pubmed.ncbi.nlm.nih.gov/22393937 22393937]|[https://pubmed.ncbi.nlm.nih.gov/19947315 19947315]|[https://pubmed.ncbi.nlm.nih.gov/27655335 27655335]|[https://pubmed.ncbi.nlm.nih.gov/14529394 14529394]|[https://pubmed.ncbi.nlm.nih.gov/2419035 2419035]|[https://pubmed.ncbi.nlm.nih.gov/22048616 22048616]|[https://pubmed.ncbi.nlm.nih.gov/23849978 23849978]|[https://pubmed.ncbi.nlm.nih.gov/10204652 10204652]|[https://pubmed.ncbi.nlm.nih.gov/28958760 28958760]|[https://pubmed.ncbi.nlm.nih.gov/12627673 12627673]|[https://pubmed.ncbi.nlm.nih.gov/9042555 9042555]|[https://pubmed.ncbi.nlm.nih.gov/15639107 15639107]|[https://pubmed.ncbi.nlm.nih.gov/28880550 28880550]|[https://pubmed.ncbi.nlm.nih.gov/27238483 27238483]|[https://pubmed.ncbi.nlm.nih.gov/1964668 1964668]|[https://pubmed.ncbi.nlm.nih.gov/16716101 16716101]|[https://pubmed.ncbi.nlm.nih.gov/10796377 10796377]|[https://pubmed.ncbi.nlm.nih.gov/25981976 25981976]|[https://pubmed.ncbi.nlm.nih.gov/24680753 24680753]|[https://pubmed.ncbi.nlm.nih.gov/2191118 2191118]|[https://pubmed.ncbi.nlm.nih.gov/21166465 21166465]|[https://pubmed.ncbi.nlm.nih.gov/30582884 30582884]|[https://pubmed.ncbi.nlm.nih.gov/1322434 1322434]|[https://pubmed.ncbi.nlm.nih.gov/15330727 15330727]|[https://pubmed.ncbi.nlm.nih.gov/9752370 9752370]|[https://pubmed.ncbi.nlm.nih.gov/6416324 6416324]|[https://pubmed.ncbi.nlm.nih.gov/14996629 14996629]|[https://pubmed.ncbi.nlm.nih.gov/20452241 20452241]|[https://pubmed.ncbi.nlm.nih.gov/1340407 1340407]|[https://pubmed.ncbi.nlm.nih.gov/29050610 29050610]|[https://pubmed.ncbi.nlm.nih.gov/345399 345399]|[https://pubmed.ncbi.nlm.nih.gov/6916469 6916469]|[https://pubmed.ncbi.nlm.nih.gov/6565376 6565376]|[https://pubmed.ncbi.nlm.nih.gov/26714061 26714061] <br> | ||
'''definition''' : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304] <br> | '''definition''' : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304] <br> | ||
'''term_xref''' : CID:772|CHEBI:28304 <br> | '''term_xref''' : CID:772|CHEBI:28304 <br> | ||
| Line 35: | Line 35: | ||
'''glytoucan_accession ''' : <br> | '''glytoucan_accession ''' : <br> | ||
'''term_in_sentence''' : Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. [PMID:[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]]<br> | '''term_in_sentence''' : Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. [PMID:[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]]<br> | ||
'''publication''' : | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/23313092 23313092]|[https://pubmed.ncbi.nlm.nih.gov/31016560 31016560]|[https://pubmed.ncbi.nlm.nih.gov/23152789 23152789]<br> | ||
'''definition''' : <br> | '''definition''' : <br> | ||
'''term_xref''' : <br> | '''term_xref''' : <br> | ||
| Line 53: | Line 53: | ||
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30605318]|[https://pubmed.ncbi.nlm.nih.gov/32371950 32371950]<br> | ||
'''definition''' : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man . <br> | '''definition''' : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man . <br> | ||
'''term_xref''' : GTC:G55220VL|CID: | '''term_xref''' : GTC:G55220VL|CID:70698382|CHEBI:71514<br> | ||
'''synonyms''' : oligomannose, high-mannose, oligomannose-type <br> | '''synonyms''' : oligomannose, high-mannose, oligomannose-type <br> | ||
'''function''' : Involved in promotion of protein folding in ER. [PMID:[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205] <br> | '''function''' : Involved in promotion of protein folding in ER. [PMID:[https://pubmed.ncbi.nlm.nih.gov/12417032 12417032]].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205] <br> | ||
| Line 69: | Line 69: | ||
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28709864 28709864]|[https://pubmed.ncbi.nlm.nih.gov/31738061 31738061]|[https://pubmed.ncbi.nlm.nih.gov/26738850 26738850]|[https://pubmed.ncbi.nlm.nih.gov/30306736 30306736]|[https://pubmed.ncbi.nlm.nih.gov/11070366 11070366]|[https://pubmed.ncbi.nlm.nih.gov/20855890 20855890]|[https://pubmed.ncbi.nlm.nih.gov/18024472 18024472]|[https://pubmed.ncbi.nlm.nih.gov/22669261 22669261]|[https://pubmed.ncbi.nlm.nih.gov/19729452 19729452]|[https://pubmed.ncbi.nlm.nih.gov/19796667 19796667]|[https://pubmed.ncbi.nlm.nih.gov/26850637 26850637]|[https://pubmed.ncbi.nlm.nih.gov/11769463 11769463]|[https://pubmed.ncbi.nlm.nih.gov/18263654 18263654]|[https://pubmed.ncbi.nlm.nih.gov/15843379 15843379]|[https://pubmed.ncbi.nlm.nih.gov/26659409 26659409]|[https://pubmed.ncbi.nlm.nih.gov/9003039 9003039]|[https://pubmed.ncbi.nlm.nih.gov/22087768 22087768]|[https://pubmed.ncbi.nlm.nih.gov/21771787 21771787]|[https://pubmed.ncbi.nlm.nih.gov/15173636 15173636]|[https://pubmed.ncbi.nlm.nih.gov/9210489 9210489]|[https://pubmed.ncbi.nlm.nih.gov/15258996 15258996]|[https://pubmed.ncbi.nlm.nih.gov/17924534 17924534]|[https://pubmed.ncbi.nlm.nih.gov/26382082 26382082]|[https://pubmed.ncbi.nlm.nih.gov/16171882 16171882]|[https://pubmed.ncbi.nlm.nih.gov/18802400 18802400]|[https://pubmed.ncbi.nlm.nih.gov/9800516 9800516]|[https://pubmed.ncbi.nlm.nih.gov/7504418 7504418]|[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229]|[https://pubmed.ncbi.nlm.nih.gov/15232286 15232286]|[https://pubmed.ncbi.nlm.nih.gov/9013478 9013478]|[https://pubmed.ncbi.nlm.nih.gov/21621858 21621858]|[https://pubmed.ncbi.nlm.nih.gov/11677051 11677051]|[https://pubmed.ncbi.nlm.nih.gov/18668221 18668221]|[https://pubmed.ncbi.nlm.nih.gov/11414798 11414798]|[https://pubmed.ncbi.nlm.nih.gov/19265195 19265195]|[https://pubmed.ncbi.nlm.nih.gov/8982638 8982638]|[https://pubmed.ncbi.nlm.nih.gov/8798480 8798480]|[https://pubmed.ncbi.nlm.nih.gov/28403522 28403522]|[https://pubmed.ncbi.nlm.nih.gov/17935701 17935701]|[https://pubmed.ncbi.nlm.nih.gov/1691305 1691305]|[https://pubmed.ncbi.nlm.nih.gov/10998116 10998116]|[https://pubmed.ncbi.nlm.nih.gov/9364602 9364602]|[https://pubmed.ncbi.nlm.nih.gov/7528651 7528651]|[https://pubmed.ncbi.nlm.nih.gov/12472892 12472892]|[https://pubmed.ncbi.nlm.nih.gov/21176892 21176892]|[https://pubmed.ncbi.nlm.nih.gov/28416698 28416698]|[https://pubmed.ncbi.nlm.nih.gov/19389918 