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'''term (main_entry)''' : Sialyl Lewis a
'''glycan_dictionary_accession''' : GSD000150
'''glytoucan_accession'''  : G00053MO
'''term_in_sentence''' : By comparing the serum O-glycan profiles from healthy controls with those of cancer patients, we identified a marker candidate, core 1 sialyl Lewis A (NeuAcα2-3Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal) (abbreviated C1SLA), whose concentration appeared to be weakly correlated with CA19-9 values.[PMID:26641888]
'''publication''' : 26641888|31424423|26530370|17760270|18343410|16033091|8829184|11907351|20592391|26641888|24128856|30249386|10773785|16149606|10996727|10436809|10667238|7720892|7630017|10612415|9836451|12511721|22623153
'''definition''' : A sialyated version of Lewis A with a branched structure of amino tetrasaccharide consisting of a sialyl residue, linked (2→3) to a galactosyl residue that in turn is linked (1→3) to a glucosaminyl residue at the reducing end, which is also carrying a fucosyl residue at the 4-position.[CHEBI:62681]
'''term_xref''' : GTC:G00053MO|GlycoEpitope:EP0008|CID:53356732|CHEBI:62681|GlycoMotif:GGM.000024
'''synonyms''' : SLea|CA19-9|CA19-9 antigen|SLe^a|Slea
'''function''' : The carbohydrate determinants,Sialyl Lea and Sialyl Lex,which are frequently expressed on human cancer cells,serve as ligands for a cell adhesion molecule of the selectin family,E-selectin,which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer.[GlycoEpitope:EP0008]
'''disease_associations''' : pancreatic adenocarcinoma[GlycoEpitope:EP0008]|hepatocellular cancer[GlycoEpitope:EP0008]|cholangiocellular cancer[GlycoEpitope:EP0008]|gastric cancer|[GlycoEpitope:EP0008]colorectal cancer[GlycoEpitope:EP0008]|ovarian cancer[GlycoEpitope:EP0008]|lung cancer[GlycoEpitope:EP0008]|breast cancer[GlycoEpitope:EP0008]|uterine cancer[GlycoEpitope:EP0008]
'''wikipedia''' :


   
===High mannose===
[[File:G55220VL.png|thumb|G55220VL]]
  '''term (main_entry)''' : High mannose <br>
'''glycan_dictionary_accession''' : GSD000108 <br>
'''glytoucan_accession ''' : [https://www.glygen.org/glycan/G55220VL G55220VL] <br>
'''term_in_sentence''' : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a></a>] <br>
'''publication''' : <a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a></a>|<a href="https://pubmed.ncbi.nlm.nih.gov/17956937">17956937</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/2059624">2059624</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/2065054">2065054</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26791533">26791533</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/4077844">4077844</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/7780197">7780197</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9136890">9136890</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30659065">30659065</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30075362">30075362</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21421994">21421994</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/31076349">31076349</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29738673">29738673</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29508223">29508223</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26747427">26747427</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30634645">30634645</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/23007868">23007868</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29051951">29051951</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24549150">24549150</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a></a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26724786">26724786</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26956389">26956389</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26493153">26493153</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/31102532">31102532</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29673624">29673624</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/8348230">8348230</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25586968">25586968</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24975601">24975601</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29803109">29803109</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28465212">28465212</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25776945">25776945</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30151520">30151520</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21097542">21097542</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24326091">24326091</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/27995699">27995699</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26003537">26003537</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/6722291">6722291</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/2925680">2925680</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25565276">25565276</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21460211">21460211</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25196214">25196214</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/27387600">27387600</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/22373601">22373601</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/3729933">3729933</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/16423983">16423983</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24174266">24174266</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30605318">30605318</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/32371950">32371950</a><br>
'''definition''' : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man . <br>
'''term_xref''' : GTC:G55220VL|CID:<a href="https://pubmed.ncbi.nlm.nih.gov/70698382">70698382</a>|CHEBI:71514<br>
'''synonyms''' : oligomannose, high-mannose, oligomannose-type <br>
'''function''' : Involved in promotion of protein folding in ER. [PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a></a>].|High Man glycans are enriched at cell surface during apoptosis.[PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/17516205">17516205</a>] <br>
'''disease_associations''' : Relative abundance changes in multiple CDGs [PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30770376">30770376</a>][PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/28484880">28484880</a>] <br>
'''wikipedia''' :  <br>
'''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17] <br>




 
===HNK-1===
 
[[File:G54406UD.png|thumb|G54406UD]]
 