19389918]|[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937]|[https://pubmed.ncbi.nlm.nih.gov/25450311 25450311] <br> | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/28709864 28709864]|[https://pubmed.ncbi.nlm.nih.gov/31738061 31738061]|[https://pubmed.ncbi.nlm.nih.gov/26738850 26738850]|[https://pubmed.ncbi.nlm.nih.gov/30306736 30306736]|[https://pubmed.ncbi.nlm.nih.gov/11070366 11070366]|[https://pubmed.ncbi.nlm.nih.gov/20855890 20855890]|[https://pubmed.ncbi.nlm.nih.gov/18024472 18024472]|[https://pubmed.ncbi.nlm.nih.gov/22669261 22669261]|[https://pubmed.ncbi.nlm.nih.gov/19729452 19729452]|[https://pubmed.ncbi.nlm.nih.gov/19796667 19796667]|[https://pubmed.ncbi.nlm.nih.gov/26850637 26850637]|[https://pubmed.ncbi.nlm.nih.gov/11769463 11769463]|[https://pubmed.ncbi.nlm.nih.gov/18263654 18263654]|[https://pubmed.ncbi.nlm.nih.gov/15843379 15843379]|[https://pubmed.ncbi.nlm.nih.gov/26659409 26659409]|[https://pubmed.ncbi.nlm.nih.gov/9003039 9003039]|[https://pubmed.ncbi.nlm.nih.gov/22087768 22087768]|[https://pubmed.ncbi.nlm.nih.gov/21771787 21771787]|[https://pubmed.ncbi.nlm.nih.gov/15173636 15173636]|[https://pubmed.ncbi.nlm.nih.gov/9210489 9210489]|[https://pubmed.ncbi.nlm.nih.gov/15258996 15258996]|[https://pubmed.ncbi.nlm.nih.gov/17924534 17924534]|[https://pubmed.ncbi.nlm.nih.gov/26382082 26382082]|[https://pubmed.ncbi.nlm.nih.gov/16171882 16171882]|[https://pubmed.ncbi.nlm.nih.gov/18802400 18802400]|[https://pubmed.ncbi.nlm.nih.gov/9800516 9800516]|[https://pubmed.ncbi.nlm.nih.gov/7504418 7504418]|[https://pubmed.ncbi.nlm.nih.gov/11891229 11891229]|[https://pubmed.ncbi.nlm.nih.gov/15232286 15232286]|[https://pubmed.ncbi.nlm.nih.gov/9013478 9013478]|[https://pubmed.ncbi.nlm.nih.gov/21621858 21621858]|[https://pubmed.ncbi.nlm.nih.gov/11677051 11677051]|[https://pubmed.ncbi.nlm.nih.gov/18668221 18668221]|[https://pubmed.ncbi.nlm.nih.gov/11414798 11414798]|[https://pubmed.ncbi.nlm.nih.gov/19265195 19265195]|[https://pubmed.ncbi.nlm.nih.gov/8982638 8982638]|[https://pubmed.ncbi.nlm.nih.gov/8798480 8798480]|[https://pubmed.ncbi.nlm.nih.gov/28403522 28403522]|[https://pubmed.ncbi.nlm.nih.gov/17935701 17935701]|[https://pubmed.ncbi.nlm.nih.gov/1691305 1691305]|[https://pubmed.ncbi.nlm.nih.gov/10998116 10998116]|[https://pubmed.ncbi.nlm.nih.gov/9364602 9364602]|[https://pubmed.ncbi.nlm.nih.gov/7528651 7528651]|[https://pubmed.ncbi.nlm.nih.gov/12472892 12472892]|[https://pubmed.ncbi.nlm.nih.gov/21176892 21176892]|[https://pubmed.ncbi.nlm.nih.gov/28416698 28416698]|[https://pubmed.ncbi.nlm.nih.gov/19389918 19389918]|[https://pubmed.ncbi.nlm.nih.gov/28427937 28427937]|[https://pubmed.ncbi.nlm.nih.gov/25450311 25450311] <br> | ||
'''definition''' : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322] <br> | '''definition''' : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322] <br> | ||
'''term_xref''' : GTC:G54406UD|GlycoEpitope:EP0001|CID: | '''term_xref''' : GTC:G54406UD|GlycoEpitope:EP0001|CID:46906103|CHEBI:60322|GlycoMotif:GGM.000058 <br> | ||
'''synonyms''' : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen <br> | '''synonyms''' : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen <br> | ||
'''function''' : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001] <br> | '''function''' : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001] <br> | ||
| Line 85: | Line 85: | ||
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27058295 27058295]|[https://pubmed.ncbi.nlm.nih.gov/15044398 15044398]|[https://pubmed.ncbi.nlm.nih.gov/28714086 28714086]|[https://pubmed.ncbi.nlm.nih.gov/29578688 29578688]|[https://pubmed.ncbi.nlm.nih.gov/26999365 26999365] <br> | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/27058295 27058295]|[https://pubmed.ncbi.nlm.nih.gov/15044398 15044398]|[https://pubmed.ncbi.nlm.nih.gov/28714086 28714086]|[https://pubmed.ncbi.nlm.nih.gov/29578688 29578688]|[https://pubmed.ncbi.nlm.nih.gov/26999365 26999365] <br> | ||
'''definition''' : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1–Asn-X-Ser/Thr is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the α-linked Man residue.[Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]] <br> | '''definition''' : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1–Asn-X-Ser/Thr is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the α-linked Man residue.[Essentials of Glycobiology:[https://www.ncbi.nlm.nih.gov/books/NBK453020/ Chapter 9]] <br> | ||
'''term_xref''' : GTC:G16828VN|CID: | '''term_xref''' : GTC:G16828VN|CID:91847108|CHEBI:147471 <br> | ||
'''synonyms''' : <br> | '''synonyms''' : <br> | ||
'''function''' : <br> | '''function''' : <br> | ||
| Line 116: | Line 116: | ||
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00058MO G00058MO]|[https://www.glygen.org/glycan/G46055MA G46055MA] <br> | '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G00058MO G00058MO]|[https://www.glygen.org/glycan/G46055MA G46055MA] <br> | ||
'''term_in_sentence''' : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]] <br> | '''term_in_sentence''' : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:[https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]] <br> | ||
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]| | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/2422274 2422274]|[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]| [https://pubmed.ncbi.nlm.nih.gov/21912254 21912254]|[https://pubmed.ncbi.nlm.nih.gov/12468428 12468428]|[https://pubmed.ncbi.nlm.nih.gov/28508465 28508465]|[https://pubmed.ncbi.nlm.nih.gov/6203982 6203982]|[https://pubmed.ncbi.nlm.nih.gov/30728302 30728302]|[https://pubmed.ncbi.nlm.nih.gov/8449405 8449405]|[https://pubmed.ncbi.nlm.nih.gov/9122902 9122902]|[https://pubmed.ncbi.nlm.nih.gov/10360315 10360315]|[https://pubmed.ncbi.nlm.nih.gov/6159787 6159787]|[https://pubmed.ncbi.nlm.nih.gov/6183759 6183759]|[https://pubmed.ncbi.nlm.nih.gov/518539 518539]|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951]|[https://pubmed.ncbi.nlm.nih.gov/21933024 21933024] <br> | ||
'''definition''' : <br> | '''definition''' : <br> | ||
'''term_xref''' : GlycoMotif:GGM.000004|GlycoMotif:GGM.000002|GTC:G46055MA|GTC:G00058MO <br> | '''term_xref''' : GlycoMotif:GGM.000004|GlycoMotif:GGM.000002|GTC:G46055MA|GTC:G00058MO <br> | ||
| Line 131: | Line 131: | ||
'''glycan_dictionary_accession''' : GSD000112 <br> | '''glycan_dictionary_accession''' : GSD000112 <br> | ||
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G56045WU G56045WU] <br> | '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G56045WU G56045WU] <br> | ||
'''term_in_sentence''' : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID: | '''term_in_sentence''' : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID:[https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]] <br> | ||
'''publication''' : | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/15679458 15679458]|[https://pubmed.ncbi.nlm.nih.gov/21912254 21912254]|[https://pubmed.ncbi.nlm.nih.gov/30705292 30705292]|[https://pubmed.ncbi.nlm.nih.gov/33403394 33403394]|[https://pubmed.ncbi.nlm.nih.gov/6715951 6715951]| [https://pubmed.ncbi.nlm.nih.gov/12468428 12468428]|[https://pubmed.ncbi.nlm.nih.gov/6088627 6088627]| [https://pubmed.ncbi.nlm.nih.gov/6159787 6159787] <br> | ||
'''definition''' : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390] <br> | '''definition''' : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390] <br> | ||
'''term_xref''' : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID: | '''term_xref''' : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:91852915|CHEBI:151390<br> | ||
'''synonyms''' : <br> | '''synonyms''' : <br> | ||
'''function''' : <br> | '''function''' : <br> | ||
| Line 149: | Line 149: | ||
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/1396705 1396705]|[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]|[https://pubmed.ncbi.nlm.nih.gov/2713378 2713378]|[https://pubmed.ncbi.nlm.nih.gov/3489485 3489485]|[https://pubmed.ncbi.nlm.nih.gov/18997175 18997175]|[https://pubmed.ncbi.nlm.nih.gov/7053385 7053385]|[https://pubmed.ncbi.nlm.nih.gov/3379797 3379797]|[https://pubmed.ncbi.nlm.nih.gov/2465279 2465279]|[https://pubmed.ncbi.nlm.nih.gov/3743633 3743633]|[https://pubmed.ncbi.nlm.nih.gov/11479210 11479210] <br> | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/1396705 1396705]|[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]|[https://pubmed.ncbi.nlm.nih.gov/2713378 2713378]|[https://pubmed.ncbi.nlm.nih.gov/3489485 3489485]|[https://pubmed.ncbi.nlm.nih.gov/18997175 18997175]|[https://pubmed.ncbi.nlm.nih.gov/7053385 7053385]|[https://pubmed.ncbi.nlm.nih.gov/3379797 3379797]|[https://pubmed.ncbi.nlm.nih.gov/2465279 2465279]|[https://pubmed.ncbi.nlm.nih.gov/3743633 3743633]|[https://pubmed.ncbi.nlm.nih.gov/11479210 11479210] <br> | ||
'''definition''' : <br> | '''definition''' : <br> | ||
'''term_xref''' : GlycoMotif:GGM.000071|GTC:G57710SU|CID: | '''term_xref''' : GlycoMotif:GGM.000071|GTC:G57710SU|CID: 91849719|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17 <br> | ||
'''synonyms''' : <br> | '''synonyms''' : <br> | ||
'''function''' : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]] <br> | '''function''' : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:[https://pubmed.ncbi.nlm.nih.gov/8504431 8504431]] <br> | ||
| Line 179: | Line 179: | ||
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G31736BK G31736BK] <br> | '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G31736BK G31736BK] <br> | ||
'''term_in_sentence''' : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:[https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]] <br> | '''term_in_sentence''' : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:[https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]] <br> | ||
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]|[https://pubmed.ncbi.nlm.nih.gov/31711843 31711843]|[https://pubmed.ncbi.nlm.nih.gov/31145522 31145522]|[https://pubmed.ncbi.nlm.nih.gov/27601469 27601469]|[https://pubmed.ncbi.nlm.nih.gov/30669833 30669833]|[https://pubmed.ncbi.nlm.nih.gov/25210040 25210040]|[https://pubmed.ncbi.nlm.nih.gov/24633693 24633693]|[https://pubmed.ncbi.nlm.nih.gov/24755437 24755437]|[https://pubmed.ncbi.nlm.nih.gov/22653491 22653491]|[https://pubmed.ncbi.nlm.nih.gov/30898876 30898876]|[https://pubmed.ncbi.nlm.nih.gov/7758724 7758724]|[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328]|[https://pubmed.ncbi.nlm.nih.gov/21305673 21305673]|[https://pubmed.ncbi.nlm.nih.gov/31558607 31558607]|[https://pubmed.ncbi.nlm.nih.gov/31271862 31271862]|[https://pubmed.ncbi.nlm.nih.gov/28549117 28549117]|[https://pubmed.ncbi.nlm.nih.gov/26213980 26213980]|[https://pubmed.ncbi.nlm.nih.gov/9134425 9134425]|[https://pubmed.ncbi.nlm.nih.gov/25561735 25561735]|[https://pubmed.ncbi.nlm.nih.gov/31756927 31756927]|[https://pubmed.ncbi.nlm.nih.gov/31170332 31170332]|[https://pubmed.ncbi.nlm.nih.gov/16282603 16282603]|[https://pubmed.ncbi.nlm.nih.gov/15265923 15265923]|[https://pubmed.ncbi.nlm.nih.gov/32267274 32267274]|[https://pubmed.ncbi.nlm.nih.gov/23015818 23015818]|[https://pubmed.ncbi.nlm.nih.gov/32676595 32676595]|[https://pubmed.ncbi.nlm.nih.gov/16728562 16728562]|[https://pubmed.ncbi.nlm.nih.gov/10814702 10814702]|[https://pubmed.ncbi.nlm.nih.gov/9591048 9591048]|[https://pubmed.ncbi.nlm.nih.gov/22245701 22245701]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628] [https://pubmed.ncbi.nlm.nih.gov/29751628 29751628]]|[https://pubmed.ncbi.nlm.nih.gov/22997242 22997242]|[https://pubmed.ncbi.nlm.nih.gov/15535969 15535969]|[https://pubmed.ncbi.nlm.nih.gov/31911241 31911241]|[https://pubmed.ncbi.nlm.nih.gov/30622255 30622255]|[https://pubmed.ncbi.nlm.nih.gov/29888905 29888905]|[https://pubmed.ncbi.nlm.nih.gov/30236114 30236114]| | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/25003135 25003135]|[https://pubmed.ncbi.nlm.nih.gov/31711843 31711843]|[https://pubmed.ncbi.nlm.nih.gov/31145522 31145522]|[https://pubmed.ncbi.nlm.nih.gov/27601469 27601469]|[https://pubmed.ncbi.nlm.nih.gov/30669833 30669833]|[https://pubmed.ncbi.nlm.nih.gov/25210040 