  '''term (main_entry)''' : HNK-1 <br>
2-Fucosyl-GM1
  '''glycan_dictionary_accession''' : GSD000109 <br>
G56526JU
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G54406UD G54406UD] <br>
  '''term_in_sentence''' : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a></a>] <br>
term (main_entry) : 2-Fucosyl-GM1
  '''publication''' : <a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a></a>|<a href="https://pubmed.ncbi.nlm.nih.gov/31738061">31738061</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26738850">26738850</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30306736">30306736</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11070366">11070366</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/20855890">20855890</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18024472">18024472</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/22669261">22669261</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19729452">19729452</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19796667">19796667</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26850637">26850637</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11769463">11769463</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18263654">18263654</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15843379">15843379</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26659409">26659409</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9003039">9003039</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/22087768">22087768</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21771787">21771787</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15173636">15173636</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9210489">9210489</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15258996">15258996</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/17924534">17924534</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26382082">26382082</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/16171882">16171882</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18802400">18802400</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9800516">9800516</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/7504418">7504418</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11891229">11891229</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15232286">15232286</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9013478">9013478</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21621858">21621858</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11677051">11677051</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18668221">18668221</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11414798">11414798</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19265195">19265195</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/8982638">8982638</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/8798480">8798480</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28403522">28403522</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/17935701">17935701</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/1691305">1691305</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/10998116">10998116</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9364602">9364602</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/7528651">7528651</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/12472892">12472892</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21176892">21176892</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28416698">28416698</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19389918">19389918</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28427937">28427937</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25450311">25450311</a> <br>
  '''definition''' : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322] <br>
glycan_dictionary_accession : GSD000004
  '''term_xref''' : GTC:G54406UD|GlycoEpitope:EP0001|CID:<a href="https://pubmed.ncbi.nlm.nih.gov/46906103">46906103</a>|CHEBI:60322|GlycoMotif:GGM.000058 <br>
  '''synonyms''' : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen <br>
glytoucan_accession  : G56526JU
'''function''' : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001] <br>
  '''disease_associations''' : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001] <br>
term_in_sentence : These glycolipid products were identified as asialo-Gs.., GM h and fucosyl-Gq, by comparison with authentic glycolipid samples.[PMID:3654655]
  '''wikipedia''' : https://en.wikipedia.org/wiki/N-linked_glycosylation <br>
  '''essentials_of_glycobiology''' : [https://www.ncbi.nlm.nih.gov/books/NBK453033/ Chapter 17]<br>
publication : 3654655
definition : (2S,4S,5R,6R)-5-Acetamido-2-[(2R,3S,4R,5R,6S)-3-[(2S,3R,4R,5R,6R)-3-acetamido-4-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid.[CHEBI:151476]
term_xref : KEGG:G12241|CHEBI:151476|CID:91849786|GlycoMotif:GGM.000101|GTC:G56526JU
synonyms : Fuc(a1-2)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc|6-deoxy-alpha-L-galacto-hexopyranosyl-(1→2)-beta-D-galacto-hexopyranosyl-(1→3)-2-acetamido-2-deoxy-beta-D-galacto-hexopyranosyl-(1→4)-[5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2→3)]-beta-D-galacto-hexopyranosyl-(1→4)-D-gluco-hexopyranose
function :
disease_associations :
wikipedia :
 
 
===2,6-Branched O-mannose===
[[File:G06953DR.png|thumb|G06953DR]]
  '''term (main_entry)''' : 2,6-Branched O-mannose
  '''glycan_dictionary_accession''' : GSD000001
  '''glytoucan_accession ''' : [https://www.glygen.org/glycan/G06953DR G06953DR]  
  '''term_in_sentence''' : Collectively, these results strongly suggest that GnT-IX may be a novel beta1,6-N-acetylglucosaminyltransferase that is responsible for the formation of the 2,6-branched structure in the brain O-mannosyl glycan.[PMID:[https://pubmed.ncbi.nlm.nih.gov/14617637 14617637]]  
  '''publication''' : 14617637|10469154
  '''definition''' : (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-acetamido-6-[[(2R,3S,4S,5S,6S)-5-[(2S,3R,4R,5S,6R)-3-acetamido-5-[(2S,3R,4S,5S,6R)-4-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,6-trihydroxyoxan-2-yl]methoxy]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid.[CHEBI:157265]
   
  '''term_xref''' : CHEBI:157265|GlycoMotif:GGM.000056|GTC:G06953DR
   
  '''synonyms''' : 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2→3)-beta-D-galacto-hexopyranosyl-(1→4)-2-acetamido-2-deoxy-beta-D-gluco-hexopyranosyl-(1→2)-[5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid-(2→3)-beta-D-galacto-hexopyranosyl-(1→4)-2-acetamido-2-deoxy-beta-D-gluco-hexopyranosyl-(1→6)]-alpha-D-manno-hexopyranose|NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)]a-Man
   
  '''function''' :
  '''disease_associations''' :