25210040]|[https://pubmed.ncbi.nlm.nih.gov/24633693 24633693]|[https://pubmed.ncbi.nlm.nih.gov/24755437 24755437]|[https://pubmed.ncbi.nlm.nih.gov/22653491 22653491]|[https://pubmed.ncbi.nlm.nih.gov/30898876 30898876]|[https://pubmed.ncbi.nlm.nih.gov/7758724 7758724]|[https://pubmed.ncbi.nlm.nih.gov/22474328 22474328]|[https://pubmed.ncbi.nlm.nih.gov/21305673 21305673]|[https://pubmed.ncbi.nlm.nih.gov/31558607 31558607]|[https://pubmed.ncbi.nlm.nih.gov/31271862 31271862]|[https://pubmed.ncbi.nlm.nih.gov/28549117 28549117]|[https://pubmed.ncbi.nlm.nih.gov/26213980 26213980]|[https://pubmed.ncbi.nlm.nih.gov/9134425 9134425]|[https://pubmed.ncbi.nlm.nih.gov/25561735 25561735]|[https://pubmed.ncbi.nlm.nih.gov/31756927 31756927]|[https://pubmed.ncbi.nlm.nih.gov/31170332 31170332]|[https://pubmed.ncbi.nlm.nih.gov/16282603 16282603]|[https://pubmed.ncbi.nlm.nih.gov/15265923 15265923]|[https://pubmed.ncbi.nlm.nih.gov/32267274 32267274]|[https://pubmed.ncbi.nlm.nih.gov/23015818 23015818]|[https://pubmed.ncbi.nlm.nih.gov/32676595 32676595]|[https://pubmed.ncbi.nlm.nih.gov/16728562 16728562]|[https://pubmed.ncbi.nlm.nih.gov/10814702 10814702]|[https://pubmed.ncbi.nlm.nih.gov/9591048 9591048]|[https://pubmed.ncbi.nlm.nih.gov/22245701 22245701]|[https://pubmed.ncbi.nlm.nih.gov/[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628] [https://pubmed.ncbi.nlm.nih.gov/29751628 29751628]]|[https://pubmed.ncbi.nlm.nih.gov/22997242 22997242]|[https://pubmed.ncbi.nlm.nih.gov/15535969 15535969]|[https://pubmed.ncbi.nlm.nih.gov/31911241 31911241]|[https://pubmed.ncbi.nlm.nih.gov/30622255 30622255]|[https://pubmed.ncbi.nlm.nih.gov/29888905 29888905]|[https://pubmed.ncbi.nlm.nih.gov/30236114 30236114]| [https://pubmed.ncbi.nlm.nih.gov/30298790 30298790]|[https://pubmed.ncbi.nlm.nih.gov/29373511 29373511]|[https://pubmed.ncbi.nlm.nih.gov/22298779 22298779]|[https://pubmed.ncbi.nlm.nih.gov/19179461 19179461]|[https://pubmed.ncbi.nlm.nih.gov/31606752 31606752]|[https://pubmed.ncbi.nlm.nih.gov/15653684 15653684]|[https://pubmed.ncbi.nlm.nih.gov/16403022 16403022]|[https://pubmed.ncbi.nlm.nih.gov/11162373 11162373]|[https://pubmed.ncbi.nlm.nih.gov/32005658 32005658]|[https://pubmed.ncbi.nlm.nih.gov/30529570 30529570] <br> | ||
'''definition''' : An amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a β-linkage.[CHEBI:61190] <br> | '''definition''' : An amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a β-linkage.[CHEBI:61190] <br> | ||
'''term_xref''' : GTC:G31736BK|GlycoEpitope:P0150|CID: | '''term_xref''' : GTC:G31736BK|GlycoEpitope:P0150|CID:25257164 25257164|CHEBI:61190|GlycoMotif:GGM.000016 <br> | ||
'''synonyms''' : LDN <br> | '''synonyms''' : LDN <br> | ||
'''function''' : Has a role of epitope.[CHEBI:61190] <br> | '''function''' : Has a role of epitope.[CHEBI:61190] <br> | ||
| Line 211: | Line 211: | ||
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G06239NA G06239NA] <br> | '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G06239NA G06239NA] <br> | ||
'''term_in_sentence''' : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br> | '''term_in_sentence''' : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br> | ||
'''publication''' : [https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]|[https://pubmed.ncbi.nlm.nih.gov/20693232 20693232]|[https://pubmed.ncbi.nlm.nih.gov/26104834 26104834]|[https://pubmed.ncbi.nlm.nih.gov/27435676 27435676]|[https://pubmed.ncbi.nlm.nih.gov/26405105 26405105]|[https://pubmed.ncbi.nlm.nih.gov/32340400 32340400]|[https://pubmed.ncbi.nlm.nih.gov/25241919 25241919]|[https://pubmed.ncbi.nlm.nih.gov/23404501 23404501]|[https://pubmed.ncbi.nlm.nih.gov/32452379 32452379]|[https://pubmed.ncbi.nlm.nih.gov/2960671 2960671]|272643|[https://pubmed.ncbi.nlm.nih.gov/27711049 27711049]|[https://pubmed.ncbi.nlm.nih.gov/33202844 33202844]|[https://pubmed.ncbi.nlm.nih.gov/4060695 4060695]|[https://pubmed.ncbi.nlm.nih.gov/27638607 27638607]|[https://pubmed.ncbi.nlm.nih.gov/20547865 20547865]|[https://pubmed.ncbi.nlm.nih.gov/2277039 2277039]|[https://pubmed.ncbi.nlm.nih.gov/6238026 6238026]|[https://pubmed.ncbi.nlm.nih.gov/8448388 8448388]|[https://pubmed.ncbi.nlm.nih.gov/8489255 8489255]|[https://pubmed.ncbi.nlm.nih.gov/9363437 9363437]|[https://pubmed.ncbi.nlm.nih.gov/11836161 11836161]|[https://pubmed.ncbi.nlm.nih.gov/6892925 6892925]|[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117]|[https://pubmed.ncbi.nlm.nih.gov/6811267 6811267]|[https://pubmed.ncbi.nlm.nih.gov/8059935 8059935]|[https://pubmed.ncbi.nlm.nih.gov/7861954 7861954]|[https://pubmed.ncbi.nlm.nih.gov/11283017 11283017]|[https://pubmed.ncbi.nlm.nih.gov/8514762 8514762]|[https://pubmed.ncbi.nlm.nih.gov/1291049 1291049]| | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]|[https://pubmed.ncbi.nlm.nih.gov/20693232 20693232]|[https://pubmed.ncbi.nlm.nih.gov/26104834 26104834]|[https://pubmed.ncbi.nlm.nih.gov/27435676 27435676]|[https://pubmed.ncbi.nlm.nih.gov/26405105 26405105]|[https://pubmed.ncbi.nlm.nih.gov/32340400 32340400]|[https://pubmed.ncbi.nlm.nih.gov/25241919 25241919]|[https://pubmed.ncbi.nlm.nih.gov/23404501 23404501]|[https://pubmed.ncbi.nlm.nih.gov/32452379 32452379]|[https://pubmed.ncbi.nlm.nih.gov/2960671 2960671]|272643|[https://pubmed.ncbi.nlm.nih.gov/27711049 27711049]|[https://pubmed.ncbi.nlm.nih.gov/33202844 33202844]|[https://pubmed.ncbi.nlm.nih.gov/4060695 4060695]|[https://pubmed.ncbi.nlm.nih.gov/27638607 27638607]|[https://pubmed.ncbi.nlm.nih.gov/20547865 20547865]|[https://pubmed.ncbi.nlm.nih.gov/2277039 2277039]|[https://pubmed.ncbi.nlm.nih.gov/6238026 6238026]|[https://pubmed.ncbi.nlm.nih.gov/8448388 8448388]|[https://pubmed.ncbi.nlm.nih.gov/8489255 8489255]|[https://pubmed.ncbi.nlm.nih.gov/9363437 9363437]|[https://pubmed.ncbi.nlm.nih.gov/11836161 11836161]|[https://pubmed.ncbi.nlm.nih.gov/6892925 6892925]|[https://pubmed.ncbi.nlm.nih.gov/1551117 1551117]|[https://pubmed.ncbi.nlm.nih.gov/6811267 6811267]|[https://pubmed.ncbi.nlm.nih.gov/8059935 8059935]|[https://pubmed.ncbi.nlm.nih.gov/7861954 7861954]|[https://pubmed.ncbi.nlm.nih.gov/11283017 11283017]|[https://pubmed.ncbi.nlm.nih.gov/8514762 8514762]|[https://pubmed.ncbi.nlm.nih.gov/1291049 1291049]|[https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]|[https://pubmed.ncbi.nlm.nih.gov/10816509 10816509]|[https://pubmed.ncbi.nlm.nih.gov/12393713 12393713]|[https://pubmed.ncbi.nlm.nih.gov/6417117 6417117]|[https://pubmed.ncbi.nlm.nih.gov/11054095 11054095]|[https://pubmed.ncbi.nlm.nih.gov/8781973 8781973]|[https://pubmed.ncbi.nlm.nih.gov/1692829 1692829] <br> | ||
'''definition''' : A linear amino trisaccharide consisting of β-D-glucose at the reducing end having an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl group attached at the 4-position.[CHEBI:61758] <br> | '''definition''' : A linear amino trisaccharide consisting of β-D-glucose at the reducing end having an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl group attached at the 4-position.[CHEBI:61758] <br> | ||
'''term_xref''' : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID: | '''term_xref''' : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:10230777|CHEBI:61758|SugarBind_Ligand:20 <br> | ||
'''synonyms''' : Lc3|Lc(3)Cer|Lc_3 <br> | '''synonyms''' : Lc3|Lc(3)Cer|Lc_3 <br> | ||
'''function''' : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br> | '''function''' : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:[https://pubmed.ncbi.nlm.nih.gov/22411838 22411838]] <br> | ||
| Line 226: | Line 226: | ||
'''glycan_dictionary_accession''' : GSD000118 <br> | '''glycan_dictionary_accession''' : GSD000118 <br> | ||
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G62554JH G62554JH] <br> | '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G62554JH G62554JH] <br> | ||
'''term_in_sentence''' : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: | '''term_in_sentence''' : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]] <br> | ||
'''publication''' : | '''publication''' : [https://pubmed.ncbi.nlm.nih.gov/3805024 3805024]|[https://pubmed.ncbi.nlm.nih.gov/33395290 33395290] <br> | ||
'''definition''' : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521] <br> | '''definition''' : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521] <br> | ||
'''term_xref''' : GlycoMotif:GGM.000075|GTC:G62554JH|CID: | '''term_xref''' : GlycoMotif:GGM.000075|GTC:G62554JH|CID:91850076|CHEBI:152521|GlycoEpitope:EP0035 <br> | ||
'''synonyms''' : <br> | '''synonyms''' : <br> | ||
'''function''' : <br> | '''function''' : <br> | ||
Revision as of 19:06, 7 April 2023
Heparan sulfate
term (main_entry) : Heparan sulfate
glycan_dictionary_accession : GSD000106
glytoucan_accession :
term_in_sentence : In Niemann-Pick C-1 fibroblasts, where deaminative degradation of heparan sulfate is defective, carbonylated proteins were abundant.[PMID: 17540770]
publication : 32266657|29554552|29032302|30003471|25197032|28538085|26236728|16917509|22899865|17080204|23042481|28982096|24146040|25081076|15719168|17453622|25325954|21110089|29797526|21967329|23313092|11212344|28465034|11746174|12512855|8836040|28394734|24182748|28264929|28745308|26555370|14718374|16767693|25246018|19584012|8274190|25034023|8370471|26571620|29920400|31731076|20816205|16880267|31547957|11457867|27241222|28718936|21204109|31016560|11166215|11457866
definition : A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.[CHEBI:28815]
term_xref : CHEBI:28815|CID: 53477715|GlycoEpitope: EP0086
synonyms : Heparan N-sulfate|Heparan sulfate|Heparan sulphate|Heparatan sulfate|Heparin monosulfate| Heparin sulfate|Heparitin monosulfate|Heparitin sulfate|N-Acetylheparan sulfate
function : Heparan sulfate proteoglycans (HSPGs) play crucial roles regulating key developmental signaling pathways, such as the Wnt, Hedgehog, transforming growth factor-beta, and fibroblast growth factor pathways.[GlycoEpitope: EP0086]
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
Heparin
term (main_entry) : Heparin
glycan_dictionary_accession : GSD000107
glytoucan_accession :
term_in_sentence : Two cellulose-based membranes, containing 5 and 20% N, N-diethyl-aminoethyl cellulose (DEAE) respectively, were investigated for ionic attachment of heparin and heparin release.[PMID:6416324]
publication : 27100512|22566218|27264866|30094590|31077659|26975675|2083874|25088334|3333067|2191809|28118750|28224913|22495506|29385025|10332503|22393937|19947315|27655335|14529394|2419035|22048616|23849978|10204652|28958760|12627673|9042555|15639107|28880550|27238483|1964668|16716101|10796377|25981976|24680753|2191118|21166465|30582884|1322434|15330727|9752370|6416324|14996629|20452241|1340407|29050610|345399|6916469|6565376|26714061
definition : A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1→4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.[CHEBI:28304]
term_xref : CID:772|CHEBI:28304
synonyms : bemiparin|bemiparin|certoparin|Cy 222|enoxaparin|fluxum|Heparin|Heparinic acid|parnaparin|reviparin|sandoparin
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
Heparan sulfate/heparin
term (main_entry) : Heparan sulfate/heparin
glycan_dictionary_accession : GSD000185
glytoucan_accession :
term_in_sentence : Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. [PMID:31016560]
publication : 23313092|31016560|23152789
definition :
term_xref :
synonyms : HS/heparin|heparan sufate (HS)/heparin|H/HS
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
High mannose
term (main_entry) : High mannose
glycan_dictionary_accession : GSD000108
glytoucan_accession : G55220VL
term_in_sentence : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:11258925]
publication : 11258925|17956937|2059624|2065054|26791533|4077844|7780197|9136890|30659065|30075362|21421994|31076349|29738673|29508223|26747427|30634645|23007868|29051951|24549150|12417032|26724786|26956389|26493153|31102532|29673624|8348230|25586968|24975601|29803109|28465212|25776945|30151520|21097542|24326091|27995699|26003537|6722291|2925680|25565276|21460211|25196214|27387600|22373601|3729933|16423983|24174266|30605318|32371950
definition : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man .