Revision as of 16:14, 29 March 2023

High mannose

G55220VL
term (main_entry) : High mannose 

glycan_dictionary_accession : GSD000108 

glytoucan_accession  : G55220VL 

term_in_sentence : Each glycoform contained a number of peaks differing by 162 Da indicating heterogeneity and suggesting the presence of high-mannose sugars.[PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a></a>] 

publication : <a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/11258925">11258925</a></a>|<a href="https://pubmed.ncbi.nlm.nih.gov/17956937">17956937</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/2059624">2059624</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/2065054">2065054</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26791533">26791533</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/4077844">4077844</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/7780197">7780197</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9136890">9136890</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30659065">30659065</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30075362">30075362</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21421994">21421994</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/31076349">31076349</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29738673">29738673</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29508223">29508223</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26747427">26747427</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30634645">30634645</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/23007868">23007868</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29051951">29051951</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24549150">24549150</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a></a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26724786">26724786</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26956389">26956389</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26493153">26493153</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/31102532">31102532</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29673624">29673624</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/8348230">8348230</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25586968">25586968</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24975601">24975601</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/29803109">29803109</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28465212">28465212</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25776945">25776945</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30151520">30151520</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21097542">21097542</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24326091">24326091</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/27995699">27995699</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26003537">26003537</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/6722291">6722291</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/2925680">2925680</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25565276">25565276</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21460211">21460211</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25196214">25196214</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/27387600">27387600</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/22373601">22373601</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/3729933">3729933</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/16423983">16423983</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/24174266">24174266</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30605318">30605318</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/32371950">32371950</a>

definition : An N-linked oligosaccharide that possesses between five and nine mannose residues attached to the chitobiose [(GlcNAc)2] core. [CHEBI:5717] None of the Man residues are substituted with any monosaccharide other than Man . 

term_xref : GTC:G55220VL|CID:<a href="https://pubmed.ncbi.nlm.nih.gov/70698382">70698382</a>|CHEBI:71514

synonyms : oligomannose, high-mannose, oligomannose-type 

function : Involved in promotion of protein folding in ER. [PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/12417032">12417032</a></a>].|High Man glycans are enriched at cell surface during apoptosis.[PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/17516205">17516205</a>] 

disease_associations : Relative abundance changes in multiple CDGs [PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30770376">30770376</a>][PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/28484880">28484880</a>] 

wikipedia :  

essentials_of_glycobiology : Chapter 17


HNK-1

G54406UD
term (main_entry) : HNK-1 

glycan_dictionary_accession : GSD000109 

glytoucan_accession  : G54406UD 

term_in_sentence : The human natural killer-1 (HNK-1) carbohydrate, a unique trisaccharide possessing sulfated glucuronic acid in a non-reducing terminus (HSO3-3GlcAß1-3Galß1-4GlcNAc-), is highly expressed in the nervous system and its spatiotemporal expression is strictly regulated.[PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a></a>] 

publication : <a href="https://pubmed.ncbi.nlm.nih.gov/<a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a>"><a href="https://pubmed.ncbi.nlm.nih.gov/28709864">28709864</a></a>|<a href="https://pubmed.ncbi.nlm.nih.gov/31738061">31738061</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26738850">26738850</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/30306736">30306736</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11070366">11070366</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/20855890">20855890</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18024472">18024472</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/22669261">22669261</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19729452">19729452</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19796667">19796667</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26850637">26850637</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11769463">11769463</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18263654">18263654</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15843379">15843379</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26659409">26659409</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9003039">9003039</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/22087768">22087768</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21771787">21771787</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15173636">15173636</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9210489">9210489</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15258996">15258996</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/17924534">17924534</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/26382082">26382082</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/16171882">16171882</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18802400">18802400</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9800516">9800516</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/7504418">7504418</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11891229">11891229</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/15232286">15232286</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9013478">9013478</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21621858">21621858</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11677051">11677051</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/18668221">18668221</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/11414798">11414798</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19265195">19265195</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/8982638">8982638</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/8798480">8798480</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28403522">28403522</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/17935701">17935701</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/1691305">1691305</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/10998116">10998116</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/9364602">9364602</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/7528651">7528651</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/12472892">12472892</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/21176892">21176892</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28416698">28416698</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/19389918">19389918</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/28427937">28427937</a>|<a href="https://pubmed.ncbi.nlm.nih.gov/25450311">25450311</a> 

definition : An amino trisaccharide consisting of a 3-O-sulfo-β-D-glucuronic acid residue, a D-galactosyl residue and an N-acetyl-D-glucosamine residue (at the reducing end) in a linear sequence.[CHEBI:60322] 

term_xref : GTC:G54406UD|GlycoEpitope:EP0001|CID:<a href="https://pubmed.ncbi.nlm.nih.gov/46906103">46906103</a>|CHEBI:60322|GlycoMotif:GGM.000058 

synonyms : HNK-1 carbohydrate epitope| CD57|HNK-1 antigen 

function : learning and memory[GlycoEpitope:EP0001]|neural crest cell migration[GlycoEpitope:EP0001]|neurite extension[GlycoEpitope:EP0001]|neuron-astrocyte adhesion[GlycoEpitope:EP0001] 

disease_associations : schizophrenia-like psychosis[GlycoEpitope:EP0001]|neuropathy[GlycoEpitope:EP0001]|exfoliation syndrome[GlycoEpitope:EP0001]|secondary cataract[GlycoEpitope:EP0001] 

wikipedia : https://en.wikipedia.org/wiki/N-linked_glycosylation 

essentials_of_glycobiology : Chapter 17
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