term_xref : GTC:G55220VL|CID:70698382|CHEBI:71514
synonyms : oligomannose, high-mannose, oligomannose-type
function : Involved in promotion of protein folding in ER. [PMID:12417032].|High Man glycans are enriched at cell surface during apoptosis.[PMID: 17516205]
disease_associations : Relative abundance changes in multiple CDGs [PMID: 30770376][PMID: 28484880]
wikipedia :
essentials_of_glycobiology : Chapter 17
HNK-1
term (main_entry) : HNK-1
glycan_dictionary_accession : GSD000109
glytoucan_accession : G54406UD
term_in_sentence : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:28709864]
publication : 28709864|31738061|26738850|30306736|11070366|20855890|18024472|22669261|19729452|19796667|26850637|11769463|18263654|15843379|26659409|9003039|22087768|21771787|15173636|9210489|15258996|17924534|26382082|16171882|18802400|9800516|7504418|11891229|15232286|9013478|21621858|11677051|18668221|11414798|19265195|8982638|8798480|28403522|17935701|1691305|10998116|9364602|7528651|12472892|21176892|28416698|19389918|28427937|25450311
definition : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322]
term_xref : GTC:G54406UD|GlycoEpitope:EP0001|CID:46906103|CHEBI:60322|GlycoMotif:GGM.000058
synonyms : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen
function : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001]
disease_associations : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001]
wikipedia : https://en.wikipedia.org/wiki/N-linked_glycosylation
essentials_of_glycobiology : Chapter 17
Hybrid
term (main_entry) : Hybrid
glycan_dictionary_accession : GSD000110
glytoucan_accession : G16828VN
term_in_sentence : A hybrid-type N-glycan was accessed by total synthesis, converted to an oxazoline, and used as a donor substrate with both wild type Endo M and an N175Q glycosynthase Endo M mutant allowing the convergent synthesis of a glycosylated amino acid bearing a hybrid N-glycan structure. [PMID:27058295]
publication : 27058295|15044398|28714086|29578688|26999365
definition : An N-linked glycan in which the Manα1-6 arm of the trimannosyl core Manα1-3(Manα1-6)Manβ1-4GlcNAcβ1–4GlcNAcβ1–Asn-X-Ser/Thr is substituted by one or more additional Man residues and the Manα1-3 arm is substituted by a GlcNAc residue added by GlcNAcT1. The GlcNAc linked to the a3 Man can be extended in the same manner as any complex glycan antenna. The trimannosyl core can also be core fucosylated and/or bisected by the addition of a GlcNAc to the 3 position of the α-linked Man residue.[Essentials of Glycobiology:Chapter 9]
term_xref : GTC:G16828VN|CID:91847108|CHEBI:147471
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
Hyaluronan
term (main_entry) : Hyaluronan
glycan_dictionary_accession : GSD000183
glytoucan_accession : G29086KO
term_in_sentence : Hyaluronan (HA) comprises a major component of the extracellular matrix (ECM) in vertebrate connective tissues and is abundant in the cartilage, skin, brain, vitreous body, umbilical cord, and synovial fluid. [PMID:33171800]
publication : 33171800|34209222
definition :
term_xref : GTC:G29086KO
synonyms : HA
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
i antigen
term (main_entry) : i antigen
glycan_dictionary_accession : GSD000111
glytoucan_accession : G00058MO|G46055MA
term_in_sentence : Inasmuch as the hybridoma was established by hybridization of lymphocytes derived from regional lymph nodes of lung cancer, and the antigen was found in the patient's lung cancer tissue, the i antigen in lung cancer is probably recognized as a tumor-associated antigen by the host's immune cell system.[PMID:2422274]
publication : 2422274|15679458| 21912254|12468428|28508465|6203982|30728302|8449405|9122902|10360315|6159787|6183759|518539|6715951|21933024
definition :
term_xref : GlycoMotif:GGM.000004|GlycoMotif:GGM.000002|GTC:G46055MA|GTC:G00058MO
synonyms : Type 2 LN2
function :
disease_associations :
wikipedia :
essentials_of_glycobiology :
I antigen
term (main_entry) : I antigen
glycan_dictionary_accession : GSD000112
glytoucan_accession : G56045WU
term_in_sentence : The I antigen is formed by the action of an enzyme (a glycosyltransferase), which adds branches onto the i antigen.[PMID:15679458]
publication : 15679458|21912254|30705292|33403394|6715951| 12468428|6088627| 6159787
definition : N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4S,5S,6R)-4-[(2R,3R,4R,5S,6R)-3-Acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,5-dihydroxyoxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide (CHEBI:151390) is a amino sugar.[CHEBI:151390]
term_xref : GlycoMotif:GGM.000003|GlycoEpitope:EP0138|GTC:G56045WU|CID:91852915|CHEBI:151390
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 9
Isoglobotetraosylceramide
term (main_entry) : Isoglobotetraosylceramide
glycan_dictionary_accession : GSD000113
glytoucan_accession : G57710SU
term_in_sentence : Furthermore, isoglobotetraosylceramide seems to play a direct role in the metastatic process since the blocking of exposed antigen with monoclonal antibodies, or their Fab fragments, results in a highly significant decrease in lung colony formation.[PMID:8504431]
publication : 1396705|8504431|2713378|3489485|18997175|7053385|3379797|2465279|3743633|11479210
definition :
term_xref : GlycoMotif:GGM.000071|GTC:G57710SU|CID: 91849719|KEGG:G03211|CHEBI:148232|SugarBind_Ligand:17
synonyms :
function : a marker for highly metastatic cells in rat mammary adenocarcinomas[PMID:8504431]
disease_associations : Actinomycosis[SugarBind_Ligand:17]
wikipedia : https://en.wikipedia.org/wiki/Ii_antigen_system
essentials_of_glycobiology :
Keratan sulfate
term (main_entry) : Keratan sulfate
glycan_dictionary_accession : GSD000114
glytoucan_accession : G82109MW
term_in_sentence : Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties.[PMID: 30578672]
publication : 29340594|30578672|12512857|29625490|25325967|30025865|29924315|9549787|11030741|28078490|8298243|29096187|30059256|26958998|26773479|22840010|15597951|28110685|28535934|2942429|18234072|8641829|8940154|2027120|30849116|41589|6238957|1907283|7722002|29275050|24274541|2527236|1731862|8991509|24291704|10517185|6451953|7688312|8663590|139406|25770829|25036480|9275006|25179279|32627425|26903438|27941632|12807022|32266652|21624346
definition : A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions.[CHEBI:60924]
term_xref : CHEBI:60924|CID:446715|GlycoEpitope: EP0085|GTC: G82109MW
synonyms : keratan| Kerato sulphate|Kerato sulfate|Keratan sulphate|kerato 6'-sulfate|keratan 6'-sulfate|Kerato 6'-sulphate|Keratan 6'-sulphate
function : Tissue hydration.[PMID: 11030741]
disease_associations :
wikipedia :
essentials_of_glycobiology :
LacdiNac
term (main_entry) : LacdiNac
glycan_dictionary_accession : GSD000115
glytoucan_accession : G31736BK
term_in_sentence : We previously showed that the expression level of the LacdiNAc group in N-glycans decreases dramatically during the progression of human breast cancer.[PMID:25003135]
publication : 25003135|31711843|31145522|27601469|30669833|25210040|24633693|24755437|22653491|30898876|7758724|22474328|21305673|31558607|31271862|28549117|26213980|9134425|25561735|31756927|31170332|16282603|15265923|32267274|23015818|32676595|16728562|10814702|9591048|22245701|[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628 29751628]|22997242|15535969|31911241|30622255|29888905|30236114| 30298790|29373511|22298779|19179461|31606752|15653684|16403022|11162373|32005658|30529570
definition : An amino disaccharide consisting of N-acetylglucosamine having an N-acetylgalactosaminyl resiude attached at the 4-position via a β-linkage.[CHEBI:61190]
term_xref : GTC:G31736BK|GlycoEpitope:P0150|CID:25257164 25257164|CHEBI:61190|GlycoMotif:GGM.000016
synonyms : LDN
function : Has a role of epitope.[CHEBI:61190]
disease_associations :
wikipedia :
essentials_of_glycobiology :
Lactosylceramide
term (main_entry) : Lactosylceramide
glycan_dictionary_accession : GSD000116
glytoucan_accession : G84224TW
term_in_sentence : In the 1970s, a neutral glycosphingolipid lactosylceramide (LacCer) was found to bind specifically to several kinds of microorganisms.[PMID:30175814]
publication : 30175814|26900161|30502090|29624959|28444900|25408340|31801289|29099167|25595946|32592089|27729551|24658420|25216636|25638276|9499377|17986153|8143857|23801329|18077097|32708181|15346887|19015977|18393821|25279740|21057870|11915327|25212460|23882130|11915329|8195125|8808768|3396945|22128256|6733104|24968752|32518749|30688114|7666005|8200356|24718572|6193809|25781947|12383912|26086247|30606995|12419803
definition : Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.[MeSH:D007790]
term_xref : GTC:G84224TW|MeSH:D007790|GlycoMotif:GGM.000064|GlycoEpitope:EP0078|SugarBind_Ligand:3
synonyms : LacCer|Lc2|CDH
function : mammalian cell receptors for Neisseria gonorrhoeae recognized by Helicobacter pylori[GlycoEpitope:EP0078]
disease_associations : chronic gastritis[GlycoEpitope:EP0078,SugarBind_Ligand:3]|duodenal ulcers[GlycoEpitope:EP0078]|gastric adenocarcinoma[GlycoEpitope:EP0078,SugarBind_Ligand:3]|gastric ulcers[GlycoEpitope:EP0078]|Pleuropneumonia[SugarBind_Ligand:3]|Porcine fibrinohemorrhagic necrotizing pleuropneumonia[SugarBind_Ligand:3]|Actinomycosis[SugarBind_Ligand:3]|Pertussis[SugarBind_Ligand:3]|Candidiasis[SugarBind_Ligand:3]|Cryptococcosis[SugarBind_Ligand:3]|Hemorrhagic colitis[SugarBind_Ligand:3]|Peptic ulcers[SugarBind_Ligand:3]|Histoplasmosis[SugarBind_Ligand:3]|Pharyngitis[SugarBind_Ligand:3]|Tracheobronchitis[SugarBind_Ligand:3]|Gonorrhea[SugarBind_Ligand:3]|Sporotrichosis[SugarBind_Ligand:3]|Plague[SugarBind_Ligand:3]|Diarrhea[SugarBind_Ligand:3]
wikipedia :
essentials_of_glycobiology : Chapter 17
Lactotriaosylceramide
term (main_entry) : Lactotriaosylceramide
glycan_dictionary_accession : GSD000117
glytoucan_accession : G06239NA
term_in_sentence : The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML.[PMID:22411838]
publication : 22411838|20693232|26104834|27435676|26405105|32340400|25241919|23404501|32452379|2960671|272643|27711049|33202844|4060695|27638607|20547865|2277039|6238026|8448388|8489255|9363437|11836161|6892925|1551117|6811267|8059935|7861954|11283017|8514762|1291049|3805024|10816509|12393713|6417117|11054095|8781973|1692829
definition : A linear amino trisaccharide consisting of β-D-glucose at the reducing end having an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl group attached at the 4-position.[CHEBI:61758]
term_xref : GTC:G06239NA|GlycoMotif:GGM.000067|MeSH:C025575|CID:10230777|CHEBI:61758|SugarBind_Ligand:20
synonyms : Lc3|Lc(3)Cer|Lc_3
function : acute myeloid leukemia-associated glycosphingolipids lactotriaosylceramide, GM3 and neolactotetraosylceramide are possibly involved in initiation and differentiation of acute myeloid leukemia.[PMID:22411838]
disease_associations : Pharyngitis[SugarBind_Ligand:20]|Tracheobronchitis[SugarBind_Ligand:20]|Gonorrhea[SugarBind_Ligand:20]|Actinomycosis[SugarBind_Ligand:20]|Diarrhea[SugarBind_Ligand:20]
wikipedia :
essentials_of_glycobiology : Chapter 14
LcGg4
term (main_entry) : LcGg4
glycan_dictionary_accession : GSD000118
glytoucan_accession : G62554JH
term_in_sentence : Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 [PMID: 3805024]
publication : 3805024|33395290
definition : N-[(2S,3R,4R,5R,6R)-2-[(2R,3S,4R,5R,6S)-4-[(2S,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide is an oligosaccharide.[CHEBI:152521]
term_xref : GlycoMotif:GGM.000075|GTC:G62554JH|CID:91850076|CHEBI:152521|GlycoEpitope:EP0035
synonyms :
function :
disease_associations :
wikipedia :
essentials_of_glycobiology : Chapter 14
Lewis a
term (main_entry) : Lewis a
glycan_dictionary_accession : GSD000119
glytoucan_accession : G00047MO
term_in_sentence : Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). [PMID:29367698]
publication : 29367698|27187324|30562693|[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625 27646625]|26911286|30225822|28600306|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|11064310|23809433|30050155|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|1675497|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|27705835|7593252|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|17630273|9350993|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001]
definition : A lewis blood group antigen with structure beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-D-GlcpNAc consisting of N-acetylglucosamine having a fucosyl residue attached at the 4-position via an alpha-linkage and a galactosyl residue attached at the 3-position via a beta-linkage. It has a role as an epitope and an antigen. It is an amino trisaccharide and a glucosamine oligosaccharide.[CHEBI:62265]
term_xref : GTC:G00047MO|CID:22806751|CHEBI:62265|GlycoMotif:GGM.000020|SugarBind_Ligand:155
synonyms : Le(a)|Lea-3|Lea|Le^a
function :
disease_associations : Gastroenteritis[SugarBind_Ligand:155]
wikipedia : https://www.wikidata.org/wiki/Q50687009
essentials_of_glycobiology :
Lewis b
term (main_entry) : Lewis b
glycan_dictionary_accession : GSD000120
glytoucan_accession : G39211DH
term_in_sentence : Human mannose-binding lectin preferentially binds to human colon adenocarcinoma cell lines expressing high amount of Lewis A and Lewis B antigens.[PMID:10328552]
publication : 10328552|23408949|31927399|26601230|28279343|[https://pubmed.ncbi.nlm.nih.gov/32527016 32527016 32527016]|30831115|27318698|[https://pubmed.ncbi.nlm.nih.gov/9207264 9207264 9207264]|23828675|[https://pubmed.ncbi.nlm.nih.gov/29527514 29527514 29527514]|[https://pubmed.ncbi.nlm.nih.gov/1615929 1615929 1615929]|[https://pubmed.ncbi.nlm.nih.gov/2385097 2385097 2385097]|[https://pubmed.ncbi.nlm.nih.gov/2579997 2579997 2579997]|25516619|[https://pubmed.ncbi.nlm.nih.gov/3677023 3677023 3677023]|8509439|19832116|15270746|3166398|30909206|7718581|18400963|[https://pubmed.ncbi.nlm.nih.gov/29751628 29751628 29751628]|8982241|30284922|24576035|30974776|[https://pubmed.ncbi.nlm.nih.gov/9098001 9098001 9098001]|31768613|1651804|25428879|15946883|[https://pubmed.ncbi.nlm.nih.gov/30298790 30298790 30298790]|30544260|29197783|8632739|7679772|18666312|20231766|29922666|95124|2247887|21519121|25153235|28751211
definition :
term_xref : GlycoMotif:GGM.000021|SugarBind_Ligand:146|GTC:G39211DH|CID:45480568|CHEBI:59440
synonyms : Le(b)|Lewis(b)|Le^b
function : possible receptor for Helicobacter pylori[https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/blood-group-lewis-system]
disease_associations : Gastroenteritis[SugarBind_Ligand:146]
wikipedia :
essentials_of_glycobiology :
Lewis x
term (main_entry) : Lewis x
glycan_dictionary_accession : GSD000121
glytoucan_accession : G00051MO
term_in_sentence : In particular, the observation of oxonium ions at m/z 512.2 and 803.2 is useful for probing outer non-reducing terminal fucosylation, which represented carbohydrate structures consisting of Hex Hex , dHex Hex , and HexNAc , and NeuNAc , Hex Hex , dHex Hex , and HexNAc , respectively, from which the Lewis X structure (Galbeta1-4(Fucalpha1-3)GlcNAc) was readily deduced.[PMID:15536627]
publication : 15536627|31666308|29019053|28296340|29593094|17607374|16581086|20858014|19962782|7912739|25121780|24059473|29210428|31276881|9015359|7628844|7499837|16850248|28425129|28869691|19576189|10223649|22593503|15632313|27198630|26582608|11500392|31256373|23399157|21984435|26244810|26162743|17335083|15388363|9556613|10760152|11267844|20876654|12131290
definition : A Lewis blood group antigen with structure α-L-Fucp-(1→3)-[β-D-Galp-(1→4)]-D-GlcpNAc where the glucosamine at the reducing end has β-configuration at its anomeric centre. Commonly known as Lewis x trisaccharide or Lex.[CHEBI:59294]
term_xref : GTC:G00051MO |GlycoEpitope:EP0011|CID:44611539|CHEBI:59294|GlycoMotif:GGM.000018
synonyms : Lex|Galbeta1-4(Fucalpha1-3)GlcNAc|Lewis x trisaccharide|Le(X)|Le^x|SSEA-1
function : Involved in carbohydrate-carbohydrate interaction[Glycoepitope:EP0011].|Also implicated in apoptosis.[Glycoepitope:EP0011]|influence antigenic presentation and interfere with pathogen transfer in breastfed infants.[Glycoepitope:EP0011]
disease_associations : acute leukemia[GlycoEpitope:EP0011]|lymphoma[GlycoEpitope:EP0011]
wikipedia :
essentials_of_glycobiology : Chapter 14
Lewis y
term (main_entry) : Lewis y
glycan_dictionary_accession : GSD000122
glytoucan_accession : G00052MO
term_in_sentence : In conclusion, Lewis y antigen and CD147 were significantly upregulated in ovarian tumors, and the altered expression of Lewis y may cause changes in CD147.[PMID:[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]]
publication : [https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]|[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467 20003467]|[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145 24692145]|[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328 24998328]|[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913 25726913]|29299130|[https://pubmed.ncbi.nlm.nih.gov/30816446 30816446 30816446]|[https://pubmed.ncbi.nlm.nih.gov/20003467 20003467 20003467]|[https://pubmed.ncbi.nlm.nih.gov/24692145 24692145 24692145]|[https://pubmed.ncbi.nlm.nih.gov/24998328 24998328 24998328]|20127027|22138668|23894390|[https://pubmed.ncbi.nlm.nih.gov/25726913 25726913 25726913]|25416440|[https://pubmed.ncbi.nlm.nih.gov/27646625 27646625 27646625]|23725446|21294926|22312289|25973320|23242548|30328452|21119363|29130097|23443083|23708102|28671040|19715603|23468946|27723168|21747684|19771739
definition : A Lewis blood group antigen which is a branched amino tetrasaccharide with structure alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, consisting of consisting of N-acetyl-beta-D-glucosamine at the reducing end having an alpha-L-fucosyl residue attached at the 3-position and an alpha-L-fucosyl-(1→2)-beta-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure. It has a role as an antigen and an epitope. [CHEBI:59045]]
term_xref : GTC:G00052MO|GlycoEpitope:EP0018|CID:45266908|CHEBI:59045|GlycoMotif:GGM.000019
synonyms : LeY|Le(y)|Ley|Le^y
function : The expression of the fucosylated histo-blood group antigen CD174 in CD34+ hematopoietic progenitor cells and down-regulation of FUT1 in mature lymphocytes may be important factors influencing the homing process of hematopoietic stem cells to the bone marrow.[GlycoEpitope:EP0018]
disease_associations : AIDS/acquired immune deficiency syndrome[GlycoEpitope:EP0018]|cholangiocarcinoma[GlycoEpitope:EP0018]|hepatocellular carcinoma[GlycoEpitope:EP0018]
wikipedia :
essentials_of_glycobiology : Chapter 14